mTORC1 Senses Lysosomal Amino Acids Through an Inside-Out Mechanism That Requires the Vacuolar H + -ATPase

Repertoires of Autophagy in the Pathogenesis of Ocular Diseases

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mTOR: from growth signal integration to cancer, diabetes and ageing

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The Rag GTPases Bind Raptor and Mediate Amino Acid Signaling to mTORC1

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Ragulator-Rag Complex Targets mTORC1 to the Lysosomal Surface and Is Necessary for Its Activation by Amino Acids

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Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling

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Tuberous Sclerosis Complex Gene Products, Tuberin and Hamartin, Control mTOR Signaling by Acting as a GTPase-Activating Protein Complex toward Rheb

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Requirement of Prorenin Receptor and Vacuolar H + -ATPase–Mediated Acidification for Wnt Signaling

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Disruption of the Rag-Ragulator Complex by c17orf59 Inhibits mTORC1

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Role of Rab GTPases and their interacting proteins in mediating metabolic signalling and regulation

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Subcellular Distribution and Activity of Mechanistic Target of Rapamycin in Aged Retinal Pigment Epithelium

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Genetic heterogeneity in familial nocturnal frontal lobe epilepsy.

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Lysosome biogenesis regulated by the amino-acid transporter SLC15A4 is critical for functional integrity of mast cells

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Insights into the transport side of the human SLC38A9 transceptor

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Ion Channels and Transporters in Autophagy

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DDRGK1, a crucial player of ufmylation system, is indispensable for autophagic degradation by regulating lysosomal function

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Autophagy Inhibition in BRAF-Driven Cancers

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ZRANB1 enhances stem-cell-like features and accelerates tumor progression by regulating Sox9-mediated USP22/Wnt/β-catenin pathway in colorectal cancer

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How Cells Deal with the Fluctuating Environment: Autophagy Regulation under Stress in Yeast and Mammalian Systems

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CryoEM of endogenous mammalian V-ATPase interacting with the TLDc protein mEAK-7

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Comparative landscape of genetic dependencies in human and chimpanzee stem cells

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Rheb Protein Binds CAD (Carbamoyl-phosphate Synthetase 2, Aspartate Transcarbamoylase, and Dihydroorotase) Protein in a GTP- and Effector Domain-dependent Manner and Influences Its Cellular Localization and Carbamoyl-phosphate Synthetase (CPSase) Activity

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Cucurbitacin E Induces Autophagy via Downregulating mTORC1 Signaling and Upregulating AMPK Activity

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Putative metal binding site in the transmembrane domain of the manganese transporter SLC30A10 is different from that of related zinc transporters

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The SLC36 transporter Pathetic is required for extreme dendrite growth in Drosophila sensory neuronsPreprint

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The rapid proximity labeling system PhastID identifies ATP6AP1 as an unconventional GEF for Rheb

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Lysosome quality control in health and neurodegenerative diseases

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Tuberous Sclerosis Complex Protein 2-Independent Activation of mTORC1 by Human Cytomegalovirus pUL38

Bai, Y., Xuan, B., Liu, H., Zhong, J., Yu, D. L., & Qian, Z. (2015) · Journal of Virology · doi:10.1128/jvi.01027-15 · Cited by 30

Lipid droplet consumption is functionally coupled to vacuole homeostasis independent of lipophagy

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Myeloid folliculin balances mTOR activation to maintain innate immunity homeostasis

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Loss of Furin in β-Cells Induces an mTORC1-ATF4 Anabolic Pathway That Leads to β-Cell Dysfunction

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Endolysosomal TRPMLs in Cancer

Xu, M., & Dong, X. (2021) · Biomolecules · doi:10.3390/biom11010065 · Cited by 33

ArfGAP1 inhibits mTORC1 lysosomal localization and activation

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eIF4A inactivates TORC1 in response to amino acid starvation

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Effects of diphyllin as a novel V-ATPase inhibitor on TE-1 and ECA-109 cells

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The Vacuolar ATPase – A Nano-scale Motor That Drives Cell Biology

Harrison, M. A., & Muench, S. P. (2018) · Sub-cellular biochemistry/Subcellular biochemistry · doi:10.1007/978-981-10-7757-9_14 · Cited by 32

KAT7-mediated CANX (calnexin) crotonylation regulates leucine-stimulated MTORC1 activity

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Regulation of lysosomes in skeletal muscle during exercise, disuse and aging

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Dynamin inhibitors block activation of mTORC1 by amino acids independently of dynamin

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PATs and SNATs: Amino Acid Sensors in Disguise

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Cytosolic glucosylceramide regulates endolysosomal function in Niemann-Pick type C disease

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Methionine supply during the periparturient period enhances insulin signaling, amino acid transporters, and mechanistic target of rapamycin pathway proteins in adipose tissue of Holstein cows

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Phagocytosis: Phenotypically Simple Yet a Mechanistically Complex Process

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Lysosomal recycling of amino acids affects ER quality control

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Possible Therapeutic Use of Natural Compounds Against COVID-19

Khan, N., Chen, X., & Geiger, J. D. (2021) · Journal of Cellular Signaling · doi:10.33696/signaling.2.036 · Cited by 30

CCDC88A/GIV promotes HBV replication and progeny secretion via enhancing endosomal trafficking and blocking autophagic degradation

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Towards a better understanding of the neuro-developmental role of autophagy in sickness and in health

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USP32-regulated LAMTOR1 ubiquitination impacts mTORC1 activation and autophagy induction

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Growth or death? Control of cell destiny by mTOR and autophagy pathways

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Sorting nexin 10 controls mTOR activation through regulating amino-acid metabolism in colorectal cancer

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A role for TOR signaling at every stage of plant life

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Host nutrient sensing is mediated by mTOR signaling in cnidarian-dinoflagellate symbiosis

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mTORC1 activity licenses its own release from the lysosomal surface

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Heavy metal-induced disruption of the autophagy-lysosomal pathway: implications for aging and neurodegenerative disorders

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Fluctuations in cell density alter protein markers of multiple cellular compartments, confounding experimental outcomes

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Amino acids stimulate the endosome-to-Golgi trafficking through Ragulator and small GTPase Arl5

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AKT Ser/Thr kinase increases V-ATPase–dependent lysosomal acidification in response to amino acid starvation in mammalian cells

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Pharmacological Targeting of Vacuolar H+-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer

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Regulation of DNA duplication by the mTOR signaling pathway

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Defective Lipid Droplet–Lysosome Interaction Causes Fatty Liver Disease as Evidenced by Human Mutations in TMEM199 and CCDC115

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New Insights into the Regulation of mTOR Signaling via Ca2+-Binding Proteins

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The role of TFEB in tumor cell autophagy: Diagnostic and therapeutic opportunities

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Comprehensive draft of the mouse embryonic fibroblast lysosomal proteome by mass spectrometry based proteomics

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Targeted Quantification of the Lysosomal Proteome in Complex Samples

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The balance of protein expression and degradation: an ESCRTs point of view

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Dimeric quinacrines as chemical tools to identify PPT1, a new regulator of autophagy in cancer cells

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Heat shock factor 4 regulates lysosome activity by modulating the αB-crystallin-ATP6V1A-mTOR complex in ocular lens

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Nanoparticle-Mediated Therapeutic Application for Modulation of Lysosomal Ion Channels and Functions

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Growth and metabolic responses of grouper juveniles (Epinephelus coioides) fed diets containing varying levels of leucine

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Comparative genomics incorporating translocation renal cell carcinoma mouse model reveals molecular mechanisms of tumorigenesis

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Fetal Bovine Serum

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The Atg1-Tor pathway regulates yolk catabolism in Drosophila embryos

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Aberrant hyper-expression of the RNA binding protein GIGYF2 in endothelial cells modulates vascular aging and function

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Ketamine Inside Neurons?

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FLCN Maintains the Leucine Level in Lysosome to Stimulate mTORC1

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The effects of reduced dietary protein level on amino acid transporters and mTOR signaling pathway in pigs

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Nanotechnology-Based Targeting of mTOR Signaling in Cancer

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High Metabolic Function and Resilience of NKG2A-Educated NK Cells

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Lysosomes in T Cell Immunity and Aging

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Autophagy and the (Pro)renin Receptor

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Role of Notch signaling during lipopolysaccharide-induced preterm labor

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Biolayer interferometry of lipid nanodisc‐reconstituted yeast vacuolar H+‐ATPase

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GSK-3-TSC axis governs lysosomal acidification through autophagy and endocytic pathways

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A GC-MS/Single-Cell Method to Evaluate Membrane Transporter Substrate Specificity and Signaling

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SPAR, a lncRNA encoded mTORC1 inhibitor

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HEPES Activates a MiT/TFE-dependent Lysosomal-Autophagic Gene Network in Cultured Cells: A Call for Caution

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Reassessment of the Role of TSC, mTORC1 and MicroRNAs in Amino Acids-Meditated Translational Control of TOP mRNAs

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The tumor suppressor p53 regulates autophagosomal and lysosomal biogenesis in lung cancer cells by targeting transcription factor EB

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Cross Talk Networks of Mammalian Target of Rapamycin Signaling With the Ubiquitin Proteasome System and Their Clinical Implications in Multiple Myeloma

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Amino Acids Enhance Polyubiquitination of Rheb and Its Binding to mTORC1 by Blocking Lysosomal ATXN3 Deubiquitinase Activity

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PERSPECTIVES

(2011)

Ragulator-Rag Complex Targets mTORC1 to the Lysosomal Surface and Is Necessary for Its Activation by Amino Acids

Sancak, Y., Bar-Peled, L., Zoncu, R., Markhard, A. L., Nada, S., & Sabatini, D. M. (2010) · Cell · doi:10.1016/j.cell.2010.02.024 · Cited by 2,464

Rag–Ragulator is the central organizer of the physical architecture of the mTORC1 nutrient-sensing pathway

Valenstein, M. L., Lalgudi, P. V., Gu, X., Kedir, J. F., Taylor, M. S., Chivukula, R. R., & Sabatini, D. M. (2024) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2322755121 · Cited by 34

Deciphering the molecular mechanisms of amino acid sensing by mTOR

Angelidaki, D. D. (2023) · Kölner Universitäts PublikationsServer (Universität zu Köln)