Tet Proteins Can Convert 5-Methylcytosine to 5-Formylcytosine and 5-Carboxylcytosine

Conversion of 5-Methylcytosine to 5-Hydroxymethylcytosine in Mammalian DNA by MLL Partner TET1

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The Nuclear DNA Base 5-Hydroxymethylcytosine Is Present in Purkinje Neurons and the Brain

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Role of Tet proteins in 5mC to 5hmC conversion, ES-cell self-renewal and inner cell mass specification

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EUKARYOTIC CYTOSINE METHYLTRANSFERASES

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Hydroxylation of 5-Methylcytosine by TET1 Promotes Active DNA Demethylation in the Adult Brain

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Active DNA demethylation: many roads lead to Rome

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Tissue Distribution of 5-Hydroxymethylcytosine and Search for Active Demethylation Intermediates

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Thymine DNA glycosylase is essential for active DNA demethylation by linked deamination-base excision repair

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The Colorful History of Active DNA Demethylation

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DNA demethylation by DNA repair

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Myeloid malignancies: mutations, models and management

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Single-base resolution analysis of active DNA demethylation using methylase-assisted bisulfite sequencing

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Redox control in cancer development and progression

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5-hydroxymethylcytosine accumulation in postmitotic neurons results in functional demethylation of expressed genes

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Epigenetic modification of Nrf2 in 5-fluorouracil-resistant colon cancer cells: involvement of TET-dependent DNA demethylation

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Nucleic acid modifications with epigenetic significance

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Mass spectrometry for the assessment of the occurrence and biological consequences of DNA adducts

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Excision of 5-hydroxymethyluracil and 5-carboxylcytosine by the thymine DNA glycosylase domain: its structural basis and implications for active DNA demethylation

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Differential Regulation of the Ten-Eleven Translocation (TET) Family of Dioxygenases by O-Linked β-N-Acetylglucosamine Transferase (OGT)

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DNA methylation, early life environment, and health outcomes

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5-Hydroxymethylcytosine Plays a Critical Role in Glioblastomagenesis by Recruiting the CHTOP-Methylosome Complex

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Low values of 5‐hydroxymethylcytosine (5hmC), the “sixth base,” are associated with anaplasia in human brain tumors

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Dysregulation of the TET family of epigenetic regulators in lymphoid and myeloid malignancies

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The mitochondrial epitranscriptome: the roles of RNA modifications in mitochondrial translation and human disease

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Sensitive and Simultaneous Determination of 5-Methylcytosine and Its Oxidation Products in Genomic DNA by Chemical Derivatization Coupled with Liquid Chromatography-Tandem Mass Spectrometry Analysis

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The Mechanism and Function of Epigenetics in Uterine Leiomyoma Development

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Acetylation Enhances TET2 Function in Protecting against Abnormal DNA Methylation during Oxidative Stress

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Epigenetic flexibility in metabolic regulation: disease cause and prevention

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Epigenetic modulation of DNA methylation by nutrition and its mechanisms in animals

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Mechanism and Stem‐Cell Activity of 5‐Carboxycytosine Decarboxylation Determined by Isotope Tracing

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Biologically relevant oxidants and terminology, classification and nomenclature of oxidatively generated damage to nucleobases and 2-deoxyribose in nucleic acids

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RNA epigenetics

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DNA methylation aberrancies as a guide for surveillance and treatment of human cancers

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Oncogenic Activities of IDH1/2 Mutations: From Epigenetics to Cellular Signaling

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Breathing-in epigenetic change with vitamin C

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DNA Methylation in Systemic Lupus Erythematosus

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Advances in targeted therapy for malignant lymphoma

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Means, mechanisms and consequences of adenine methylation in DNA

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Genome-wide profiling identifies a DNA methylation signature that associates with TET2 mutations in diffuse large B-cell lymphoma

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TET Enzymes and 5hmC in Adaptive and Innate Immune Systems

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Tet3 Reads 5-Carboxylcytosine through Its CXXC Domain and Is a Potential Guardian against Neurodegeneration

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Phosphorylation of TET Proteins Is Regulated via O-GlcNAcylation by the O-Linked N-Acetylglucosamine Transferase (OGT)

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Structure of a Naegleria Tet-like dioxygenase in complex with 5-methylcytosine DNA

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Quantitative assessment of Tet-induced oxidation products of 5-methylcytosine in cellular and tissue DNA

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Functions and Malfunctions of Mammalian DNA-Cytosine Deaminases

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Epigenetic Regulations in Neuropsychiatric Disorders

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Hypoxia Drives Breast Tumor Malignancy through a TET–TNFα–p38–MAPK Signaling Axis

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Ten-eleven translocation 1 (TET1) methylation is associated with childhood asthma and traffic-related air pollution

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Enhanced 5-methylcytosine detection in single-molecule, real-time sequencing via Tet1 oxidation

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Methylcytosine and Normal Cytosine Deamination by the Foreign DNA Restriction Enzyme APOBEC3A

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Quantification of 5-Methylcytosine and 5-Hydroxymethylcytosine in Genomic DNA from Hepatocellular Carcinoma Tissues by Capillary Hydrophilic-Interaction Liquid Chromatography/Quadrupole TOF Mass Spectrometry

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Age‐Dependent Levels of 5‐Methyl‐, 5‐Hydroxymethyl‐, and 5‐Formylcytosine in Human and Mouse Brain Tissues

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Novel genetic and epigenetic factors of importance for inter-individual differences in drug disposition, response and toxicity

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Epigenetic mechanisms in Alzheimer's disease: Implications for pathogenesis and therapy

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Environmental Toxicants, Epigenetics, and Cancer

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Role of DNMT3A, TET2, and IDH1/2 mutations in pre-leukemic stem cells in acute myeloid leukemia

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Silencing of endogenous retroviruses: when and why do histone marks predominate?

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5-Hydroxymethylcytosine: generation, fate, and genomic distribution

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PRDM14 promotes active DNA demethylation through the Ten-eleven translocation (TET)-mediated base excision repair pathway in embryonic stem cells

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Epiblast Stem Cell-Based System Reveals Reprogramming Synergy of Germline Factors

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Hopefully devoted to Q: targeting glutamine addiction in cancer

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Epigenetic regulation in B-cell maturation and its dysregulation in autoimmunity

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Tissue-specific 5-hydroxymethylcytosine landscape of the human genome

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Methamphetamine Downregulates Striatal Glutamate Receptors via Diverse Epigenetic Mechanisms

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O-GlcNAc signaling in cancer metabolism and epigenetics

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Detection of Human Urinary 5-Hydroxymethylcytosine by Stable Isotope Dilution HPLC-MS/MS Analysis

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Computational identification of novel biochemical systems involved in oxidation, glycosylation and other complex modifications of bases in DNA

Iyer, L. M., Zhang, D., Burroughs, A. M., & Aravind, L. (2013) · Nucleic Acids Research · doi:10.1093/nar/gkt573 · Cited by 137

Mammalian epigenetic mechanisms

Zhang, G., & Pradhan, S. (2014) · IUBMB Life · doi:10.1002/iub.1264 · Cited by 143

Loss of 5-hydroxymethylcytosine in cancer: Cause or consequence?

Ficz, G., & Gribben, J. G. (2014) · Genomics · doi:10.1016/j.ygeno.2014.08.017 · Cited by 135

Vitamin C in Stem Cell Biology: Impact on Extracellular Matrix Homeostasis and Epigenetics

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Melatonin improves the fertilization capacity and developmental ability of bovine oocytes by regulating cytoplasmic maturation events

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Genome-Wide Variation of Cytosine Modifications Between European and African Populations and the Implications for Complex Traits

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Cross-region reduction in 5-hydroxymethylcytosine in Alzheimer's disease brain

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Hepatic stellate cell transdifferentiation involves genome-wide remodeling of the DNA methylation landscape

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Epigenetics and inheritance of phenotype variation in livestock

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Quantitative LC–MS Provides No Evidence for m6dA or m4dC in the Genome of Mouse Embryonic Stem Cells and Tissues

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Epigenetic and Neurological Impairments Associated with Early Life Exposure to Persistent Organic Pollutants

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Cytosine-Based TET Enzyme Inhibitors

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Electrochemical, electrochemiluminescent and photoelectrochemical bioanalysis of epigenetic modifiers: A comprehensive review

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The function and regulation of TET2 in innate immunity and inflammation

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Tet Enzymes, Variants, and Differential Effects on Function

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Selective advantage of mutant stem cells in human clonal hematopoiesis is associated with attenuated response to inflammation and aging

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Strategies for discovery and validation of methylated and hydroxymethylated DNA biomarkers

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Mass Spectrometry of Structurally Modified DNA

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Genome-wide Bisulfite Sequencing in Zygotes Identifies Demethylation Targets and Maps the Contribution of TET3 Oxidation

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TET1 is a maintenance DNA demethylase that prevents methylation spreading in differentiated cells

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N 6-Methyladenosine (m6A) Methylation in mRNA with A Dynamic and Reversible Epigenetic Modification

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The chemistries and consequences of DNA and RNA methylation and demethylation

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Effect of aging on 5-hydroxymethylcytosine in the mouse hippocampus

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Epigenetic regulation in pluripotent stem cells: a key to breaking the epigenetic barrier

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N6-Methyladenine: A Conserved and Dynamic DNA Mark

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Connections Between Metabolism and Epigenetics in Programming Cellular Differentiation

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Epigenetic control of gene regulation during development and disease: A view from the retina

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Redox-active quinones induces genome-wide DNA methylation changes by an iron-mediated and Tet-dependent mechanism

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5-Methylcytosine DNA Demethylation: More Than Losing a Methyl Group

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Wilms tumor protein recognizes 5-carboxylcytosine within a specific DNA sequencePreprint

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An atomic model of Zfp57 recognition of CpG methylation within a specific DNA sequencePreprint

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Nucleic Acid Oxidation in DNA Damage Repair and Epigenetics

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Single-Base Resolution Analysis of 5-Formyl and 5-Carboxyl Cytosine Reveals Promoter DNA Methylation Dynamics

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5-Hydroxymethylcytosine: A stable or transient DNA modification?

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MicroRNA-26a targets ten eleven translocation enzymes and is regulated during pancreatic cell differentiation

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Active DNA Demethylation in Plants and AnimalsPreprint

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Simultaneous deletion of the methylcytosine oxidases Tet1 and Tet3 increases transcriptome variability in early embryogenesis

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DNA phosphorothioate modification—a new multi-functional epigenetic system in bacteria

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Going beyond five bases in DNA sequencing

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Epigenetics and Its Role in Periodontal Diseases: A State‐of‐the‐Art Review

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Tet1 and Tet2 maintain mesenchymal stem cell homeostasis via demethylation of the P2rX7 promoter

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Paradoxical association of TET loss of function with genome-wide DNA hypomethylation

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The existence of 5-hydroxymethylcytosine and 5-formylcytosine in both DNA and RNA in mammals

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Materials and Methods Figs. S1 to S19 Tables S1 to S15

(2011)

Role and regulation of TET-mediated \nDNA modifications in gene expression

Müller, U. (2014) · Electronic Theses of LMU Munich (Ludwig-Maximilians-Universität München)

Mechanisms and functions of Tet protein-mediated 5-methylcytosine oxidationPreprint

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Role and regulation of TET-mediated DNA modifications in gene expression

Müller, U. (2014) · doi:10.5282/edoc.17823

Results and Discussion

(2016)