mTORC1 Senses Lysosomal Amino Acids Through an Inside-Out Mechanism That Requires the Vacuolar H + -ATPase

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Tuberous Sclerosis Complex Gene Products, Tuberin and Hamartin, Control mTOR Signaling by Acting as a GTPase-Activating Protein Complex toward Rheb

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MITF in Normal Melanocytes, Cutaneous and Uveal Melanoma: A Delicate Balance

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Roles for PI(3,5)P2 in nutrient sensing through TORC1

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Serine and one-carbon metabolism, a bridge that links mTOR signaling and DNA methylation in cancer

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Nutrients: Signal 4 in T cell immunity

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Modulation of mTOR signaling as a strategy for the treatment of Pompe disease

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Hybrid Structure of the RagA/C-Ragulator mTORC1 Activation Complex

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DRAM1 Regulates Autophagy Flux through Lysosomes

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Mode of Cell Death Induction by Pharmacological Vacuolar H+-ATPase (V-ATPase) Inhibition

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A vitamin-B2-sensing mechanism that regulates gut protease activity to impact animal’s food behavior and growth

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Emerging roles and regulation of MiT/TFE transcriptional factors

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Autophagosome biogenesis and human health

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Pyrimidine Biosynthetic Enzyme CAD: Its Function, Regulation, and Diagnostic Potential

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Activation of the Mechanistic Target of Rapamycin in SLE: Explosion of Evidence in the Last Five Years

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SH3BP4 Is a Negative Regulator of Amino Acid-Rag GTPase-mTORC1 Signaling

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Lysosomes Support the Degradation, Signaling, and Mitochondrial Metabolism Necessary for Human Epidermal Differentiation

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Sugar metabolism and the plant target of rapamycin kinase: a sweet operaTOR?

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Leucyl-tRNA Synthetase Activates Vps34 in Amino Acid-Sensing mTORC1 Signaling

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Subcellular Trafficking of Mammalian Lysosomal Proteins: An Extended View

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The Regulation and Function of the L-Type Amino Acid Transporter 1 (LAT1) in Cancer

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Ribosomal Protein S6: A Potential Therapeutic Target against Cancer?

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Glucose Starvation Inhibits Autophagy via Vacuolar Hydrolysis and Induces Plasma Membrane Internalization by Down-regulating Recycling

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Lysosomes: regulators of autophagy in the retinal pigmented epithelium

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Review of the Correlation of LAT1 With Diseases: Mechanism and Treatment

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p38γ and p38δ: From Spectators to Key Physiological Players

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Sestrin modulator NV-5138 produces rapid antidepressant effects via direct mTORC1 activation

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Mutations in the X-linked ATP6AP2 cause a glycosylation disorder with autophagic defects

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Autophagy stimulation as a promising approach in treatment of neurodegenerative diseases

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Regulation of metabolic health by essential dietary amino acids

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New concepts of endoplasmic reticulum function in the heart: Programmed to conserve

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mTOR Activity and Autophagy in Senescent Cells, a Complex Partnership

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Novel Approaches for Molecular Targeted Therapy of Breast Cancer: Interfering with PI3K/AKT/mTOR Signaling

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Efficacy and Safety of Leucine Supplementation in the Elderly

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Consumption of milk protein or whey protein results in a similar increase in muscle protein synthesis in middle aged men

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Rab12 regulates mTORC1 activity and autophagy through controlling the degradation of amino‐acid transporter PAT4

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AMP-activated protein kinase – not just an energy sensor

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An mTORC1-Mdm2-Drosha Axis for miRNA Biogenesis in Response to Glucose- and Amino Acid-Deprivation

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Glutamine deprivation stimulates mTOR-JNK-dependent chemokine secretion

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Aldolase is a sensor for both low and high glucose, linking to AMPK and mTORC1

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Aminoacyl-tRNA synthetases and amino acid signaling

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Sex Differences in Autophagy Contribute to Female Vulnerability in Alzheimer's Disease

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Lysosomal degradation of newly formed insulin granules contributes to β cell failure in diabetes

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A nanobuffer reporter library for fine-scale imaging and perturbation of endocytic organelles

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Amino Acids Regulate mTORC1 by an Obligate Two-step Mechanism

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Helicobacter pylori Infection Modulates Host Cell Metabolism through VacA-Dependent Inhibition of mTORC1

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The Importance of TOR Kinase in Plant Development

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The ion channels of endomembranes

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Retrograde signaling from autophagy modulates stress responses

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Lysosomal dysfunction in Down syndrome and Alzheimer mouse models is caused by v-ATPase inhibition by Tyr 682 -phosphorylated APP βCTF

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Arginine methylation is required for canonical Wnt signaling and endolysosomal trafficking

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Lysosomal retargeting of Myoferlin mitigates membrane stress to enable pancreatic cancer growth

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Mitf is a master regulator of the v-ATPase forming an Mitf/v-ATPase/TORC1 control module for cellular homeostasis

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Conserved regulators of Rag GTPases orchestrate amino acid-dependent TORC1 signaling

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Impairment of Lysosome Function and Autophagy in Rare Neurodegenerative Diseases

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Phagosome resolution regenerates lysosomes and maintains the degradative capacity in phagocytes

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The Architecture of the Rag GTPase Signaling Network

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Drug discovery targeting the mTOR pathway

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The post‐translational regulation of transcription factor EB (TFEB) in health and disease

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Liver Autophagy in Anorexia Nervosa and Acute Liver Injury

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The mTORC1/4E-BP pathway coordinates hemoglobin production with L -leucine availability

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Enhanced translation expands the endo-lysosome size and promotes antigen presentation during phagocyte activation

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Autophagy in cancer cell remodeling and quality control

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Macrophages recycle phagocytosed bacteria to fuel immunometabolic responses

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The Effects of Testosterone Deprivation and Supplementation on Proteasomal and Autophagy Activity in the Skeletal Muscle of the Male Mouse: Differential Effects on High-Androgen Responder and Low-Androgen Responder Muscle Groups

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Dietary methionine imbalance alters the transcriptional regulation of genes involved in glucose, lipid and amino acid metabolism in the liver of rainbow trout (Oncorhynchus mykiss)

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GSK3-mediated raptor phosphorylation supports amino-acid-dependent mTORC1-directed signalling

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PERSPECTIVES

(2011)

Ragulator-Rag Complex Targets mTORC1 to the Lysosomal Surface and Is Necessary for Its Activation by Amino Acids

Sancak, Y., Bar-Peled, L., Zoncu, R., Markhard, A. L., Nada, S., & Sabatini, D. M. (2010) · Cell · doi:10.1016/j.cell.2010.02.024 · Cited by 2,464

Rag–Ragulator is the central organizer of the physical architecture of the mTORC1 nutrient-sensing pathway

Valenstein, M. L., Lalgudi, P. V., Gu, X., Kedir, J. F., Taylor, M. S., Chivukula, R. R., & Sabatini, D. M. (2024) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2322755121 · Cited by 34

Deciphering the molecular mechanisms of amino acid sensing by mTOR

Angelidaki, D. D. (2023) · Kölner Universitäts PublikationsServer (Universität zu Köln)