The DOI matches its Crossref record; 17 of the 17 references it cites were found in a registry or an index.
Tet Proteins Can Convert 5-Methylcytosine to 5-Formylcytosine and 5-Carboxylcytosine
Open accessAbstract
Evidence for a possible route for DNA demethylation in animals is suggested.
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In the citing paper
“TET proteins can oxidize 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC), 5-formyl cytosine (5fC), and 5-carboxylcytosine (5caC) (He et al., 2011; Ito et al., 2011; Tahiliani et al., 2009).”
From Influence of Metabolism on Epigenetics and Disease (2013) · cites this paper as Ito et al., 2011
In the citing paper
“TET-catalyzed oxidation of 5mC followed by decarboxylation or base excision is strongly suspected of contributing to DNA demethylation (Cortellino et al., 2011; He et al., 2011; Ito et al., 2011), yet there are currently conflicting reports regarding the effect of TET inactivation on global DNA methylation patterns in somatic cells (Figueroa et al., 2010; Ko et al., 2010; Yamazaki et al., 2012).”
From Influence of Metabolism on Epigenetics and Disease (2013) · cites this paper as Ito et al., 2011
In the citing paper
“TET proteins are responsible for conversion of 5mC in 5hmC [34], 5fC, and 5cac [36].”
From PU.1 target genes undergo Tet2-coupled demethylation and DNMT3b-mediated methylation in monocyte-to-osteoclast differentiation (2013) · cites this paper as [36]
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Citations
Cites
Conversion of 5-Methylcytosine to 5-Hydroxymethylcytosine in Mammalian DNA by MLL Partner TET1
Tahiliani, M., Koh, K. P., Shen, Y., Pastor, W. A., Bandukwala, H., Brudno, Y., Agarwal, S., Iyer, L. M., Liu, D. R., Aravind, L., et al. (2009) · Science · doi:10.1126/science.1170116 · Cited by 5,836
The Nuclear DNA Base 5-Hydroxymethylcytosine Is Present in Purkinje Neurons and the Brain
Kriaucionis, S., & Heintz, N. (2009) · Science · doi:10.1126/science.1169786 · Cited by 2,700
Ito, S., D’Alessio, A. C., Taranova, O., Hong, K., Sowers, L. C., & Zhang, Y. (2010) · Nature · doi:10.1038/nature09303 · Cited by 2,628
Self-citationEUKARYOTIC CYTOSINE METHYLTRANSFERASES
Goll, M. G., & Bestor, T. H. (2005) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.74.010904.153721 · Cited by 2,162
Hydroxylation of 5-Methylcytosine by TET1 Promotes Active DNA Demethylation in the Adult Brain
Guo, J. U., Su, Y., Zhong, C., Ming, G., & Song, H. (2011) · Cell · doi:10.1016/j.cell.2011.03.022 · Cited by 1,404
Active DNA demethylation: many roads lead to Rome
Wu, S. C., & Zhang, Y. (2010) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2950 · Cited by 1,091
Self-citationTissue Distribution of 5-Hydroxymethylcytosine and Search for Active Demethylation Intermediates
Globisch, D., Münzel, M., Müller, M., Michalakis, S., Wagner, M., Koch, S., Brückl, T., Biel, M., & Carell, T. (2010) · PLoS ONE · doi:10.1371/journal.pone.0015367 · Cited by 865
Cortellino, S., Xu, J., Sannai, M., Moore, R., Caretti, E., Cigliano, A., Le Coz, M., Devarajan, K., Wessels, A., Soprano, D., et al. (2011) · Cell · doi:10.1016/j.cell.2011.06.020 · Cited by 809
The Colorful History of Active DNA Demethylation
Ooi, S. K. T., & Bestor, T. H. (2008) · Cell · doi:10.1016/j.cell.2008.06.009 · Cited by 537
DNA demethylation by DNA repair
Gehring, M. A., Reik, W., & Henikoff, S. (2009) · Trends in Genetics · doi:10.1016/j.tig.2008.12.001 · Cited by 288
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Wang, Q., & Su, L. (2019) · mBio · doi:10.1128/mbio.01344-19 · Cited by 34
Association of TET1 expression with colorectal cancer progression
Tian, Y., Pan, F., Sun, X., Gan, M., Lin, A., Zhang, D., Zhu, Y., & Lai, M. (2017) · Scandinavian Journal of Gastroenterology · doi:10.1080/00365521.2016.1253767 · Cited by 34
TET-TDG active DNA demethylation at CpG and non-CpG sites
DeNizio, J. E., Dow, B. J., Serrano, J. C., Ghanty, U., Drohat, A. C., & Kohli, R. M. (2021) · Journal of Molecular Biology · doi:10.1016/j.jmb.2021.166877 · Cited by 32
Svoboda, L. K., Ishikawa, T., & Dolinoy, D. C. (2022) · Environmental Epigenetics · doi:10.1093/eep/dvac017 · Cited by 27
Modeling methyl-sensitive transcription factor motifs with an expanded epigenetic alphabet
Viner, C., Ishak, C. A., Johnson, J., Walker, N. J., Shi, H., Sjöberg-Herrera, M. K., Shen, S. Y., Lardo, S. M., Adams, D. J., Ferguson-Smith, A. C., et al. (2016) · doi:10.1101/043794 · Cited by 18
Analog epigenetic memory revealed by targeted chromatin editing
Palacios, S., Bruno, S., Weiss, R., Salibi, E., Kane, A., Ilia, K., & Del Vecchio, D. (2024) · doi:10.1101/2024.02.13.580200 · Cited by 13
Vaher, K., Anier, K., Jürgenson, M., Harro, J., & Kalda, A. (2020) · Journal of Psychopharmacology · doi:10.1177/0269881120916137 · Cited by 12
Epigenetic preparation of future gene induction kinetics
Xiong, J., & Zhu, B. (2025) · Annual Review of Genetics · doi:10.1146/annurev-genet-012825-093148 · Cited by 12
TET dioxygenases localize at splicing speckles and promote RNA splicing
Hastert, F. D., Weber, J., Bauer, C., Zhadan, A., Singh, D. N. D., Dix, T. C., Arnold, R., Bessonov, S., Soller, M., Leonhardt, H., et al. (2025) · Nucleus · doi:10.1080/19491034.2025.2536902 · Cited by 5
“NMD affects mRNAs containing premature translation termination codons (PTCs), which recruit the ATP-dependent RNA helicases Upf1–34.”
Metadata
- Authors
- Ito, S., Shen, L., Dai, Q., Wu, S. C., Collins, L. B., Swenberg, J. A., He, C., & Zhang, Y.
- Affiliations
- University of North Carolina at Chapel Hill (US)
- University of Chicago (US)
- Corresponding author
- Ito, Shinsuke
- Shen, Li
- Zhang, Yi
- Venue
- Science
- Published
- 2011-09-02
- Volume
- 333
- Issue
- 6047
- Pages
- 1300-1303
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- PMC
- PMC3495246
- OpenAlex
- W1997453048
- Cited by
- 3,451
- References
- 17
- Citations by year
- 2026: 105 · 2025: 160 · 2024: 180 · 2023: 204 · 2022: 209 · 2021: 236 · 2020: 261 · 2019: 258 · 2018: 268 · 2017: 263 · 2016: 279 · 2015: 253 · 2014: 280 · 2013: 259 · 2012: 198
- FWCI
- 100.34
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Carolina Digital Repository (University of North Carolina at Chapel Hill) (submittedVersion)
- UNC Libraries
- Funders
- Howard Hughes Medical Institute
- National Institutes of Health
- Japan Society for the Promotion of Science
- National Institute of General Medical Sciences (GM071440, GM68804, R01GM071440, R01GM068804)
- National Institute of Diabetes and Digestive and Kidney Diseases (U01DK089565)
- National Institute of Environmental Health Sciences (P30ES10126), P42ES005948, P30ES010126, P42 ES/5948)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA modifications and cancer
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Keywords
- TET enzymes, 5-methylcytosine, 5-formylcytosine, 5-carboxylcytosine, 5-hydroxymethylcytosine, DNA demethylation, DNA oxidation, decarboxylation, genomic DNA, mouse embryonic stem cells, epigenetic modifications
- MeSH terms
- Animals, Cell Line, Cytosine, DNA, DNA-Binding Proteins, Humans, Oxidation-Reduction, Proto-Oncogene Proteins, Recombinant Fusion Proteins, DNA Methylation, 5-Methylcytosine, Dioxygenases, Mice, Embryonic Stem Cells
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