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Circadian Integration of Metabolism and Energetics
Open accessAbstract
Circadian clocks align behavioral and biochemical processes with the day/night cycle. Nearly all vertebrate cells possess self-sustained clocks that couple endogenous rhythms with changes in cellular environment. Genetic disruption of clock genes in mice perturbs metabolic functions of specific tissues at distinct phases of the sleep/wake cycle. Circadian desynchrony, a characteristic of shift work and sleep disruption in humans, also leads to metabolic pathologies. Here, we review advances in understanding the interrelationship among circadian disruption, sleep deprivation, obesity, and diabetes and implications for rational therapeutics for these conditions.
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“Systemic and tissue-specific disruption of the circadian machinery leads to changes in cellular functions such as cell division and metabolism, both highly relevant to cancer (Bass and Takahashi, 2010; Hanahan and Weinberg, 2011; Masri et al., 2016; Sahar and Sassone-Corsi, 2009).”
From Circadian Rhythm Disruption Promotes Lung Tumorigenesis (2016) · cites this paper as Bass and Takahashi, 2010
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“This complex interconnected regulatory framework, ensures that the same molecules that regulate metabolism and reproduction, also contribute to a bidirectional feedback system with the autonomous circadian circuits [224,231]. This results in synchronicity of internal physiology with environmental cues, to optimize both individual and species survival.”
From Polycystic Ovary Syndrome: An Evolutionary Adaptation to Lifestyle and the Environment (2022) · cites this paper as [231]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
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“The molecular mechanisms of circadian clocks are similar across all species and are regulated by genetic enhancer/repressor elements, epigenetic modulation by methylation and acetylation, post-translation modification of regulatory proteins, and a variety of hormonal and signaling molecules [220,229,231].”
From Polycystic Ovary Syndrome: An Evolutionary Adaptation to Lifestyle and the Environment (2022) · cites this paper as [231]
Experimental — accuracy not yet measuredIn the citing paper
“The liver is the focus of circadian regulation of metabolic pathways, especially those controlling the synthesis and metabolism of glucose, lipid, cholesterol and bile acid (Bass and Takahashi, 2010).”
From Circadian Homeostasis of Liver Metabolism Suppresses Hepatocarcinogenesis (2016) · cites this paper as Bass and Takahashi, 2010
In the citing paper
“Circadian dysfunction among night-shift workers and individuals suffering from sleep dyspnea has been identified as a common risk factor of obesity, metabolic disorders, NAFLD and cancer including HCC (Bass and Takahashi, 2010; Fu and Kettner, 2013; Hu et al., 2013; Kao et al., 2012; Kim et al., 2013; Zimberg et al., 2012).”
From Circadian Homeostasis of Liver Metabolism Suppresses Hepatocarcinogenesis (2016) · cites this paper as Bass and Takahashi, 2010
In the citing paper
“Sleep loss is often accompanied with circadian misalignment, also known to cause changes in the regulation of the immune system and metabolism and associate to cardiovascular diseases7273.”
From Prolonged sleep restriction induces changes in pathways involved in cholesterol metabolism and inflammatory responses (2016) · cites this paper as [72]
In the citing paper
“Evidence is rapidly accumulating to indicate that misalignment between central and peripheral clocks has a host of adverse effects, including an increased risk of obesity and type 2 diabetes (37, 39).”
From Adverse effects of two nights of sleep restriction on the hypothalamic-pituitary-adrenal axis in healthy men (2014) · cites this paper as [39]
In the citing paper
“For the metabolic syndrome, a systematic review by Canuto et al. in 2013 of ten studies, identified eight studies that found a positive association between shift work and metabolic syndrome after adjustment for sociodemographic and behavioural factors (19) .”
From Meal irregularity and cardiometabolic consequences: results from observational and intervention studies (2016) · cites this paper as [19]
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“However, only three studies also adjusted for sleep duration and these showed conflicting results.”
From Meal irregularity and cardiometabolic consequences: results from observational and intervention studies (2016) · cites this paper as [19]
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Metadata
- Authors
- Bass, J., & Takahashi, J. S.
- Affiliations
- Northwestern University (US)
- Howard Hughes Medical Institute (US)
- Corresponding author
- Bass, Joseph
- Venue
- Science
- Published
- 2010-12-03
- Volume
- 330
- Issue
- 6009
- Pages
- 1349-1354
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- PMC
- PMC3756146
- OpenAlex
- W2157481078
- Cited by
- 1,910
- References
- 69
- Citations by year
- 2026: 112 · 2025: 123 · 2024: 106 · 2023: 112 · 2022: 146 · 2021: 124 · 2020: 125 · 2019: 137 · 2018: 112 · 2017: 124 · 2016: 117 · 2015: 130 · 2014: 129 · 2013: 123 · 2012: 117
- FWCI
- 9.99
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Howard Hughes Medical Institute
- National Institutes of Health (5p50mh074924-05)
- National Institute on Aging (P01AG011412)
- National Heart, Lung, and Blood Institute (R01HL097817)
- National Institute of Mental Health (P50 MH-074924, R01MH078024)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
- Health Sciences › Medicine › Physiology (medical) › Dietary Effects on Health
- Keywords
- circadian clock, clock genes, circadian rhythm, metabolism, cellular energetics, sleep deprivation, shift work, circadian desynchrony, obesity, diabetes mellitus, sleep-wake cycle
- MeSH terms
- Animals, Diabetes Mellitus, Energy Metabolism, Gene Expression Regulation, Homeostasis, Humans, Metabolism, Obesity, Sleep Deprivation, Transcription, Genetic, Protein Biosynthesis, Signal Transduction, Sleep Disorders, Circadian Rhythm, Feedback, Physiological, Gene Regulatory Networks, Metabolic Networks and Pathways, Circadian Clocks
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