The DOI matches its Crossref record; 69 of the 69 references it cites were found in a registry or an index.
Circadian Integration of Metabolism and Energetics
Open accessAbstract
Circadian clocks align behavioral and biochemical processes with the day/night cycle. Nearly all vertebrate cells possess self-sustained clocks that couple endogenous rhythms with changes in cellular environment. Genetic disruption of clock genes in mice perturbs metabolic functions of specific tissues at distinct phases of the sleep/wake cycle. Circadian desynchrony, a characteristic of shift work and sleep disruption in humans, also leads to metabolic pathologies. Here, we review advances in understanding the interrelationship among circadian disruption, sleep deprivation, obesity, and diabetes and implications for rational therapeutics for these conditions.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“This complex interconnected regulatory framework, ensures that the same molecules that regulate metabolism and reproduction, also contribute to a bidirectional feedback system with the autonomous circadian circuits [224,231]. This results in synchronicity of internal physiology with environmental cues, to optimize both individual and species survival.”
From Polycystic Ovary Syndrome: An Evolutionary Adaptation to Lifestyle and the Environment (2022) · cites this paper as [231]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“The molecular mechanisms of circadian clocks are similar across all species and are regulated by genetic enhancer/repressor elements, epigenetic modulation by methylation and acetylation, post-translation modification of regulatory proteins, and a variety of hormonal and signaling molecules [220,229,231].”
From Polycystic Ovary Syndrome: An Evolutionary Adaptation to Lifestyle and the Environment (2022) · cites this paper as [231]
Experimental — accuracy not yet measuredIn the citing paper
“The liver is the focus of circadian regulation of metabolic pathways, especially those controlling the synthesis and metabolism of glucose, lipid, cholesterol and bile acid (Bass and Takahashi, 2010).”
From Circadian Homeostasis of Liver Metabolism Suppresses Hepatocarcinogenesis (2016) · cites this paper as Bass and Takahashi, 2010
In the citing paper
“Circadian dysfunction among night-shift workers and individuals suffering from sleep dyspnea has been identified as a common risk factor of obesity, metabolic disorders, NAFLD and cancer including HCC (Bass and Takahashi, 2010; Fu and Kettner, 2013; Hu et al., 2013; Kao et al., 2012; Kim et al., 2013; Zimberg et al., 2012).”
From Circadian Homeostasis of Liver Metabolism Suppresses Hepatocarcinogenesis (2016) · cites this paper as Bass and Takahashi, 2010
In the citing paper
“Systemic and tissue-specific disruption of the circadian machinery leads to changes in cellular functions such as cell division and metabolism, both highly relevant to cancer (Bass and Takahashi, 2010; Hanahan and Weinberg, 2011; Masri et al., 2016; Sahar and Sassone-Corsi, 2009).”
From Circadian Rhythm Disruption Promotes Lung Tumorigenesis (2016) · cites this paper as Bass and Takahashi, 2010
In the citing paper
“Sleep loss is often accompanied with circadian misalignment, also known to cause changes in the regulation of the immune system and metabolism and associate to cardiovascular diseases7273.”
From Prolonged sleep restriction induces changes in pathways involved in cholesterol metabolism and inflammatory responses (2016) · cites this paper as [72]
In the citing paper
“Evidence is rapidly accumulating to indicate that misalignment between central and peripheral clocks has a host of adverse effects, including an increased risk of obesity and type 2 diabetes (37, 39).”
From Adverse effects of two nights of sleep restriction on the hypothalamic-pituitary-adrenal axis in healthy men (2014) · cites this paper as [39]
In the citing paper
“For the metabolic syndrome, a systematic review by Canuto et al. in 2013 of ten studies, identified eight studies that found a positive association between shift work and metabolic syndrome after adjustment for sociodemographic and behavioural factors (19) .”
From Meal irregularity and cardiometabolic consequences: results from observational and intervention studies (2016) · cites this paper as [19]
In the citing paper
“However, only three studies also adjusted for sleep duration and these showed conflicting results.”
From Meal irregularity and cardiometabolic consequences: results from observational and intervention studies (2016) · cites this paper as [19]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Hypothalamic regulation of sleep and circadian rhythms
Saper, C. B., Scammell, T. E., & Lu, J. (2005) · Nature · doi:10.1038/nature04284 · Cited by 2,804
Obesity and Metabolic Syndrome in Circadian Clock Mutant Mice
Turek, F. W., Joshu, C., Kohsaka, A., Lin, E., Ivanova, G., McDearmon, E., Laposky, A., Losee-Olson, S., Easton, A., Jensen, D. R., et al. (2005) · Science · doi:10.1126/science.1108750 · Cited by 2,485
Self-citationAdverse metabolic and cardiovascular consequences of circadian misalignment
Scheer, F. A. J. L., Hilton, M. F., Mantzoros, C. S., & Shea, S. A. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0808180106 · Cited by 2,351
Preitner, N., Damiola, F., Luis-Lopez-Molina, Zakany, J., Duboule, D., Albrecht, U., & Schibler, U. (2002) · Cell · doi:10.1016/s0092-8674(02)00825-5 · Cited by 2,198
New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk
DIAGRAM Consortium, Dupuis, J., GIANT Consortium, Global BPgen Consortium, Anders Hamsten on behalf of Procardis Consortium, the MAGIC investigators, Langenberg, C., Prokopenko, I., Saxena, R., Soranzo, N., et al. (2010) · Nature Genetics · doi:10.1038/ng.520 · Cited by 2,166
A Serum Shock Induces Circadian Gene Expression in Mammalian Tissue Culture Cells
Balsalobre, A., Damiola, F., & Schibler, U. (1998) · Cell · doi:10.1016/s0092-8674(00)81199-x · Cited by 2,001
Resetting of circadian time in peripheral tissues by glucocorticoid signaling
Balsalobre, A., Brown, S. A., Marcacci, L., Tronche, F., Kellendonk, C., Reichardt, H. M., Schütz, G., & Schibler, U. (2000) · Science · doi:10.1126/science.289.5488.2344 · Cited by 1,859
Entrainment of the circadian clock in the liver by feeding
Stokkan, K.-A., Yamazaki, S., Tei, H., Sakaki, Y., & Menaker, M. (2001) · Science · doi:10.1126/science.291.5503.490 · Cited by 1,800
The genetics of mammalian circadian order and disorder: implications for physiology and disease
Takahashi, J. S., Hong, H.-K., Ko, C. H., & McDearmon, E. L. (2008) · Nature Reviews Genetics · doi:10.1038/nrg2430 · Cited by 1,611
Self-citationHigh-Fat Diet Disrupts Behavioral and Molecular Circadian Rhythms in Mice
Kohsaka, A., Laposky, A. D., Ramsey, K. M., Estrada, C., Joshu, C., Kobayashi, Y., Turek, F. W., & Bass, J. (2007) · Cell Metabolism · doi:10.1016/j.cmet.2007.09.006 · Cited by 1,528
Self-citation
Flagged first, then by citations
Cited by
Sorted by citations
Items 301–400 of 1,001
Kang, H. S., Okamoto, K., Takeda, Y., Beak, J. Y., Gerrish, K., Bortner, C. D., DeGraff, L. M., Wada, T., Xie, W., & Jetten, A. M. (2011) · Physiological Genomics · doi:10.1152/physiolgenomics.00206.2010 · Cited by 95
Homeostatic and circadian contribution to EEG and molecular state variables of sleep regulation
Curie, T., Mongrain, V., Dorsaz, S., Mang, G. M., Emmenegger, Y., & Franken, P. (2013) · SLEEP · doi:10.5665/sleep.2440 · Cited by 94
Chrono-biology, Chrono-pharmacology and Chrono-nutrition
Tahara, Y., & Shibata, S. (2014) · Journal of Pharmacological Sciences · doi:10.1254/jphs.13r06cr · Cited by 94
Circadian Rhythm: Potential Therapeutic Target for Atherosclerosis and Thrombosis
Man, A. W. C., Li, H., & Xia, N. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22020676 · Cited by 96
Cell maturation: Hallmarks, triggers, and manipulation
Alvarez‐Dominguez, J. R., & Melton, D. A. (2022) · Cell · doi:10.1016/j.cell.2021.12.012 · Cited by 96
Takeda, Y., Kang, H. S., Freudenberg, J., DeGraff, L. M., Jothi, R., & Jetten, A. M. (2014) · PLoS Genetics · doi:10.1371/journal.pgen.1004331 · Cited by 94
The Circadian Clock in Oral Health and Diseases
Papagerakis, S. M., Zheng, L., Schnell, S. D., Sartor, M., Somers, E. C., Marder, W., McAlpin, B. R., Kim, D. W., McHugh, J. B., & Papagerakis, P. (2013) · Journal of Dental Research · doi:10.1177/0022034513505768 · Cited by 95
Reciprocal Control of the Circadian Clock and Cellular Redox State - a Critical Appraisal
Putker, M., & O'Neill, J. S. (2016) · Molecules and Cells · doi:10.14348/molcells.2016.2323 · Cited by 94
Consequences of Circadian and Sleep Disturbances for the Cardiovascular System
Alibhai, F. J., Tsimakouridze, E. V., Reitz, C. J., Pyle, W. G., & Martino, T. A. (2015) · Canadian Journal of Cardiology · doi:10.1016/j.cjca.2015.01.015 · Cited by 93
Endocrine regulation of circadian rhythms
Begemann, K., Rawashdeh, O., Olejniczak, I., Pilorz, V., de Assis, L. V. M., Osorio-Mendoza, J., & Oster, H. (2025) · npj Biological Timing and Sleep · doi:10.1038/s44323-025-00024-6 · Cited by 93
Circadian clocks, rhythmic synaptic plasticity and the sleep-wake cycle in zebrafish
Elbaz, I., Foulkes, N. S., Gothilf, Y., & Appelbaum, L. (2013) · Frontiers in Neural Circuits · doi:10.3389/fncir.2013.00009 · Cited by 93
Muscle Directs Diurnal Energy Homeostasis through a Myokine-Dependent Hormone Module in Drosophila
Zhao, X. L., & Karpac, J. (2017) · Current Biology · doi:10.1016/j.cub.2017.06.004 · Cited by 93
Inflammatory pathways in children with insufficient or disordered sleep
Kim, J., Hakim, F., Gozal, D., & Gozal, D. (2011) · Respiratory Physiology & Neurobiology · doi:10.1016/j.resp.2011.04.024 · Cited by 92
Transcriptional Control of Antioxidant Defense by the Circadian Clock
Patel, S. A., Velingkaar, N., & Kondratov, R. V. (2013) · Antioxidants and Redox Signaling · doi:10.1089/ars.2013.5671 · Cited by 92
The circadian rhythm controls telomeres and telomerase activity
Chen, W.-D., Wen, M., Shie, S., Lo, Y., Wo, H.-T., Wang, C., Hsieh, C., Lee, T., & Wang, C. (2014) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2014.07.138 · Cited by 91
Modulation of ATR-mediated DNA damage checkpoint response by cryptochrome 1
Kang, T., & Leem, S.-H. (2014) · Nucleic Acids Research · doi:10.1093/nar/gku094 · Cited by 91
Disruption of normal circadian clock function in a mouse model of tauopathy
Stevanovic, K. D., Yunus, A., Joly‐Amado, A., Gordon, M. N., Morgan, D., Gulick, D., & Gamsby, J. J. (2017) · Experimental Neurology · doi:10.1016/j.expneurol.2017.04.015 · Cited by 91
Insulin-FOXO3 Signaling Modulates Circadian Rhythms via Regulation of Clock Transcription
Chaves, I., van der Horst, G. T. J., Schellevis, R. D., Nijman, R., Koerkamp, M. J. A. G., Holstege, F. C. P., Smidt, M. P., & Hoekman, M. F. M. (2014) · Current Biology · doi:10.1016/j.cub.2014.04.018 · Cited by 90
Circadian redox oscillations and metabolism
Milev, N. B., & Reddy, A. B. (2015) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2015.05.012 · Cited by 89
Borniger, J. C., Maurya, S. K., Periasamy, M., & Nelson, R. J. (2014) · Chronobiology International · doi:10.3109/07420528.2014.926911 · Cited by 92
The Circadian Clock Regulates Adipogenesis by a Per3 Crosstalk Pathway to Klf15
Aggarwal, A., Costa, M. J. D. C., Rivero‐Gutiérrez, B., Ji, L., Morgan, S. L., & Feldman, B. J. (2017) · Cell Reports · doi:10.1016/j.celrep.2017.11.004 · Cited by 89
Multilevel Interactions of Stress and Circadian System: Implications for Traumatic Stress
Agorastos, A., Nicolaides, N. C., Bozikas, V. P., Chrousos, G. P., & Pervanidou, P. (2020) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2019.01003 · Cited by 89
Neuroendocrine abnormalities in Parkinson's disease
Pablo‐Fernández, E. D., Breen, D. P., Bouloux, P. M., Barker, R. A., Foltynie, T., & Warner, T. T. (2016) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp-2016-314601 · Cited by 89
Maukonen, M., Kanerva, N., Partonen, T., & Männistö, S. (2018) · Chronobiology International · doi:10.1080/07420528.2018.1515772 · Cited by 89
Human milk as “chrononutrition”: implications for child health and development
Hahn‐Holbrook, J., Saxbe, D., Bixby, C., Steele, C., & Glynn, L. M. (2019) · Pediatric Research · doi:10.1038/s41390-019-0368-x · Cited by 88
Yuan, P., Yang, T., Mu, J., Zhao, J., Yang, Y., Yan, Z., Hou, Y., Chen, C., Xing, J., Zhang, H., et al. (2019) · Cancer Letters · doi:10.1016/j.canlet.2019.11.024 · Cited by 88
Effects and mechanisms of action of light-emitting diodes on the human retina and internal clock
Touitou, Y., & Point, S. (2020) · Environmental Research · doi:10.1016/j.envres.2020.109942 · Cited by 88
Deviation of innate circadian period from 24 h reduces longevity in mice
Libert, S., Bonkowski, M. S., Pointer, K. B., Pletcher, S. D., & Guarente, L. (2012) · Aging Cell · doi:10.1111/j.1474-9726.2012.00846.x · Cited by 88
Chronotherapy: Intuitive, Sound, Founded…But Not Broadly Applied
Selfridge, J. M., Gotoh, T., Schiffhauer, S., Liu, J., Stauffer, P. E., Li, A., Capelluto, D. G. S., & Finkielstein, C. V. (2016) · Drugs · doi:10.1007/s40265-016-0646-4 · Cited by 88
Update on Energy Homeostasis and Insufficient Sleep
Penev, P. D. (2012) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2012-1067 · Cited by 87
NPAS2 promotes cell survival of hepatocellular carcinoma by transactivating CDC25A
Yuan, P., Li, J., Zhou, F., Huang, Q., Zhang, J., Guo, X., Lyu, Z., Zhang, H., & Xing, J. (2017) · Cell Death and Disease · doi:10.1038/cddis.2017.131 · Cited by 87
Coupling the Circadian Clock to Homeostasis: The Role of Period in Timing Physiology
Kim, P., Oster, H., Lehnert, H., Schmid, S. M., Salamat, N., Barclay, J. L., Maronde, E., Inder, W. J., & Rawashdeh, O. (2018) · Endocrine Reviews · doi:10.1210/er.2018-00049 · Cited by 87
Pastore, N., Vainshtein, A., Herz, N. J., Huynh, T., Brunetti, L., Klisch, T. J., Mutarelli, M., Annunziata, P., Kinouchi, K., Brunetti‐Pierri, N., et al. (2019) · The EMBO Journal · doi:10.15252/embj.2018101347 · Cited by 87
Reznick, J., Preston, E., Wilks, D. L., Beale, S. M., Turner, N., & Cooney, G. J. (2013) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2012.08.010 · Cited by 86
Melatonin synthesis impairment as a new deleterious outcome of diabetes‐derived hyperglycemia
do Amaral, F. G., Turati, A. D. O., Barone, M. T. U., Scialfa, J. H., Buonfiglio, D. D. C., Peres, R., Garcia, R. A. P., Afeche, S. C., Lima, L. D. S., Scavone, C., et al. (2014) · Journal of Pineal Research · doi:10.1111/jpi.12144 · Cited by 86
Chromatin landscape and circadian dynamics: Spatial and temporal organization of clock transcription
Aguilar‐Arnal, L., & Sassone‐Corsi, P. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1411264111 · Cited by 86
Functional network inference of the suprachiasmatic nucleus
Abel, J. H., Meeker, K., Granados‐Fuentes, D., John, P. C. S., Wang, T. J., Bales, B. B., Doyle, F. J., Herzog, E. D., & Petzold, L. R. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1521178113 · Cited by 86
Normal sleep requires the astrocyte brain-type fatty acid binding protein FABP7
Gerstner, J. R., Perron, I. J., Riedy, S. M., Yoshikawa, T., Kadotani, H., Owada, Y., Dongen, H. P. A. V., Galante, R. J., Dickinson, K., Yin, J. C. P., et al. (2017) · Science Advances · doi:10.1126/sciadv.1602663 · Cited by 86
Consequences of Metabolic Disruption in Alzheimer's Disease Pathology
Ryu, J. C., Zimmer, E. R., Rosa‐Neto, P., & Yoon, S. O. (2019) · Neurotherapeutics · doi:10.1007/s13311-019-00755-y · Cited by 87
The Krüppel-Like Factors and Control of Energy Homeostasis
Hsieh, P. N., Fan, L., Sweet, D. R., & Jain, M. K. (2018) · Endocrine Reviews · doi:10.1210/er.2018-00151 · Cited by 85
Chronobiology of Micturition: Putative Role of the Circadian Clock
Negoro, H., Kanematsu, A., Yoshimura, K., & Ogawa, O. (2013) · The Journal of Urology · doi:10.1016/j.juro.2013.02.024 · Cited by 85
Sedentary Behavior and Health Outcomes in Children and Adolescents
Mitchell, J. A., & Byun, W. (2013) · American Journal of Lifestyle Medicine · doi:10.1177/1559827613498700 · Cited by 85
Glucagon-like peptide 1 regulates adipogenesis in 3T3-L1 preadipocytes
YANG, J., REN, J., SONG, J., LIU, F., WU, C., WANG, X., GONG, L., LI, W., XIAO, F., YAN, F., et al. (2013) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2013.1350 · Cited by 84
Husse, J., Hintze, S. C., Gregor Eichele, C., Lehnert, H., & Oster, H. (2012) · PLoS ONE · doi:10.1371/journal.pone.0052983 · Cited by 84
HSP90 functions in the circadian clock through stabilization of the client F-box protein ZEITLUPE
Kim, T.-S., Kim, W. Y., Fujiwara, S., Kim, J., Cha, J., Park, J., Lee, S. Y., & Somers, D. E. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1110406108 · Cited by 84
Chronotype, social jet lag, sleep debt and food timing in inflammatory bowel disease
Chakradeo, P. S., Keshavarzian, A., Singh, S., Dera, A. E., Esteban, J. P., Lee, A. A., Burgess, H. J., Fogg, L., & Swanson, G. R. (2018) · Sleep Medicine · doi:10.1016/j.sleep.2018.08.002 · Cited by 84
Chronobiology and obesity: Interactions between circadian rhythms and energy regulation
Summa, K. C., & Turek, F. W. (2014) · Advances in Nutrition · doi:10.3945/an.113.005132 · Cited by 82
Bray, M. S., & Young, M. E. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.r110.214643 · Cited by 82
Potential Roles of Dec and Bmal1 Genes in Interconnecting Circadian Clock and Energy Metabolism
Sato, F., Kohsaka, A., BHAWAL, U. K., & Muragaki, Y. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19030781 · Cited by 85
Reciprocal regulation of chaperone-mediated autophagy and the circadian clock
Juste, Y. R., Kaushik, S., Bourdenx, M., Aflakpui, R., Bandyopadhyay, S., García, F., Díaz, A., Lindenau, K. L., Tu, V., Krause, G. J., et al. (2021) · Nature Cell Biology · doi:10.1038/s41556-021-00800-z · Cited by 82
Optimized Chemical Probes for REV-ERBα
Trump, R. P., Bresciani, S., Cooper, A. W. J., Tellam, J. P., Wojno, J., Blaikley, J., Orband‐Miller, L. A., Kashatus, J. A., Boudjelal, M., Dawson, H. C., et al. (2013) · Journal of Medicinal Chemistry · doi:10.1021/jm400458q · Cited by 81
Chronomedicine and type 2 diabetes: shining some light on melatonin
Forrestel, A. C., Miedlich, S. U., Yurcheshen, M. E., Wittlin, S. D., & Sellix, M. T. (2016) · Diabetologia · doi:10.1007/s00125-016-4175-1 · Cited by 82
Qi, G., Mi, Y., Liu, Z., Fan, R., Qiao, Q., Sun, Y., Ren, B., & Liu, X. (2017) · Journal of Functional Foods · doi:10.1016/j.jff.2017.04.031 · Cited by 81
Minutes, days and years: molecular interactions among different scales of biological timing
Golombek, D. A., Bussi, I. L., & Agostino, P. V. (2014) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2012.0465 · Cited by 80
Environmental Control of Biological Rhythms: Effects on Development, Fertility and Metabolism
Amaral, F. G., Castrucci, A. M., Cipolla‐Neto, J., Poletini, M. O., Mendez, N., Richter, H. G., & Sellix, M. T. (2014) · Journal of Neuroendocrinology · doi:10.1111/jne.12144 · Cited by 80
Wang, X., Kooijman, S., Gao, Y., Tzeplaeff, L., Cosquer, B., Milanova, I. V., Wolff, S. E. C., Korpel, N. L., Champy, M., Petit‐Demoulière, B., et al. (2021) · Molecular Psychiatry · doi:10.1038/s41380-021-01169-z · Cited by 80
The adipocyte clock controls brown adipogenesis via TGF-β/BMP signaling pathway
Nam, D., Guo, B., Chatterjee, S., Chen, M.-H., Nelson, D. L., Yechoor, V. K., & Ma, K. (2015) · Journal of Cell Science · doi:10.1242/jcs.167643 · Cited by 80
Translational Profiling of Clock Cells Reveals Circadianly Synchronized Protein Synthesis
Huang, Y., Ainsley, J. A., Reijmers, L. G. J. E., & Jackson, F. R. (2013) · PLoS Biology · doi:10.1371/journal.pbio.1001703 · Cited by 80
Fuse, Y., Hirao, A., Kuroda, H., Otsuka, M., Tahara, Y., & Shibata, S. (2012) · Journal of Circadian Rhythms · doi:10.1186/1740-3391-10-4 · Cited by 80
Ng, D. W.-K., Miller, M. E., Yu, H. H., Huang, T., Kim, E., Lu, J., Xie, Q., McClung, C. R., & Chen, Z. J. (2014) · The Plant Cell · doi:10.1105/tpc.113.115980 · Cited by 80
The PPAR–microbiota–metabolic organ trilogy to fine‐tune physiology
Oh, H. Y. P., Visvalingam, V., & Wahli, W. (2019) · The FASEB Journal · doi:10.1096/fj.201802681rr · Cited by 79
Deficiency of the Circadian Clock Gene Bmal1 Reduces Microglial Immunometabolism
Wang, X., Wolff, S. E. C., Korpel, N. L., Milanova, I. V., Sandu, C., Rensen, P. C. N., Kooijman, S., Cassel, J., Kalsbeek, A., Boutillier, A., et al. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.586399 · Cited by 79
Role of orexin in the central regulation of glucose and energy homeostasis [Review]
Tsuneki, H., Wada, T., & Sasaoka, T. (2012) · Endocrine Journal · doi:10.1507/endocrj.ej12-0030 · Cited by 79
Rakshit, K., Hsu, T. W., & Matveyenko, A. V. (2016) · Diabetologia · doi:10.1007/s00125-015-3859-2 · Cited by 79
The hepatic circadian clock fine-tunes the lipogenic response to feeding through RORα/γPreprint
Zhang, Y., Papazyan, R., Damle, M., Fang, B., Jager, J., Feng, D., Peed, L. C., Guan, D., Sun, Z., & Lazar, M. A. (2017) · Genes & Development · doi:10.1101/gad.302323.117 · Cited by 79
Hippocampal clock regulates memory retrieval via Dopamine and PKA-induced GluA1 phosphorylation
Hasegawa, S., Fukushima, H., Hosoda, H., Serita, T., Ishikawa, R., Rokukawa, T., Kawahara‐Miki, R., Zhang, Y., Ohta, M., Okada, S., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-13554-y · Cited by 78
Circadian Clock Regulates Inflammation and the Development of Neurodegeneration
Wang, X., & Li, L. (2021) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2021.696554 · Cited by 78
Integrating Physiological Regulation with Stem Cell and Tissue Homeostasis
Nakada, D., Levi, B. P., & Morrison, S. J. (2011) · Neuron · doi:10.1016/j.neuron.2011.05.011 · Cited by 78
Humphries, P. S., Bersot, R., Kincaid, J., Mabery, E. M., McCluskie, K., Park, T., Renner, T., Riegler, E., Steinfeld, T., Turtle, E. D., et al. (2015) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2015.12.102 · Cited by 78
Hypothalamic AMPK as a Regulator of Energy Homeostasis
Huynh, M. K. Q., Kinyua, A. W., Yang, D. J., & Kim, K. W. (2016) · Neural Plasticity · doi:10.1155/2016/2754078 · Cited by 78
Trypanosoma brucei metabolism is under circadian control
Rijo‐Ferreira, F., Pinto‐Neves, D., Barbosa‐Morais, N. L., Takahashi, J. S., & Figueiredo, L. M. (2017) · Nature Microbiology · doi:10.1038/nmicrobiol.2017.32 · Cited by 78
Self-citationNutrition, metabolism, and epigenetics: pathways of circadian reprogramming
Sato, T., & Sassone‐Corsi, P. (2022) · EMBO Reports · doi:10.15252/embr.202152412 · Cited by 77
Shimomura, K., Kumar, V., Koike, N., Kim, T.-K., Chong, J. L., Buhr, E. D., Whiteley, A. R., Low-Zeddies, S. S., Omura, C., Fenner, D., et al. (2013) · eLife · doi:10.7554/elife.00426 · Cited by 77
Self-citationTimmons, G. A., Carroll, R. G., O’Siorain, J. R., Cervantes‐Silva, M. P., Fagan, L. E., Cox, S. L., Pålsson‐McDermott, E. M., Finlay, D. K., Vincent, E. E., Jones, N., et al. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.700431 · Cited by 76
García‐Ríos, A., Gómez-Delgado, F., Garaulet, M., Alcala-Diaz, J. F., Delgado‐Lista, J., Marı́n, C., Rangel-Zúñiga, O. A., Rodríguez-Cantalejo, F., Gómez-Luna, P., Ordovás, J. M., et al. (2013) · Chronobiology International · doi:10.3109/07420528.2013.864300 · Cited by 76
CREBH Couples Circadian Clock With Hepatic Lipid Metabolism
Zheng, Z., Kim, H., Qiu, Y., Chen, X., Méndez, R., Dandekar, A. P., Zhang, X., Zhang, C., Liu, A. C., Yin, L., et al. (2016) · Diabetes · doi:10.2337/db16-0298 · Cited by 76
The Circadian Gene Clock Regulates Bone Formation Via PDIA3
Yuan, G., Hua, B., Yang, Y., Xu, L., Cai, T., Sun, N., Yan, Z., Lü, C., & Qian, R. (2016) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.3046 · Cited by 75
Honma, A., Revell, V. L., Gunn, P. J., Davies, S. K., Middleton, B., Raynaud, F. I., & Skene, D. J. (2019) · European Journal of Neuroscience · doi:10.1111/ejn.14411 · Cited by 75
Haupt, S., Eckstein, M. L., Wolf, A., Zimmer, R. T., Wachsmuth, N. B., & Moser, O. (2021) · Biomolecules · doi:10.3390/biom11040516 · Cited by 75
Eat, sleep, repeat – endocrine regulation of behavioural circadian rhythms
Koop, S., & Oster, H. (2021) · FEBS Journal · doi:10.1111/febs.16109 · Cited by 75
Chrononutrition—When We Eat Is of the Essence in Tackling Obesity
Ahluwalia, M. K. (2022) · Nutrients · doi:10.3390/nu14235080 · Cited by 76
Xia, J., Guo, W., Hu, M., Jin, X., Zhang, S., Liu, B., Qiu, H., Wang, K., Zhuge, A., Li, S., et al. (2023) · Gut Microbes · doi:10.1080/19490976.2023.2221450 · Cited by 75
Cardinali, D. P., Brown, G. M., & Pandi-Perumal, S. R. (2021) · Handbook of clinical neurology · doi:10.1016/b978-0-12-819975-6.00023-6 · Cited by 76
Sympathetic Activation Induces Skeletal Fgf23 Expression in a Circadian Rhythm-dependent Manner
Kawai, M., Kinoshita, S., Shimba, S., Ozono, K., & Michigami, T. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.500850 · Cited by 74
SRC-2 Is an Essential Coactivator for Orchestrating Metabolism and Circadian Rhythm
Stashi, E., Lanz, R. B., Mao, J., Michailidis, G. C., Zhu, B., Kettner, N. M., Putluri, N., Reineke, E. L., Reineke, L. C., Dasgupta, S., et al. (2014) · Cell Reports · doi:10.1016/j.celrep.2014.01.027 · Cited by 74
Sancar, C., Sancar, G., Ha, N., Cesbron, F., & Brunner, M. (2015) · BMC Biology · doi:10.1186/s12915-015-0126-4 · Cited by 74
Metabolic Stress and Cardiovascular Disease in Diabetes Mellitus
Chen, Y., Zhao, X., & Wu, H. (2019) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.119.312192 · Cited by 73
Lee, Y., Fong, S. Y., Shon, J. H., Zhang, S., Brooks, R. C., Lahens, N. F., Chen, D., Dang, C. V., Field, J. M., & Sehgal, A. (2021) · Science Advances · doi:10.1126/sciadv.abd2645 · Cited by 74
Repeated evolution of circadian clock dysregulation in cavefish populations
Mack, K. L., Jaggard, J. B., Persons, J. L., Roback, E. Y., Passow, C. N., Stanhope, B. A., Ferrufino, E., Tsuchiya, D., Smith, S. E., Slaughter, B. D., et al. (2021) · PLoS Genetics · doi:10.1371/journal.pgen.1009642 · Cited by 73
Circadian Variation in Gastric Vagal Afferent Mechanosensitivity
Kentish, S. J., Frisby, C. L., Kennaway, D. J., Wittert, G., & Page, A. J. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.3846-13.2013 · Cited by 73
Convergence and synchronization in heterogeneous networks of smooth and piecewise smooth systems
Lellis, P. D., di Bernardo, M., & Liuzza, D. (2015) · Automatica · doi:10.1016/j.automatica.2015.03.003 · Cited by 73
Circadian rhythms, alcohol and gut interactions
Forsyth, C. B., Voigt, R. M., Burgess, H. J., Swanson, G. R., & Keshavarzian, A. (2014) · Alcohol · doi:10.1016/j.alcohol.2014.07.021 · Cited by 73
Circadian rhythms affect bone reconstruction by regulating bone energy metabolism
Luo, B., Zhou, X., Tang, Q., Yin, Y., Feng, G., Li, S., & Chen, L. (2021) · Journal of Translational Medicine · doi:10.1186/s12967-021-03068-x · Cited by 72
Saini, C., Brown, S. A., & Dibner, C. (2015) · Frontiers in Neurology · doi:10.3389/fneur.2015.00095 · Cited by 72
Chen, K., Ma, J., Jia, X., Ai, W., Ma, Z., & Pan, Q. (2018) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2018.11.005 · Cited by 72
Molecular Clocks in Pharmacology
Musiek, E. S., & FitzGerald, G. A. (2013) · Handbook of experimental pharmacology · doi:10.1007/978-3-642-25950-0_10 · Cited by 71
Oda, M., Koyanagi, S., Tsurudome, Y., Kanemitsu, T., Matsunaga, N., & Ohdo, S. (2014) · Molecular Pharmacology · doi:10.1124/mol.113.089805 · Cited by 71
Osonoi, Y., Mita, T., Osonoi, T., Saito, M., Tamasawa, A., Nakayama, S., Someya, Y., Ishida, H., Kanazawa, A., Gosho, M., et al. (2014) · Chronobiology International · doi:10.3109/07420528.2014.943843 · Cited by 71
Regulatory T cells as metabolic sensors
de Candia, P., Procaccini, C., Russo, C., Lepore, M. T., & Matarese, G. (2022) · Immunity · doi:10.1016/j.immuni.2022.10.006 · Cited by 71
The pyruvate dehydrogenase complex: Life’s essential, vulnerable and druggable energy homeostat
Stacpoole, P. W., & McCall, C. E. (2023) · Mitochondrion · doi:10.1016/j.mito.2023.02.007 · Cited by 70
Metadata
- Authors
- Bass, J., & Takahashi, J. S.
- Affiliations
- Northwestern University (US)
- Howard Hughes Medical Institute (US)
- Corresponding author
- Bass, Joseph
- Venue
- Science
- Published
- 2010-12-03
- Volume
- 330
- Issue
- 6009
- Pages
- 1349-1354
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- PMC
- PMC3756146
- OpenAlex
- W2157481078
- Cited by
- 1,910
- References
- 69
- Citations by year
- 2026: 112 · 2025: 123 · 2024: 106 · 2023: 112 · 2022: 146 · 2021: 124 · 2020: 125 · 2019: 137 · 2018: 112 · 2017: 124 · 2016: 117 · 2015: 130 · 2014: 129 · 2013: 123 · 2012: 117
- FWCI
- 9.99
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Howard Hughes Medical Institute
- National Institutes of Health (5p50mh074924-05)
- National Institute on Aging (P01AG011412)
- National Heart, Lung, and Blood Institute (R01HL097817)
- National Institute of Mental Health (P50 MH-074924, R01MH078024)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
- Health Sciences › Medicine › Physiology (medical) › Dietary Effects on Health
- Keywords
- circadian clock, clock genes, circadian rhythm, metabolism, cellular energetics, sleep deprivation, shift work, circadian desynchrony, obesity, diabetes mellitus, sleep-wake cycle
- MeSH terms
- Animals, Diabetes Mellitus, Energy Metabolism, Gene Expression Regulation, Homeostasis, Humans, Metabolism, Obesity, Sleep Deprivation, Transcription, Genetic, Protein Biosynthesis, Signal Transduction, Sleep Disorders, Circadian Rhythm, Feedback, Physiological, Gene Regulatory Networks, Metabolic Networks and Pathways, Circadian Clocks
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
