Biochemistry of Nitric Oxide and Its Redox-Activated Forms

Nitric oxide: physiology, pathophysiology, and pharmacology.

Moncada, S., Palmer, R. M., & Higgs, E. A. (1991) · Pharmacological Reviews · doi:10.1016/s0031-6997(25)06663-3 · Cited by 15,525

Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor

Palmer, R. M. J., Ferrige, A. G., & Moncada, S. (1987) · Nature · doi:10.1038/327524a0 · Cited by 10,704

Apparent hydroxyl radical production by peroxynitrite: Implications for endothelial injury from nitric oxide and superoxide

Beckman, J. S., Beckman, T. W., Chen, J., Marshall, P. A., & Freeman, B. A. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.4.1620 · Cited by 7,029

Endothelium-derived relaxing factor produced and released from artery and vein is nitric oxide.

Ignarro, L. J., Buga, G. M., Wood, K. S., Byrns, R. E., & Chaudhuri, G. (1987) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.84.24.9265 · Cited by 5,074

Nitric oxide as a secretory product of mammalian cells

Nathan, C. (1992) · The FASEB Journal · doi:10.1096/fasebj.6.12.1381691 · Cited by 4,350

Peroxynitrite oxidation of sulfhydryls.

Radí, R., Beckman, J. S., Bush, K., & Freeman, B. Α. (1991) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(20)64313-7 · Cited by 2,492

Cloned and expressed nitric oxide synthase structurally resembles cytochrome P-450 reductase

Bredt, D. S., Hwang, P. M., Glatt, C. E., Lowenstein, C. J., Reed, R. R., & Snyder, S. H. (1991) · Nature · doi:10.1038/351714a0 · Cited by 2,354

Macrophage cytotoxicity: role for L-arginine deiminase and imino nitrogen oxidation to nitrite

Hibbs, J. B., Taintor, R. R., & Vavrin, Z. (1987) · Science · doi:10.1126/science.2432665 · Cited by 1,527

S-nitrosylation of proteins with nitric oxide: synthesis and characterization of biologically active compounds.

Stamler, J. S., Simon, D. I., Osborne, J. A., Mullins, M. E., Jaraki, O., Michel, T. M., Singel, D. J., & Loscalzo, J. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.1.444 · Cited by 1,471

DNA Deaminating Ability and Genotoxicity of Nitric Oxide and its Progenitors

Wink, D. A., Kasprzak, K. S., Maragos, C. M., Elespuru, R. K., Misra, M., Dunams, T. M., Cebula, T. A., Koch, W. H., Andrews, A. W., Allen, J. S., et al. (1991) · Science · doi:10.1126/science.1948068 · Cited by 1,243

Free Radicals in the Physiological Control of Cell Function

Dröge, W. (2002) · Physiological Reviews · doi:10.1152/physrev.00018.2001 · Cited by 9,855

Nitric Oxide and Peroxynitrite in Health and Disease

Pacher, P., Beckman, J. S., & Liaudet, L. (2007) · Physiological Reviews · doi:10.1152/physrev.00029.2006 · Cited by 6,390

Oxidants, antioxidants, and the degenerative diseases of aging.

Ames, B. N., Shigenaga, M. K., & Hagen, T. M. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.17.7915 · Cited by 5,958

Oxidative Stress and Neurodegenerative Diseases: A Review of Upstream and Downstream Antioxidant Therapeutic Options

Uttara, B., Singh, A., Zamboni, P., & Mahajan, R. (2009) · Current Neuropharmacology · doi:10.2174/157015909787602823 · Cited by 3,378

Structure of Serum Albumin

Carter, D. C., & Ho, J. X. (1994) · Advances in protein chemistry · doi:10.1016/s0065-3233(08)60640-3 · Cited by 3,184

THE HEME OXYGENASE SYSTEM:A Regulator of Second Messenger Gases

Maines, M. D. (1997) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.37.1.517 · Cited by 2,489

A redox-based mechanism for the neuroprotective and neurodestructive effects of nitric oxide and related nitroso-compounds

Lipton, S. A., Choi, Y.-B., Pan, Z.-H., Lei, S. Z., Chen, H.-S. V., Sucher, N. J., Loscalzo, J., Singel, D. J., & Stamler, J. S. (1993) · Nature · doi:10.1038/364626a0 · Cited by 2,433

Endothelial cells in physiology and in the pathophysiology of vascular disorders.

Cines, D. B., Pollak, E. S., Buck, C. A., Loscalzo, J., Zimmerman, G. A., McEver, R. P., Pober, J. S., Wick, T. M., Konkle, B. A., Schwartz, B. S., et al. (1998) · PubMed · doi:10.1182/blood.v91.10.3527 · Cited by 2,246

Oxidative stress and autophagy: The clash between damage and metabolic needs

Filomeni, G., De Zio, D., & Cecconi, F. (2015) · Cell Death & Differentiation · doi:10.1038/cdd.2014.150 · Cited by 2,195

Superoxide dismutases: Dual roles in controlling ROS damage and regulating ROS signaling

Wang, Y., Branicky, R. S., Noë, A., & Hekimi, S. (2018) · The Journal of Cell Biology · doi:10.1083/jcb.201708007 · Cited by 2,284

Protein S-nitrosylation: Purview and parameters

Hess, D. T., Matsumoto, A., Kim, S.-O., Marshall, H. E., & Stamler, J. S. (2005) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1569 · Cited by 2,153

Oxidative stress as a mediator of apoptosis

Buttke, T. M., & Sandstrom, P. A. (1994) · Immunology Today · doi:10.1016/0167-5699(94)90018-3 · Cited by 2,149

Mesenchymal stem cell-mediated immunosuppression occurs via concerted action of chemokines and nitric oxide

Ren, G., Zhang, L., Zhao, X., Xu, G., Zhang, Y., Roberts, A. I., Zhao, R. C., & Shi, Y. (2008) · Cell Stem Cell · doi:10.1016/j.stem.2007.11.014 · Cited by 2,101

From endoplasmic-reticulum stress to the inflammatory response

Zhang, K., & Kaufman, R. J. (2008) · Nature · doi:10.1038/nature07203 · Cited by 2,010

Soil microorganisms as controllers of atmospheric trace gases (H2, CO, CH4, OCS, N2O, and NO)

Conrad, R. (1996) · Microbiological Reviews · doi:10.1128/mr.60.4.609-640.1996 · Cited by 1,785

Redox signaling: Nitrosylation and related target interactions of nitric oxide

Stamler, J. S. (1994) · Cell · doi:10.1016/0092-8674(94)90269-0 · Cited by 1,723

Nitric oxide directly activates calcium-dependent potassium channels in vascular smooth muscle

Bolotina, V. M., Najibi, S., Palacino, J. J., Pagano, P. J., & Cohen, R. A. (1994) · Nature · doi:10.1038/368850a0 · Cited by 1,690

Effects of Cerebral Ischemia in Mice Deficient in Neuronal Nitric Oxide Synthase

Huang, Z., Huang, P. L., Panahian, N., Dalkara, T., Fishman, M. C., & Moskowitz, M. A. (1994) · Science · doi:10.1126/science.7522345 · Cited by 1,562

The chemistry of peroxynitrite: A product from the reaction of nitric oxide with superoxide

Pryor, W. A., & Squadrito, G. L. (1995) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.1995.268.5.l699 · Cited by 1,511

Nitric oxide regulation of superoxide and peroxynitrite-dependent lipid peroxidation. Formation of novel nitrogen-containing oxidized lipid derivatives

Rubbo, H., Radí, R., Trujillo, M., Telleri, R., Kalyanaraman, B., Barnes, S., KIRK, M. C., & Freeman, B. Α. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)47160-8 · Cited by 1,350

Defense gene induction in tobacco by nitric oxide, cyclic GMP, and cyclic ADP-ribose

Durner, J., Wendehenne, D., & Klessig, D. F. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.17.10328 · Cited by 1,320

Hyperglycemic Pseudohypoxia and Diabetic Complications

Williamson, J. R., Chang, K. C., Frangos, M., Hasan, K. S., Ido, Y., Kawamura, T., Nyengaard, J. R., den Enden, M. V., Kilo, C., & Tilton, R. G. (1993) · Diabetes · doi:10.2337/diab.42.6.801 · Cited by 1,092

Physiology of Nitric Oxide in Skeletal Muscle

Stamler, J. S., & Meissner, G. (2001) · Physiological Reviews · doi:10.1152/physrev.2001.81.1.209 · Cited by 1,080

Chronic infections and inflammatory processes as cancer risk factors: possible role of nitric oxide in carcinogenesis

Ohshima, H., & Bartsch, H. (1994) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/0027-5107(94)90245-3 · Cited by 1,050

Gases as biological messengers: nitric oxide and carbon monoxide in the brain

Dawson, T., & Snyder, S. (1994) · The Journal of Neuroscience · doi:10.1523/jneurosci.14-09-05147.1994 · Cited by 1,043

Nanomedicine Applications of Hybrid Nanomaterials Built from Metal–Ligand Coordination Bonds: Nanoscale Metal–Organic Frameworks and Nanoscale Coordination Polymers

He, C., Liu, D., & Lin, W. (2015) · Chemical Reviews · doi:10.1021/acs.chemrev.5b00125 · Cited by 1,011

Nitric oxide in skeletal muscle

Kobzik, L., Reid, M. B., Bredt, D. S., & Stamler, J. S. (1994) · Nature · doi:10.1038/372546a0 · Cited by 955

Radicals and oxidative stress in diabetes

West, I. C. (2000) · Diabetic Medicine · doi:10.1046/j.1464-5491.2000.00259.x · Cited by 913

Nitric oxide in health and disease of the respiratory system

Ricciardolo, F. L. M., Sterk, P. J., Gaston, B., & Folkerts, G. (2004) · Physiological Reviews · doi:10.1152/physrev.00034.2003 · Cited by 903

Analysis of nitrite and nitrate in biological fluids by assays based on the Griess reaction: Appraisal of the Griess reaction in the l-arginine/nitric oxide area of research

Tsikas, D. (2006) · Journal of Chromatography B · doi:10.1016/j.jchromb.2006.07.054 · Cited by 897

Nitric Oxide: The Versatility of an Extensive Signal Molecule

Lamattina, L., García‐Mata, C., Graziano, M., & Pagnussat, G. C. (2003) · Annual Review of Plant Biology · doi:10.1146/annurev.arplant.54.031902.134752 · Cited by 877

Nitric oxide signalling in plants

Neill, S. J., Desikan, R., & Hancock, J. T. (2003) · New Phytologist · doi:10.1046/j.1469-8137.2003.00804.x · Cited by 872

Stress (Heat Shock) Proteins

Benjamin, I. J., & McMillan, D. R. (1998) · Circulation Research · doi:10.1161/01.res.83.2.117 · Cited by 840

Inhibition of Viral Replication by Interferon-γ-Induced Nitric Oxide Synthase

Karupiah, G., Xie, Q. W., Buller, R. M. L., Nathan, C., Duarte, C. J., & MacMicking, J. D. (1993) · Science · doi:10.1126/science.7690156 · Cited by 810

Formation of reactive nitrogen species during peroxidase-catalyzed oxidation of nitrite

van der Vliet, A., Eiserich, J. P., Halliwell, B., & Cross, C. E. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.12.7617 · Cited by 780

Regulation of protein function by S‐glutathiolation in response to oxidative and nitrosative stress

Klatt, P., & Lamas, S. (2000) · European Journal of Biochemistry · doi:10.1046/j.1432-1327.2000.01601.x · Cited by 757

The nitric oxide and cGMP signal transduction system: regulation and mechanism of action

Schmidt, H. H. H. W., Lohmann, S. M., & Walter, U. (1993) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/0167-4889(93)90006-b · Cited by 742

Superoxide dismutase delays neuronal apoptosis: A role for reactive oxygen species in programmed neuronal death

Greenlund, L. J. S., Deckwerth, T. L., & Johnson, E. M. (1995) · Neuron · doi:10.1016/0896-6273(95)90287-2 · Cited by 738

Proteomic Identification of S -Nitrosylated Proteins in Arabidopsis

Lindermayr, C., Saalbach, G., & Durner, J. (2005) · PLANT PHYSIOLOGY · doi:10.1104/pp.104.058719 · Cited by 737

Nitric Oxide and Cardiac Function

Kelly, R. A., Balligand, J., & Smith, T. W. (1996) · Circulation Research · doi:10.1161/01.res.79.3.363 · Cited by 715

The physiology and pathophysiology of nitric oxide in the brain

Guix, F. X., Uribesalgo, I., Coma, M., & Muñoz, F. J. (2005) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2005.06.001 · Cited by 723

The molecular mechanisms of the metabolism and transport of iron in normal and neoplastic cells

Richardson, D. R., & Ponka, P. (1997) · Biochimica et Biophysica Acta (BBA) - Reviews on Biomembranes · doi:10.1016/s0304-4157(96)00014-7 · Cited by 714

Induction and Stabilization of IκBα by Nitric Oxide Mediates Inhibition of NF-κB

Peng, H., Libby, P., & Liao, J. K. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.23.14214 · Cited by 703

Metabolic rate depression in animals: transcriptional and translational controls

Storey, K. B., & Storey, J. M. (2004) · Biological reviews/Biological reviews of the Cambridge Philosophical Society · doi:10.1017/s1464793103006195 · Cited by 696

Nitric oxide stimulates seed germination and de-etiolation, and inhibits hypocotyl elongation, three light-inducible responses in plants

Beligni, M. V., & Lamattina, L. (2000) · Planta · doi:10.1007/pl00008128 · Cited by 680

(S)NO Signals: Translocation, Regulation, and a Consensus Motif

Stamler, J. S., Toone, E. J., Lipton, S. A., & Sucher, N. J. (1997) · Neuron · doi:10.1016/s0896-6273(00)80310-4 · Cited by 679

Structure of the [NiFe] Hydrogenase Active Site: Evidence for Biologically Uncommon Fe Ligands

Volbeda, A., Garcin, E. D., Piras, C., Lacey, A. L. D., Fernández, V. M., Hatchikian, E. C., Frey, M., & Fontecilla-Camps, J. C. (1996) · Journal of the American Chemical Society · doi:10.1021/ja962270g · Cited by 682

Inhibition of mitochondrial beta-oxidation as a mechanism of hepatotoxicity

Fromenty, B., & Pessayre, D. (1995) · Pharmacology & Therapeutics · doi:10.1016/0163-7258(95)00012-6 · Cited by 665

Nitric Oxide Synthase Inhibition and Cerebrovascular Regulation

Iadecola, C., Pelligrino, D. A., Moskowitz, M. A., & Lassen, N. A. (1994) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.1994.25 · Cited by 649

Mechanisms of suppression of macrophage nitric oxide release by transforming growth factor beta.

Yoram Vodovotz, B., Bogdan, C., Paik, J., Xie, Q. W., & Nathan, C. (1993) · The Journal of Experimental Medicine · doi:10.1084/jem.178.2.605 · Cited by 649

Determination of nitrite/nitrate in human biological material by the simple Griess reaction

Guevara, I., Iwanejko, J., Dembinska-Kiec, A., Pankiewicz, J. E., Wanat, A., Anna, P., Leszczynska-Golabek, I., Bartuś, S., Malczewska-Malec, M., & Szczudlik, A. (1998) · Clinica Chimica Acta · doi:10.1016/s0009-8981(98)00060-6 · Cited by 647

Synthesis of nitric oxide in CNS glial cells

Murphy, S. P., Simmons, M. L., Agulló, L., Garcı́a, A., Feinstein, D. L., Galea, E., Reis, D. J., Minc‐Golomb, D., & Schwartz, J. P. (1993) · Trends in Neurosciences · doi:10.1016/0166-2236(93)90109-y · Cited by 633

Endogenous nitrogen oxides and bronchodilator S-nitrosothiols in human airways.

Gaston, B. M., Reilly, J., Drazen, J. M., Fackler, J. C., Ramdev, P., Arnelle, D. R., Mullins, M. E., Sugarbaker, D. J., Chee, C., Singel, D. J., et al. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.23.10957 · Cited by 620

Chemical basis of inflammation-induced carcinogenesis

Ohshima, H., Tatemichi, M., & Sawa, T. (2003) · Archives of Biochemistry and Biophysics · doi:10.1016/s0003-9861(03)00283-2 · Cited by 623

Nitric Oxide Insufficiency, Platelet Activation, and Arterial Thrombosis

Loscalzo, J. (2001) · Circulation Research · doi:10.1161/hh0801.089861 · Cited by 612

A Molecular Web: Endoplasmic Reticulum Stress, Inflammation, and Oxidative Stress

Chaudhari, N., Talwar, P., Parimisetty, A., Lefebvre d’Hellencourt, C., & Ravanan, P. (2014) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2014.00213 · Cited by 600

The transferrin receptor: role in health and disease

Ponka, P., & Lok, C. (1999) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/s1357-2725(99)00070-9 · Cited by 609

Nitric oxide and its role in the cardiovascular system

Loscalzo, J., & Welch, G. N. (1995) · Progress in Cardiovascular Diseases · doi:10.1016/s0033-0620(05)80001-5 · Cited by 613

Species Variation in the Mechanisms of Mesenchymal Stem Cell-Mediated Immunosuppression

Ren, G., Su, J., Zhang, L., Zhao, X., Ling, W., L'huillie, A., Zhang, J., Lu, Y., Roberts, A. I., Ji, W., et al. (2009) · Stem Cells · doi:10.1002/stem.118 · Cited by 597

Constitutive and inducible nitric oxide synthase gene expression, regulation, and activity in human lung epithelial cells.

Asano, K., Chee, C. B. E., Gaston, B. M., Lilly, C. M., Gerard, C. J., Drazen, J. M., & Stamler, J. S. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.21.10089 · Cited by 586

Ascorbic Acid Reverses Endothelial Vasomotor Dysfunction in Patients With Coronary Artery Disease

Levine, G. N., Frei, B., Koulouris, S. N., Gerhard, M. D., Keaney, J. F., & Vita, J. A. (1996) · Circulation · doi:10.1161/01.cir.93.6.1107 · Cited by 582

Regulation and measurement of oxidative stress in apoptosis

Curtin, J. F., Donovan, M., & Cotter, T. G. (2002) · Journal of Immunological Methods · doi:10.1016/s0022-1759(02)00070-4 · Cited by 581

Molecular biology of glutamate receptors in the central nervous system and their role in excitotoxicity, oxidative stress and aging

Michaelis, E. K. (1998) · Progress in Neurobiology · doi:10.1016/s0301-0082(97)00055-5 · Cited by 578

Nitric oxide: comparative synthesis and signaling in animal and plant cells

Wendehenne, D., Pugin, A., Klessig, D. F., & Durner, J. (2001) · Trends in Plant Science · doi:10.1016/s1360-1385(01)01893-3 · Cited by 571

Role of nitric oxide in carcinogenesis and tumour progression

Lala, P. K., & Chakraborty, C. (2001) · The Lancet Oncology · doi:10.1016/s1470-2045(00)00256-4 · Cited by 571

New insights into the regulation of inducible nitric oxide synthesis

Morris, S. M., & Billiar, T. R. (1994) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1994.266.6.e829 · Cited by 570

Nutrition and health aspects of free radicals and antioxidants

Aruoma, O. I. (1994) · Food and Chemical Toxicology · doi:10.1016/0278-6915(94)90011-6 · Cited by 572

Chronic ethanol consumption:from neuroadaptation to neurodegeneration

Fadda, F. (1998) · Progress in Neurobiology · doi:10.1016/s0301-0082(98)00032-x · Cited by 570

Reactions between nitric oxide and haemoglobin under physiological conditions

Gow, A. J., & Stamler, J. S. (1998) · Nature · doi:10.1038/34402 · Cited by 562

Role of nitric oxide in wound repair

Witte, M. B., & Barbul, A. (2002) · The American Journal of Surgery · doi:10.1016/s0002-9610(02)00815-2 · Cited by 556

Metalloenzymes, Structural Motifs, and Inorganic Models

Karlin, K. D. (1993) · Science · doi:10.1126/science.7688141 · Cited by 553

The chemistry of DNA damage from nitric oxide and peroxynitrite

Burney, S., Caulfield, J. L., Niles, J. C., Wishnok, J. S., & Tannenbaum, S. R. (1999) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/s0027-5107(99)00006-8 · Cited by 556

NO as a signalling molecule in the nervous system

Esplugues, J. V. (2002) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0704569 · Cited by 554

Dissimilatory Nitrite and Nitric Oxide Reductases

Averill, B. A. (1996) · Chemical Reviews · doi:10.1021/cr950056p · Cited by 545

The antioxidant role of coenzyme Q

Bentinger, M., Brismar, K., & Dallner, G. (2007) · Mitochondrion · doi:10.1016/j.mito.2007.02.006 · Cited by 543

Heme Oxygenase-1

Morse, D., & Choi, A. M. K. (2002) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/ajrcmb.27.1.4862 · Cited by 535

The dual role of iNOS in cancer

Vannini, F., Kashfi, K., & Nath, N. (2015) · Redox Biology · doi:10.1016/j.redox.2015.08.009 · Cited by 545

Molecular Mechanisms and Clinical Implications of Reversible Protein S -Glutathionylation

Mieyal, J. J., Gallogly, M. M., Qanungo, S., Sabens, E. A., & Shelton, M. D. (2008) · Antioxidants & Redox Signaling · doi:10.1089/ars.2008.2089 · Cited by 523

Nitric Oxide Signaling in Pseudomonas aeruginosa Biofilms Mediates Phosphodiesterase Activity, Decreased Cyclic Di-GMP Levels, and Enhanced Dispersal

Barraud, N., Schleheck, D., Klebensberger, J., Webb, J. S., Hassett, D. J., Rice, S. A., & Kjelleberg, S. J. (2009) · Journal of Bacteriology · doi:10.1128/jb.00975-09 · Cited by 515

Nitric oxide regulates basal systemic and pulmonary vascular resistance in healthy humans.

Stamler, J. S., Loh, E., Roddy, M.-A., Currie, K., & Creager, M. A. (1994) · Circulation · doi:10.1161/01.cir.89.5.2035 · Cited by 512

Nitric Oxide in the Nervous System

Zhang, J., & Snyder, S. H. (1995) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pa.35.040195.001241 · Cited by 512

Nitric oxide and iron proteins

Cooper, C. E. (1999) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/s0005-2728(99)00021-3 · Cited by 510

Nitric oxide produced by human B lymphocytes inhibits apoptosis and Epstein-Barr virus reactivation

Mannick, J. B., Asano, K., Izumi, K. M., Kieff, E. D., & Stamler, J. S. (1994) · Cell · doi:10.1016/0092-8674(94)90005-1 · Cited by 501

Chronic inhibition of nitric oxide production accelerates neointima formation and impairs endothelial function in hypercholesterolemic rabbits.

Cayatte, A. J., Palacino, J. J., Horten, K., & Cohen, R. A. (1994) · Arteriosclerosis and Thrombosis A Journal of Vascular Biology · doi:10.1161/01.atv.14.5.753 · Cited by 491

Pathogenesis of influenza virus-induced pneumonia: involvement of both nitric oxide and oxygen radicals.

Akaike, T., Noguchi, Y., Ijiri, S., Setoguchi, K., Suga, M., Zheng, Y., Dietzschold, B., & Maeda, H. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.6.2448 · Cited by 490

Nitric Oxide Donors and Cardiovascular Agents Modulating the Bioactivity of Nitric Oxide

Ignarro, L. J., Claudio Napoli, A., & Loscalzo, J. (2002) · Circulation Research · doi:10.1161/hh0102.102330 · Cited by 495

Inhibition of NF- B DNA Binding by Nitric Oxide

Matthews, J. R., Botting, C. H., Panico, M., Morris, H. R., & Hay, R. T. (1996) · Nucleic Acids Research · doi:10.1093/nar/24.12.2236 · Cited by 490

CHEMICAL PHYSIOLOGY OF BLOOD FLOW REGULATION BY RED BLOOD CELLS: The Role of Nitric Oxide and S-Nitrosohemoglobin

Singel, D. J., & Stamler, J. S. (2005) · Annual Review of Physiology · doi:10.1146/annurev.physiol.67.060603.090918 · Cited by 481

The role of nitrite and free nitrous acid (FNA) in wastewater treatment plants

Zhou, Y., Oehmen, A., Lim, M., Vadivelu, V. M., & Ng, W. J. (2011) · Water Research · doi:10.1016/j.watres.2011.06.025 · Cited by 476

Nitric oxide function in plant biology: a redox cue in deconvolution

Yu, M., Lamattina, L., Spoel, S. H., & Loake, G. J. (2014) · New Phytologist · doi:10.1111/nph.12739 · Cited by 478

Nitric oxide regulates cardiac Ca2+ current. Involvement of cGMP-inhibited and cGMP-stimulated phosphodiesterases through guanylyl cyclase activation.

Méry, P., Pavoine, C., Belhassen, L., Pecker, F., & Fischmeister, R. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)74313-0 · Cited by 467

Activation of Matrix Metalloproteinases by Peroxynitrite-induced Protein S-Glutathiolation via Disulfide S-Oxide Formation

Okamoto, T., Akaike, T., Sawa, T., Miyamoto, Y., van der Vliet, A., & Maeda, H. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m102417200 · Cited by 468

Role of NO Production in NMDA Receptor-Mediated Neurotransmitter Release in Cerebral Cortex

Montague, P. R., Gancayco, C. D., Winn, M. J., Marchase, R. B., & Friedlander, M. J. (1994) · Science · doi:10.1126/science.7508638 · Cited by 466

Aging Progressively Impairs Endothelium-Dependent Vasodilation in Forearm Resistance Vessels of Humans

Gerhard, M. D., Roddy, M.-A., Creager, S. J., & Creager, M. A. (1996) · Hypertension · doi:10.1161/01.hyp.27.4.849 · Cited by 468

The paradox of nitric oxide in cirrhosis and portal hypertension: Too much, not enough

Wiest, R., & Groszmann, R. J. (2002) · Hepatology · doi:10.1053/jhep.2002.31432 · Cited by 466

Berries: emerging impact on cardiovascular health

Basu, A., Rhone, M., & Lyons, T. J. (2010) · Nutrition Reviews · doi:10.1111/j.1753-4887.2010.00273.x · Cited by 462

Acute and Chronic Effects of Cigarette Smoking on Exhaled Nitric Oxide

Kharitonov, S. A., Robbins, R. A., Yates, D. H., Keatings, V. M., & Barnes, P. J. (1995) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.152.2.7543345 · Cited by 461

Nitric oxide and cell death

Murphy, M. P. (1999) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/s0005-2728(99)00029-8 · Cited by 460

Formation of Nitrating and Chlorinating Species by Reaction of Nitrite with Hypochlorous Acid

Eiserich, J. P., Cross, C. E., Jones, A. D., Halliwell, B., & van der Vliet, A. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.32.19199 · Cited by 447

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Shepherd, M., Giordano, D., Verde, C., & Poole, R. K. (2022) · Antioxidants · doi:10.3390/antiox11071222 · Cited by 20

Chemical biology of nitric oxide: Regulation and protective and toxic mechanisms

Wink, D. A., Hanbauer, I., Grisham, M. B., Laval, F., Nims, R. W., Laval, J., Cook, J. C., Pacelli, R., Liebmann, J., Krishna, M. C., et al. (1996) · Current topics in cellular regulation · doi:10.1016/s0070-2137(96)80006-9 · Cited by 288

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Aicardo, A., Martinez, D. M., Campolo, N., Bartesaghi, S., & Radí, R. (2016) · Springer eBooks · doi:10.1007/978-3-319-45865-6_5 · Cited by 21

Biochemical targets of nitric oxide-induced toxicity.

Grudziński, I. P. (2003) · PubMed · Cited by 3

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Fukuto, J. M., Cho, J. Y., & Switzer, C. H. (2000) · Elsevier eBooks · doi:10.1016/b978-012370420-7/50003-4 · Cited by 79