mTORC1 Senses Lysosomal Amino Acids Through an Inside-Out Mechanism That Requires the Vacuolar H + -ATPase

Repertoires of Autophagy in the Pathogenesis of Ocular Diseases

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mTOR: from growth signal integration to cancer, diabetes and ageing

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The Rag GTPases Bind Raptor and Mediate Amino Acid Signaling to mTORC1

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Ragulator-Rag Complex Targets mTORC1 to the Lysosomal Surface and Is Necessary for Its Activation by Amino Acids

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Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling

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Vacuolar ATPases: rotary proton pumps in physiology and pathophysiology

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Tuberous Sclerosis Complex Gene Products, Tuberin and Hamartin, Control mTOR Signaling by Acting as a GTPase-Activating Protein Complex toward Rheb

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Requirement of Prorenin Receptor and Vacuolar H + -ATPase–Mediated Acidification for Wnt Signaling

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Cerebellar Development and Autism Spectrum Disorder in Tuberous Sclerosis Complex

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Luminal and Cytosolic pH Feedback on Proton Pump Activity and ATP Affinity of V-type ATPase from Arabidopsis

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V-ATPase: a master effector of E2F1-mediated lysosomal trafficking, mTORC1 activation and autophagy

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Age-related endolysosome dysfunction in the rat urothelium

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SESN2 negatively regulates cell proliferation and casein synthesis by inhibition the amino acid-mediated mTORC1 pathway in cow mammary epithelial cells

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Making sense of amino acid sensing

Abraham, R. T. (2015) · Science · doi:10.1126/science.aaa4570 · Cited by 42

Intestinal apical polarity mediates regulation of TORC1 by glucosylceramide in C. elegansPreprint

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Amino acids-Rab1A-mTORC1 signaling controls whole-body glucose homeostasis

Zhang, X., Wang, X., Yuan, Z., Radford, S. J., Liu, C., Libutti, S. K., & Zheng, X. F. S. (2021) · Cell Reports · doi:10.1016/j.celrep.2021.108830 · Cited by 41

TOR kinase, a GPS in the complex nutrient and hormonal signaling networks to guide plant growth and development

Meng, Y., Zhang, N., Li, J., Shen, X., Sheen, J., & Xiong, Y. (2022) · Journal of Experimental Botany · doi:10.1093/jxb/erac282 · Cited by 47

An mTORC1-mediated negative feedback loop constrains amino acid-induced FLCN-Rag activation in renal cells with TSC2 loss

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Dual phosphorylation of Sin1 at T86 and T398 negatively regulates mTORC2 complex integrity and activity

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The vesicular ATPase: A missing link between acidification and exocytosis

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Lysosomes contribute to radioresistance in cancer

Zhang, X., Wang, J., Li, X., & Wang, D. (2018) · Cancer Letters · doi:10.1016/j.canlet.2018.08.029 · Cited by 40

The Effect of Cellular Coenzyme Q10 Deficiency on Lysosomal Acidification

Heaton, R. A., Heales, S., Rahman, K., Sexton, D. W., & Hargreaves, I. P. (2020) · Journal of Clinical Medicine · doi:10.3390/jcm9061923 · Cited by 41

Amino Acid Transporters Are a Vital Focal Point in the Control of mTORC1 Signaling and Cancer

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The solute carrier SLC15A4 is required for optimal trafficking of nucleic acid–sensing TLRs and ligands to endolysosomes

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Monoterpene Glycoside ESK246 from Pittosporum Targets LAT3 Amino Acid Transport and Prostate Cancer Cell Growth

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Lysosomes at the Crossroads of Cell Metabolism, Cell Cycle, and Stemness

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Ras-mutant cancers are sensitive to small molecule inhibition of V-type ATPases in mice

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Chemical Genetics of Rapamycin-Insensitive TORC2 in S. cerevisiae

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Integrating autophagy and metabolism in cancer

Cheong, H. (2015) · Archives of Pharmacal Research · doi:10.1007/s12272-015-0562-2 · Cited by 40

The lysosomal signaling anchor p18/LAMTOR1 controls epidermal development by regulating lysosome-mediated catabolic processes

Soma‐Nagae, T., Nada, S., Kitagawa, M., Takahashi, Y., Mori, S., Oneyama, C., & Okada, M. (2013) · Journal of Cell Science · doi:10.1242/jcs.121913 · Cited by 40

Target of rapamycin signaling mediates vacuolar fission caused by endoplasmic reticulum stress inSaccharomyces cerevisiae

Stauffer, B., & Powers, T. (2015) · Molecular Biology of the Cell · doi:10.1091/mbc.e15-06-0344 · Cited by 39

Improved transcription and translation with L-leucine stimulation of mTORC1 in Roberts syndrome

Xu, B., Gogol, M., Gaudenz, K., & Gerton, J. L. (2016) · BMC Genomics · doi:10.1186/s12864-015-2354-y · Cited by 40

The E3 ubiquitin ligase ZNRF2 is a substrate of mTORC1 and regulates its activation by amino acids

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Giant Cellular Vacuoles Induced by Rare Earth Oxide Nanoparticles are Abnormally Enlarged Endo/Lysosomes and Promote mTOR-Dependent TFEB Nucleus Translocation

Lin, J., Shi, S.-S., Zhang, J., Zhang, Y., Zhang, L., Liu, Y., Jin, P., Wei, P., Shi, R., Zhou, W., et al. (2016) · Small · doi:10.1002/smll.201601903 · Cited by 40

The yeast H+-ATPase Pma1 promotes Rag/Gtr-dependent TORC1 activation in response to H+-coupled nutrient uptake

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Src regulates amino acid-mediated mTORC1 activation by disrupting GATOR1-Rag GTPase interaction

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Spatial control of AMPK signaling at subcellular compartments

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Enzyme Replacement Therapy Can Reverse Pathogenic Cascade in Pompe Disease

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Current Sarcoidosis Models and the Importance of Focusing on the Granuloma

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Mechanism of Activation of Mechanistic Target of Rapamycin Complex 1 by Methionine

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Loss of PKD1/polycystin-1 impairs lysosomal activity in a CAPN (calpain)-dependent manner

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The regulation of healthspan and lifespan by dietary amino acids

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Roles of mTOR in the Regulation of Pancreatic β-Cell Mass and Insulin Secretion

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Regulatory Cells and Transplantation TolerancePreprint

Cobbold, S. P., & Waldmann, H. (2013) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a015545 · Cited by 38

mTOR Signaling Pathway and Gut Microbiota in Various Disorders: Mechanisms and Potential Drugs in Pharmacotherapy

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The V-ATPase/ATG16L1 axis is controlled by the V1H subunit

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Heterogeneity of late endosome/lysosomes shown by multiplexed DNA-PAINT imaging

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Autophagy and Cell Death to Target Cancer Cells: Exploiting Synthetic Lethality as Cancer Therapies

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Metformin: An Inhibitor of mTORC1 Signaling

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Fine-tuning autophagy: from transcriptional to posttranslational regulation

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Direct interaction of the Golgi V-ATPase a-subunit isoform with PI(4)P drives localization of Golgi V-ATPases in yeast

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Exploiting cancer vulnerabilities: mTOR, autophagy, and homeostatic imbalance

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Sensors for the mTORC1 pathway regulated by amino acids

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Systematic Comparison of Strategies for the Enrichment of Lysosomes by Data Independent Acquisition

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Degradation and beyond

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A conformational change in the N terminus of SLC38A9 signals mTORC1 activation

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Lysosomal Functions in Glia Associated with Neurodegeneration

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TMEM135 links peroxisomes to the regulation of brown fat mitochondrial fission and energy homeostasis

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Phosphorylation of Ribosomal Protein S6 Mediates Mammalian Target of Rapamycin Complex 1–Induced Parathyroid Cell Proliferation in Secondary Hyperparathyroidism

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Sepsis-induced changes in amino acid transporters and leucine signaling via mTOR in skeletal muscle

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Sensing the Environment Through Sestrins: Implications for Cellular Metabolism

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Enteroendocrine-derived glucagon-like peptide-2 controls intestinal amino acid transport

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Branched-chain amino acids enhance cyst development in autosomal dominant polycystic kidney disease

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Target of rapamycin, a master regulator of multiple signalling pathways and a potential candidate gene for crop improvement

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Hepatic Lysosomal iNOS Activity Impairs Autophagy in Obesity

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A virulence factor as a therapeutic: the probiotic Enterococcus faecium SF68 arginine deiminase inhibits innate immune signaling pathways

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Towards dual function of autophagy in breast cancer: A potent regulator of tumor progression and therapy response

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The TRAF2-p62 axis promotes proliferation and survival of liver cancer by activating mTORC1 pathway

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Phagocytosed photoreceptor outer segments activate mTORC1 in the retinal pigment epithelium

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Detection and quantification of the vacuolar H+ATPase using the Legionella effector protein SidK

Maxson, M. E., Abbas, Y. M., Wu, J., Plumb, J. D., Grinstein, S., & Rubinstein, J. L. (2021) · The Journal of Cell Biology · doi:10.1083/jcb.202107174 · Cited by 37

Endosomal acidification by Na+/H+exchanger NHE5 regulates TrkA cell-surface targeting and NGF-induced PI3K signaling

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ATP-driven and AMPK-independent autophagy in an early branching eukaryotic parasite

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LC3B is lipidated to large lipid droplets during prolonged starvation for noncanonical autophagy

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Transcriptional and Epigenetic Regulation by the Mechanistic Target of Rapamycin Complex 1 Pathway

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Dorsal ruffles enhance activation of Akt by growth factors

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Stress Responses in Down Syndrome Neurodegeneration: State of the Art and Therapeutic Molecules

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The role of lysosomal ion channels in lysosome dysfunction

Kendall, R. L., & Holian, A. (2021) · Inhalation Toxicology · doi:10.1080/08958378.2021.1876188 · Cited by 38

Lysosomes in acute myeloid leukemia: potential therapeutic targets?

Rafiq, S., McKenna, S. L., Muller, S., Tschan, M. P., & Humbert, M. (2021) · Leukemia · doi:10.1038/s41375-021-01388-x · Cited by 34

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Molecular Mechanisms of Type 2 Diabetes-Related Heart Disease and Therapeutic Insights

Giraldo, G. C., Román-Gonzaléz, A., Cañas, F., & García, A. M. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26104548 · Cited by 38

Phospholipase D and mTORC1: Nutrients Are What Bring Them Together

Wiczer, B. M., & Thomas, G. (2012) · Science Signaling · doi:10.1126/scisignal.2003019 · Cited by 37

Discordant signaling and autophagy response to fasting in hearts of obese mice: Implications for ischemia tolerance

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Loss of hepatic DEPTOR alters the metabolic transition to fasting

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Amino acid and small GTPase regulation of mTORC1

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Energetic adaptations: Metabolic control of endocytic membrane traffic

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N-myristoyltransferase-1 is necessary for lysosomal degradation and mTORC1 activation in cancer cells

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From the inside out: Ion fluxes at the centre of endocytic traffic

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The V-ATPase a3 Subunit: Structure, Function and Therapeutic Potential of an Essential Biomolecule in Osteoclastic Bone Resorption

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The Hippo kinase LATS2 impairs pancreatic β-cell survival in diabetes through the mTORC1-autophagy axis

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Hexamethylene amiloride engages a novel reactive oxygen species- and lysosome-dependent programmed necrotic mechanism to selectively target breast cancer cells

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Diverse Functions of Lipids and Lipid Metabolism in Development

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mTORC1 controls Golgi architecture and vesicle secretion by phosphorylation of SCYL1

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PERSPECTIVES

(2011)

Ragulator-Rag Complex Targets mTORC1 to the Lysosomal Surface and Is Necessary for Its Activation by Amino Acids

Sancak, Y., Bar-Peled, L., Zoncu, R., Markhard, A. L., Nada, S., & Sabatini, D. M. (2010) · Cell · doi:10.1016/j.cell.2010.02.024 · Cited by 2,464

Rag–Ragulator is the central organizer of the physical architecture of the mTORC1 nutrient-sensing pathway

Valenstein, M. L., Lalgudi, P. V., Gu, X., Kedir, J. F., Taylor, M. S., Chivukula, R. R., & Sabatini, D. M. (2024) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2322755121 · Cited by 34

Deciphering the molecular mechanisms of amino acid sensing by mTOR

Angelidaki, D. D. (2023) · Kölner Universitäts PublikationsServer (Universität zu Köln)