Cited by 2,744Nitric Oxide and Endothelin EffectsRedox biology and oxidative stressHemoglobin structure and function

The DOI matches its Crossref record; 88 of the 88 references it cites were found in a registry or an index.

Biochemistry of Nitric Oxide and Its Redox-Activated Forms

Abstract

Nitric oxide (NO.), a potentially toxic molecule, has been implicated in a wide range of biological functions. Details of its biochemistry, however, remain poorly understood. The broader chemistry of nitrogen monoxide (NO) involves a redox array of species with distinctive properties and reactivities: NO+ (nitrosonium), NO., and NO- (nitroxyl anion). The integration of this chemistry with current perspectives of NO biology illuminates many aspects of NO biochemistry, including the enzymatic mechanism of synthesis, the mode of transport and targeting in biological systems, the means by which its toxicity is mitigated, and the function-regulating interaction with target proteins.

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Crossref · 10.1126/science.1281928

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88 of 88 references verified0 citation errors · 0 not checkable

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Show all 88 references

Research works printed but not linked: 13

  1. BOTTOMLEY, F, JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS: 919 (1973).
  2. Bunton, C. A., Recent Aspects of the Inorganic Chemistry of Nitrogen: 113 (1957).
  3. CHALLIS, B. C., IARC SCIENTIFIC PUBLICATIONS 31: 127 (1980).
  4. EBERSON, L, ACTA CHEMICA SCANDINAVICA SERIES B-ORGANIC CHEMISTRY AND BIOCHEMISTRY 38: 861 (1984).
  5. Fukuto, J. M., Journal of Pharmacology and Experimental Therapeutics 263: 546 (1992).
  6. HENRY, Y, EUROPEAN BIOPHYSICS JOURNAL 20: 1 (1991).
  7. MARLETTA, M.A., BIOFACTORS 2: 219 (1990).
  8. MORRIS, S.L., IDENTIFICATION AND CHARACTERIZATION OF SOME BACTERIAL-MEMBRANE SULFHYDRYL-GROUPS WHICH ARE TARGETS OF BACTERIOSTATIC AND ANTIBIOTIC ACTION, JOURNAL OF BIOLOGICAL CHEMISTRY 259: 3590 (1984).
  9. OH, S. M. N., JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 2: 685 (1991).
  10. SEN, N. P., IARC SCIENTIFIC PUBLICATIONS 9: 103 (1975).
  11. Stamler, J. S., 2nd International Meeting of the Biology of Nitric Oxide: 20 (1992).
  12. VANIN, A.F., BIOKHIMIYA 32: 277 (1967).
  13. Williams, D. C., Nitrosation: 1 (1988).

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Metadata

Authors
Stamler, J. S., Singel, D. J., & Loscalzo, J.
Affiliations
  • Brigham and Women's Hospital (US)
  • Harvard University (US)
Venue
Science
Published
1992-12-18
Volume
258
Issue
5090
Pages
1898-1902
ISSN
  • 0036-8075 (ISSN-L)
  • 1095-9203
OpenAlex
W2019814232
Cited by
2,744
References
88
Citations by year
2026: 10 · 2025: 25 · 2024: 33 · 2023: 25 · 2022: 31 · 2021: 32 · 2020: 34 · 2019: 33 · 2018: 34 · 2017: 44 · 2016: 54 · 2015: 53 · 2014: 72 · 2013: 67 · 2012: 58
FWCI
17.41
Type
journal article
Language
en
Open access
closed
Locations
  • Science (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health (5r01hl040411-02, 5r01hl043344-04)
  • National Heart, Lung, and Blood Institute (HL43344, HL-40411)
  • National Center for Research Resources (RRO4870)
Topics
  • Health Sciences › Medicine › Physiology (medical) › Nitric Oxide and Endothelin Effects
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Hemoglobin structure and function
Keywords
nitric oxide, nitrosonium, nitric oxide transport, nitric oxide toxicity
MeSH terms
Amino Acid Oxidoreductases, Animals, Arginine, Humans, Nitric Oxide, Oxidation-Reduction, Nitric Oxide Synthase

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