Tet Proteins Can Convert 5-Methylcytosine to 5-Formylcytosine and 5-Carboxylcytosine

Conversion of 5-Methylcytosine to 5-Hydroxymethylcytosine in Mammalian DNA by MLL Partner TET1

Tahiliani, M., Koh, K. P., Shen, Y., Pastor, W. A., Bandukwala, H., Brudno, Y., Agarwal, S., Iyer, L. M., Liu, D. R., Aravind, L., et al. (2009) · Science · doi:10.1126/science.1170116 · Cited by 5,836

The Nuclear DNA Base 5-Hydroxymethylcytosine Is Present in Purkinje Neurons and the Brain

Kriaucionis, S., & Heintz, N. (2009) · Science · doi:10.1126/science.1169786 · Cited by 2,700

Role of Tet proteins in 5mC to 5hmC conversion, ES-cell self-renewal and inner cell mass specification

Ito, S., D’Alessio, A. C., Taranova, O., Hong, K., Sowers, L. C., & Zhang, Y. (2010) · Nature · doi:10.1038/nature09303 · Cited by 2,628

EUKARYOTIC CYTOSINE METHYLTRANSFERASES

Goll, M. G., & Bestor, T. H. (2005) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.74.010904.153721 · Cited by 2,162

Hydroxylation of 5-Methylcytosine by TET1 Promotes Active DNA Demethylation in the Adult Brain

Guo, J. U., Su, Y., Zhong, C., Ming, G., & Song, H. (2011) · Cell · doi:10.1016/j.cell.2011.03.022 · Cited by 1,404

Active DNA demethylation: many roads lead to Rome

Wu, S. C., & Zhang, Y. (2010) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2950 · Cited by 1,091

Tissue Distribution of 5-Hydroxymethylcytosine and Search for Active Demethylation Intermediates

Globisch, D., Münzel, M., Müller, M., Michalakis, S., Wagner, M., Koch, S., Brückl, T., Biel, M., & Carell, T. (2010) · PLoS ONE · doi:10.1371/journal.pone.0015367 · Cited by 865

Thymine DNA glycosylase is essential for active DNA demethylation by linked deamination-base excision repair

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The Colorful History of Active DNA Demethylation

Ooi, S. K. T., & Bestor, T. H. (2008) · Cell · doi:10.1016/j.cell.2008.06.009 · Cited by 537

DNA demethylation by DNA repair

Gehring, M. A., Reik, W., & Henikoff, S. (2009) · Trends in Genetics · doi:10.1016/j.tig.2008.12.001 · Cited by 288

Effects of DNA, RNA, and Protein Methylation on the Regulation of Ferroptosis

Wang, X., Kong, X., Feng, X., & Jiang, D. (2023) · International Journal of Biological Sciences · doi:10.7150/ijbs.85454 · Cited by 62

TET-catalyzed 5-methylcytosine hydroxylation is dynamically regulated by metabolites

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Molecular pathogenesis of atypical CML, CMML and MDS/MPN-unclassifiable

Zoi, K., & Cross, N. C. P. (2014) · International Journal of Hematology · doi:10.1007/s12185-014-1670-3 · Cited by 62

Regulation of SOD2 in Cancer by Histone Modifications and CpG Methylation: Closing the Loop Between Redox Biology and Epigenetics

Cyr, A. R., Hitchler, M. J., & Domann, F. E. (2012) · Antioxidants and Redox Signaling · doi:10.1089/ars.2012.4850 · Cited by 62

Lesion processing by a repair enzyme is severely curtailed by residues needed to prevent aberrant activity on undamaged DNA

Maiti, A., Noon, M. S., MacKerell, A. D., Pozharski, E. V., & Drohat, A. C. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1201010109 · Cited by 61

Developing DNA methylation-based diagnostic biomarkers

Kim, H.-R., Wang, X., & Jin, P. (2018) · Journal of genetics and genomics/Journal of Genetics and Genomics · doi:10.1016/j.jgg.2018.02.003 · Cited by 61

OGT binds a conserved C-terminal domain of TET1 to regulate TET1 activity and function in development

Hrit, J. A., Goodrich, L., Cheng, L., Wang, B.-A., Nie, J., Cui, X., Martin, E. A., Simental, E., Fernandez, J. A., Liu, M. Y., et al. (2018) · eLife · doi:10.7554/elife.34870 · Cited by 63

Effects of Tet-induced oxidation products of 5-methylcytosine on Dnmt1- and DNMT3a-mediated cytosine methylation

Ji, D., Lin, K., Song, J., & Wang, Y. (2014) · Molecular BioSystems · doi:10.1039/c4mb00150h · Cited by 60

Vitamin C Transporters and Their Implications in Carcinogenesis

Linowiecka, K., Foksiński, M., & Brożyna, A. A. (2020) · Nutrients · doi:10.3390/nu12123869 · Cited by 61

Connections between metabolism and epigenetics: mechanisms and novel anti-cancer strategy

Chen, C., Wang, Z., & Qin, Y. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.935536 · Cited by 62

5mC-hydroxylase activity is influenced by the PARylation of TET1 enzyme

Ciccarone, F., Valentini, E., Zampieri, M., & Caiafa, P. (2015) · Oncotarget · doi:10.18632/oncotarget.4476 · Cited by 60

Identification of CD34+ and CD34− leukemia-initiating cells in MLL-rearranged human acute lymphoblastic leukemia

Aoki, Y., Watanabe, T., Saito, Y., Kuroki, Y., Hijikata, A., Takagi, M., Tomizawa, D., Eguchi, M., Eguchi‐Ishimae, M., Kaneko, A., et al. (2014) · Blood · doi:10.1182/blood-2014-03-563304 · Cited by 60

Integrated analyses of DNA methylation and hydroxymethylation reveal tumor suppressive roles of ECM1, ATF5, and EOMESin human hepatocellular carcinoma

Gao, F., Xia, Y., Wang, J., Lin, Z., Ou, Y., Liu, X., Liu, W., Zhou, B., Luo, H., Zhou, B., et al. (2014) · Genome biology · doi:10.1186/s13059-014-0533-9 · Cited by 61

Selective Detection of 5-Formyl-2′-deoxycytidine in DNA Using a Fluorogenic Hydroxylamine Reagent

Guo, P., Yan, S., Hu, J., Xing, X., Wang, C., Xu, X., Qiu, X., Ma, W., Lu, C., Weng, X., et al. (2013) · Organic Letters · doi:10.1021/ol401290d · Cited by 62

A primary role of TET proteins in establishment and maintenance ofDe Novobivalency at CpG islands

Kong, L., Tan, L., Lyu, R., Shi, Z., Xiong, L., Wu, F., Rabidou, K., Smith, M., He, C., Zhang, L., et al. (2016) · Nucleic Acids Research · doi:10.1093/nar/gkw529 · Cited by 64

Dysregulation and prognostic potential of 5-methylcytosine (5mC), 5-hydroxymethylcytosine (5hmC), 5-formylcytosine (5fC), and 5-carboxylcytosine (5caC) levels in prostate cancer

Storebjerg, T. M., Strand, S. H., Høyer, S., Lynnerup, A.-S., Borre, M., Orntoft, T. F., & Sørensen, K. D. (2018) · Clinical Epigenetics · doi:10.1186/s13148-018-0540-x · Cited by 60

Zinc Finger Readers of Methylated DNA

Hudson, N. O., & Buck‐Koehntop, B. A. (2018) · Molecules · doi:10.3390/molecules23102555 · Cited by 63

Selective and Sensitive Detection of Methylcytosine by Aerolysin Nanopore under Serum Condition

Yu, J., Cao, C., & Long, Y. (2017) · Analytical Chemistry · doi:10.1021/acs.analchem.7b03133 · Cited by 60

Epigenetic Regulators in the Development, Maintenance, and Therapeutic Targeting of Acute Myeloid Leukemia

Sun, Y., Chen, B.-R., & Deshpande, A. J. (2018) · Frontiers in Oncology · doi:10.3389/fonc.2018.00041 · Cited by 64

Environmental enrichment modulates 5-hydroxymethylcytosine dynamics in hippocampus

Irier, H. A., Street, R. C., Dave, R., Lin, L., Cai, C. W., Davis, T., Yao, B., Cheng, Y., & Jin, P. (2014) · Genomics · doi:10.1016/j.ygeno.2014.08.019 · Cited by 59

Genome-wide alteration of 5-hydroxymenthylcytosine in a mouse model of Alzheimer’s disease

Shu, L., Sun, W., Li, L., Xu, Z., Lin, L., Xie, P., Shen, H., Huang, L., Xu, Q., Jin, P., et al. (2016) · BMC Genomics · doi:10.1186/s12864-016-2731-1 · Cited by 59

Single-Cell Quantification of Cytosine Modifications by Hyperspectral Dark-Field Imaging

Wang, X., Cui, Y., & Irudayaraj, J. (2015) · ACS Nano · doi:10.1021/acsnano.5b04451 · Cited by 61

Epigenetic regulators: multifunctional proteins modulating hypoxia-inducible factor-α protein stability and activity

Luo, W., & Wang, Y. (2017) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-017-2684-9 · Cited by 59

What impact does oocyte vitrification have on epigenetics and gene expression?

Barberet, J., Barry, F., Choux, C., Guilleman, M., Karoui, S., Simonot, R., Bruno, C., & Fauque, P. (2020) · Clinical Epigenetics · doi:10.1186/s13148-020-00911-8 · Cited by 59

TET-Mediated Epigenetic Regulation in Immune Cell Development and Disease

Tsiouplis, N. J., Bailey, D. W., Chiou, L. F., Wissink, F. J., & Tsagaratou, A. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.623948 · Cited by 63

Modification mapping by nanopore sequencing

White, L. K., & Hesselberth, J. R. (2022) · Frontiers in Genetics · doi:10.3389/fgene.2022.1037134 · Cited by 61

Epigenetic regulation in the inner ear and its potential roles in development, protection, and regeneration

Layman, W. S., & Zuo, J. (2015) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2014.00446 · Cited by 61

Epigenetic markers of prostate cancer in plasma circulating DNA

Cortese, R., Kwan, A., Lalonde, E., Bryzgunova, O. E., Bondar, A. A., Wu, Y., Gordevičius, J., Park, M., Oh, G., Kaminsky, Z. A., et al. (2012) · Human Molecular Genetics · doi:10.1093/hmg/dds192 · Cited by 58

The Yin and Yang of Chromatin Dynamics In Stem Cell Fate Selection

Adam, R. C., & Fuchs, E. V. (2015) · Trends in Genetics · doi:10.1016/j.tig.2015.11.002 · Cited by 62

Arsenite Targets the Zinc Finger Domains of Tet Proteins and Inhibits Tet-Mediated Oxidation of 5-Methylcytosine

Liu, S., Jiang, J., Li, L., Amato, N. J., Wang, Z., & Wang, Y. (2015) · Environmental Science & Technology · doi:10.1021/acs.est.5b03386 · Cited by 58

Epigenetics in the Vascular Endothelium

Yan, M. S., & Marsden, P. A. (2015) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.115.305043 · Cited by 62

DNA Methylome Analysis Identifies Transcription Factor-Based Epigenomic Signatures of Multilineage Competence in Neural Stem/Progenitor Cells

Sanosaka, T., Imamura, T., Hamazaki, N., Chai, M., Igarashi, K., Ideta-Otsuka, M., Miura, F., Ito, T., Fujii, N., Ikeo, K., et al. (2017) · Cell Reports · doi:10.1016/j.celrep.2017.08.086 · Cited by 66

The epigenetics of perinatal stress

Moshe Szyf, A. (2019) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2019.21.4/mszyf · Cited by 58

The NTP pyrophosphatase DCTPP1 contributes to the homoeostasis and cleansing of the dNTP pool in human cells

Requena, C. E., Pérez‐Moreno, G., Ruiz-Pérez, L. M., Vidal, A. E., & González‐Pacanowska, D. (2014) · Biochemical Journal · doi:10.1042/bj20130894 · Cited by 57

Epigenetic Regulation of Neuroinflammation in Alzheimer’s Disease

Ma, Y., Wang, W., Liu, S., Qiao, X., Xing, Y., Zhou, Q., & Zhang, Z. (2023) · Cells · doi:10.3390/cells13010079 · Cited by 58

Reduction of global 5-hydroxymethylcytosine is a poor prognostic factor in breast cancer patients, especially for an ER/PR-negative subtype

Tsai, K., Li, G., Chen, C., Yeh, M.-H., Huang, J., Tseng, H., Fu, T., Liou, H., Pan, H., Huang, S., et al. (2015) · Breast Cancer Research and Treatment · doi:10.1007/s10549-015-3525-x · Cited by 57

Epigenetics advancing personalized nanomedicine in cancer therapy

Liu, S. (2012) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2012.08.004 · Cited by 59

Cell‐Penetrating and Neurotargeting Dendritic siRNA Nanostructures

Brunner, K., Harder, J., Halbach, T. S., Willibald, J., Spada, F., Gnerlich, F. A., Sparrer, K. M. J., Beil, A., Möckl, L., Bräuchle, C., et al. (2014) · Angewandte Chemie International Edition · doi:10.1002/anie.201409803 · Cited by 58

Identification of the Glucosyltransferase That Converts Hydroxymethyluracil to Base J in the Trypanosomatid Genome

Bullard, W. L., da Rosa, J. L., Liu, S., Wang, Y., & Sabatini, R. S. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.579821 · Cited by 57

5-Hydroxymethylcytosine Profiling as an Indicator of Cellular State

Laird, A., Thomson, J. P., Harrison, D. J., & Meehan, R. R. (2013) · Epigenomics · doi:10.2217/epi.13.69 · Cited by 58

Mechanisms of epigenetic memory and addiction

Tuesta, L. M., & Zhang, Y. (2014) · The EMBO Journal · doi:10.1002/embj.201488106 · Cited by 58

Epigenomics and the Regulation of Aging

Boyd-Kirkup, J. D., Green, C. D., Wu, G., Wang, D., & Han, J. J. (2013) · Epigenomics · doi:10.2217/epi.13.5 · Cited by 57

Hydrophilic Material for the Selective Enrichment of 5-Hydroxymethylcytosine and Its Liquid Chromatography–Tandem Mass Spectrometry Detection

Tang, Y., Chu, J.-M., Huang, W., Xiong, J., Xing, X., Zhou, X., Feng, Y., & Yuan, B. (2013) · Analytical Chemistry · doi:10.1021/ac4010869 · Cited by 57

CRISPR‐Based Targeted Epigenetic Editing Enables Gene Expression Modulation of the Silenced Beta‐Galactoside Alpha‐2,6‐Sialyltransferase 1 in CHO Cells

Marx, N., Grünwald‐Gruber, C., Bydlinski, N., Dhiman, H., Ly, N. N., Klanert, G., & Borth, N. (2018) · Biotechnology Journal · doi:10.1002/biot.201700217 · Cited by 57

Effect of PFOA on DNA Methylation and Alternative Splicing in Mouse Liver

Wen, Y., Chen, J., Li, J., Arif, W., Kalsotra, A., & Irudayaraj, J. (2020) · Toxicology Letters · doi:10.1016/j.toxlet.2020.04.012 · Cited by 57

The DNA methylation landscape of hematological malignancies: an update

Blecua, P., Martinez‐Verbo, L., & Esteller, M. (2020) · Molecular Oncology · doi:10.1002/1878-0261.12744 · Cited by 57

Targeted next-generation sequencing reveals high frequency of mutations in epigenetic regulators across treatment-naïve patient melanomas

Lee, J. J., Sholl, L. M., Lindeman, N. I., Granter, S. R., Laga, A. C., Shivdasani, P., Chin, G., Luke, J. J., Ott, P. A., Hodi, F. S., et al. (2015) · Clinical Epigenetics · doi:10.1186/s13148-015-0091-3 · Cited by 59

Aberrant DNA and histone methylation during zygotic genome activation in goat cloned embryos

Deng, M., Liu, Z., Chen, B., Wan, Y., Yang, H., Zhang, Y., Cai, Y., Zhou, J., & Wang, F. (2020) · Theriogenology · doi:10.1016/j.theriogenology.2020.02.036 · Cited by 56

Direct enzymatic sequencing of 5-methylcytosine at single-base resolution

Wang, T., Fowler, J. M., Liu, L., Loo, C. E., Luo, M., Schutsky, E. K., Berríos, K. N., DeNizio, J. E., Dvorak, A., Downey, N., et al. (2023) · Nature Chemical Biology · doi:10.1038/s41589-023-01318-1 · Cited by 56

Clonal hematopoiesis and hematological malignancy

Dunn, W. G., McLoughlin, M. A., & Vassiliou, G. S. (2024) · Journal of Clinical Investigation · doi:10.1172/jci180065 · Cited by 63

Base-resolution detection ofN4-methylcytosine in genomic DNA using 4mC-Tet-assisted-bisulfite- sequencing

Yu, M., Ji, L., Neumann, D. A., Chung, D.-H., Groom, J. D., Westpheling, J., He, C., & Schmitz, R. J. (2015) · Nucleic Acids Research · doi:10.1093/nar/gkv738 · Cited by 56

Next-Generation Sequencing Approaches in Cancer: Where Have They Brought Us and Where Will They Take Us?

Leblanc, V., & Marra, M. A. (2015) · Cancers · doi:10.3390/cancers7030869 · Cited by 57

Genome-wide alteration of 5-hydroxymethylcytosine in a mouse model of fragile X-associated tremor/ataxia syndrome

Yao, B., Lin, L., Street, R. C., Zalewski, Z. A., Galloway, J. N., Wu, H., Nelson, D. L., & Jin, P. (2013) · Human Molecular Genetics · doi:10.1093/hmg/ddt504 · Cited by 57

Histone H3 Variant Regulates RNA Polymerase II Transcription Termination and Dual Strand Transcription of siRNA Loci in Trypanosoma brucei

Reynolds, D. L., Hofmeister, B. T., Cliffe, L. J., Alabady, M., Siegel, T. N., Schmitz, R. J., & Sabatini, R. S. (2016) · PLoS Genetics · doi:10.1371/journal.pgen.1005758 · Cited by 56

Distributive Processing by the Iron(II)/α-Ketoglutarate-Dependent Catalytic Domains of the TET Enzymes Is Consistent with Epigenetic Roles for Oxidized 5-Methylcytosine Bases

Tamanaha, E., Guan, S., Marks, K., & Saleh, L. (2016) · Journal of the American Chemical Society · doi:10.1021/jacs.6b03243 · Cited by 57

Epigenetic studies in Developmental Origins of Health and Disease: pitfalls and key considerations for study design and interpretation

Yamada, L., & Chong, S. (2016) · Journal of Developmental Origins of Health and Disease · doi:10.1017/s2040174416000507 · Cited by 59

DNMT3A and TET2 in the Pre-Leukemic Phase of Hematopoietic Disorders

Sato, H., Wheat, J. C., Steidl, U. G., & Ito, K. (2016) · Frontiers in Oncology · doi:10.3389/fonc.2016.00187 · Cited by 59

Analysis of the machinery and intermediates of the 5hmC-mediated DNA demethylation pathway in aging on samples from the MARK-AGE Study

Valentini, E., Zampieri, M., Malavolta, M., Bacalini, M. G., Calabrese, R., Guastafierro, T., Reale, A., Franceschi, C., Hervonen, A., Koller, B., et al. (2016) · Aging · doi:10.18632/aging.101022 · Cited by 56

Differential DNA methylation and transcription profiles in date palm roots exposed to salinity

Al-Harrasi, I., Al-Yahyai, R. A., & Yaish, M. W. F. (2018) · PLoS ONE · doi:10.1371/journal.pone.0191492 · Cited by 56

Genome-wide mapping reveals that deoxyuridine is enriched in the human centromeric DNA

Shu, X., Liu, M., Lu, Z., Zhu, C., Meng, H., Huang, S., Zhang, X., & Yi, C. (2018) · Nature Chemical Biology · doi:10.1038/s41589-018-0065-9 · Cited by 57

TET enzymes control antibody production and shape the mutational landscape in germinal centre B cells

Schoeler, K., Aufschnaiter, A., Messner, S., Derudder, E., Herzog, S., Villunger, A., Rajewsky, K., & Labi, V. (2019) · FEBS Journal · doi:10.1111/febs.14934 · Cited by 59

HMCES Functions in the Alternative End-Joining Pathway of the DNA DSB Repair during Class Switch Recombination in B Cells

Shukla, V., Halabelian, L., Balagere, S., Samaniego‐Castruita, D., Feldman, D. E., Arrowsmith, C. H., Rao, A., & Aravind, L. (2019) · Molecular Cell · doi:10.1016/j.molcel.2019.10.031 · Cited by 56

Hydroxymethylation and tumors: can 5-hydroxymethylation be used as a marker for tumor diagnosis and treatment?

Xu, T., & Gao, H. (2020) · Human Genomics · doi:10.1186/s40246-020-00265-5 · Cited by 55

5-Hydroxymethylcytosine-mediated active demethylation is required for mammalian neuronal differentiation and function

Stoyanova, E. I., Riad, M. H., Rao, A., & Heintz, N. (2021) · eLife · doi:10.7554/elife.66973 · Cited by 57

TET enzymes regulate skeletal development through increasing chromatin accessibility of RUNX2 target genes

Wang, L., You, X., Ruan, D., Shao, R., Dai, H., Shen, W., Xu, G., Liu, W., & Zou, W. (2022) · Nature Communications · doi:10.1038/s41467-022-32138-x · Cited by 55

Exploring the crop epigenome: a comparison of DNA methylation profiling techniques

Agius, D., Kapazoglou, A., Avramidou, E. V., Baránek, M., Carneros, E., Caro, E., Castiglione, S., Cicatelli, A., Radanović, A., Ebejer, J.-P., et al. (2023) · Frontiers in Plant Science · doi:10.3389/fpls.2023.1181039 · Cited by 60

DNA methylation and hydroxymethylation in stem cells

Cheng, Y., Xie, N., Jin, P., & Wang, T. (2015) · Cell Biochemistry and Function · doi:10.1002/cbf.3101 · Cited by 56

A nucleolin-DNMT1 regulatory axis in acute myeloid leukemogenesis

Shen, N., Yan, F., Pang, J., Wu, L., Al‐Kali, A., Litzow, M. R., & Liu, S. (2014) · Oncotarget · doi:10.18632/oncotarget.2131 · Cited by 55

Stable 5-Hydroxymethylcytosine (5hmC) Acquisition Marks Gene Activation During Chondrogenic Differentiation

Taylor, S. E. B., Li, Y. H., Smeriglio, P., Rath, M., Wong, W. H., & Bhutani, N. (2015) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.2711 · Cited by 55

Crystal structures of isoorotate decarboxylases reveal a novel catalytic mechanism of 5-carboxyl-uracil decarboxylation and shed light on the search for DNA decarboxylase

Xu, S., Li, W., Zhu, J., Wang, R., Li, Z., Xu, G., & Ding, J. (2013) · Cell Research · doi:10.1038/cr.2013.107 · Cited by 55

A mechanistic overview of TET-mediated 5-methylcytosine oxidation

Ponnaluri, V. K. C., Maciejewski, J. P., & Mukherji, M. (2013) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2013.05.077 · Cited by 55

Biochemical characterization of a Naegleria TET-like oxygenase and its application in single molecule sequencing of 5-methylcytosine

Pais, J. E., Dai, N., Tamanaha, E., Vaisvila, R., Fomenkov, A. I., Bitinaite, J., Sun, Z., Guan, S., Junior, I. R. C., Noren, C. J., et al. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1417939112 · Cited by 55

Accurate Measurement of 5-Methylcytosine and 5-Hydroxymethylcytosine in Human Cerebellum DNA by Oxidative Bisulfite on an Array (OxBS-Array)

Field, S. F., Beraldi, D., Bachman, M., Stewart, S. K., Beck, S., & Balasubramanian, S. (2015) · PLoS ONE · doi:10.1371/journal.pone.0118202 · Cited by 56

Recent advances in the analysis of 5-methylcytosine and its oxidation products

Yuan, B., & Feng, Y. (2013) · TrAC Trends in Analytical Chemistry · doi:10.1016/j.trac.2013.11.002 · Cited by 56

Role of diet in prostate cancer: the epigenetic link

Labbé, D. P., Zadra, G., Ebot, E. M., Mucci, L. A., Kantoff, P. W., Loda, M. F., & Brown, M. A. (2014) · Oncogene · doi:10.1038/onc.2014.422 · Cited by 56

The evolving epigenome

Weichenhan, D., & Plass, C. (2013) · Human Molecular Genetics · doi:10.1093/hmg/ddt348 · Cited by 58

TET family proteins and 5-hydroxymethylcytosine in esophageal squamous cell carcinoma

Murata, A., Baba, Y., Ishimoto, T., Miyake, K., Kosumi, K., Harada, K., Kurashige, J., Iwagami, S., Sakamoto, Y., Miyamoto, Y., et al. (2015) · Oncotarget · doi:10.18632/oncotarget.4281 · Cited by 55

Simultaneous single-molecule epigenetic imaging of DNA methylation and hydroxymethylation

Song, C., Diao, J., Brünger, A. T., & Quake, S. R. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1600223113 · Cited by 55

Hippocampal TET1 and TET2 Expression and DNA Hydroxymethylation Are Affected by Physical Exercise in Aged Mice

Jessop, P., & Toledo‐Rodriguez, M. (2018) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2018.00045 · Cited by 55

TET enzymes in neurophysiology and brain function

Antunes, C., Sousa, N., Pinto, L., & Marques, C. J. (2019) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2019.05.006 · Cited by 57

TET2: A cornerstone in normal and malignant hematopoiesis

Kunimoto, H., & Nakajima, H. (2020) · Cancer Science · doi:10.1111/cas.14688 · Cited by 56

TET Enzymes and 5-Hydroxymethylcytosine in Neural Progenitor Cell Biology and Neurodevelopment

MacArthur, I. C., & Dawlaty, M. M. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.645335 · Cited by 58

Sperm Functional Genome Associated With Bull Fertility

Özbek, M., Hitit, M., Kaya, A., Jousan, F. D., & Memili, E. (2021) · Frontiers in Veterinary Science · doi:10.3389/fvets.2021.610888 · Cited by 55

LncRNA NUTM2A‐AS1 positively modulates TET1 and HIF‐1A to enhance gastric cancer tumorigenesis and drug resistance by sponging miR‐376a

Wang, J., Yu, Z., Wang, J., Shen, Y., Qiu, J., & Zhuang, Z. (2020) · Cancer Medicine · doi:10.1002/cam4.3544 · Cited by 54

Epigenetic therapy: use of agents targeting deacetylation and methylation in cancer management

Chan, T. A.-T., Ho, A. S., & Turcan, Ş. (2013) · OncoTargets and Therapy · doi:10.2147/ott.s34680 · Cited by 54

Crosstalk Between Inflammatory Signaling and Methylation in Cancer

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NSUN2 stimulates tumor progression via enhancing TIAM2 mRNA stability in pancreatic cancer

Zhang, G., Liu, L., Li, J., Chen, Y., Wang, Y., Zhang, Y., Dong, Z., Xue, W., Sun, R., & Cui, G. (2023) · Cell Death Discovery · doi:10.1038/s41420-023-01521-y · Cited by 54

A Global Increase in 5‐Hydroxymethylcytosine Levels Marks Osteoarthritic Chondrocytes

Taylor, S. E. B., Smeriglio, P., Dhulipala, L., Rath, M., & Bhutani, N. (2013) · Arthritis & Rheumatology · doi:10.1002/art.38200 · Cited by 55

DNA methylation and cognitive aging

Xu, X. Z. S. (2015) · Oncotarget · doi:10.18632/oncotarget.4215 · Cited by 57

5-Hydroxymethylcytosine and disease

Wang, J., Tang, J., Lai, M., & Zhang, H. (2014) · Mutation Research/Reviews in Mutation Research · doi:10.1016/j.mrrev.2014.09.003 · Cited by 54

Epigenetic drugs against cancer: an evolving landscape

Costanzo, A. D., Gaudio, N. D., Migliaccio, A., & Altucci, L. (2014) · Archives of Toxicology · doi:10.1007/s00204-014-1315-6 · Cited by 54

The good, the bad and the ugly: Epigenetic mechanisms in glioblastoma

Carén, H., Pollard, S. M., & Beck, S. (2012) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2012.06.007 · Cited by 55

New insights into mechanisms that regulate DNA methylation patterning

Ficz, G. (2015) · Journal of Experimental Biology · doi:10.1242/jeb.107961 · Cited by 54

TET-catalyzed 5-hydroxymethylcytosine regulates gene expression in differentiating colonocytes and colon cancer

Chapman, C. G., Mariani, C. J., Wu, F., Meckel, K. R., Butun, F. A., Chuang, A., Madžo, J., Bissonnette, M. B., Kwon, J. H., & Godley, L. A. (2015) · Scientific Reports · doi:10.1038/srep17568 · Cited by 54

The 5-Hydroxymethylcytosine (5hmC) Reader UHRF2 Is Required for Normal Levels of 5hmC in Mouse Adult Brain and Spatial Learning and Memory

Chen, R., Zhang, Q., Duan, X., York, J. P., Chen, G., Yin, P., Zhu, H., Xu, M., Chen, P., Wu, Q., et al. (2017) · Journal of Biological Chemistry · doi:10.1074/jbc.m116.754580 · Cited by 56

TET1 promotes cisplatin‐resistance via demethylating the vimentin promoter in ovarian cancer

Han, X., Zhou, Y., You, Y., Lu, J., Wang, L., Hou, H., Li, J., Chen, W., Zhao, L., & Li, X. (2017) · Cell Biology International · doi:10.1002/cbin.10734 · Cited by 54

Target specificity of mammalian DNA methylation and demethylation machinery

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Expression and prognosis analysis of DNMT family in acute myeloid leukemia

Zhang, T., Zhang, L.-C., Xu, Z., & Zhou, J. (2020) · Aging · doi:10.18632/aging.103520 · Cited by 54

Oxidative DNA demethylation mediated by Tet enzymes

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A fast and label-free detection of hydroxymethylated DNA using a nozzle-jet printed AuNPs@Ti3C2 MXene-based electrochemical sensor

Bhat, K. S., Byun, S., Alam, A., Ko, M., An, J., & Lim, S. (2022) · Talanta · doi:10.1016/j.talanta.2022.123421 · Cited by 53

Materials and Methods Figs. S1 to S19 Tables S1 to S15

(2011)

Role and regulation of TET-mediated \nDNA modifications in gene expression

Müller, U. (2014) · Electronic Theses of LMU Munich (Ludwig-Maximilians-Universität München)

Mechanisms and functions of Tet protein-mediated 5-methylcytosine oxidationPreprint

Wu, H., & Zhang, Y. (2011) · Genes & Development · doi:10.17615/800j-yk16 · Cited by 686

Role and regulation of TET-mediated DNA modifications in gene expression

Müller, U. (2014) · doi:10.5282/edoc.17823

Results and Discussion

(2016)