Cited by 583T-cell and B-cell ImmunologyImmunodeficiency and Autoimmune Disordersinterferon and immune responses

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Requirement for the Transcription Factor LSIRF/IRF4 for Mature B and T Lymphocyte Function

Mittrücker, Hans-Willi, Matsuyama, Toshifumi, Grossman, Alex, Kündig, Thomas M., Potter, Julia, Shahinian, Arda, Wakeham, Andrew, Patterson, Bruce, Ohashi, Pamela S., Mak, Tak W.·1997·Science

DOI 10.1126/science.275.5299.540

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Abstract

Lymphocyte-specific interferon regulatory factor (LSIRF) (now called IRF4) is a transcription factor expressed only in lymphocytes. Mice deficient in IRF4 showed normal distribution of B and T lymphocyes at 4 to 5 weeks of age but developed progressive generalized lymphadenopathy. IRF4-deficient mice exhibited a profound reduction in serum immunoglobulin concentrations and did not mount detectable antibody responses. T lymphocyte function was also impaired in vivo; these mice could not generate cytotoxic or antitumor responses. Thus, IRF4 is essential for the function and homeostasis of both mature B and mature T lymphocytes.

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Self-citation
Interleukin-2 receptor α chain regulates the size and content of the peripheral lymphoid compartment
Willerford, D. M., Chen, J., Ferry, J. A., Davidson, L., Ma, A. I., & Alt, F. W. (1995) · Immunity · doi:10.1016/1074-7613(95)90180-9 · Cited by 1,079
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Kamijo, R., Harada, H., Matsuyama, T., Bosland, M. C., Gerecitano, J. F., Shapiro, D., Le, J., Koh, S. I., Kimura, T., Green, S. J., et al. (1994) · Science · doi:10.1126/science.7510419 · Cited by 843
Self-citation
Cellular commitment to oncogene-induced transformation or apoptosis is dependent on the transcription factor IRF-1
Tanaka, N., Ishihara, M., Kitagawa, M., Harada, H., Kimura, T., Matsuyama, T., Lamphier, M. S., Aizawa, S., Mak, T. W., & Taniguchi, T. (1994) · Cell · doi:10.1016/0092-8674(94)90132-5 · Cited by 491
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Pip, a novel IRF family member, is a lymphoid-specific, PU.1-dependent transcriptional activator.
Eisenbeis, C. F., Singh, H., & Storb, U. (1995) · Genes & Development · doi:10.1101/gad.9.11.1377 · Cited by 447
An IRF-1-dependent pathway of DNA damage-induced apoptosis in mitogen-activated T lymphocytes
Tamura, T., Ishihara, M., Lamphier, M. S., Tanaka, N., Oishi, I., Aizawa, S., Matsuyama, T., Mak, T. W., Taki, S., & Taniguchi, T. (1995) · Nature · doi:10.1038/376596a0 · Cited by 431
Self-citation
Elements regulating somatic hypermutation of an immunoglobulin κ gene: Critical role for the intron enhancer/matrix attachment region
Betz, A. G., Milstein, C., González‐Fernández, Á., Pannell, R., Larson, T., & Neuberger, M. S. (1994) · Cell · doi:10.1016/0092-8674(94)90316-6 · Cited by 379
An IRF-1-dependent pathway of DNA damage-induced apoptosis in mitogen-activated T lymphocytes
石原, 正. (1997) · Cited by 366
Transitional B cells are the target of negative selection in the B cell compartment.
Carsetti, R., Köhler, G., & Lamers, M. C. (1995) · The Journal of Experimental Medicine · doi:10.1084/jem.181.6.2129 · Cited by 358
Interferon-Induced Antiviral Actions and Their Regulation
Sen, G. C., & Ransohoff, R. M. (1993) · Advances in virus research · doi:10.1016/s0065-3527(08)60083-4 · Cited by 334

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Lamphier M., Taniguchi T., Immunologist 2, 167 (1994);
Vaughan P. S., et al., ibid. 377, 362 (1995);
Schmits R., et al., ibid., p. 1415.
Healthy 5- to 7-week-old mice were used for all experiments. Mice were maintained according to the guidelines of the Canadian Council of Animal Care. H.-W.M. is a recipient of a grant from the Deutsche Forschungsgemeinschaft. The authors thank M. Bachmann G. Boehmelt G. Duncan D. Ferrick C. Furlonger D. Kägi F. Kiefer L. Marengere C. Paige J. Penninger M. Saunders R. Schmits D. Siderovski D. Speiser S. Yoshinaga and P. Waterhouse for providing reagents and for helpful comments.

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Billingsley, J. M., Rajakumar, P. A., Connole, M., Salisch, N. C., Adnan, S., Kuzmichev, Y. V., Hong, H. S., Reeves, R. K., Kang, H., Li, W., et al. (2015) · PLoS Pathogens · doi:10.1371/journal.ppat.1004740 · Cited by 47
Mutation analysis of the Pip interaction domain reveals critical residues for protein–protein interactions
Ortiz, M. A., Light, J. P., Maki, R. A., & Assa‐Munt, N. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.6.2740 · Cited by 44
Feed-forward regulatory loop driven by IRF4 and NF-κB in adult T-cell leukemia/lymphoma
Wong, R. W. J., Tan, T. K., Amanda, S., Ngoc, P. C. T., Leong, W. Z., Tan, S. H., Asamitsu, K., Hibi, Y., Ueda, R., Okamoto, T., et al. (2020) · Blood · doi:10.1182/blood.2019002639 · Cited by 46
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Ren, R. (2002) · Oncogene · doi:10.1038/sj.onc.1206090 · Cited by 43
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T cell exhaustion in human cancers
Kang, K., Lin, X., Chen, P., Liu, H., Liu, F., Xiong, W., Li, G., Yi, M., Li, X., Wang, H., et al. (2024) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2024.189162 · Cited by 49
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Multiplexed histology analyses for the phenotypic and spatial characterization of human innate lymphoid cells
Reguant, A. P., Köhler, R., Mothes, R., Bauherr, S., Hernández, D. C., Uecker, R., Holzwarth, K., Kotsch, K., Seidl, M., Philipsen, L., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-21994-8 · Cited by 42
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Lee, J., Zhang, J., Chung, Y., Kim, J. H., Kook, C. M., González-Navajas, J. M., Herdman, D. S., Nürnberg, B., Insel, P. A., Corr, M., et al. (2020) · eLife · doi:10.7554/elife.49416 · Cited by 41
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Sharma, S., Mamane, Y., Grandvaux, N., Bartlett, J., Petropoulos, L., Lin, R., & Hiscott, J. B. (2000) · AIDS Research and Human Retroviruses · doi:10.1089/08892220050193047 · Cited by 41
PRDM1 is involved in chemoresistance of T-cell lymphoma and down-regulated by the proteasome inhibitor
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Interferon Regulatory Factor 4 (IRF-4) Targets IRF-5 to Regulate Epstein-Barr Virus Transformation
Xu, D., Meyer, F., Ehlers, E., Blasnitz, L., & Zhang, L. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.210542 · Cited by 39
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Ortmann, C. A. (2005) · Nucleic Acids Research · doi:10.1093/nar/gki1001 · Cited by 40
Regulation of IRF and STAT Gene Expression by Retinoic Acid
Matikainen, S., Lehtonen, A., Sareneva, T., & Julkunen, I. (1998) · Leukemia & lymphoma/Leukemia and lymphoma · doi:10.3109/10428199809050930 · Cited by 40
The expression of MUM1 in cutaneous T-cell lymphoproliferative disorders
Wasco, M. J., Fullen, D. R., Su, L. D., & Ma, L. (2008) · Human Pathology · doi:10.1016/j.humpath.2007.08.013 · Cited by 40
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Myers, D. R., Lau, T. A., Markegard, E., Lim, H. W., Kasler, H. G., Zhu, M., Barczak, A. J., Huizar, J., Zikherman, J., Erle, D. J., et al. (2017) · Cell Reports · doi:10.1016/j.celrep.2017.04.076 · Cited by 39
Mechanisms of Interferon Action
Leaman, D. W. (1998) · Progress in molecular and subcellular biology · doi:10.1007/978-3-642-72149-6_6 · Cited by 39
Cooperative interaction between the DNA-binding domains of PU.1 and IRF4
Yee, A. A., Yin, P., Siderovski, D. P., Mak, T. W., Litchfield, D. W., & Arrowsmith, C. H. (1998) · Journal of Molecular Biology · doi:10.1006/jmbi.1998.1838 · Cited by 38
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Jo, S., Schatz, J. H., Acquaviva, J., Singh, H., & Ren, R. (2010) · Blood · doi:10.1182/blood-2009-07-234559 · Cited by 37
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CSF-1 in Inflammatory and Arthritic Pain Development
Saleh, R., Lee, M.-C., Khiew, S. H. W., Louis, C., Fleetwood, A. J., Achuthan, A. A., Förster, I., Cook, A. D., & Hamilton, J. A. (2018) · The Journal of Immunology · doi:10.4049/jimmunol.1800665 · Cited by 37

Authors: Mittrücker, H.-W., Matsuyama, T., Grossman, A., Kündig, T. M., Potter, J., Shahinian, A., Wakeham, A., Patterson, B., Ohashi, P. S., & Mak, T. W.
Affiliations: University of Toronto (CA)
Nagasaki University (JP)
B. Patterson, Department of Oncologic Pathology, Ontario Cancer Institute, 610 University Avenue, Toronto, Ontario, M5G 2C1, Canada.
ORCID: Mittrücker, Hans-Willi
Matsuyama, Toshifumi
Kündig, Thomas M.
Ohashi, Pamela S.
Mak, Tak W.
Venue: Science
Publisher: American Association for the Advancement of Science (AAAS)
Published: 1997-01-24
Volume: 275
Issue: 5299
Pages: 540-543
ISSN: 0036-8075 (ISSN-L)
1095-9203
DOI: 10.1126/science.275.5299.540
OpenAlex: W2022687427
Cited by: 583
References: 21
Citations by year: 2026: 7 · 2025: 15 · 2024: 12 · 2023: 20 · 2022: 23 · 2021: 23 · 2020: 17 · 2019: 15 · 2018: 16 · 2017: 20 · 2016: 15 · 2015: 18 · 2014: 25 · 2013: 32 · 2012: 20
FWCI: 8.58
Type: journal article
Language: en
Open access: closed
Locations: Science (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
Life Sciences › Immunology and Microbiology › Immunology › Immunodeficiency and Autoimmune Disorders
Life Sciences › Immunology and Microbiology › Immunology › interferon and immune responses
Keywords: IRF4, transcription factors, B cells, T cells, lymphocyte homeostasis, lymphadenopathy, antibody deficiency, antibody response, cytotoxic T lymphocytes, antitumor immunity
MeSH terms: Lymphadenopathy, Interferon Regulatory Factor-4, Animals, Antibody Formation, B-Lymphocytes, Cell Differentiation, Cells, Cultured, Homeostasis, Mice, Inbred BALB C, T-Lymphocytes, Cytotoxic, Transcription, Genetic, Mice, SCID, Mice, Knockout, Cell Proliferation, Interferon Regulatory Factors, Mice

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Requirement for the Transcription Factor LSIRF/IRF4 for Mature B and T Lymphocyte Function

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