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Human Fatty Liver Disease: Old Questions and New Insights
Open accessAbstract
Nonalcoholic fatty liver disease (NAFLD) is a burgeoning health problem that affects one-third of adults and an increasing number of children in developed countries. The disease begins with the aberrant accumulation of triglyceride in the liver, which in some individuals elicits an inflammatory response that can progress to cirrhosis and liver cancer. Although NAFLD is strongly associated with obesity and insulin resistance, its pathogenesis remains poorly understood, and therapeutic options are limited. Here, we discuss recent mechanistic insights into NAFLD, focusing primarily on those that have emerged from human genetic and metabolic studies.
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“Impairment in mitochondrial function and ATP generation is also observed.”
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“Oxidative stress contributes to the production of reactive oxygen species, lipid peroxidation products and decreases the levels of antioxidants such as superoxide dismutase, glutathione, and catalase.”
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Metadata
- Authors
- Cohen, J. C., Horton, J. D., & Hobbs, H. H.
- Affiliations
- The University of Texas Southwestern Medical Center (US)
- Howard Hughes Medical Institute (US)
- Corresponding author
- Hobbs, Helen H.
- Venue
- Science
- Published
- 2011-06-24
- Volume
- 332
- Issue
- 6037
- Pages
- 1519-1523
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- PMC
- PMC3229276
- OpenAlex
- W2065612971
- Cited by
- 2,089
- References
- 53
- Citations by year
- 2026: 38 · 2025: 88 · 2024: 103 · 2023: 118 · 2022: 139 · 2021: 152 · 2020: 168 · 2019: 158 · 2018: 166 · 2017: 170 · 2016: 153 · 2015: 171 · 2014: 143 · 2013: 171 · 2012: 122
- FWCI
- 17.33
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Heart, Lung, and Blood Institute (P01 HL-20948, P01HL020948, RL1HL092550)
- National Institute of Diabetes and Digestive and Kidney Diseases (R01DK090066)
- National Institute of Dental and Craniofacial Research (UL1DE019584, UL1DE109584)
- Topics
- Health Sciences › Medicine › Hepatology › Liver Disease Diagnosis and Treatment
- Health Sciences › Medicine › Pathology and Forensic Medicine › Alcohol Consumption and Health Effects
- Health Sciences › Medicine › Hepatology › Liver physiology and pathology
- Keywords
- non-alcoholic fatty liver disease, hepatic triglyceride accumulation, liver inflammation, liver cirrhosis, hepatocellular carcinoma, obesity, insulin resistance, NAFLD pathogenesis, genetic susceptibility, metabolic mechanisms
- MeSH terms
- Animals, Dietary Fats, Disease Models, Animal, Fatty Liver, Female, Humans, Insulin Resistance, Liver, Liver Cirrhosis, Liver Neoplasms, Male, Obesity, Triglycerides, Disease Progression, Genetic Predisposition to Disease, Non-alcoholic Fatty Liver Disease
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