mTORC1 Senses Lysosomal Amino Acids Through an Inside-Out Mechanism That Requires the Vacuolar H + -ATPase

Repertoires of Autophagy in the Pathogenesis of Ocular Diseases

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mTOR: from growth signal integration to cancer, diabetes and ageing

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The Rag GTPases Bind Raptor and Mediate Amino Acid Signaling to mTORC1

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Ragulator-Rag Complex Targets mTORC1 to the Lysosomal Surface and Is Necessary for Its Activation by Amino Acids

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Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling

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Tuberous Sclerosis Complex Gene Products, Tuberin and Hamartin, Control mTOR Signaling by Acting as a GTPase-Activating Protein Complex toward Rheb

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Requirement of Prorenin Receptor and Vacuolar H + -ATPase–Mediated Acidification for Wnt Signaling

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Leucine supplementation is anti-atrophic during paradoxical sleep deprivation in rats

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Unsolved mysteries of Rag GTPase signaling in yeast

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Isoform-specific gene disruptions reveal a role for the V-ATPase subunit a4 isoform in the invasiveness of 4T1-12B breast cancer cells

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Growth and metabolic responses of juvenile grouper (Epinephelus coioides) to dietary methionine/cystine ratio at constant sulfur amino acid levels

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The phagosomal solute transporter SLC15A4 promotes inflammasome activity via mTORC1 signaling and autophagy restraint in dendritic cells

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Branched-Chain Amino Acids Metabolism and Their Roles in Retinopathy: From Relevance to Mechanism

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mTORC1 regulates phagosome digestion of symbiotic bacteria for intracellular nutritional symbiosis in a deep-sea mussel

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The V-ATPase accessory protein Atp6ap1b mediates dorsal forerunner cell proliferation and left–right asymmetry in zebrafish

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Hijacking Leucyl-tRNA Synthetase for Amino Acid-Dependent Regulation of TORC1

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Dietary deprivation of each essential amino acid induces differential systemic adaptive responses in mice

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Potential therapeutic approaches for Angelman syndrome

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Lysosomes relax in the cellular suburbs

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Disruption of the vacuolar-type H+-ATPase complex in liver causes MTORC1-independent accumulation of autophagic vacuoles and lysosomes

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Co-ordinated activation of classical and novel PKC isoforms is required for PMA-induced mTORC1 activation

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Functional characterization of lysosomal interaction of Akt with VRK2

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Defective collagen proteostasis and matrix formation in the pathogenesis of lysosomal storage disorders

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Amino acids stimulate glycyl‐tRNA synthetase nuclear localization for mammalian target of rapamycin expression in bovine mammary epithelial cells

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Vacuolar H+-ATPase Subunit V0C Regulates Aerobic Glycolysis of Esophageal Cancer Cells via PKM2 Signaling

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Synaptojanin1 deficiency upregulates basal autophagosome formation in astrocytes

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Direct quantification of autophagic flux by a single molecule-based probe

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Endosomal Acid-Base Homeostasis in Neurodegenerative Diseases

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Rotary Ion-Translocating ATPases/ATP Synthases: Diversity, Similarities, and Differences

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Crosstalk of the Caspase Family and Mammalian Target of Rapamycin Signaling

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Targeting Autophagy Triggers Apoptosis and Complements the Action of Venetoclax in Chronic Lymphocytic Leukemia Cells

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Intracellular accumulation of tau inhibits autophagosome formation by activating TIA1-amino acid-mTORC1 signaling

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The Role of mTORC1 Pathway and Autophagy in Resistance to Platinum-Based Chemotherapeutics

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Linking Peroxiredoxin and Vacuolar-ATPase Functions in Calorie Restriction-Mediated Life Span Extension

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Pleiotropic roles of mTOR complexes in haemato-lymphopoiesis and leukemogenesis

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VapA of Rhodococcus equi binds phosphatidic acid

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mTORC2 Activity Disrupts Lysosome Acidification in Systemic Lupus Erythematosus by Impairing Caspase-1 Cleavage of Rab39a

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Time-resolved transcriptomics in neural stem cells identifies a v-ATPase/Notch regulatory loop

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The TOR Pathway at the Neuromuscular Junction: More Than a Metabolic Player?

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mTOR Signaling in Aquaculture Animals: A Central Nutrient‐Sensing Hub Orchestrating Growth, Metabolism, Health and Quality

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Agent-based modeling of autophagy reveals emergent regulatory behavior of spatio-temporal autophagy dynamics

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SAC1 regulates autophagosomal phosphatidylinositol-4-phosphate for xenophagy-directed bacterial clearance

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The regulatory mechanism and therapeutic potential of transcription factor EB in neurodegenerative diseases

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Structure of the Lipid Nanodisc-reconstituted Vacuolar ATPase Proton Channel

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Alternative Splicing and Cleavage of GLUT8

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Suppression of mTORC1 activation in acid-α-glucosidase-deficient cells and mice is ameliorated by leucine supplementation

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Cancer with low cathepsin D levels is susceptible to vacuolar (H+)‐ATPase inhibition

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Loss of coordination between basic cellular processes in human aging

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Reversing lysosomal dysfunction restores youthful state in aged hematopoietic stem cells

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Cryo-EM studies of the structure and dynamics of vacuolar-type ATPases

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Simple nutrients bypass the requirement for HLH-30 in coupling lysosomal nutrient sensing to survival

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The Regulation of MiTF/TFE Transcription Factors Across Model Organisms: from Brain Physiology to Implication for Neurodegeneration

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V-ATPase/TORC1-mediated ATFS-1 translation directs mitochondrial UPR activation in C. elegans

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Leucyl-tRNA synthetase: double duty in amino acid sensing

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A pure chloride channel mutant of CLC-5 causes Dent’s disease via insufficient V-ATPase activation

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SILAC-Based Comparative Proteomic Analysis of Lysosomes from Mammalian Cells Using LC-MS/MS

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Cln3‐mutations underlying juvenile neuronal ceroid lipofuscinosis cause significantly reduced levels of Palmitoyl‐protein thioesterases‐1 (Ppt1)‐protein and Ppt1‐enzyme activity in the lysosome

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Multiple facets of TRPML1 in autophagy

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Quick and Mild Isolation of Intact Lysosomes Using Magnetic–Plasmonic Hybrid Nanoparticles

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A lysosomal surveillance response to stress extends healthspan

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Cell-type resolved protein atlas of brain lysosomes identifies SLC45A1-associated disease as a lysosomal disorder

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Adipocytes control food intake and weight regain via Vacuolar-type H+ ATPase

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SMURF1 controls the PPP3/calcineurin complex and TFEB at a regulatory node for lysosomal biogenesis

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Human V-ATPase function is positively and negatively regulated by TLDc proteins

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Diversity of amino acid signaling pathways on autophagy regulation: A novel pathway for arginine

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Target of rapamycin signaling mediates vacuolar fragmentation

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Vacuolar H+-ATPases (V-ATPases) as therapeutic targets: a brief review and recent developments

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Determining AMPK Activation via the Lysosomal v-ATPase-Ragulator-AXIN/LKB1 Axis

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Therapeutic opportunities for pain medicines via targeting of specific translation signaling mechanisms

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Proteomic Analysis of Lysosomal Membrane Proteins in Bovine Mammary Epithelial Cells Illuminates Potential Novel Lysosome Functions in Lactation

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TRPML1 and RAS-driven cancers – exploring a link with great therapeutic potential

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Pib2-Dependent Feedback Control of the TORC1 Signaling Network by the Npr1 Kinase

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mTORC1-dependent protein synthesis and autophagy uncouple in the regulation of Apolipoprotein A-I expression

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Methionine-chelated Zn promotes anabolism by integrating mTOR signal and autophagy pathway in juvenile yellow catfish

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Regulation of Notch signaling and endocytosis by the Lgl neoplastic tumor suppressor

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Advances in the regulatory mechanisms of mTOR in necroptosis

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Lysosomal NKG7 restrains mTORC1 activity to promote CD8+ T cell durability and tumor control

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Genetic modulation of rare earth nanoparticle biotransformation shapes biological outcomes

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AKT-mediated phosphorylation of TSC2 controls stimulus- and tissue-specific mTORC1 signaling and organ growth

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The Role of IL-6 Released During Exercise to Insulin Sensitivity and Muscle Hypertrophy

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Tuberous Sclerosis, Type II Diabetes Mellitus and the PI3K/AKT/mTOR Signaling Pathways—Case Report and Literature Review

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The resolution of phagosomes

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TRPML3/BK complex promotes autophagy and bacterial clearance by providing a positive feedback regulation of mTOR via PI3P

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Catabolic pathways regulated by mTORC1 are pivotal for survival and growth of cancer cells expressing mutant Ras

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Dynamin-dependent amino acid endocytosis activates mechanistic target of rapamycin complex 1 (mTORC1)

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Metabolism in Immune Cell Differentiation and Function

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Cancer: Linking Powerhouses to Suicidal Bags

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The Vacuolar H+ ATPase α3 Subunit Negatively Regulates Migration and Invasion of Human Pancreatic Ductal Adenocarcinoma Cells

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Molecular Mechanisms and Biological Functions of Autophagy for Genetics of Hearing Impairment

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Development of a specific live-cell assay for native autophagic flux

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PERSPECTIVES

(2011)

Ragulator-Rag Complex Targets mTORC1 to the Lysosomal Surface and Is Necessary for Its Activation by Amino Acids

Sancak, Y., Bar-Peled, L., Zoncu, R., Markhard, A. L., Nada, S., & Sabatini, D. M. (2010) · Cell · doi:10.1016/j.cell.2010.02.024 · Cited by 2,464

Rag–Ragulator is the central organizer of the physical architecture of the mTORC1 nutrient-sensing pathway

Valenstein, M. L., Lalgudi, P. V., Gu, X., Kedir, J. F., Taylor, M. S., Chivukula, R. R., & Sabatini, D. M. (2024) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2322755121 · Cited by 34

Deciphering the molecular mechanisms of amino acid sensing by mTOR

Angelidaki, D. D. (2023) · Kölner Universitäts PublikationsServer (Universität zu Köln)