Cited by 583T-cell and B-cell ImmunologyImmunodeficiency and Autoimmune Disordersinterferon and immune responses

The DOI matches its Crossref record; 21 of the 21 references it cites were found in a registry or an index.

Requirement for the Transcription Factor LSIRF/IRF4 for Mature B and T Lymphocyte Function

Mittrücker, Hans-Willi, Matsuyama, Toshifumi, Grossman, Alex, Kündig, Thomas M., Potter, Julia, Shahinian, Arda, Wakeham, Andrew, Patterson, Bruce, Ohashi, Pamela S., Mak, Tak W.·1997·Science

DOI 10.1126/science.275.5299.540

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Abstract

Lymphocyte-specific interferon regulatory factor (LSIRF) (now called IRF4) is a transcription factor expressed only in lymphocytes. Mice deficient in IRF4 showed normal distribution of B and T lymphocyes at 4 to 5 weeks of age but developed progressive generalized lymphadenopathy. IRF4-deficient mice exhibited a profound reduction in serum immunoglobulin concentrations and did not mount detectable antibody responses. T lymphocyte function was also impaired in vivo; these mice could not generate cytotoxic or antitumor responses. Thus, IRF4 is essential for the function and homeostasis of both mature B and mature T lymphocytes.

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Differential T Cell Costimulatory Requirements in CD28-Deficient Mice
Shahinian, A., Pfeffer, K., Lee, K. P., Kündig, T. M., Kishihara, K., Wakeham, A. C., Kawai, K., Ohashi, P. S., Thompson, C. B., & Mak, T. W. (1993) · Science · doi:10.1126/science.7688139 · Cited by 1,258
Self-citation
Interleukin-2 receptor α chain regulates the size and content of the peripheral lymphoid compartment
Willerford, D. M., Chen, J., Ferry, J. A., Davidson, L., Ma, A. I., & Alt, F. W. (1995) · Immunity · doi:10.1016/1074-7613(95)90180-9 · Cited by 1,079
Requirement for Transcription Factor IRF-1 in NO Synthase Induction in Macrophages
Kamijo, R., Harada, H., Matsuyama, T., Bosland, M. C., Gerecitano, J. F., Shapiro, D., Le, J., Koh, S. I., Kimura, T., Green, S. J., et al. (1994) · Science · doi:10.1126/science.7510419 · Cited by 843
Self-citation
Cellular commitment to oncogene-induced transformation or apoptosis is dependent on the transcription factor IRF-1
Tanaka, N., Ishihara, M., Kitagawa, M., Harada, H., Kimura, T., Matsuyama, T., Lamphier, M. S., Aizawa, S., Mak, T. W., & Taniguchi, T. (1994) · Cell · doi:10.1016/0092-8674(94)90132-5 · Cited by 491
Self-citation
Pip, a novel IRF family member, is a lymphoid-specific, PU.1-dependent transcriptional activator.
Eisenbeis, C. F., Singh, H., & Storb, U. (1995) · Genes & Development · doi:10.1101/gad.9.11.1377 · Cited by 447
An IRF-1-dependent pathway of DNA damage-induced apoptosis in mitogen-activated T lymphocytes
Tamura, T., Ishihara, M., Lamphier, M. S., Tanaka, N., Oishi, I., Aizawa, S., Matsuyama, T., Mak, T. W., Taki, S., & Taniguchi, T. (1995) · Nature · doi:10.1038/376596a0 · Cited by 431
Self-citation
Elements regulating somatic hypermutation of an immunoglobulin κ gene: Critical role for the intron enhancer/matrix attachment region
Betz, A. G., Milstein, C., González‐Fernández, Á., Pannell, R., Larson, T., & Neuberger, M. S. (1994) · Cell · doi:10.1016/0092-8674(94)90316-6 · Cited by 379
An IRF-1-dependent pathway of DNA damage-induced apoptosis in mitogen-activated T lymphocytes
石原, 正. (1997) · Cited by 366
Transitional B cells are the target of negative selection in the B cell compartment.
Carsetti, R., Köhler, G., & Lamers, M. C. (1995) · The Journal of Experimental Medicine · doi:10.1084/jem.181.6.2129 · Cited by 358
Interferon-Induced Antiviral Actions and Their Regulation
Sen, G. C., & Ransohoff, R. M. (1993) · Advances in virus research · doi:10.1016/s0065-3527(08)60083-4 · Cited by 334

Show all 21 references

Research works printed but not linked: 4

Lamphier M., Taniguchi T., Immunologist 2, 167 (1994);
Vaughan P. S., et al., ibid. 377, 362 (1995);
Schmits R., et al., ibid., p. 1415.
Healthy 5- to 7-week-old mice were used for all experiments. Mice were maintained according to the guidelines of the Canadian Council of Animal Care. H.-W.M. is a recipient of a grant from the Deutsche Forschungsgemeinschaft. The authors thank M. Bachmann G. Boehmelt G. Duncan D. Ferrick C. Furlonger D. Kägi F. Kiefer L. Marengere C. Paige J. Penninger M. Saunders R. Schmits D. Siderovski D. Speiser S. Yoshinaga and P. Waterhouse for providing reagents and for helpful comments.

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Authors: Mittrücker, H.-W., Matsuyama, T., Grossman, A., Kündig, T. M., Potter, J., Shahinian, A., Wakeham, A., Patterson, B., Ohashi, P. S., & Mak, T. W.
Affiliations: University of Toronto (CA)
Nagasaki University (JP)
B. Patterson, Department of Oncologic Pathology, Ontario Cancer Institute, 610 University Avenue, Toronto, Ontario, M5G 2C1, Canada.
ORCID: Mittrücker, Hans-Willi
Matsuyama, Toshifumi
Kündig, Thomas M.
Ohashi, Pamela S.
Mak, Tak W.
Venue: Science
Publisher: American Association for the Advancement of Science (AAAS)
Published: 1997-01-24
Volume: 275
Issue: 5299
Pages: 540-543
ISSN: 0036-8075 (ISSN-L)
1095-9203
DOI: 10.1126/science.275.5299.540
OpenAlex: W2022687427
Cited by: 583
References: 21
Citations by year: 2026: 7 · 2025: 15 · 2024: 12 · 2023: 20 · 2022: 23 · 2021: 23 · 2020: 17 · 2019: 15 · 2018: 16 · 2017: 20 · 2016: 15 · 2015: 18 · 2014: 25 · 2013: 32 · 2012: 20
FWCI: 8.58
Type: journal article
Language: en
Open access: closed
Locations: Science (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
Life Sciences › Immunology and Microbiology › Immunology › Immunodeficiency and Autoimmune Disorders
Life Sciences › Immunology and Microbiology › Immunology › interferon and immune responses
Keywords: IRF4, transcription factors, B cells, T cells, lymphocyte homeostasis, lymphadenopathy, antibody deficiency, antibody response, cytotoxic T lymphocytes, antitumor immunity
MeSH terms: Lymphadenopathy, Interferon Regulatory Factor-4, Animals, Antibody Formation, B-Lymphocytes, Cell Differentiation, Cells, Cultured, Homeostasis, Mice, Inbred BALB C, T-Lymphocytes, Cytotoxic, Transcription, Genetic, Mice, SCID, Mice, Knockout, Cell Proliferation, Interferon Regulatory Factors, Mice

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Requirement for the Transcription Factor LSIRF/IRF4 for Mature B and T Lymphocyte Function

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