Cited by 2,744Nitric Oxide and Endothelin EffectsRedox biology and oxidative stressHemoglobin structure and function

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Biochemistry of Nitric Oxide and Its Redox-Activated Forms

Stamler, Jonathan S., Singel, David J., Loscalzo, Joseph·1992·Science

DOI 10.1126/science.1281928

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Abstract

Nitric oxide (NO.), a potentially toxic molecule, has been implicated in a wide range of biological functions. Details of its biochemistry, however, remain poorly understood. The broader chemistry of nitrogen monoxide (NO) involves a redox array of species with distinctive properties and reactivities: NO+ (nitrosonium), NO., and NO- (nitroxyl anion). The integration of this chemistry with current perspectives of NO biology illuminates many aspects of NO biochemistry, including the enzymatic mechanism of synthesis, the mode of transport and targeting in biological systems, the means by which its toxicity is mitigated, and the function-regulating interaction with target proteins.

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Authors: Stamler, J. S., Singel, D. J., & Loscalzo, J.
Affiliations: Brigham and Women's Hospital (US)
Harvard University (US)
ORCID: Stamler, Jonathan S.
Loscalzo, Joseph
Venue: Science
Publisher: American Association for the Advancement of Science (AAAS)
Published: 1992-12-18
Volume: 258
Issue: 5090
Pages: 1898-1902
ISSN: 0036-8075 (ISSN-L)
1095-9203
DOI: 10.1126/science.1281928
OpenAlex: W2019814232
Cited by: 2,744
References: 88
Citations by year: 2026: 10 · 2025: 25 · 2024: 33 · 2023: 25 · 2022: 31 · 2021: 32 · 2020: 34 · 2019: 33 · 2018: 34 · 2017: 44 · 2016: 54 · 2015: 53 · 2014: 72 · 2013: 67 · 2012: 58
FWCI: 17.41
Type: journal article
Language: en
Open access: closed
Locations: Science (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health (5r01hl040411-02, 5r01hl043344-04)
National Heart, Lung, and Blood Institute (HL43344, HL-40411)
National Center for Research Resources (RRO4870)
Topics: Health Sciences › Medicine › Physiology (medical) › Nitric Oxide and Endothelin Effects
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Hemoglobin structure and function
Keywords: nitric oxide, nitrosonium, nitric oxide transport, nitric oxide toxicity
MeSH terms: Amino Acid Oxidoreductases, Animals, Arginine, Humans, Nitric Oxide, Oxidation-Reduction, Nitric Oxide Synthase

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Biochemistry of Nitric Oxide and Its Redox-Activated Forms

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