Cited by 3,451Epigenetics and DNA MethylationRNA modifications and cancerGenomics and Chromatin Dynamics

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Tet Proteins Can Convert 5-Methylcytosine to 5-Formylcytosine and 5-Carboxylcytosine

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Ito, Shinsuke, Shen, Li, Dai, Qing, Wu, Susan C., Collins, Leonard B., Swenberg, James A., He, Chuan, Zhang, Yi·2011·Science

DOI 10.1126/science.1210597PMC PMC3495246

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Abstract

Evidence for a possible route for DNA demethylation in animals is suggested.

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Conversion of 5-Methylcytosine to 5-Hydroxymethylcytosine in Mammalian DNA by MLL Partner TET1
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EUKARYOTIC CYTOSINE METHYLTRANSFERASES
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Tissue Distribution of 5-Hydroxymethylcytosine and Search for Active Demethylation Intermediates
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10.1021/ol201189n · DOI
10.1038/nature09303 · DOI
10.1016/j.jchromb.2009.12.004 · DOI

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Authors: Ito, S., Shen, L., Dai, Q., Wu, S. C., Collins, L. B., Swenberg, J. A., He, C., & Zhang, Y.
Affiliations: University of North Carolina at Chapel Hill (US)
University of Chicago (US)
Corresponding author: Ito, Shinsuke
Shen, Li
Zhang, Yi
ORCID: Ito, Shinsuke
Shen, Li
Dai, Qing
Collins, Leonard B.
He, Chuan
Zhang, Yi
Venue: Science
Publisher: American Association for the Advancement of Science (AAAS)
Published: 2011-09-02
Volume: 333
Issue: 6047
Pages: 1300-1303
ISSN: 0036-8075 (ISSN-L)
1095-9203
DOI: 10.1126/science.1210597
PMC: PMC3495246
OpenAlex: W1997453048
Cited by: 3,451
References: 17
Citations by year: 2026: 105 · 2025: 160 · 2024: 180 · 2023: 204 · 2022: 209 · 2021: 236 · 2020: 261 · 2019: 258 · 2018: 268 · 2017: 263 · 2016: 279 · 2015: 253 · 2014: 280 · 2013: 259 · 2012: 198
FWCI: 100.34
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: Science (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Carolina Digital Repository (University of North Carolina at Chapel Hill) (submittedVersion)
UNC Libraries
Funders: Howard Hughes Medical Institute
National Institutes of Health
Japan Society for the Promotion of Science
National Institute of General Medical Sciences (GM071440, GM68804, R01GM071440, R01GM068804)
National Institute of Diabetes and Digestive and Kidney Diseases (U01DK089565)
National Institute of Environmental Health Sciences (P30ES10126), P42ES005948, P30ES010126, P42 ES/5948)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA modifications and cancer
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
Keywords: TET enzymes, 5-methylcytosine, 5-formylcytosine, 5-carboxylcytosine, 5-hydroxymethylcytosine, DNA demethylation, DNA oxidation, decarboxylation, genomic DNA, mouse embryonic stem cells, epigenetic modifications
MeSH terms: Animals, Cell Line, Cytosine, DNA, DNA-Binding Proteins, Humans, Oxidation-Reduction, Proto-Oncogene Proteins, Recombinant Fusion Proteins, DNA Methylation, 5-Methylcytosine, Dioxygenases, Mice, Embryonic Stem Cells

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Tet Proteins Can Convert 5-Methylcytosine to 5-Formylcytosine and 5-Carboxylcytosine

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