mTORC1 Senses Lysosomal Amino Acids Through an Inside-Out Mechanism That Requires the Vacuolar H + -ATPase

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Orexin/Hypocretin Activates mTOR Complex 1 (mTORC1) via an Erk/Akt-independent and Calcium-stimulated Lysosome v-ATPase Pathway

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A Compendium of Information on the Lysosome

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Host mTORC1 Signaling Regulates Andes Virus Replication

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Osteoclast proton pump regulator Atp6v1c1 enhances breast cancer growth by activating the mTORC1 pathway and bone metastasis by increasing V-ATPase activity

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Whi2 is a conserved negative regulator of TORC1 in response to low amino acids

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NOX1-Dependent mTORC1 Activation via S100A9 Oxidation in Cancer Stem-like Cells Leads to Colon Cancer Progression

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Lysosomes mediate the mitochondrial UPR via mTORC1-dependent ATF4 phosphorylation

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Progress and Challenges in the Use of MAP1LC3 as a Legitimate Marker for Measuring Dynamic Autophagy In Vivo

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SARS-CoV-2 Neuronal Invasion and Complications: Potential Mechanisms and Therapeutic Approaches

Swain, O., Romano, S. K., Miryala, R., Tsai, J., Parikh, V., & Umanah, G. K. E. (2021) · Journal of Neuroscience · doi:10.1523/jneurosci.3188-20.2021 · Cited by 44

FBXW11 contributes to stem-cell-like features and liver metastasis through regulating HIC1-mediated SIRT1 transcription in colorectal cancer

Yao, J., Yang, H. J., Yang, Z., Wang, X., Yang, T., Ji, B., & Zhang, Z.-Y. (2021) · Cell Death and Disease · doi:10.1038/s41419-021-04185-7 · Cited by 44

βA3/A1-crystallin: More than a lens protein

Zigler, J. S., & Sinha, D. (2014) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2014.11.002 · Cited by 42

Lysosomal cystine export regulates mTORC1 signaling to guide kidney epithelial cell fate specialization

Berquez, M., Chen, Z., Festa, B. P., Krohn, P., Keller, S. A., Parolo, S., Korzinkin, M., Gaponova, A. V., Laczkó, E., Domenici, E., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-39261-3 · Cited by 51

PRKAA2, MTOR, and TFEB in the regulation of lysosomal damage response and autophagy

Shariq, M., Khan, M. F., Raj, R., Ahsan, N., & Kumar, P. (2024) · Journal of Molecular Medicine · doi:10.1007/s00109-023-02411-7 · Cited by 42

Stay in touch with the endoplasmic reticulum

Sun, S., Gan, Z., Jia, M., Jiang, Q., Li, S., Wang, H., Li, W., Wang, Y., Bian, X., Zhao, Y. G., et al. (2024) · Science China Life Sciences · doi:10.1007/s11427-023-2443-9 · Cited by 45

Stress eating and tuning out: Cancer cells re-wire metabolism to counter stress

Stine, Z. E., & Dang, C. V. (2013) · Critical Reviews in Biochemistry and Molecular Biology · doi:10.3109/10409238.2013.844093 · Cited by 44

The Putative HORMA Domain Protein Atg101 Dimerizes and Is Required for Starvation-Induced and Selective Autophagy inDrosophila

Hegedűs, K., Nagy, P., Gáspári, Z., & Juhász, G. (2014) · BioMed Research International · doi:10.1155/2014/470482 · Cited by 47

Key mediators of intracellular amino acids signaling to mTORC1 activation

Duan, Y., Li, F., Tan, K., Liu, H., Li, Y., Liu, Y., Kong, X., Tang, Y., Wu, G., & Yin, Y. (2015) · Amino Acids · doi:10.1007/s00726-015-1937-x · Cited by 43

Discovery of a Small-Molecule Probe for V-ATPase Function

Aldrich, L. N., Kuo, S.-Y., Castoreno, A. B., Goel, G., Kuballa, P., Rees, M. G., Seashore-Ludlow, B. A., Cheah, J. H., Latorre, I. J., Schreiber, S. L., et al. (2015) · Journal of the American Chemical Society · doi:10.1021/jacs.5b02150 · Cited by 44

TMEM 55B contributes to lysosomal homeostasis and amino acid–induced mTORC 1 activation

Hashimoto, Y., Shirane, M., & Nakayama, K. I. (2018) · Genes to Cells · doi:10.1111/gtc.12583 · Cited by 46

Glycine Enhances Satellite Cell Proliferation, Cell Transplantation, and Oligonucleotide Efficacy in Dystrophic Muscle

Lin, C., Han, G., Ning, H., Song, J., Ran, N., Yi, X., Seow, Y., & Yin, H. (2020) · Molecular Therapy · doi:10.1016/j.ymthe.2020.03.003 · Cited by 43

Kinase mTOR: Regulation and role in maintenance of cellular homeostasis, tumor development, and aging

Parkhitko, A. A., Favorova, O. O., Khabibullin, D., Anisimov, V. N., & Henske, E. P. (2014) · Biochemistry (Moscow) · doi:10.1134/s0006297914020023 · Cited by 44

Elevated Glucosylsphingosine in Gaucher Disease induced Pluripotent Stem Cell Neurons Deregulates Lysosomal Compartment through Mammalian Target of Rapamycin Complex 1

Srikanth, M. P., Jones, J. W., Kane, M. A., Awad, O., Park, T. S., Zambidis, E. T., & Feldman, R. A. (2021) · Stem Cells Translational Medicine · doi:10.1002/sctm.20-0386 · Cited by 44

Lysosomes in retinal health and disease

Boya, P., Kaarniranta, K., Handa, J. T., & Sinha, D. (2023) · Trends in Neurosciences · doi:10.1016/j.tins.2023.09.006 · Cited by 44

Chemoproteomic development of SLC15A4 inhibitors with anti-inflammatory activity

Chiu, T.-Y., Lazar, D. C., Wang, W., Wozniak, J. M., Jadhav, A. M., Li, W., Gazaniga, N. R., Theofilopoulos, A. N., Teijaro, J. R., & Parker, C. G. (2024) · Nature Chemical Biology · doi:10.1038/s41589-023-01527-8 · Cited by 44

Amino acid signalling upstream of mTOR

Jewell, J. L., Russell, R. C., & Guan, K.-L. (2013) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3522 · Cited by 894

PERSPECTIVES

(2011)

Ragulator-Rag Complex Targets mTORC1 to the Lysosomal Surface and Is Necessary for Its Activation by Amino Acids

Sancak, Y., Bar-Peled, L., Zoncu, R., Markhard, A. L., Nada, S., & Sabatini, D. M. (2010) · Cell · doi:10.1016/j.cell.2010.02.024 · Cited by 2,464

Rag–Ragulator is the central organizer of the physical architecture of the mTORC1 nutrient-sensing pathway

Valenstein, M. L., Lalgudi, P. V., Gu, X., Kedir, J. F., Taylor, M. S., Chivukula, R. R., & Sabatini, D. M. (2024) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2322755121 · Cited by 34

Deciphering the molecular mechanisms of amino acid sensing by mTOR

Angelidaki, D. D. (2023) · Kölner Universitäts PublikationsServer (Universität zu Köln)