Tet Proteins Can Convert 5-Methylcytosine to 5-Formylcytosine and 5-Carboxylcytosine

Conversion of 5-Methylcytosine to 5-Hydroxymethylcytosine in Mammalian DNA by MLL Partner TET1

Tahiliani, M., Koh, K. P., Shen, Y., Pastor, W. A., Bandukwala, H., Brudno, Y., Agarwal, S., Iyer, L. M., Liu, D. R., Aravind, L., et al. (2009) · Science · doi:10.1126/science.1170116 · Cited by 5,836

The Nuclear DNA Base 5-Hydroxymethylcytosine Is Present in Purkinje Neurons and the Brain

Kriaucionis, S., & Heintz, N. (2009) · Science · doi:10.1126/science.1169786 · Cited by 2,700

Role of Tet proteins in 5mC to 5hmC conversion, ES-cell self-renewal and inner cell mass specification

Ito, S., D’Alessio, A. C., Taranova, O., Hong, K., Sowers, L. C., & Zhang, Y. (2010) · Nature · doi:10.1038/nature09303 · Cited by 2,628

EUKARYOTIC CYTOSINE METHYLTRANSFERASES

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Hydroxylation of 5-Methylcytosine by TET1 Promotes Active DNA Demethylation in the Adult Brain

Guo, J. U., Su, Y., Zhong, C., Ming, G., & Song, H. (2011) · Cell · doi:10.1016/j.cell.2011.03.022 · Cited by 1,404

Active DNA demethylation: many roads lead to Rome

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Tissue Distribution of 5-Hydroxymethylcytosine and Search for Active Demethylation Intermediates

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Thymine DNA glycosylase is essential for active DNA demethylation by linked deamination-base excision repair

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The Colorful History of Active DNA Demethylation

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DNA demethylation by DNA repair

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Quantitative sequencing of 5-formylcytosine in DNA at single-base resolution

Booth, M. J., Marsico, G., Bachman, M., Beraldi, D., & Balasubramanian, S. (2014) · Nature Chemistry · doi:10.1038/nchem.1893 · Cited by 214

Active turnover of DNA methylation during cell fate decisions

Parry, A., Rulands, S., & Reik, W. (2020) · Nature Reviews Genetics · doi:10.1038/s41576-020-00287-8 · Cited by 214

PU.1 target genes undergo Tet2-coupled demethylation and DNMT3b-mediated methylation in monocyte-to-osteoclast differentiation

de la Rica, L., Rodríguez-Ubreva, J., García, M., Islam, A. B., Urquiza, J. M., Hernando, H., Christensen, J., Helin, K., Gómez-Vaquero, C., & Ballestar, E. (2013) · Genome Biology · doi:10.1186/gb-2013-14-9-r99 · Cited by 211

TET-mediated DNA demethylation controls gastrulation by regulating Lefty-Nodal signalling

Dai, H.-Q., Wang, B.-A., Yang, L., Chen, J.-J., Zhu, G.-C., Sun, M.-L., Ge, H., Wang, R., Chapman, D. L., Tang, F., et al. (2016) · Nature · doi:10.1038/nature20095 · Cited by 206

Single-Cell (Multi)omics Technologies

Chappell, L., Russell, A. J. C., & Voet, T. (2018) · Annual Review of Genomics and Human Genetics · doi:10.1146/annurev-genom-091416-035324 · Cited by 207

Emerging role of PI3K/AKT in tumor-related epigenetic regulation

Yang, Q., Jiang, W., & Hou, P. (2019) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2019.04.001 · Cited by 210

How to stomach an epigenetic insult: the gastric cancer epigenome

Padmanabhan, N., Ushijima, T., & Tan, P. B. O. (2017) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2017.53 · Cited by 209

Acute loss of TET function results in aggressive myeloid cancer in mice

An, J., González‐Avalos, E., Chawla, A., Jeong, M., López-Moyado, I. F., Li, W., Goodell, M. A., Chávez, L., Ko, M., & Rao, A. (2015) · Nature Communications · doi:10.1038/ncomms10071 · Cited by 215

Mapping recently identified nucleotide variants in the genome and transcriptome

Song, C., Yi, C., & He, C. (2012) · Nature Biotechnology · doi:10.1038/nbt.2398 · Cited by 202

5-hydroxymethylcytosine and its potential roles in development and cancer

Pfeifer, G. P., Kadam, S., & Jin, S. (2013) · Epigenetics & Chromatin · doi:10.1186/1756-8935-6-10 · Cited by 205

Chemical and structural effects of base modifications in messenger RNA

Harcourt, E. M., Kietrys, A. M., & Kool, E. T. (2017) · Nature · doi:10.1038/nature21351 · Cited by 201

Characterizing DNA methylation alterations from The Cancer Genome Atlas

Weisenberger, D. J. (2014) · Journal of Clinical Investigation · doi:10.1172/jci69740 · Cited by 200

Occurrence, Biological Consequences, and Human Health Relevance of Oxidative Stress-Induced DNA Damage

Yu, Y., Cui, Y., Niedernhofer, L. J., & Wang, Y. (2016) · Chemical Research in Toxicology · doi:10.1021/acs.chemrestox.6b00265 · Cited by 200

The DNA Methylcytosine Dioxygenase Tet2 Sustains Immunosuppressive Function of Tumor-Infiltrating Myeloid Cells to Promote Melanoma Progression

Pan, W. Q., Zhu, S., Qu, K., Meeth, K. M., Cheng, J., He, K., Ma, H., Liao, Y., Wen, X., Roden, C., et al. (2017) · Immunity · doi:10.1016/j.immuni.2017.07.020 · Cited by 202

5-Hydroxymethylcytosine Marks Sites of DNA Damage and Promotes Genome Stability

Kafer, G. R., Li, X., Horii, T., Suetake, I., Tajima, S., Hatada, I., & Carlton, P. M. (2016) · Cell Reports · doi:10.1016/j.celrep.2016.01.035 · Cited by 197

TET proteins and 5‐methylcytosine oxidation in hematological cancers

Ko, M., An, J., Pastor, W. A., Koralov, S. B., Rajewsky, K., & Rao, A. (2014) · Immunological Reviews · doi:10.1111/imr.12239 · Cited by 202

Mechanisms of human histone and nucleic acid demethylases

Walport, L. J., Hopkinson, R. J., & Schofield, C. J. (2012) · Current Opinion in Chemical Biology · doi:10.1016/j.cbpa.2012.09.015 · Cited by 194

Tet3 regulates synaptic transmission and homeostatic plasticity via DNA oxidation and repair

Yu, H., Su, Y., Shin, J., Zhong, C., Guo, J. U., Weng, Y., Gao, F., Geschwind, D. H., Coppola, G., Ming, G., et al. (2015) · Nature Neuroscience · doi:10.1038/nn.4008 · Cited by 199

TET1 is a tumour suppressor that inhibits colon cancer growth by derepressing inhibitors of the WNT pathway

Neri, F., Dettori, D., Incarnato, D., Křepelová, A., Rapelli, S., Maldotti, M., Parlato, C., Paliogiannis, P., & Oliviero, S. (2014) · Oncogene · doi:10.1038/onc.2014.356 · Cited by 194

Epigenetic changes in the progression of Alzheimer's disease

Bradley‐Whitman, M. A., & Lovell, M. A. (2013) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2013.08.005 · Cited by 198

Dynamics of 5-hydroxymethylcytosine during mouse spermatogenesis

Gan, H., Wen, L., Liao, S., Lin, X., Ma, T., Liu, J., Song, C., Wang, M., He, C., Han, C., et al. (2013) · Nature Communications · doi:10.1038/ncomms2995 · Cited by 203

Analysis of microRNA-target interactions across diverse cancer types

Skanderup, A. J., Silber, J., Harinath, G., Huse, J. T., Schultz, N. D., & Sander, C. (2013) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.2678 · Cited by 197

Metabolism and Epigenetics

Janke, R., Dodson, A. E., & Rine, J. (2015) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev-cellbio-100814-125544 · Cited by 199

DNA mismatch repair and its many roles in eukaryotic cells

Liu, D., Keijzers, G., & Rasmussen, L. J. (2017) · Mutation Research/Reviews in Mutation Research · doi:10.1016/j.mrrev.2017.07.001 · Cited by 209

A human tissue map of 5-hydroxymethylcytosines exhibits tissue specificity through gene and enhancer modulation

Cui, X., Nie, J., Ku, J., Dougherty, U., West-Szymanski, D. C., Collin, F., Ellison, C. K., Sieh, L., Ning, Y., Deng, Z., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-20001-w · Cited by 196

DNA Methylation in Plants: Relationship to Small RNAs and Histone Modifications, and Functions in Transposon Inactivation

Saze, H., Tsugane, K., Kanno, T., & Nishimura, T. (2012) · Plant and Cell Physiology · doi:10.1093/pcp/pcs008 · Cited by 199

Structure and Function of Noncanonical Nucleobases

Carell, T., Brandmayr, C., Hienzsch, A., Müller, M., Pearson, D., Reiter, V., Thoma, I., Thumbs, P., & Wagner, M. (2012) · Angewandte Chemie International Edition · doi:10.1002/anie.201201193 · Cited by 200

Epigenetic targets of some toxicologically relevant metals: a review of the literature

Cheng, T., Choudhuri, S., & Muldoon‐Jacobs, K. (2012) · Journal of Applied Toxicology · doi:10.1002/jat.2717 · Cited by 194

Formation and Abundance of 5‐Hydroxymethylcytosine in RNA

Huber, S. M., van Delft, P., Mendil, L., Bachman, M., Smollett, K. L., Werner, F., Miska, E. A., & Balasubramanian, S. (2015) · ChemBioChem · doi:10.1002/cbic.201500013 · Cited by 187

The Curious Chemical Biology of Cytosine: Deamination, Methylation,and Oxidation as Modulators of Genomic Potential

Nabel, C. S., Manning, S. A., & Kohli, R. M. (2011) · ACS Chemical Biology · doi:10.1021/cb2002895 · Cited by 197

Neocortical Tet3-mediated accumulation of 5-hydroxymethylcytosine promotes rapid behavioral adaptation

Li, X., Wei, W., Zhao, Q., Widagdo, J., Baker‐Andresen, D., Flavell, C. R., D’Alessio, A. C., Zhang, Y., & Bredy, T. W. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1318906111 · Cited by 192

TET family dioxygenases and DNA demethylation in stem cells and cancers

An, J., Rao, A., & Ko, M. (2017) · Experimental & Molecular Medicine · doi:10.1038/emm.2017.5 · Cited by 191

Dynamic hydroxymethylation of deoxyribonucleic acid marks differentiation-associated enhancers

Sérandour, A. A., Avner, S., Oger, F., Bizot, M., Percevault, F., Lucchetti-Miganeh, C., Palierne, G., Gheeraert, C., Barloy-Hubler, F., Péron, C. L., et al. (2012) · Nucleic Acids Research · doi:10.1093/nar/gks595 · Cited by 199

Parallel mechanisms of epigenetic reprogramming in the germline

Hackett, J. A., Żylicz, J. J., & Surani, M. A. (2012) · Trends in Genetics · doi:10.1016/j.tig.2012.01.005 · Cited by 195

Dynamics and Context-Dependent Roles of DNA Methylation

Ambrosi, C. M., Manzo, M., & Baubec, T. (2017) · Journal of Molecular Biology · doi:10.1016/j.jmb.2017.02.008 · Cited by 201

Driver mutations of cancer epigenomes

Roy, D. M., Walsh, L. A., & Chan, T. A.-T. (2014) · Protein & Cell · doi:10.1007/s13238-014-0031-6 · Cited by 188

Clonal hematopoiesis and non-hematologic disorders

Jaiswal, S. (2020) · Blood · doi:10.1182/blood.2019000989 · Cited by 182

Error rates for nanopore discrimination among cytosine, methylcytosine, and hydroxymethylcytosine along individual DNA strands

Schreiber, J. M., Wescoe, Z. L., Abu-Shumays, R. L., Vivian, J., Baatar, B., Karplus, K. J., & Akeson, M. A. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1310615110 · Cited by 183

A Decade of Exploring the Mammalian Sperm Epigenome: Paternal Epigenetic and Transgenerational Inheritance

Champroux, A., Cocquet, J., Henry-Berger, J., Drevet, J. R., & Kocer, A. (2018) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2018.00050 · Cited by 191

Recent advances in the structural mechanisms of DNA glycosylases

Brooks, S. C., Adhikary, S., Rubinson, E. H., & Eichman, B. F. (2012) · Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics · doi:10.1016/j.bbapap.2012.10.005 · Cited by 183

Reprogramming of cell fate: epigenetic memory and the erasure of memories past

Nashun, B., Hill, P. W. S., & Hájková, P. (2015) · The EMBO Journal · doi:10.15252/embj.201490649 · Cited by 184

An Intrinsic Epigenetic Barrier for Functional Axon Regeneration

Weng, Y., An, R., Cassin, J., Joseph, J., Mi, R., Wang, C., Zhong, C., Jin, S., Pfeifer, G. P., Bellacosa, A., et al. (2017) · Neuron · doi:10.1016/j.neuron.2017.03.034 · Cited by 178

TET2 Deficiency Causes Germinal Center Hyperplasia, Impairs Plasma Cell Differentiation, and Promotes B-cell Lymphomagenesis

Domínguez, P. M., Ghamlouch, H., Rosikiewicz, W., Kumar, P., Béguelin, W., Fontán, L., Rivas, M. A., Pawlikowska, P., Armand, M., Mouly, E., et al. (2018) · Cancer Discovery · doi:10.1158/2159-8290.cd-18-0657 · Cited by 188

A heterozygous IDH1R132H/WT mutation induces genome-wide alterations in DNA methylationPreprint

Duncan, C. G., Barwick, B. G., Jin, G., Rago, C., Kapoor-Vazirani, P., Powell, D. R., Chi, J., Bigner, D. D., Vertino, P. M., & Yan, H. (2012) · Genome Research · doi:10.1101/gr.132738.111 · Cited by 183

The Mammalian de Novo DNA Methyltransferases DNMT3A and DNMT3B Are Also DNA 5-Hydroxymethylcytosine Dehydroxymethylases

Chen, C.-C., Wang, K.-Y., & Shen, C.-K. J. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.c112.406975 · Cited by 175

Role of Tet1 and 5-hydroxymethylcytosine in cocaine action

Feng, J., Shao, N., Szulwach, K. E., Vialou, V., Huynh, J. L., Zhong, C., Le, T. T., Ferguson, D., Cahill, M. E., Li, Y., et al. (2015) · Nature Neuroscience · doi:10.1038/nn.3976 · Cited by 181

Role of epigenetic aberrations in the development and progression of human hepatocellular carcinoma

Pogribny, I. P., & Rusyn, I. (2012) · Cancer Letters · doi:10.1016/j.canlet.2012.01.038 · Cited by 174

Profiling DNA Methylation Based on Next-Generation Sequencing Approaches: New Insights and Clinical Applications

Barros‐Silva, D., Marques, C. J., Henrique, R., & Jerónimo, C. (2018) · Genes · doi:10.3390/genes9090429 · Cited by 174

Mechanisms of DNA methylation and demethylation in mammals

Auclair, G., & Weber, M. (2012) · Biochimie · doi:10.1016/j.biochi.2012.05.016 · Cited by 185

Dissecting the dynamic changes of 5-hydroxymethylcytosine in T-cell development and differentiation

Tsagaratou, A., Äijö, T., Lio, C. J., Yue, X., Huang, Y., Jacobsen, S. E., Lähdesmäki, H. J., & Rao, A. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1412327111 · Cited by 186

Rapid reprogramming of epigenetic and transcriptional profiles in mammalian culture systems

Nestor, C. E., Ottaviano, R., Reinhardt, D., Cruickshanks, H. A., Mjoseng, H. K., McPherson, R. C., Lentini, A., Thomson, J. P., Dunican, D. S., Pennings, S., et al. (2015) · Genome biology · doi:10.1186/s13059-014-0576-y · Cited by 178

Dynamics of 5-methylcytosine and 5-hydroxymethylcytosine during germ cell reprogramming

Yamaguchi, S., Hong, K., Liu, R., Inoue, A., Shen, L., Zhang, K., & Zhang, Y. (2013) · Cell Research · doi:10.1038/cr.2013.22 · Cited by 172

Vitamin C Facilitates Demethylation of the Foxp3 Enhancer in a Tet-Dependent Manner

Nair, V. S., Song, M. H., & Oh, K. I. (2016) · The Journal of Immunology · doi:10.4049/jimmunol.1502352 · Cited by 177

DNA demethylation pathways: Additional players and regulators

Bochtler, M., Kolano, A., & Xu, G. (2016) · BioEssays · doi:10.1002/bies.201600178 · Cited by 180

Mechanisms that regulate the activities of TET proteins

Joshi, K., Liu, S., Breslin, P., & Zhang, J. (2022) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-022-04396-x · Cited by 177

The importance of DNA methylation of exons on alternative splicing

Shayevitch, R., Askayo, D., Keydar, I., & Ast, G. (2018) · RNA · doi:10.1261/rna.064865.117 · Cited by 186

A genome-scale map of DNA methylation turnover identifies site-specific dependencies of DNMT and TET activity

Ginno, P. A., Gaidatzis, D., Feldmann, A., Hoerner, L., Imanci, D., Burger, L., Zilbermann, F., Peters, A. H. F. M., Edenhofer, F., Smallwood, S. A., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-16354-x · Cited by 179

Tet2 and Tet3 cooperate with B-lineage transcription factors to regulate DNA modification and chromatin accessibility

Lio, C.-W., Zhang, J., González-Avalos, E., Hogan, P. G., Chang, X., & Rao, A. (2016) · eLife · doi:10.7554/elife.18290 · Cited by 170

High-Resolution Enzymatic Mapping of Genomic 5-Hydroxymethylcytosine in Mouse Embryonic Stem Cells

Sun, Z., Terragni, J., Borgaro, J. G., Liu, Y., Yu, L., Guan, S., Wang, H., Sun, D., Cheng, X., Zhu, Z., et al. (2013) · Cell Reports · doi:10.1016/j.celrep.2013.01.001 · Cited by 173

Meta-analysis of IDH-mutant cancers identifies EBF1 as an interaction partner for TET2

Guilhamon, P., Eskandarpour, M., Halai, D., Wilson, G. A., Feber, A., Teschendorff, A. E., Gómez, V., Hergovich, A., Tirabosco, R., Amary, F. M., et al. (2013) · Nature Communications · doi:10.1038/ncomms3166 · Cited by 169

Adenine methylation in eukaryotes: Apprehending the complex evolutionary history and functional potential of an epigenetic modification

Iyer, L. M., Zhang, D., & Aravind, L. (2015) · BioEssays · doi:10.1002/bies.201500104 · Cited by 183

The Loss of TET2 Promotes CD8+ T Cell Memory Differentiation

Carty, S. A., Gohil, M., Banks, L. B., Cotton, R. M., Johnson, M. E., Stelekati, E., Wells, A. D., Wherry, E. J., Koretzky, G. A., & Jordan, M. S. (2017) · The Journal of Immunology · doi:10.4049/jimmunol.1700559 · Cited by 175

Epigenetics of hematopoiesis and hematological malignanciesPreprint

Hu, D., & Shilatifard, A. (2016) · Genes & Development · doi:10.1101/gad.284109.116 · Cited by 175

Tet2-mediated clonal hematopoiesis in nonconditioned mice accelerates age-associated cardiac dysfunction

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The landscape of DNA methylation amid a perfect storm of autism aetiologies

Ciernia, A. V., & LaSalle, J. M. (2016) · Nature reviews. Neuroscience · doi:10.1038/nrn.2016.41 · Cited by 168

Cancer-associated mutation and beyond: The emerging biology of isocitrate dehydrogenases in human disease

Tommasini-Ghelfi, S., Murnan, K., Kouri, F. M., Mahajan, A., May, J., & Stegh, A. H. (2019) · Science Advances · doi:10.1126/sciadv.aaw4543 · Cited by 166

Induced DNA demethylation by targeting Ten-Eleven Translocation 2 to the human ICAM-1 promoter

Chen, H., Kazemier, H. G., de Groote, M. L., Ruiters, M. H. J., Xu, G., & Rots, M. G. (2013) · Nucleic Acids Research · doi:10.1093/nar/gkt1019 · Cited by 164

Retinol and ascorbate drive erasure of epigenetic memory and enhance reprogramming to naïve pluripotency by complementary mechanisms

Hore, T. A., von Meyenn, F., Ravichandran, M., Bachman, M., Ficz, G., Oxley, D., Santos, F., Balasubramanian, S., Jurkowski, T. P., & Reik, W. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1608679113 · Cited by 172

Epigenetic regulation: A new frontier for biomedical engineers

Chen, Z., Li, S., Subramaniam, S., Shyy, J. Y.-J., & Chien, S. (2017) · Annual Review of Biomedical Engineering · doi:10.1146/annurev-bioeng-071516-044720 · Cited by 163

The Roles of Jumonji-Type Oxygenases in Human Disease

Johansson, C., Tumber, A., Che, K., Cain, P., Nowak, R. P., Gileadi, C., & Oppermann, U. C. T. (2014) · Epigenomics · doi:10.2217/epi.13.79 · Cited by 167

Somatic Mutations and Clonal Hematopoiesis

Fuster, J. J., & Walsh, K. X. (2018) · Circulation Research · doi:10.1161/circresaha.117.312115 · Cited by 166

Cardiovascular Disease, Aging, and Clonal Hematopoiesis

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Inflammation, DNA methylation and colitis-associated cancer

Hartnett, L., & Egan, L. J. (2012) · Carcinogenesis · doi:10.1093/carcin/bgs006 · Cited by 165

An Adenine Code for DNA: A Second Life for N6-Methyladenine

Heyn, H., & Esteller, M. (2015) · Cell · doi:10.1016/j.cell.2015.04.021 · Cited by 167

In Response to Abiotic Stress, DNA Methylation Confers EpiGenetic Changes in Plants

Akhter, Z., Bi, Z., Ali, K., Sun, C., Fiaz, S., Haider, F. U., & Bai, J. (2021) · Plants · doi:10.3390/plants10061096 · Cited by 169

DNA Repair by Reversal of DNA Damage

Yi, C., & He, C. (2013) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a012575 · Cited by 161

Decrease of 5-Hydroxymethylcytosine Is Associated with Progression of Hepatocellular Carcinoma through Downregulation of TET1

Liu, C., Liu, L., Chen, X., Shen, J., Shan, J., Xu, Y., Yang, Z., Wu, L., Xia, F., Bie, P., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0062828 · Cited by 161

DNA demethylation, Tet proteins and 5-hydroxymethylcytosine in epigenetic reprogramming: An emerging complex story

Hill, P. W. S., Amouroux, R., & Hájková, P. (2014) · Genomics · doi:10.1016/j.ygeno.2014.08.012 · Cited by 161

Identification of Epigenetically Altered Genes in Sporadic Amyotrophic Lateral Sclerosis

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Epigenetic drug discovery: breaking through the immune barrier

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An Extensive Network of TET2-Targeting MicroRNAs Regulates Malignant Hematopoiesis

Cheng, J., Guo, S., Chen, S., Mastriano, S., Liu, C., D’Alessio, A. C., Hysolli, E., Guo, Y., Yao, H., Megyola, C. M., et al. (2013) · Cell Reports · doi:10.1016/j.celrep.2013.08.050 · Cited by 164

5-Formylcytosine alters the structure of the DNA double helix

Raiber, E., Murat, P., Chirgadze, D. Y., Beraldi, D., Luisi, B. F., & Balasubramanian, S. (2014) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.2936 · Cited by 159

Single-Cell 5-Formylcytosine Landscapes of Mammalian Early Embryos and ESCs at Single-Base Resolution

Zhu, C., Gao, Y., Guo, H., Xia, B., Song, J., Wu, X., Zeng, H., Kee, K., Tang, F., & Yi, C. (2017) · Cell stem cell · doi:10.1016/j.stem.2017.02.013 · Cited by 164

Functions of DNA Methylation and Hydroxymethylation in Mammalian Development

Guibert, S., & Weber, M. (2013) · Current topics in developmental biology/Current Topics in Developmental Biology · doi:10.1016/b978-0-12-416027-9.00002-4 · Cited by 173

Epigenetic cancer therapy: rationales, targets and drugs

Rius, M., & Lyko, F. (2012) · Oncogene · doi:10.1038/onc.2011.601 · Cited by 157

TET1-Mediated Hypomethylation Activates Oncogenic Signaling in Triple-Negative Breast Cancer

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DNMT3A and TET1 cooperate to regulate promoter epigenetic landscapes in mouse embryonic stem cells

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Loss of TET2 and TET3 in regulatory T cells unleashes effector function

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The histone deacetylase SIRT6 controls embryonic stem cell fate via TET-mediated production of 5-hydroxymethylcytosine

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Potential functional roles of DNA demethylation intermediates

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miR-29 Represses the Activities of DNA Methyltransferases and DNA Demethylases

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DNA Methylation in Solid Tumors: Functions and Methods of Detection

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TET proteins regulate the lineage specification and TCR-mediated expansion of iNKT cells

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Molecular basis for 5-carboxycytosine recognition by RNA polymerase II elongation complex

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Hydroxyl-radical-induced oxidation of 5-methylcytosine in isolated and cellular DNA

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TET1 regulates hypoxia-induced epithelial-mesenchymal transition by acting as a co-activator

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Materials and Methods Figs. S1 to S19 Tables S1 to S15

(2011)

Role and regulation of TET-mediated \nDNA modifications in gene expression

Müller, U. (2014) · Electronic Theses of LMU Munich (Ludwig-Maximilians-Universität München)

Mechanisms and functions of Tet protein-mediated 5-methylcytosine oxidationPreprint

Wu, H., & Zhang, Y. (2011) · Genes & Development · doi:10.17615/800j-yk16 · Cited by 686

Role and regulation of TET-mediated DNA modifications in gene expression

Müller, U. (2014) · doi:10.5282/edoc.17823

Results and Discussion

(2016)