Requirement for the Transcription Factor LSIRF/IRF4 for Mature B and T Lymphocyte Function

Differential T Cell Costimulatory Requirements in CD28-Deficient Mice

Shahinian, A., Pfeffer, K., Lee, K. P., Kündig, T. M., Kishihara, K., Wakeham, A. C., Kawai, K., Ohashi, P. S., Thompson, C. B., & Mak, T. W. (1993) · Science · doi:10.1126/science.7688139 · Cited by 1,258

Interleukin-2 receptor α chain regulates the size and content of the peripheral lymphoid compartment

Willerford, D. M., Chen, J., Ferry, J. A., Davidson, L., Ma, A. I., & Alt, F. W. (1995) · Immunity · doi:10.1016/1074-7613(95)90180-9 · Cited by 1,079

Requirement for Transcription Factor IRF-1 in NO Synthase Induction in Macrophages

Kamijo, R., Harada, H., Matsuyama, T., Bosland, M. C., Gerecitano, J. F., Shapiro, D., Le, J., Koh, S. I., Kimura, T., Green, S. J., et al. (1994) · Science · doi:10.1126/science.7510419 · Cited by 843

Cellular commitment to oncogene-induced transformation or apoptosis is dependent on the transcription factor IRF-1

Tanaka, N., Ishihara, M., Kitagawa, M., Harada, H., Kimura, T., Matsuyama, T., Lamphier, M. S., Aizawa, S., Mak, T. W., & Taniguchi, T. (1994) · Cell · doi:10.1016/0092-8674(94)90132-5 · Cited by 491

Pip, a novel IRF family member, is a lymphoid-specific, PU.1-dependent transcriptional activator.

Eisenbeis, C. F., Singh, H., & Storb, U. (1995) · Genes & Development · doi:10.1101/gad.9.11.1377 · Cited by 447

An IRF-1-dependent pathway of DNA damage-induced apoptosis in mitogen-activated T lymphocytes

Tamura, T., Ishihara, M., Lamphier, M. S., Tanaka, N., Oishi, I., Aizawa, S., Matsuyama, T., Mak, T. W., Taki, S., & Taniguchi, T. (1995) · Nature · doi:10.1038/376596a0 · Cited by 431

Elements regulating somatic hypermutation of an immunoglobulin κ gene: Critical role for the intron enhancer/matrix attachment region

Betz, A. G., Milstein, C., González‐Fernández, Á., Pannell, R., Larson, T., & Neuberger, M. S. (1994) · Cell · doi:10.1016/0092-8674(94)90316-6 · Cited by 379

An IRF-1-dependent pathway of DNA damage-induced apoptosis in mitogen-activated T lymphocytes

石原, 正. (1997) · Cited by 366

Transitional B cells are the target of negative selection in the B cell compartment.

Carsetti, R., Köhler, G., & Lamers, M. C. (1995) · The Journal of Experimental Medicine · doi:10.1084/jem.181.6.2129 · Cited by 358

Interferon-Induced Antiviral Actions and Their Regulation

Sen, G. C., & Ransohoff, R. M. (1993) · Advances in virus research · doi:10.1016/s0065-3527(08)60083-4 · Cited by 334

Identification and validation of hub genes in drug induced acute kidney injury basing on integrated transcriptomic analysis

Deng, Y., Liu, K., Qiu, Q.-X., Tang, Z.-Y., Que, R.-M., Li, D.-K., Gu, X., Zhou, G., Wu, Y.-F., Zhou, L., et al. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1126348 · Cited by 17

Prognostic Impact of MUM1/IRF4 Expression in Burkitt Lymphoma (BL)

Satou, A., Asano, N., Kato, S. X., Elsayed, A. A., Nakamura, N., Miyoshi, H., Ohshima, K., & Nakamura, S. (2017) · The American Journal of Surgical Pathology · doi:10.1097/pas.0000000000000804 · Cited by 17

Irf4 Expression in Thymic Epithelium Is Critical for Thymic Regulatory T Cell Homeostasis

Haljasorg, U., Dooley, J., Laan, M., Kisand, K. E., Bichele, R., Liston, A., & Peterson, P. (2017) · The Journal of Immunology · doi:10.4049/jimmunol.1601698 · Cited by 17

Weak vaccinia virus-induced NK cell regulation of CD4 T cells is associated with reduced NK cell differentiation and cytolytic activity

Hatfield, S. D., Daniels, K. A., O’Donnell, C. L., Waggoner, S. N., & Welsh, R. M. (2018) · Virology · doi:10.1016/j.virol.2018.04.012 · Cited by 17

Making genome expression data meaningful: prediction and discovery of classes of cancer through a connectionist learning approach

Azuaje, F. J. (2002) · IEEE International Symposium on Bio-Informatics and Biomedical Engineering (BIBE) · doi:10.1109/bibe.2000.889609 · Cited by 17

1α,25-dihydroxyvitamin D3 inhibits anti-CD40 plus IL-4-mediated IgE production in vitro

Heine, G., Anton, K., Henz, B. M., & Worm, M. (2002) · European Journal of Immunology · doi:10.1002/1521-4141(200212)32:12 · Cited by 124

Vav Proteins Regulate the Plasma Cell Program and Secretory Ig Production

Stephenson, L. M., Miletic, A. V., Kloeppel, T., Kusin, S. G., & Swat, W. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.177.12.8620 · Cited by 17

Irf4 is a positional and functional candidate gene for the control of serum IgM levels in the mouse

Côrte‐Real, J., Rodo, J., Almeida, P., García, J. F., Coutinho, A., Demengeot, J., & Penha‐Gonçalves, C. (2008) · Genes and Immunity · doi:10.1038/gene.2008.73 · Cited by 16

Large Cell Lymphoma: Correlation of HIV Status and Prognosis with Differentiation Profiles Assessed by Immunophenotyping

Pather, S., Mohamed, Z., McLeod, H., & Pillay, K. (2013) · Pathology & Oncology Research · doi:10.1007/s12253-013-9632-2 · Cited by 16

Ubiquitin specific peptidase 4 stabilizes interferon regulatory factor protein and promotes its function to facilitate interleukin-4 expression in T helper type 2 cells

Guo, Z., Xu, P., Ge, S., Zhang, C., Zheng, X., Xu, J., Liu, Z., Li, B., & Ge, S. (2017) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2017.3087 · Cited by 16

Targeting Positive Regulatory Domain I-Binding Factor 1 and X Box-Binding Protein 1 Transcription Factors by Multiple Myeloma-Reactive CTL

Lotz, C., Mutallib, S. A., Oehlrich, N., Liewer, U., Ferreira, E. A., Moos, M., Hundemer, M., Schneider, S., Strand, S., Huber, C., et al. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.175.2.1301 · Cited by 16

Identification of novel Stat6 regulated proteins in IL‐4‐treated mouse lymphocytes

Tuomela, S., Rautajoki, K. J., Moulder, R., Nyman, T. A., & Lahesmaa, R. (2009) · PROTEOMICS · doi:10.1002/pmic.200800161 · Cited by 16

Modulation and function of caspase pathways in B lymphocytes

Graves, J. D., Craxton, A., & Clark, E. A. (2004) · Immunological Reviews · doi:10.1111/j.0105-2896.2004.0110.x · Cited by 16

Aloe-Emodin Ameliorates Diabetic Nephropathy by Targeting Interferon Regulatory Factor 4

Lü, L., & Li, Y. (2022) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2022/2421624 · Cited by 15

IRF4 drives clonal evolution and lineage choice in a zebrafish model of T-cell lymphoma

Amanda, S., Tan, T. K., Ong, J. Z. L., Theardy, M. S., Wong, R. W. J., Huang, X. Z., Ali, M. Z., Li, Y., Gong, Z., Inagaki, H., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-30053-9 · Cited by 17

An arrayed CRISPR screen of primary B cells reveals the essential elements of the antibody secretion pathway

Trezise, S., Kong, I. Y., Hawkins, E. D., Herold, M. J., Willis, S. N., & Nutt, S. L. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1089243 · Cited by 15

Transcription factors PU.1 and IRF4 regulate activation induced cytidine deaminase in chicken B cells

Luo, H., & Tian, M. (2010) · Molecular Immunology · doi:10.1016/j.molimm.2010.02.016 · Cited by 15

Downregulation of IRF4 induces lytic reactivation of KSHV in primary effusion lymphoma cells

Forero, A., McCormick, K. D., Jenkins, F. J., & Sarkar, S. N. (2014) · Virology · doi:10.1016/j.virol.2014.04.020 · Cited by 14

Macrophage-Specific MCPIP1/Regnase-1 Attenuates Kidney Ischemia-Reperfusion Injury by Shaping the Local Inflammatory Response and Tissue Regeneration

Ribeiro, A., Dobosz, E., Krill, M., Köhler, P., Wadowska, M., Steiger, S., Schmaderer, C., Kozieł, J., & Lech, M. (2022) · Cells · doi:10.3390/cells11030397 · Cited by 15

PRC2 mediated KLF2 down regulation: a therapeutic and diagnostic axis during tumor progression

Taghehchian, N., Maharati, A., Akhlaghipour, I., Zangouei, A. S., & Moghbeli, M. (2023) · Cancer Cell International · doi:10.1186/s12935-023-03086-3 · Cited by 15

IRF4 is required for migration of CD4+ T cells to the intestine but not for Th2 and Th17 cell maintenance

Schmidt, C., Harberts, A., Reimers, D., Bertram, T., Voß, L. C., Schmid, J., Lory, N. C., Spohn, M., Koch‐Nolte, F., Huber, S., et al. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1182502 · Cited by 14

Roles of IRF4 in various immune cells in systemic lupus erythematosus

Xiao, Z. X., Liang, R., Olsen, N. J., & Zheng, S. G. (2024) · International Immunopharmacology · doi:10.1016/j.intimp.2024.112077 · Cited by 14

Blimp1: Driving Terminal Differentiation to a T

Xin, A., Nutt, S. L., Belz, G. T., & Kallies, A. (2011) · Advances in experimental medicine and biology · doi:10.1007/978-1-4419-5632-3_8 · Cited by 14

Chromosomal and genetic abnormalities in myeloma.

Ho, P. (2002) · Clinical & Laboratory Haematology · doi:10.1046/j.1365-2257.2002.00456.x · Cited by 6

IRF4 Couples Anabolic Metabolism to Th1 Cell Fate Determination

Kratchmarov, R., Nish, S. A., Lin, W.-H. W., Adams, W. C. T., Chen, Y., Yen, B., Rothman, N. J., Klein, U., & Reiner, S. L. (2017) · ImmunoHorizons · doi:10.4049/immunohorizons.1700012 · Cited by 14

R-CHOP regimen can significantly decrease the risk of disease relapse and progression in patients with non-germinal center B-cell subtype diffuse large B-cell lymphoma

He, X., Li, B., Yang, S., Lü, N., Zhang, X., Zou, S., Li, Y., Song, Y.-W., Zheng, S., Dong, M., et al. (2012) · 癌症：英文版 · doi:10.5732/cjc.011.10420 · Cited by 14

Identification of a PU.1–IRF4 protein interaction surface predicted by chemical exchange line broadening

McKercher, S. R., Lombardo, C. R., Bobkov, A. A., Jia, X., & Assa‐Munt, N. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0136910100 · Cited by 14

Macrophage interferon regulatory factor 4 deletion ameliorates aristolochic acid nephropathy via reduced migration and increased apoptosis

Sasaki, K., Terker, A. S., Tang, J., Cao, S., Arroyo, J. P., Niu, A., Wang, S., Fan, X., Zhang, Y., Bennett, S. R., et al. (2022) · JCI Insight · doi:10.1172/jci.insight.150723 · Cited by 13

Transcriptomes of an Array of Chicken Ovary, Intestinal, and Immune Cells and Tissues

Overbey, E. G., Ng, T. T., Catini, P., Griggs, L., Stewart, P., Tkalčić, S., Hawkins, R. D., & Drechsler, Y. (2021) · Frontiers in Genetics · doi:10.3389/fgene.2021.664424 · Cited by 12

Getting to the root of the problem: the causes of relapse in multiple myeloma

Chung, K. C., & Tiedemann, R. E. (2014) · Expert Review of Anticancer Therapy · doi:10.1586/14737140.2014.868776 · Cited by 12

Swaying the advantage: multifaceted functions of inflammasomes in adaptive immunity

Zouali, M. (2024) · FEBS Journal · doi:10.1111/febs.17204 · Cited by 12

Multi-tissue transcriptomic aging atlas reveals predictive aging biomarkers in the killifish

Costa, E. K., Chen, J., Guldner, I. H., Mboning, L., Schmahl, N., Tsenter, A., Nagvekar, R., Wu, M.-R., Losada, P. M., Bouchard, L.-S., et al. (2026) · Nature Aging · doi:10.1038/s43587-026-01074-6 · Cited by 18

Interferon regulatory factor-4 activates IL-2 and IL-4 promoters in cooperation with c-Rel

Shindo, H., Yasui, K., Yamamoto, K., Honma, K., Yui, K., Kohno, T., Ma, Y., Chua, K. J., Kubo, Y., Aihara, H., et al. (2011) · Cytokine · doi:10.1016/j.cyto.2011.08.014 · Cited by 12

Risk of genome-wide association study-identified genetic variants for non-Hodgkin lymphoma in a Chinese population

Qiao, Y., Zhou, Y., Wu, C. H., Zhai, K., Han, X., Chen, J., Tian, X., Chang, J., Lu, Z., Zhang, B., et al. (2013) · Carcinogenesis · doi:10.1093/carcin/bgt082 · Cited by 12

Targeting plasma cells: are we any closer to a panacea for diseases of antibody‐secreting cells?

Low, M. S. Y., Infantino, S., Grigoriadis, G., & Tarlinton, D. M. (2016) · Immunological Reviews · doi:10.1111/imr.12388 · Cited by 13

IRF4 deficiency vulnerates B-cell progeny for leukemogenesis via somatically acquired Jak3 mutations conferring IL-7 hypersensitivity

Gupta, D. D., Paul, C., Samel, N., Bieringer, M., Staudenraus, D., Marini, F., Raifer, H., Menke, L., Hansal, L., Camara, B., et al. (2022) · Cell Death and Differentiation · doi:10.1038/s41418-022-01005-z · Cited by 12

Gene expression profiling in NOD mice reveals that B cells are highly educated by the pancreatic environment during autoimmune diabetes

Boldison, J., Hopkinson, J. R., Davies, J. E., Pearson, J. A., Leete, P., Richardson, S. J., Morgan, N. G., & Wong, F. S. (2022) · Diabetologia · doi:10.1007/s00125-022-05839-7 · Cited by 12

Haploinsufficiency of interferon regulatory factor 4 strongly protects against autoimmune diabetes in NOD mice

Akazawa, S., Kobayashi, M., Kuriya, G., Horie, I., Yu, L., Yamasaki, H., Okita, M., Nagayama, Y., Matsuyama, T., Akbari, M., et al. (2015) · Diabetologia · doi:10.1007/s00125-015-3724-3 · Cited by 12

Intratumor childhood vaccine-specific CD4+ T-cell recall coordinates antitumor CD8+ T cells and eosinophils

Brown, M. C., Beasley, G. M., McKay, Z. P., Yang, Y., Desjardins, A., Randazzo, D. M., Landi, D. B., Ashley, D. M., Bigner, D. D., Nair, S. K., et al. (2023) · Journal for ImmunoTherapy of Cancer · doi:10.1136/jitc-2022-006463 · Cited by 11

Germline copy number variation associated with Mendelian inheritance of CLL in two families

Brown, J. R., Hanna, M., Tesar, B. M., Pochet, N. L. M. M., Vartanov, A. R., Fernandes, S. M., Werner, L. L., Ash, M., Roden, C., MacConaill, L. E., et al. (2012) · Leukemia · doi:10.1038/leu.2012.33 · Cited by 11

Lineage- and Stage-Specific Oncogenicity of IRF4

Amanda, S., Tan, T. K., Iida, S., & Sanda, T. (2022) · Experimental Hematology · doi:10.1016/j.exphem.2022.07.300 · Cited by 11

The Xbp1-regulated transcription factor Mist1 restricts antibody secretion by restraining Blimp1 expression in plasma cells

Wöhner, M., Pinter, T., Bönelt, P., Hagelkrüys, A., Kostanova‐Poliakova, D., Stadlmann, J., Konieczny, S. F., Fischer, M., Jaritz, M., & Busslinger, M. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.859598 · Cited by 11

BRAD4 plays a critical role in germinal center response by regulating Bcl-6 and NF-κB activation

Gao, F., Yang, Y., Wang, Z., Gao, X., & Zheng, B. Q. (2015) · Cellular Immunology · doi:10.1016/j.cellimm.2015.01.010 · Cited by 11

OBF-1 is essential for the generation of antibody-secreting cells and the development of autoimmunity in MRL-lpr mice

Zuo, J., Ge, H., Zhu, G., Matthias, P., & Sun, J. L. (2007) · Journal of Autoimmunity · doi:10.1016/j.jaut.2007.05.001 · Cited by 11

IRF4 promotes Epstein–Barr virus activation in Burkitt’s lymphoma cells

Gao, Y., Wang, L., Lei, Z., Li, J., Forrest, J. C., & Liang, X. (2019) · Journal of General Virology · doi:10.1099/jgv.0.001249 · Cited by 11

Metabolic Regulation of T Cell Immunity

Vignali, P., Barbi, J. J., & Pan, F. (2017) · Advances in experimental medicine and biology · doi:10.1007/978-94-024-1170-6_2 · Cited by 10

MicroRNA-3662 expression correlates with antiviral drug resistance in adult T-cell leukemia/lymphoma cells

Yasui, K., Izumida, M., Nakagawa, T., Kubo, Y., Hayashi, H., Ito, T., Ikeda, H., & Matsuyama, T. (2018) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2018.04.159 · Cited by 10

Deletion of Irf4 in T Cells Suppressed Autoimmune Uveitis and Dysregulated Transcriptional Programs Linked to CD4+ T Cell Differentiation and Metabolism

Kang, M., Lee, H., Choi, J. K., Yu, C., & Egwuagu, C. E. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22052775 · Cited by 9

Differential requirements for IRF4 in the clonal expansion and homeostatic proliferation of naive and memory murine CD8+ T cells

Miyakoda, M., Honma, K., Kimura, D., Akbari, M., Kimura, K., Matsuyama, T., & Yui, K. (2018) · European Journal of Immunology · doi:10.1002/eji.201747120 · Cited by 10

IRF4 as an Oncogenic Biomarker for Hematological Malignancies

Ning, S. (2013) · Journal of Oncobiomarkers · doi:10.13188/2325-2340.1000003 · Cited by 10

Interleukin-5 (IL-5) Therapy Prevents Allograft Rejection by Promoting CD4+CD25+ Ts2 Regulatory Cells That Are Antigen-Specific and Express IL-5 Receptor

Hall, B. M., Hall, R. M., Tran, G. T., Robinson, C. M., Wilcox, P. L., Rakesh, P., Wang, C., Sharland, A. F., Verma, N. D., & Hodgkinson, S. J. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.714838 · Cited by 11

The Roles of IRF-8 in Regulating IL-9-Mediated Immunologic Mechanisms in the Development of DLBCL: A State-of-the-Art Literature Review

Cai, M., & Chen, N. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.817069 · Cited by 10

Alloactivation of Naïve CD4+CD8−CD25+T Regulatory Cells: Expression of CD8α Identifies Potent Suppressor Cells That Can Promote Transplant Tolerance Induction

Verma, N. D., Robinson, C. M., Carter, N. M., Wilcox, P. L., Tran, G. T., Wang, C., Sharland, A. F., Nomura, M., Plain, K. M., Bishop, G. A., et al. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.02397 · Cited by 10

End game for B cells

Calame, K. L. (2001) · Nature · doi:10.1038/35085679 · Cited by 10

ACCOMMODATION AND THE REVERSIBILITY OF BIOLOGICAL SYSTEMS1

Holzknecht, Z. E., & Platt, J. L. (2001) · Transplantation · doi:10.1097/00007890-200103150-00002 · Cited by 10

Repression of DNA Repair Mechanisms in IRF-4-Expressing and HTLV-I-Infected T Lymphocytes

Mamane, Y., Loignon, M., Palmer, J., Hernandez, E., Césaire, R., Alaoui‐Jamali, M. A., & Hiscott, J. B. (2005) · Journal of Interferon & Cytokine Research · doi:10.1089/jir.2005.25.43 · Cited by 10

Transcriptional repression of type I IFN genes

Lopez, S., & Navarro, S. (1998) · Biochimie · doi:10.1016/s0300-9084(99)80022-4 · Cited by 10

IRF4 expression by NK precursors predetermines exhaustion of NK cells during tumor metastasis

Zhang, X., Yin, Z., Wu, J., Xiao, X., Zou, D., Wang, G., Fu, J., Lan, P., Minze, L. J., Li, X. C., et al. (2025) · Nature Immunology · doi:10.1038/s41590-025-02176-w · Cited by 9

The immature B‐cell subpopulation with low RAG1 expression is increased in the autoimmune New Zealand Black mouse

Toda, T., Kitabatake, M., Igarashi, H., & Sakaguchi, N. (2009) · European Journal of Immunology · doi:10.1002/eji.200838644 · Cited by 9

RNAi Transfection Optimized in Primary Naïve B Cells for the Targeted Analysis of Human Plasma Cell Differentiation

Shih, T. L., De, S., & Barnes, B. J. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.01652 · Cited by 9

Th17 Cell-Mediated Colitis Is Positively Regulated by Interferon Regulatory Factor 4 in a T Cell-Extrinsic Manner

Buchele, V., Konein, P., Vogler, T., Kunert, T., Enderle, K., Khan, H., Büttner-Herold, M. J., Lehmann, C. H. K., Amon, L., Wirtz, S. J., et al. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2020.590893 · Cited by 9

Chronic Lymphocytic Leukaemia: A Review of the Immuno-architecture

Rosati, S., & Kluin, P. M. (2005) · Springer eBooks · doi:10.1007/3-540-29933-5_6 · Cited by 9

Arc/Arg3.1 defines dendritic cells and Langerhans cells with superior migratory ability independent of phenotype and ontogeny in mice

Tintelnot, J., Ufer, F., Engler, J. B., Winkler, H., Lücke, K., Mittrücker, H., & Friese, M. A. (2019) · European Journal of Immunology · doi:10.1002/eji.201847797 · Cited by 7

Influence of nutrients and metabolites on the differentiation of plasma cells and implications for autoimmunity

Föh, B., Buhre, J. S., Sina, C., & Ehlers, M. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.1004644 · Cited by 7

Studies of palatine rugae and interferon regulatory factor 6 variations in a group of families with sporadic hypodontia

Murdoch, A. M., Patir, A., Seymen, F., & Vieira, A. R. (2009) · Journal of Oral Science · doi:10.2334/josnusd.51.521 · Cited by 9

Common skin cancers and their association with other non-cutaneous primary malignancies: a review of the literature

Holic, L. (2024) · Medical Oncology · doi:10.1007/s12032-024-02385-7 · Cited by 7

IRF4 Deficiency Leads to Altered BCR Signalling Revealed by Enhanced PI3K Pathway, Decreased SHIP Expression and Defected Cytoskeletal Responses

Budzyńska, P. M., Niemelä, M., Sarapulov, A. V., Kyläniemi, M. K., Nera, K. ‐., Junttila, S., Laiho, A., Mattila, P. K., Alinikula, J., & Lassila, O. (2015) · Scandinavian Journal of Immunology · doi:10.1111/sji.12343 · Cited by 7

Role of IRF4-Mediated Inflammation: Implication in Neurodegenerative Diseases

Liu, F. (2017) · Neurology & Neurotherapy Open Access Journal · doi:10.23880/nnoaj-16000107 · Cited by 5

Characterization of orange-spotted grouper (Epinephelus coioides) interferon regulatory factor 4 regulated by heat shock factor 1 during heat stress in response to antiviral immunity

Lai, C. F., Wang, T., Yeh, M.-I., & Chen, T.-Y. (2020) · Fish & Shellfish Immunology · doi:10.1016/j.fsi.2020.08.033 · Cited by 7

Roles of interferon regulatory factor 4 in the AKI-CKD transition, glomerular diseases and kidney allograft rejection

Song, J., Ke, B., Tu, W., & Fang, X. (2023) · Renal Failure · doi:10.1080/0886022x.2023.2259228 · Cited by 7

Host T Cell Dedifferentiation Effects Drive HIV-1 Latency Stability

Dalecki, A. G., Greer, B. D., Duverger, A. E., Strange, E. L., Carlin, E., Wagner, F., Shi, B., Lowman, K. E., Perez, M. D., Tidwell, C., et al. (2022) · Journal of Virology · doi:10.1128/jvi.01974-21 · Cited by 7

Immunohistochemical expression of Mum-1, Oct-2 and Bcl-6 in systemic anaplastic large cell lymphomas

Sağlam, A., & Üner, A. (2011) · Tumori Journal · doi:10.1177/030089161109700516 · Cited by 7

Transcriptional Control of B Cell Activation

Corcoran, L. M. (2005) · Springer eBooks · doi:10.1007/3-540-26363-2_6 · Cited by 7

Comprehensive CRISPR-Cas9 screen identifies factors which are important for plasmablast development

Pinter, T., Fischer, M., Schäfer, M., Fellner, M., Jude, J., Zuber, J. A., Busslinger, M., & Wöhner, M. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.979606 · Cited by 6

B Cell–Intrinsic IRF4 Haploinsufficiency Impairs Affinity Maturation

Cook, S. L., Sievert, E. P., & Sciammas, R. (2021) · The Journal of Immunology · doi:10.4049/jimmunol.2100747 · Cited by 6

Transcriptional Reprogramming during T Helper Cell Differentiation

Aune, T. M. (2001) · Immunologic Research · doi:10.1385/ir:23:2-3:193 · Cited by 6

Erratum: correction: Signalling through CD30 protects against autoimmune diabetes mediated by CD8 T cells

Kurts, C., Carbone, F., Krummel, M. F., Koch, K. M., MILLER, J. F. A. P., & Heath, W. R. (2000) · Nature · doi:10.1038/35030185 · Cited by 6

Overview of Germinal Center Function and Structure in Normal and Genetically Engineered Mice

Tsiagbe, V. K., & Thorbecke, G. J. (1998) · Springer eBooks · doi:10.1007/978-3-662-13141-1_1 · Cited by 6

The transcriptional repressor BLIMP1 enforces TCF-1-dependent and -independent restriction of the memory fate of CD8+ T cells

Murphy, M. K., McCullen, M. V. D., Deffenbaugh, J. L., Chen, A. Y., Pai, J. A., Dániel, B., Yousif, A., Raju, S., Hsiung, S., Wang, Z., et al. (2025) · Immunity · doi:10.1016/j.immuni.2025.09.008 · Cited by 8

In vivo CRISPR/Cas9 screens identify new regulators of B cell activation and plasma cell differentiation

Calderón, L., Schäfer, M., Rončević, M., Rauschmeier, R., Jaritz, M., Schwickert, T. A., Sun, Q., Pauli, A., Zuber, J. A., & Busslinger, M. (2026) · The Journal of Experimental Medicine · doi:10.1084/jem.20250594 · Cited by 6

Inflammasome functional activities in B lymphocytes

Hsu, M. L., Jhuang, K. F., & Zouali, M. (2024) · Immunologic Research · doi:10.1007/s12026-024-09490-9 · Cited by 5

Whole transcriptome analysis for T cell receptor-affinity and IRF4-regulated clonal expansion of T cells

Shi, W., Man, K., Smyth, G. K., Nutt, S. L., & Kallies, A. (2014) · Genomics Data · doi:10.1016/j.gdata.2014.10.019 · Cited by 5

Programmed T cell differentiation: Implications for transplantation

Crepeau, R. L., & Ford, M. L. (2020) · Cellular Immunology · doi:10.1016/j.cellimm.2020.104099 · Cited by 5

Identification of a novel GC-rich binding protein that binds to an indispensable element for constitutive IRF-4 promoter activity in B cells

Nishiya, N., Yamamoto, K., Imaizumi, Y., Kohno, T., & Matsuyama, T. (2004) · Molecular Immunology · doi:10.1016/j.molimm.2004.05.001 · Cited by 5

Insights into the transcriptional regulation of CD22 in B cell chronic lymphocytic leukemia

Enkhbayar, B., Lu, S., Tsai, H.-Y., Liang, S., Wu, S., Lin, K., & Angata, T. (2025) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2025.108386 · Cited by 4

Chronically elevated cortisol levels increase cognate pathogen load but reduce red mark syndrome pathology in rainbow trout (Oncorhynchus mykiss)

Schmidt, J., Tafalla, C., Martin, D. L., & Lorenzen, N. (2025) · Fish & Shellfish Immunology · doi:10.1016/j.fsi.2025.110984 · Cited by 4

Novel maternal duplication of 6p22.3-p25.3 with subtelomeric 6p25.3 deletion: new clinical findings and genotype–phenotype correlations

Zhang, L., Tie, X., Che, F., Wang, G., Ge, Y., Li, B., & Yang, Y. (2023) · Molecular Cytogenetics · doi:10.1186/s13039-023-00640-6 · Cited by 5

Double-Hit Lymphoma Demonstrating t(6;14;18)(p25;q32;q21), Suggesting Two Independent Dual-Hit Translocations, MYC/BCL-2 and IRF4/BCL-2

Tabata, R., Yasumizu, R., Tabata, C., & Kojima, M. (2013) · Journal of the Japan Society of the Reticuloendothelial System · doi:10.3960/jslrt.53.141 · Cited by 4

Zkscan3 gene is a potential negative regulator of plasma cell differentiation

Li, Z., Wen, C., Li, J., Meng, H., Ji, C., Han, Z., An, G., & Yang, L. (2019) · European Journal of Inflammation · doi:10.1177/2058739219850008 · Cited by 4

IRF4−/−Vh11 mice: a novel mouse model of CLL

Zhong, Y., & Byrd, J. C. (2013) · Blood · doi:10.1182/blood-2013-08-521120 · Cited by 4

No evidence for a genetic association of IRF4 with systemic lupus erythematosus in a Chinese population

Liu, S.-S., Ye, D., Lou, J., Fan, Z., & Ye, D. (2013) · Zeitschrift für Rheumatologie · doi:10.1007/s00393-013-1279-6 · Cited by 4

Signaling Molecules Affecting Immune Response

Hertzog, P. J., Fenner, J. E., & Mansell, A. S. (2005) · Elsevier eBooks · doi:10.1016/b978-012455900-4/50267-1 · Cited by 4

In vivo Screen Identifies Zdhhc2 as a Critical Regulator of Germinal Center B Cell Differentiation

Zhao, R., Zhang, H., Zhang, Y., Li, D., Huang, C., & Li, F. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.01025 · Cited by 4

Interferon Regulatory Factor 4 dose-dependently controls peripheral Treg cell differentiation and homeostasis by modulating chromatin accessibility in mice

Voß, L. C., Schmidt, C., Harberts, A., Spohn, M., Bradtke, P., Borchers, A., Fertig, S., Schmid, J., Koch‐Nolte, F., Krebs, C. F., et al. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1604888 · Cited by 3

Monogenic disorders of the IRF transcription factors

Stojcic, M. P., Yousefi, P., Biggs, C. M., & Turvey, S. E. (2025) · The Journal of Experimental Medicine · doi:10.1084/jem.20250939 · Cited by 4

Blimp-1 integrates alarmin signals in ILC2s and drives proinflammatory functions required for type 2 immunity

Forster, P. M., Preußer, A., Yano, H., Deshpande, D., Zhang, W., Kowalczyk, A., Velleman, L., Dubik, M., Uddin, J., Emanuel, E., et al. (2026) · The Journal of Experimental Medicine · doi:10.1084/jem.20250781 · Cited by 3

Molecular characterization and functional analysis of interferon regulatory factor-4 in the Red Claw Crayfish (Cherax quadricarinatus)

Chen, D., Wang, Z., Cao, S., Lu, J., Liu, C., Yang, L., Du, X., Wang, H., & Li, Y. (2022) · Aquaculture Reports · doi:10.1016/j.aqrep.2022.101456 · Cited by 3

A pre-B acute lymphoblastic leukemia cell line model reveals the mechanism of thalidomide therapy-related B-cell leukemogenesis

Ramani, M. V., Singh, R. K., Shrivastva, S., Ribeyron, L., Gupta, S. K., & Roy, A. (2024) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2024.107578 · Cited by 3

Decoding transcriptional regulation via a human gene expression predictor

Wang, Y., Zhang, Y., Ning, Y., Li, B., Gong, J., Mei, Y., Bao, J., & Ma, S. (2023) · Journal of genetics and genomics/Journal of Genetics and Genomics · doi:10.1016/j.jgg.2023.01.006 · Cited by 3

Interferon regulatory factor 4 plays a pivotal role in the development of aGVHD-associated colitis

Frueh, J. T., Campe, J., Sunaga, D. Y., Verheyden, N. A., Ghimire, S., Meedt, E., Haslinger, D., Harenkamp, S., Staudenraus, D., Sauer, S., et al. (2023) · OncoImmunology · doi:10.1080/2162402x.2023.2296712 · Cited by 3

Pillars Article: Requirement for the Transcription Factor LSIRF/IRF4 for Mature B and T Lymphocyte Function. Science. 1997. 275: 540–543

Mittrücker, H., Matsuyama, T., Grossman, A., Kündig, T. M., Potter, J., Shahinian, A., Wakeham, A. C., Patterson, B. J., Ohashi, P. S., & Mak, T. W. (2017) · The Journal of Immunology · doi:10.1093/jimmunol/199.11.3717

IRF-4

Mak, T. W., Penninger, J. M., Roder, J., Rossant, J., & Saunders, M. E. (1998) · Elsevier eBooks · doi:10.1016/b978-012466044-1/50357-4

Critical Functions of IRF4 in B and T Lymphocytes

Hagman, J. R. (2017) · The Journal of Immunology · doi:10.4049/jimmunol.1701385 · Cited by 22

Review: The Role of IRF-4 in B and T Cell Activation and Differentiation

Pernis, A. B. (2002) · Journal of Interferon & Cytokine Research · doi:10.1089/107999002753452728 · Cited by 63

Aged IRF-4-deficient lupus-prone MRL/lpr mice show peripheral B-cell deficiency with elevated serum IFN-? levels and increased expression of IFN-?-receptor-1 on B cells

Machida, T., Natsumi, S., Honma, K., Matsuyama, T., Yui, K., & Sekine, H. (2013) · Frontiers in Immunology · doi:10.3389/conf.fimmu.2013.02.00861