The DOI matches its Crossref record; 88 of the 88 references it cites were found in a registry or an index.
Biochemistry of Nitric Oxide and Its Redox-Activated Forms
Abstract
Nitric oxide (NO.), a potentially toxic molecule, has been implicated in a wide range of biological functions. Details of its biochemistry, however, remain poorly understood. The broader chemistry of nitrogen monoxide (NO) involves a redox array of species with distinctive properties and reactivities: NO+ (nitrosonium), NO., and NO- (nitroxyl anion). The integration of this chemistry with current perspectives of NO biology illuminates many aspects of NO biochemistry, including the enzymatic mechanism of synthesis, the mode of transport and targeting in biological systems, the means by which its toxicity is mitigated, and the function-regulating interaction with target proteins.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“While increased iNOS expression leads to the proinflammatory effects of NO, generation of NO by endothelial nitric oxide synthase (eNOS) plays a crucial role in maintaining cardiovascular homeostasis by favorably modulating blood pressure and reducing endothelial dysfunction.”
From Berries: emerging impact on cardiovascular health (2010) · cites this paper as [66]
In the citing paper
“Nitric oxide (NO), when formed through activation of inducible nitric oxide synthase (iNOS), has proinflammatory effects, leading to increased vascular permeability, induction of inflammatory cytokines, and the formation of peroxynitrite, a strong oxidizing agent.”
From Berries: emerging impact on cardiovascular health (2010) · cites this paper as [66]
Citations
Cites
Nitric oxide: physiology, pathophysiology, and pharmacology.
Moncada, S., Palmer, R. M., & Higgs, E. A. (1991) · Pharmacological Reviews · doi:10.1016/s0031-6997(25)06663-3 · Cited by 15,525
Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor
Palmer, R. M. J., Ferrige, A. G., & Moncada, S. (1987) · Nature · doi:10.1038/327524a0 · Cited by 10,704
Beckman, J. S., Beckman, T. W., Chen, J., Marshall, P. A., & Freeman, B. A. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.4.1620 · Cited by 7,029
Endothelium-derived relaxing factor produced and released from artery and vein is nitric oxide.
Ignarro, L. J., Buga, G. M., Wood, K. S., Byrns, R. E., & Chaudhuri, G. (1987) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.84.24.9265 · Cited by 5,074
Nitric oxide as a secretory product of mammalian cells
Nathan, C. (1992) · The FASEB Journal · doi:10.1096/fasebj.6.12.1381691 · Cited by 4,350
Peroxynitrite oxidation of sulfhydryls.
Radí, R., Beckman, J. S., Bush, K., & Freeman, B. Α. (1991) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(20)64313-7 · Cited by 2,492
Cloned and expressed nitric oxide synthase structurally resembles cytochrome P-450 reductase
Bredt, D. S., Hwang, P. M., Glatt, C. E., Lowenstein, C. J., Reed, R. R., & Snyder, S. H. (1991) · Nature · doi:10.1038/351714a0 · Cited by 2,354
Macrophage cytotoxicity: role for L-arginine deiminase and imino nitrogen oxidation to nitrite
Hibbs, J. B., Taintor, R. R., & Vavrin, Z. (1987) · Science · doi:10.1126/science.2432665 · Cited by 1,527
Stamler, J. S., Simon, D. I., Osborne, J. A., Mullins, M. E., Jaraki, O., Michel, T. M., Singel, D. J., & Loscalzo, J. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.1.444 · Cited by 1,471
Self-citationDNA Deaminating Ability and Genotoxicity of Nitric Oxide and its Progenitors
Wink, D. A., Kasprzak, K. S., Maragos, C. M., Elespuru, R. K., Misra, M., Dunams, T. M., Cebula, T. A., Koch, W. H., Andrews, A. W., Allen, J. S., et al. (1991) · Science · doi:10.1126/science.1948068 · Cited by 1,243
Research works printed but not linked: 13
- BOTTOMLEY, F, JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS: 919 (1973).
- Bunton, C. A., Recent Aspects of the Inorganic Chemistry of Nitrogen: 113 (1957).
- CHALLIS, B. C., IARC SCIENTIFIC PUBLICATIONS 31: 127 (1980).
- EBERSON, L, ACTA CHEMICA SCANDINAVICA SERIES B-ORGANIC CHEMISTRY AND BIOCHEMISTRY 38: 861 (1984).
- Fukuto, J. M., Journal of Pharmacology and Experimental Therapeutics 263: 546 (1992).
- HENRY, Y, EUROPEAN BIOPHYSICS JOURNAL 20: 1 (1991).
- MARLETTA, M.A., BIOFACTORS 2: 219 (1990).
- MORRIS, S.L., IDENTIFICATION AND CHARACTERIZATION OF SOME BACTERIAL-MEMBRANE SULFHYDRYL-GROUPS WHICH ARE TARGETS OF BACTERIOSTATIC AND ANTIBIOTIC ACTION, JOURNAL OF BIOLOGICAL CHEMISTRY 259: 3590 (1984).
- OH, S. M. N., JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 2: 685 (1991).
- SEN, N. P., IARC SCIENTIFIC PUBLICATIONS 9: 103 (1975).
- Stamler, J. S., 2nd International Meeting of the Biology of Nitric Oxide: 20 (1992).
- VANIN, A.F., BIOKHIMIYA 32: 277 (1967).
- Williams, D. C., Nitrosation: 1 (1988).
Cited by
Sorted by citations
Items 101–200 of 1,003
Nitric Oxide Regulates Exocytosis by S-Nitrosylation of N-ethylmaleimide-Sensitive Factor
Matsushita, K., Morrell, C. N., Cambien, B., Yang, S.-X., Yamakuchi, M., Bao, C., Hara, M. R., Quick, R. A., Cao, W., O'Rourke, B. P., et al. (2003) · Cell · doi:10.1016/s0092-8674(03)00803-1 · Cited by 446
Nitric oxide and its role in apoptosis
Brüne, B., von Knethen, A., & Sandau, K. B. (1998) · European Journal of Pharmacology · doi:10.1016/s0014-2999(98)00274-x · Cited by 444
Campbell, D. L., Stamler, J. S., & Strauss, H. C. (1996) · The Journal of general physiology · doi:10.1085/jgp.108.4.277 · Cited by 441
Self-citationWeinberg, J., Misukonis, M., Shami, P., Mason, S. N., Sauls, D., Dittman, W. A., Wood, E., Smith, G., McDonald, B., & Bachus, K. (1995) · Blood · doi:10.1182/blood.v86.3.1184.1184 · Cited by 435
Nitric oxide and lung disease.
Barnes, P. J., & Belvisi, M. G. (1993) · Thorax · doi:10.1136/thx.48.10.1034 · Cited by 433
Oxidative damage to DNA: Formation, measurement, and biological significance
Cadet, J., Berger, M., Douki, T., & Ravanat, J. (1997) · Springer eBooks · doi:10.1007/3-540-61992-5_5 · Cited by 449
Ryan, S. D., Dolatabadi, N., Chan, S. F., Zhang, X., Akhtar, M. W., Parker, J., Soldner, F., Sunico, C. R., Nagar, S., Talantova, M. V., et al. (2013) · Cell · doi:10.1016/j.cell.2013.11.009 · Cited by 445
Transition-Metal-Free: A Highly Efficient Catalytic Aerobic Alcohol Oxidation Process
Liu, R., Liang, X., Dong, C., & Hu, X. (2004) · Journal of the American Chemical Society · doi:10.1021/ja031765k · Cited by 427
Autoxidation kinetics of aqueous nitric oxide
Ford, P. C., Wink, D. A., & Stanbury, D. M. (1993) · FEBS Letters · doi:10.1016/0014-5793(93)81748-o · Cited by 419
Endogenous Nitric Oxide Protects Bacteria Against a Wide Spectrum of Antibiotics
Gusarov, I., Shatalin, K., Starodubtseva, M., & Nudler, E. (2009) · Science · doi:10.1126/science.1175439 · Cited by 417
Interferon-γ: Biology and Role in Pathogenesis
Billiau, A. (1996) · Advances in immunology · doi:10.1016/s0065-2776(08)60428-9 · Cited by 417
Nitric Oxide Impairs Normoxic Degradation of HIF-1α by Inhibition of Prolyl Hydroxylases
Metzen, E., Zhou, J., Jelkmann, W., Fandrey, J., & Brüne, B. (2003) · Molecular Biology of the Cell · doi:10.1091/mbc.e02-12-0791 · Cited by 414
Nitric oxide as a bioactive signalling molecule in plant stress responses
Arasimowicz‐Jelonek, M., & Floryszak‐Wieczorek, J. (2007) · Plant Science · doi:10.1016/j.plantsci.2007.02.005 · Cited by 414
The oxyhemoglobin reaction of nitric oxide
Gow, A. J., Luchsinger, B. P., Pawloski, J. R., Singel, D. J., & Stamler, J. S. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.16.9027 · Cited by 418
Self-citationReduction of nitrite to nitric oxide catalyzed by xanthine oxidoreductase
Godber, B. L. J., Doel, J. J., Sapkota, G. P., Blake, D. R., Stevens, C. R., Eisenthal, R., & Harrison, R. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.11.7757 · Cited by 411
Nagano, T., & Yoshimura, T. (2002) · Chemical Reviews · doi:10.1021/cr010152s · Cited by 414
Hara, H., Huang, P. L., Panahian, N., Fishman, M. C., & Moskowitz, M. A. (1996) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1097/00004647-199607000-00010 · Cited by 410
Koskenkorva-Frank, T. S., Weiss, G., Koppenol, W. H., & Burckhardt, S. (2013) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2013.09.001 · Cited by 406
Bryan, N. S., Rassaf, T., Maloney, R. E., Rodriguez, C. M., Saijo, F., Rodriguez, J. R., & Feelisch, M. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0306706101 · Cited by 400
p53 expression in nitric oxide‐induced apoptosis
Meßmer, U. K., Ankarcrona, M., Nicotera, P., & Brüne, B. (1994) · FEBS Letters · doi:10.1016/0014-5793(94)01161-3 · Cited by 400
van der Zee, R., Murohara, T., Luo, Z., Zollmann, F. S., Passeri, J. J., Lekutat, C., & Isner, J. M. (1997) · Circulation · doi:10.1161/01.cir.95.4.1030 · Cited by 399
Nitric Oxide Is a Physiological Substrate for Mammalian Peroxidases
Abu‐Soud, H. M., & Hazen, S. L. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.48.37524 · Cited by 399
Inhaled Nitric Oxide Therapy in Adults
Griffiths, M., & Evans, T. W. (2005) · New England Journal of Medicine · doi:10.1056/nejmra051884 · Cited by 397
Translational regulation via iron‐responsive elements by the nitric oxide/NO‐synthase pathway.
Weiss, G., Goossen, B., Doppler, W., Fuchs, D., Pantopoulos, K., Werner‐Felmayer, G., Wachter, H., & Hentze, M. W. (1993) · The EMBO Journal · doi:10.1002/j.1460-2075.1993.tb06039.x · Cited by 389
Besson‐Bard, A., Gravot, A., Richaud, P., Auroy, P., Duc, C., Gaymard, F., Soubigou‐Taconnat, L., Renou, J., Pugin, A., & Wendehenne, D. (2009) · PLANT PHYSIOLOGY · doi:10.1104/pp.108.133348 · Cited by 383
Potential genotoxicity of chronically elevated nitric oxide: A review
Liu, R. H., & Hotchkiss, J. H. (1995) · Mutation Research/Reviews in Genetic Toxicology · doi:10.1016/0165-1110(95)90004-7 · Cited by 381
Asai, S., Ohta, K., & Yoshioka, H. (2008) · The Plant Cell · doi:10.1105/tpc.107.055855 · Cited by 390
Gobert, A. P., McGee, D. J., Akhtar, M., Mendz, G. L., Newton, J. C., Cheng, Y., Mobley, H. L. T., & Wilson, K. T. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.241443798 · Cited by 386
Cysteine regulation of protein function – as exemplified by NMDA-receptor modulation
Lipton, S. A., Choi, Y.-B., Takahashi, H., Zhang, D., Li, W., Godzik, A., & Bankston, L. A. (2002) · Trends in Neurosciences · doi:10.1016/s0166-2236(02)02245-2 · Cited by 375
Rovira, C., Kunc, K., Hutter, J., Ballone, P., & Parrinello, M. (1997) · The Journal of Physical Chemistry A · doi:10.1021/jp9722115 · Cited by 374
EPR characterization of molecular targets for NO in mammalian cells and organelles
Henry, Y. A., Lepoivre, M., Drapier, J., Ducrocq, C., Boucher, J., & Guissani, A. (1993) · The FASEB Journal · doi:10.1096/fasebj.7.12.8397130 · Cited by 367
Paulus, W. J., Vantrimpont, P. J. M. J., & Shah, A. M. (1994) · Circulation · doi:10.1161/01.cir.89.5.2070 · Cited by 367
ABA crosstalk with ethylene and nitric oxide in seed dormancy and germination
Arc, E., Séchet, J., Corbineau, F., Rajjou, L., & Marion‐Poll, A. (2013) · Frontiers in Plant Science · doi:10.3389/fpls.2013.00063 · Cited by 384
In vivo imaging of an elicitor‐induced nitric oxide burst in tobacco
Foissner, I., Wendehenne, D., Langebartels, C., & Durner, J. (2000) · The Plant Journal · doi:10.1046/j.1365-313x.2000.00835.x · Cited by 366
Oxidative and nitrosative stress in acute renal ischemia
Noiri, E., Nakao, A., Uchida, K., Tsukahara, H., Ohno, M., Fujita, T., Brodsky, S. V., & Goligorsky, M. S. (2001) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.2001.281.5.f948 · Cited by 366
Nitric oxide-stimulated guanine nucleotide exchange on p21ras
Lander, H. M., Ogiste, J. S., Pearce, S. F. A., Levi, R., & Novogrodsky, A. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.13.7017 · Cited by 364
Nitric oxide and virus infection
Akaike, T., & Maeda, H. (2000) · Immunology · doi:10.1046/j.1365-2567.2000.00142.x · Cited by 362
Nitrosative Stress: Activation of the Transcription Factor OxyR
Hausladen, A., Privalle, C. T., Keng, T., DeAngelo, J., & Stamler, J. S. (1996) · Cell · doi:10.1016/s0092-8674(00)80147-6 · Cited by 359
Self-citationRole of nitric oxide in parasitic infections
James, S. L. (1995) · Microbiological Reviews · doi:10.1128/mr.59.4.533-547.1995 · Cited by 357
Tsikas, D. (2005) · Free Radical Research · doi:10.1080/10715760500053651 · Cited by 357
NO/redox disequilibrium in the failing heart and cardiovascular system
Hare, J. M., & Stamler, J. S. (2005) · Journal of Clinical Investigation · doi:10.1172/jci200524459 · Cited by 361
Self-citationFunctions and dysfunctions of nitric oxide in brain
Picón-Pagès, P., Garcia-Buendia, J., & Muñoz, F. J. (2018) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2018.11.007 · Cited by 369
Ting, H. H., Timimi, F. K., Haley, E. A., Roddy, M.-A., Ganz, P., & Creager, M. A. (1997) · Circulation · doi:10.1161/01.cir.95.12.2617 · Cited by 355
Schmidt, H. H. H. W., Hofmann, H., Schindler, U., Shutenko, Z. S., Cunningham, D. D., & Feelisch, M. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.25.14492 · Cited by 353
NO Inhibitions: Antimicrobial Properties of Nitric Oxide
Groote, M. A. D., & Fang, F. C. (1995) · Clinical Infectious Diseases · doi:10.1093/clinids/21.supplement_2.s162 · Cited by 353
S-Nitrosylation of Peroxiredoxin II E Promotes Peroxynitrite-Mediated Tyrosine Nitration
Romero‐Puertas, M. C., Laxa, M., Mattè, A., Zaninotto, F., Finkemeier, I., Jones, A. M. E., Perazzolli, M., Vandelle, E., Dietz, K., & Delledonne, M. (2007) · The Plant Cell · doi:10.1105/tpc.107.055061 · Cited by 359
Handbook of Fermented Meat and Poultry
(2007) · Wiley eBooks · doi:10.1002/9780470376430 · Cited by 347
Kaesemeyer, W. H., Caldwell, R. B., Huang, J., & Caldwell, R. W. (1999) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(98)00514-2 · Cited by 343
Murphy, M. P. (2011) · Antioxidants and Redox Signaling · doi:10.1089/ars.2011.4289 · Cited by 351
Antioxidants, inflammation and cardiovascular disease
Mangge, H. (2014) · World Journal of Cardiology · doi:10.4330/wjc.v6.i6.462 · Cited by 347
The basic chemistry of nitrogen monoxide and peroxynitrite
Koppenol, W. H. (1998) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(98)00093-8 · Cited by 340
Filipovic, M. R., Miljkovic, J. L., Nauser, T., Royzen, M., Klos, K., Shubina, T., Koppenol, W. H., Lippard, S. J., & Ivanović-Burmazović, I. (2012) · Journal of the American Chemical Society · doi:10.1021/ja3009693 · Cited by 336
Nitric oxide signaling: Classical, less classical, and nonclassical mechanisms
Martínez-Ruiz, A., Cadenas, S., & Lamas, S. (2011) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2011.04.010 · Cited by 340
Melatonin and mitochondrial function
León, J., Acuña-Castroviejo, D., Sainz, R. M., Mayo, J. C., Tan, D., & Reiter, R. J. (2004) · Life Sciences · doi:10.1016/j.lfs.2004.03.003 · Cited by 331
The Role of Biomechanics and Inflammation in Cartilage Injury and Repair
Guilak, F., Fermor, B., Keefe, F. J., Kraus, V. B., Olson, S. A., Pisetsky, D. S., Setton, L. A., & Weinberg, J. B. (2004) · Clinical Orthopaedics and Related Research · doi:10.1097/01.blo.0000131233.83640.91 · Cited by 322
Differential Activation of Mitogen-activated Protein Kinases by Nitric Oxide-related Species
Lander, H. M., Jacovina, A. T., Davis, R. J., & Tauras, J. M. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.33.19705 · Cited by 322
Nitric Oxide: A Review of Its Role in Retinal Function and Disease
Goldstein, I. M., Ostwald, P., & Roth, S. (1996) · Vision Research · doi:10.1016/0042-6989(96)00017-x · Cited by 313
Causes and consequences of cysteine S-glutathionylation
Grek, C. L., Zhang, J., Manevich, Y., Townsend, D. M., & Tew, K. D. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.r113.461368 · Cited by 312
Inactivation of Glutathione Peroxidase by Nitric Oxide
Asahi, M., Fujii, J., Suzuki, K., Seo, H. G., Kuzuya, T., Hori, M., Tada, M., Fujii, S., & Taniguchi, N. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.36.21035 · Cited by 309
Mohr, S., Hallak, H., de Boitte, A., Lapetina, E. G., & Brüne, B. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.14.9427 · Cited by 309
Clancy, R. M., Levartovsky, D., Leszczynska-Piziak, J., Yegudin, J., & Abramson, S. B. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.9.3680 · Cited by 308
Antioxidant responses to oxidant-mediated lung diseases
COMHAIR, S. A. A., & ERZURUM, S. C. (2002) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00491.2001 · Cited by 307
Nitric oxide synthesis in the lung. Regulation by oxygen through a kinetic mechanism.
Dweik, R. A., Laskowski, D. M., Abu‐Soud, H. M., Kaneko, F., Hutte, R. S., Stuehr, D. J., & ERZURUM, S. C. (1998) · Journal of Clinical Investigation · doi:10.1172/jci1378 · Cited by 307
Thigmomorphogenesis: a complex plant response to mechano-stimulation
Chehab, E. W., Eich, E., & Braam, J. (2008) · Journal of Experimental Botany · doi:10.1093/jxb/ern315 · Cited by 306
Potential Antiatherogenic Mechanisms of Ascorbate (Vitamin C) and α-Tocopherol (Vitamin E)
Carr, A. C., Zhu, B., & Frei, B. B. (2000) · Circulation Research · doi:10.1161/01.res.87.5.349 · Cited by 305
Oxidative stress, protein modification and Alzheimer disease
Tramutola, A., Lanzillotta, C., Perluigi, M., & Butterfield, D. A. (2017) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2016.06.005 · Cited by 303
Immunopathology of tuberculosis: roles of macrophages and monocytes
Fenton, M. J., & Vermeulen, M. W. (1996) · Infection and Immunity · doi:10.1128/iai.64.3.683-690.1996 · Cited by 303
Nitric Oxide in Vascular Biology
Walford, G., & Loscalzo, J. (2003) · Journal of Thrombosis and Haemostasis · doi:10.1046/j.1538-7836.2003.00345.x · Cited by 302
Self-citationvan der Vliet, A., Eiserich, J. P., Shigenaga, M. K., & Cross, C. E. (1999) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.160.1.9807044 · Cited by 300
The ‘fingerprint’ that X-rays can leave on structures
Ravelli, R. B. G., & McSweeney, S. M. (2000) · Structure · doi:10.1016/s0969-2126(00)00109-x · Cited by 297
Huang, X., von Rad, U., & Durner, J. (2002) · Planta · doi:10.1007/s00425-002-0828-z · Cited by 296
Nitrite and nitrosyl compounds in food preservation
Cammack, R., Joannou, C. L., Cui, X.-Y., Martinez, C. T., Maraj, S. R., & Hughes, M. (1999) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/s0005-2728(99)00033-x · Cited by 297
Stomberski, C. T., Hess, D. T., & Stamler, J. S. (2017) · Antioxidants and Redox Signaling · doi:10.1089/ars.2017.7403 · Cited by 297
Self-citationRole of oxidative stress and nitric oxide in atherothrombosis
Lubos, E. (2008) · Frontiers in bioscience · doi:10.2741/3084 · Cited by 296
Use of Salsalate to Target Inflammation in the Treatment of Insulin Resistance and Type 2 Diabetes
Goldfine, A. B., Silver, R., Aldhahi, W., Cai, D., Tatro, E., Lee, J., & Shoelson, S. E. (2008) · Clinical and Translational Science · doi:10.1111/j.1752-8062.2008.00026.x · Cited by 293
Denitrification: production and consumption of nitric oxide
Ye, R. W., Averill, B. A., & Tiedje, J. M. (1994) · Applied and Environmental Microbiology · doi:10.1128/aem.60.4.1053-1058.1994 · Cited by 288
Scharfstein, J., Keaney, J. F., Slivka, A., Welch, G. N., Vita, J. A., Stamler, J. S., & Loscalzo, J. (1994) · Journal of Clinical Investigation · doi:10.1172/jci117480 · Cited by 288
Self-citationStefanović-Račić, M., Stadler, J., & Evans, C. H. (1993) · Arthritis & Rheumatism · doi:10.1002/art.1780360803 · Cited by 286
The biological role of nitric oxide in bacteria
Zumft, W. G. (1993) · Archives of Microbiology · doi:10.1007/bf00292074 · Cited by 280
Regulation of Weibel–Palade Body Exocytosis
Lowenstein, C. J., Morrell, C. N., & Yamakuchi, M. (2005) · Trends in Cardiovascular Medicine · doi:10.1016/j.tcm.2005.09.005 · Cited by 281
Thach, W. T. (1996) · Behavioral and Brain Sciences · doi:10.1017/s0140525x00081504 · Cited by 276
Ponka, P. (1999) · Kidney International · doi:10.1046/j.1523-1755.1999.055suppl.69002.x · Cited by 278
Foresti, R., & Motterlini, R. (1999) · Free Radical Research · doi:10.1080/10715769900301031 · Cited by 271
Nitric oxide production during focal cerebral ischemia in rats.
Kader, A., Frazzini, V. I., Solomon, R. A., & Trifiletti, R. R. (1993) · Stroke · doi:10.1161/01.str.24.11.1709 · Cited by 270
Deng, W., Tang, S.-T., Tseng, H.-P., & Wu, K. K. (2006) · Blood · doi:10.1182/blood-2005-09-3691 · Cited by 267
Gaston, B. M. (1999) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/s0005-2728(99)00023-7 · Cited by 265
Retinopathy of prematurity: understanding ischemic retinal vasculopathies at an extreme of life
Sapieha, P. S., Joyal, J., Rivera, J. C., Kermorvant‐Duchemin, E., Sennlaub, F., Hardy, P., Lachapelle, P., & Chemtob, S. (2010) · Journal of Clinical Investigation · doi:10.1172/jci42142 · Cited by 264
Nitric oxide signalling in kidney regulation and cardiometabolic health
Carlström, M. (2021) · Nature Reviews Nephrology · doi:10.1038/s41581-021-00429-z · Cited by 268
Biological Chemistry of Thiols in the Vasculature and in Vascular-related Disease
Stamler, J. S., & Slivka, A. (2009) · Nutrition Reviews · doi:10.1111/j.1753-4887.1996.tb03770.x · Cited by 264
Self-citationNitrite and Nitrate Analyses: A Clinical Biochemistry Perspective
Ellis, G., Adatia, I., Yazdanpanah, M., & Makela, S. K. (1998) · Clinical Biochemistry · doi:10.1016/s0009-9120(98)00015-0 · Cited by 263
Role of nitric oxide in skeletal muscle: synthesis, distribution and functional importance
Reid, M. B. (1998) · Acta Physiologica Scandinavica · doi:10.1046/j.1365-201x.1998.0303f.x · Cited by 263
Glomerular actions of nitric oxide
Raij, L. R., & Baylis, C. (1995) · Kidney International · doi:10.1038/ki.1995.262 · Cited by 262
Nitric oxide and inflammatory mediators in the perpetuation of osteoarthritis
Abramson, S. B., Attur, M., Amin, A. R., & Clancy, R. (2001) · Current Rheumatology Reports · doi:10.1007/s11926-001-0069-3 · Cited by 261
Nitric oxide is induced by wounding and influences jasmonic acid signaling in Arabidopsis thaliana
Huang, X., Stettmaier, K., Michel, C., Hutzler, P., Mueller, M. J., & Durner, J. (2004) · Planta · doi:10.1007/s00425-003-1178-1 · Cited by 260
Nitric Oxide Improves Internal Iron Availability in Plants
Graziano, M., Beligni, M. V., & Lamattina, L. (2002) · PLANT PHYSIOLOGY · doi:10.1104/pp.009076 · Cited by 260
S-nitrosation of serum albumin by dinitrosyl-iron complex
Boese, M., Mordvintcev, P. I., Vanin, A. F., Busse, R., & Mülsch, A. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.49.29244 · Cited by 259
Pathologically activated therapeutics for neuroprotection
Lipton, S. A. (2007) · Nature reviews. Neuroscience · doi:10.1038/nrn2229 · Cited by 268
Frungillo, L., Skelly, M. J., Loake, G. J., Spoel, S. H., & Salgado, I. (2014) · Nature Communications · doi:10.1038/ncomms6401 · Cited by 257
Discovery of the nitric oxide signaling pathway and targets for drug development
Nathan, S. B. (2009) · Frontiers in bioscience · doi:10.2741/3228 · Cited by 260
Nitric Oxide: A Key Mediator of Biofilm Dispersal with Applications in Infectious Diseases
Barraud, N., Kelso, M. J., Rice, S., & Kjelleberg, S. J. (2014) · Current Pharmaceutical Design · doi:10.2174/1381612820666140905112822 · Cited by 263
Metadata
- Authors
- Stamler, J. S., Singel, D. J., & Loscalzo, J.
- Affiliations
- Brigham and Women's Hospital (US)
- Harvard University (US)
- Venue
- Science
- Published
- 1992-12-18
- Volume
- 258
- Issue
- 5090
- Pages
- 1898-1902
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2019814232
- Cited by
- 2,744
- References
- 88
- Citations by year
- 2026: 10 · 2025: 25 · 2024: 33 · 2023: 25 · 2022: 31 · 2021: 32 · 2020: 34 · 2019: 33 · 2018: 34 · 2017: 44 · 2016: 54 · 2015: 53 · 2014: 72 · 2013: 67 · 2012: 58
- FWCI
- 17.41
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5r01hl040411-02, 5r01hl043344-04)
- National Heart, Lung, and Blood Institute (HL43344, HL-40411)
- National Center for Research Resources (RRO4870)
- Topics
- Health Sciences › Medicine › Physiology (medical) › Nitric Oxide and Endothelin Effects
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Hemoglobin structure and function
- Keywords
- nitric oxide, nitrosonium, nitric oxide transport, nitric oxide toxicity
- MeSH terms
- Amino Acid Oxidoreductases, Animals, Arginine, Humans, Nitric Oxide, Oxidation-Reduction, Nitric Oxide Synthase
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review