Corticosteroid responses to limbic stimulation in man: Localization of stimulus sites
Abstract
Corticosteroids in human plasma and urine increase after amygdala stimulation, and plasma corticosteroids decrease after hippocampus stimulation. Five subjects underwent unilateral temporal lobectomy, and histopathologic localization of electrode sites was attempted. Localization was successful for six sites: three in basolateral amygdala and three in hippocampus.
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Electrical stimulation of the amygdala can produce fear, anxiety, dysphoria, sympathetic autonomic arousal, social withdrawal, and cortisol release.
“Electrical stimulation of the amygdala can produce fear, anxiety, dysphoria, sympathetic autonomic arousal, social withdrawal, and cortisol release (61, 62).”
From Localization of Dysfunction in Major Depressive Disorder: Prefrontal Cortex and Amygdala (2011) · cites this paper as [62]
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- Authors
- Rubin, R. T., Mandell, A. J., & Crandall, P. H.
- Affiliations
- Departments of Psychiatry and Neurosurgery, University of California Center for the Health Sciences, Los Angeles 90024
- University of California, Los Angeles (US)
- Venue
- Science
- Published
- 1966-08-12
- Volume
- 153
- Issue
- 3737
- Pages
- 767-768
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1976647119
- Cited by
- 148
- References
- 4
- Citations by year
- 2025: 2 · 2023: 1 · 2022: 5 · 2021: 3 · 2020: 2 · 2019: 2 · 2018: 1 · 2017: 3 · 2016: 9 · 2015: 5 · 2014: 7 · 2013: 1 · 2012: 10
- FWCI
- 2.69
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
- Keywords
- corticosteroids, limbic system, amygdala, hippocampus, temporal lobectomy, electrical stimulation, plasma corticosteroids, urinary corticosteroids, basolateral amygdala
- MeSH terms
- Amygdala, Blood, Electric Stimulation, Electrophysiology, Hippocampus, Humans, Urine, 17-Hydroxycorticosteroids, In Vitro Techniques
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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