Tet Proteins Can Convert 5-Methylcytosine to 5-Formylcytosine and 5-Carboxylcytosine

Conversion of 5-Methylcytosine to 5-Hydroxymethylcytosine in Mammalian DNA by MLL Partner TET1

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The Nuclear DNA Base 5-Hydroxymethylcytosine Is Present in Purkinje Neurons and the Brain

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Role of Tet proteins in 5mC to 5hmC conversion, ES-cell self-renewal and inner cell mass specification

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EUKARYOTIC CYTOSINE METHYLTRANSFERASES

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Hydroxylation of 5-Methylcytosine by TET1 Promotes Active DNA Demethylation in the Adult Brain

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Active DNA demethylation: many roads lead to Rome

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Tissue Distribution of 5-Hydroxymethylcytosine and Search for Active Demethylation Intermediates

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Thymine DNA glycosylase is essential for active DNA demethylation by linked deamination-base excision repair

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The Colorful History of Active DNA Demethylation

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DNA demethylation by DNA repair

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Chemical Methods for Decoding Cytosine Modifications in DNA

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Origins of aberrant DNA methylation in acute myeloid leukemia

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Cooperative Action between SALL4A and TET Proteins in Stepwise Oxidation of 5-Methylcytosine

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CRL4 complex regulates mammalian oocyte survival and reprogramming by activation of TET proteins

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A strategy based on nucleotide specificity leads to a subfamily-selective and cell-active inhibitor of N 6 -methyladenosine demethylase FTO

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Alterations of metabolic genes and metabolites in cancer

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Pathogenesis of Autoimmune Hepatitis—Cellular and Molecular Mechanisms

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Vitamin C epigenetically controls osteogenesis and bone mineralization

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The interaction of mycobacterial protein Rv2966c with host chromatin is mediated through non-CpG methylation and histone H3/H4 binding

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The complex methylome of the human gastric pathogen Helicobacter pylori

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Epigenetic Control of Smooth Muscle Cell Identity and Lineage Memory

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Isoform‐specific localization of DNMT3A regulates DNA methylation fidelity at bivalent CpG islands

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Particulate matter-induced senescence of skin keratinocytes involves oxidative stress-dependent epigenetic modifications

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In utero alcohol exposure, epigenetic changes, and their consequences

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The early‐life social environment and DNA methylation

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Alteration of genic 5-hydroxymethylcytosine patterning in olfactory neurons correlates with changes in gene expression and cell identity

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The involvement of nucleotide excision repair proteins in the removal of oxidative DNA damage

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Tet2 loss leads to hypermutagenicity in haematopoietic stem/progenitor cells

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Chemical Modification-Assisted Bisulfite Sequencing (CAB-Seq) for 5-Carboxylcytosine Detection in DNA

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Germline Stem Cells: Origin and Destiny

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Playing TETris with DNA modifications

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Role of glutathione in the regulation of epigenetic mechanisms in disease

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TET Enzymes in the Immune System: From DNA Demethylation to Immunotherapy, Inflammation, and Cancer

López-Moyado, I. F., Ko, M., Hogan, P. G., & Rao, A. (2024) · Annual Review of Immunology · doi:10.1146/annurev-immunol-080223-044610 · Cited by 121

The role of 5-hydroxymethylcytosine in human cancer

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Conceptual links between DNA methylation reprogramming in the early embryo and primordial germ cells

Seisenberger, S., Peat, J. R., & Reik, W. (2013) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2013.02.013 · Cited by 115

Role of Base Excision “Repair” Enzymes in Erasing Epigenetic Marks from DNA

Drohat, A. C., & Coey, C. T. (2016) · Chemical Reviews · doi:10.1021/acs.chemrev.6b00191 · Cited by 118

Function determinants of TET proteins: the arrangements of sequence motifs with specific codes

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Genetic and epigenetic regulation of growth, reproduction, disease resistance and stress responses in aquaculture

Liu, Z., Zhou, T., & Gao, D. (2022) · Frontiers in Genetics · doi:10.3389/fgene.2022.994471 · Cited by 121

TET2-mediated mRNA demethylation regulates leukemia stem cell homing and self-renewal

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The Neuron Identity Problem: Form Meets Function

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5-hydroxymethylcytosine in cancer: significance in diagnosis and therapy

Vasanthakumar, A., & Godley, L. A. (2015) · Cancer Genetics · doi:10.1016/j.cancergen.2015.02.009 · Cited by 116

Zinc Fingers, TALEs, and CRISPR Systems: A Comparison of Tools for Epigenome Editing

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Derivatization for liquid chromatography-electrospray ionization-mass spectrometry analysis of small-molecular weight compounds

Zhang, T., Li, S., Zhu, Q., Wang, Q., Hussain, D., & Feng, Y. (2019) · TrAC Trends in Analytical Chemistry · doi:10.1016/j.trac.2019.07.019 · Cited by 114

Mechanisms of Binding Specificity among bHLH Transcription Factors

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Epigenetic mechanisms of drug addiction

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CDA directs metabolism of epigenetic nucleosides revealing a therapeutic window in cancer

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TET Family Proteins: Oxidation Activity, Interacting Molecules, and Functions in Diseases

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Epigenetic mechanisms of memory formation and reconsolidation

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Reprogramming the genome to totipotency in mouse embryos

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Environmentally induced epigenetic toxicity: potential public health concerns

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Delineation of a Human Mendelian Disorder of the DNA Demethylation Machinery: TET3 Deficiency

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Neuroblastoma and the epigenome

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Efficient and accurate determination of genome-wide DNA methylation patterns in Arabidopsis thaliana with enzymatic methyl sequencing

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TET2 as an epigenetic master regulator for normal and malignant hematopoiesis

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A vitamin-C-derived DNA modification catalysed by an algal TET homologue

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An epigenetic mechanism for cavefish eye degeneration

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Genomic distribution and possible functions of DNA hydroxymethylation in the brain

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Genome-wide comparison of DNA hydroxymethylation in mouse embryonic stem cells and neural progenitor cells by a new comparative hMeDIP-seq method

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TGF-β-Dependent Active Demethylation and Expression of the p15ink4b Tumor Suppressor Are Impaired by the ZNF217/CoREST Complex

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Role of base excision repair in maintaining the genetic and epigenetic integrity of CpG sites

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Defending the genome from the enemy within: mechanisms of retrotransposon suppression in the mouse germline

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Lineage-specific functions of TET1 in the postimplantation mouse embryo

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Epigenetic regulation of DNA repair genes and implications for tumor therapy

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SNIP1 Recruits TET2 to Regulate c-MYC Target Genes and Cellular DNA Damage Response

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Increasing role of UHRF1 in the reading and inheritance of the epigenetic code as well as in tumorogenesis

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Entering the era of bacterial epigenomics with single molecule real time DNA sequencing

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Distinct and overlapping control of 5-methylcytosine and 5-hydroxymethylcytosine by the TET proteins in human cancer cells

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Regulation of TET Protein Stability by Calpains

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A reusable laser wrapped graphene-Ag array based SERS sensor for trace detection of genomic DNA methylation

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5-Formylcytosine Yields DNA–Protein Cross-Links in Nucleosome Core Particles

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Global DNA 5‐Hydroxymethylcytosine and 5‐Formylcytosine Contents Are Decreased in the Early Stage of Hepatocellular Carcinoma

Liu, J., Jiang, J., Mo, J., Liu, D., Cao, D., Wang, H., He, Y., & Wang, H. (2018) · Hepatology · doi:10.1002/hep.30146 · Cited by 108

5-Formylcytosine organizes nucleosomes and forms Schiff base interactions with histones in mouse embryonic stem cells

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Estradiol-Induced Epigenetically Mediated Mechanisms and Regulation of Gene Expression

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TETs compete with DNMT3 activity in pluripotent cells at thousands of methylated somatic enhancers

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CRL4VprBP E3 Ligase Promotes Monoubiquitylation and Chromatin Binding of TET Dioxygenases

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Structural Basis for Hydroxymethylcytosine Recognition by the SRA Domain of UHRF2

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Non-catalytic Roles of Tet2 Are Essential to Regulate Hematopoietic Stem and Progenitor Cell Homeostasis

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Epigenetics and cancer metabolism

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Developmental windows of susceptibility for epigenetic inheritance through the male germline

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β-Cell MicroRNAs: Small but Powerful

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Clinical, molecular, and prognostic correlates of number, type, and functional localization of TET2 mutations in chronic myelomonocytic leukemia (CMML)—a study of 1084 patients

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TET family dioxygenases and the TET activator vitamin C in immune responses and cancer

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The crosstalk between m6A RNA methylation and other epigenetic regulators: a novel perspective in epigenetic remodeling

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Epigenetic Regulation of Genomic Stability by Vitamin C

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Clonal hematopoiesis, somatic mosaicism, and age-associated disease

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Choline Nutrition Programs Brain Development Via DNA and Histone Methylation

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Implications of DNA Methylation in Parkinson’s Disease

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Epigenetic Control of Macrophage Polarisation and Soluble Mediator Gene Expression during Inflammation

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Ten-eleven translocation 2 interacts with forkhead box O3 and regulates adult neurogenesis

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Telomerase Regulation: A Role for Epigenetics

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Epigenetic Changes in Pediatric Solid Tumors: Promising New Targets

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A unique role for DNA (hydroxy)methylation in epigenetic regulation of human inhibitory neurons

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Enhanced Reduced Representation Bisulfite Sequencing for Assessment of DNA Methylation at Base Pair Resolution

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Non‐canonical Bases in the Genome: The Regulatory Information Layer in DNA

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Aberrant DNA Methylation in Acute Myeloid Leukemia and Its Clinical Implications

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A common mode of recognition for methylated CpG

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Epigenetics of major psychosis: progress, problems and perspectives

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TET‐catalyzed oxidation of intragenic 5‐methylcytosine regulates CTCF‐dependent alternative splicing

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Determination of Oxidation Products of 5-Methylcytosine in Plants by Chemical Derivatization Coupled with Liquid Chromatography/Tandem Mass Spectrometry Analysis

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Nanopores Discriminate among Five C5-Cytosine Variants in DNA

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Materials and Methods Figs. S1 to S19 Tables S1 to S15

(2011)

Role and regulation of TET-mediated \nDNA modifications in gene expression

Müller, U. (2014) · Electronic Theses of LMU Munich (Ludwig-Maximilians-Universität München)

Mechanisms and functions of Tet protein-mediated 5-methylcytosine oxidationPreprint

Wu, H., & Zhang, Y. (2011) · Genes & Development · doi:10.17615/800j-yk16 · Cited by 686

Role and regulation of TET-mediated DNA modifications in gene expression

Müller, U. (2014) · doi:10.5282/edoc.17823

Results and Discussion

(2016)