Cited by 583T-cell and B-cell ImmunologyImmunodeficiency and Autoimmune Disordersinterferon and immune responses

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Requirement for the Transcription Factor LSIRF/IRF4 for Mature B and T Lymphocyte Function

Mittrücker, Hans-Willi, Matsuyama, Toshifumi, Grossman, Alex, Kündig, Thomas M., Potter, Julia, Shahinian, Arda, Wakeham, Andrew, Patterson, Bruce, Ohashi, Pamela S., Mak, Tak W.·1997·Science

DOI 10.1126/science.275.5299.540

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Abstract

Lymphocyte-specific interferon regulatory factor (LSIRF) (now called IRF4) is a transcription factor expressed only in lymphocytes. Mice deficient in IRF4 showed normal distribution of B and T lymphocyes at 4 to 5 weeks of age but developed progressive generalized lymphadenopathy. IRF4-deficient mice exhibited a profound reduction in serum immunoglobulin concentrations and did not mount detectable antibody responses. T lymphocyte function was also impaired in vivo; these mice could not generate cytotoxic or antitumor responses. Thus, IRF4 is essential for the function and homeostasis of both mature B and mature T lymphocytes.

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Self-citation
Interleukin-2 receptor α chain regulates the size and content of the peripheral lymphoid compartment
Willerford, D. M., Chen, J., Ferry, J. A., Davidson, L., Ma, A. I., & Alt, F. W. (1995) · Immunity · doi:10.1016/1074-7613(95)90180-9 · Cited by 1,079
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Kamijo, R., Harada, H., Matsuyama, T., Bosland, M. C., Gerecitano, J. F., Shapiro, D., Le, J., Koh, S. I., Kimura, T., Green, S. J., et al. (1994) · Science · doi:10.1126/science.7510419 · Cited by 843
Self-citation
Cellular commitment to oncogene-induced transformation or apoptosis is dependent on the transcription factor IRF-1
Tanaka, N., Ishihara, M., Kitagawa, M., Harada, H., Kimura, T., Matsuyama, T., Lamphier, M. S., Aizawa, S., Mak, T. W., & Taniguchi, T. (1994) · Cell · doi:10.1016/0092-8674(94)90132-5 · Cited by 491
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Pip, a novel IRF family member, is a lymphoid-specific, PU.1-dependent transcriptional activator.
Eisenbeis, C. F., Singh, H., & Storb, U. (1995) · Genes & Development · doi:10.1101/gad.9.11.1377 · Cited by 447
An IRF-1-dependent pathway of DNA damage-induced apoptosis in mitogen-activated T lymphocytes
Tamura, T., Ishihara, M., Lamphier, M. S., Tanaka, N., Oishi, I., Aizawa, S., Matsuyama, T., Mak, T. W., Taki, S., & Taniguchi, T. (1995) · Nature · doi:10.1038/376596a0 · Cited by 431
Self-citation
Elements regulating somatic hypermutation of an immunoglobulin κ gene: Critical role for the intron enhancer/matrix attachment region
Betz, A. G., Milstein, C., González‐Fernández, Á., Pannell, R., Larson, T., & Neuberger, M. S. (1994) · Cell · doi:10.1016/0092-8674(94)90316-6 · Cited by 379
An IRF-1-dependent pathway of DNA damage-induced apoptosis in mitogen-activated T lymphocytes
石原, 正. (1997) · Cited by 366
Transitional B cells are the target of negative selection in the B cell compartment.
Carsetti, R., Köhler, G., & Lamers, M. C. (1995) · The Journal of Experimental Medicine · doi:10.1084/jem.181.6.2129 · Cited by 358
Interferon-Induced Antiviral Actions and Their Regulation
Sen, G. C., & Ransohoff, R. M. (1993) · Advances in virus research · doi:10.1016/s0065-3527(08)60083-4 · Cited by 334

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Lamphier M., Taniguchi T., Immunologist 2, 167 (1994);
Vaughan P. S., et al., ibid. 377, 362 (1995);
Schmits R., et al., ibid., p. 1415.
Healthy 5- to 7-week-old mice were used for all experiments. Mice were maintained according to the guidelines of the Canadian Council of Animal Care. H.-W.M. is a recipient of a grant from the Deutsche Forschungsgemeinschaft. The authors thank M. Bachmann G. Boehmelt G. Duncan D. Ferrick C. Furlonger D. Kägi F. Kiefer L. Marengere C. Paige J. Penninger M. Saunders R. Schmits D. Siderovski D. Speiser S. Yoshinaga and P. Waterhouse for providing reagents and for helpful comments.

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Antigen-specific B cells direct T follicular-like helper cells into lymphoid follicles to mediate Mycobacterium tuberculosis control
Swanson, R. V., Gupta, A., Foreman, T. W., Lu, L., Choreño-Parra, J. A., Mbandi, S. K., Rosa, B. A., Akter, S., Das, S., Ahmed, M., et al. (2023) · Nature Immunology · doi:10.1038/s41590-023-01476-3 · Cited by 94
Gene expression profiling reveals a highly specialized genetic program of plasma cells
Underhill, G. H., George, D., Bremer, E. G., & Kansas, G. S. (2003) · Blood · doi:10.1182/blood-2002-08-2673 · Cited by 93
Monocyte Differentiation to Macrophage Requires Interferon Regulatory Factor 7
Lu, R., & Pitha, P. M. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.c100421200 · Cited by 89
The development of functional B lymphocytes in conditional PU.1 knock-out mice
Polli, M., Dakic, A., Light, A., Wu, L., Tarlinton, D. M., & Nutt, S. L. (2005) · Blood · doi:10.1182/blood-2005-01-0283 · Cited by 89
Cellular and molecular mechanisms breaking immune tolerance in inborn errors of immunity
Sogkas, G., Atschekzei, F., Adriawan, I. R., Dubrowinskaja, N., Witte, T., & Schmidt, R. E. (2021) · Cellular and Molecular Immunology · doi:10.1038/s41423-020-00626-z · Cited by 95
Development of Th1 and not Th2 immune responses in mice lacking IFN-regulatory factor-4
Tominaga, N. (2002) · International Immunology · doi:10.1093/intimm/dxg001 · Cited by 92
Differential Expression and Distinct Functions of IFN Regulatory Factor 4 and IFN Consensus Sequence Binding Protein in Macrophages
Marecki, S., Atchison, M. L., & Fenton, M. J. (1999) · The Journal of Immunology · doi:10.4049/jimmunol.163.5.2713 · Cited by 87
Repression of BCL-6 is required for the formation of human memory B cells in vitro
Kuo, T. C., Shaffer, A. L., Haddad, J., Choi, Y. S., Staudt, L. M., & Calame, K. L. (2007) · The Journal of Experimental Medicine · doi:10.1084/jem.20062104 · Cited by 87
Determining germinal centre B cell fate
Zotos, D., & Tarlinton, D. M. (2012) · Trends in Immunology · doi:10.1016/j.it.2012.04.003 · Cited by 97
IRF4 and BATF are critical for CD8+ T-cell function following infection with LCMV
Grusdat, M., McIlwain, D. R., Xu, H. C., Pozdeev, V. I., Knievel, J., Crome, S. Q., Robert-Tissot, C., Dress, R. J., Pandyra, A. A., Speiser, D. E., et al. (2014) · Cell Death and Differentiation · doi:10.1038/cdd.2014.19 · Cited by 86
Self-citation
The interferon regulatory factors and oncogenesis
Tanaka, N., & Taniguchi, T. (2000) · Seminars in Cancer Biology · doi:10.1006/scbi.2000.0310 · Cited by 85
IFN-Stimulated Gene 15 Is Synergistically Activated Through Interactions Between the Myelocyte/Lymphocyte-Specific Transcription Factors, PU.1, IFN Regulatory Factor-8/IFN Consensus Sequence Binding Protein, and IFN Regulatory Factor-4: Characterization of a New Subtype of IFN-Stimulated Response Element
Meraro, D., Gleit-Kielmanowicz, M., Hauser, H., & Levi, B.-Z. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.168.12.6224 · Cited by 105
Interferon Regulatory Factors in Hematopoietic Cell Differentiation and Immune Regulation
Battistini, A. (2009) · Journal of Interferon & Cytokine Research · doi:10.1089/jir.2009.0030 · Cited by 87
Interferon regulatory factor 1 inactivation in human cancer
Alsamman, K., & El-Masry, O. S. (2018) · Bioscience Reports · doi:10.1042/bsr20171672 · Cited by 86
CCR7 and IRF4-dependent dendritic cells regulate lymphatic collecting vessel permeability
Ivanov, S., Scallan, J. P., Kim, K.-W., Werth, K., Johnson, M. W., Saunders, B. T., Wang, P. L., Kuan, E. L., Straub, A. C., Ouhachi, M., et al. (2016) · Journal of Clinical Investigation · doi:10.1172/jci84518 · Cited by 81
IRF4 Activity Is Required in Established Plasma Cells to Regulate Gene Transcription and Mitochondrial Homeostasis
Low, M. S. Y., Brodie, E. J., Fedele, P. L., Liao, Y., Grigoriadis, G., Strasser, A., Kallies, A., Willis, S. N., Tellier, J., Shi, W., et al. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.10.097 · Cited by 87
Type I interferons: expression and signalization
Doly, J., Civas, A., Navarro, S., & Uzé, G. (1998) · Cellular and Molecular Life Sciences · doi:10.1007/s000180050240 · Cited by 82
Regulating B‐cell activation and survival in response to TLR signals
Gerondakis, S., Grumont, R. J., & Banerjee, A. (2007) · Immunology and Cell Biology · doi:10.1038/sj.icb.7100097 · Cited by 84
The EBV Latent Antigen 3C Inhibits Apoptosis through Targeted Regulation of Interferon Regulatory Factors 4 and 8
Banerjee, S., Lu, J. L., Cai, Q., Saha, A., Jha, H. C., Dzeng, R. K., & Robertson, E. S. (2013) · PLoS Pathogens · doi:10.1371/journal.ppat.1003314 · Cited by 81
IRF4 and its regulators: evolving insights into the pathogenesis of inflammatory arthritis?
Biswas, P. S., Bhagat, G., & Pernis, A. B. (2009) · Immunological Reviews · doi:10.1111/j.0105-2896.2009.00864.x · Cited by 84
Distinct regulation of effector and memory T‐cell differentiation
Kallies, A. (2008) · Immunology and Cell Biology · doi:10.1038/icb.2008.16 · Cited by 76
Interferon Regulatory Factor 4 controls TH1 cell effector function and metabolism
Mahnke, J., Schumacher, V., Ahrens, S., Käding, N., Feldhoff, L., Huber, M., Rupp, J., Raczkowski, F., & Mittrücker, H. (2016) · Scientific Reports · doi:10.1038/srep35521 · Cited by 81
Self-citation
IRF-4 and c-Rel expression in antiviral-resistant adult T-cell leukemia/lymphoma
Ramos, J. C., Ruiz, P., Ratner, L., dos Reis, I. M., Brites, C. R., Pedroso, C., Byrne, G. E., Toomey, N., Andela, V. B., Harhaj, E. W., et al. (2006) · Blood · doi:10.1182/blood-2006-07-036368 · Cited by 81
Targeting IRF4 in autoimmune diseases
Xu, W., Pan, H., Ye, D., & Xu, Y. (2012) · Autoimmunity Reviews · doi:10.1016/j.autrev.2012.08.011 · Cited by 82
Oct2 enhances antibody-secreting cell differentiation through regulation of IL-5 receptor α chain expression on activated B cells
Emslie, D., D’Costa, K., Hasbold, J., Metcalf, D., Takatsu, K., Hodgkin, P. D., & Corcoran, L. M. (2008) · The Journal of Experimental Medicine · doi:10.1084/jem.20072049 · Cited by 79
MUM1/IRF4
Gualco, G., Weiss, L. M., & Bacchi, C. E. (2010) · Applied immunohistochemistry & molecular morphology · doi:10.1097/pai.0b013e3181cf1126 · Cited by 80
MUM1: a step ahead toward the understanding of lymphoma histogenesis
Gaïdano, G., & Carbone, A. (2000) · Leukemia · doi:10.1038/sj.leu.2401748 · Cited by 78
A Two-Step Mechanism for Recruitment of Pip by PU.1
Perkel, J. M., & Atchison, M. L. (1998) · The Journal of Immunology · doi:10.4049/jimmunol.160.1.241 · Cited by 77
PU.1/Interferon Regulatory Factor Interactions; Mechanisms of Transcriptional Regulation
Marecki, S., & Fenton, M. J. (2000) · Cell Biochemistry and Biophysics · doi:10.1385/cbb:33:2:127 · Cited by 74

Authors: Mittrücker, H.-W., Matsuyama, T., Grossman, A., Kündig, T. M., Potter, J., Shahinian, A., Wakeham, A., Patterson, B., Ohashi, P. S., & Mak, T. W.
Affiliations: University of Toronto (CA)
Nagasaki University (JP)
B. Patterson, Department of Oncologic Pathology, Ontario Cancer Institute, 610 University Avenue, Toronto, Ontario, M5G 2C1, Canada.
ORCID: Mittrücker, Hans-Willi
Matsuyama, Toshifumi
Kündig, Thomas M.
Ohashi, Pamela S.
Mak, Tak W.
Venue: Science
Publisher: American Association for the Advancement of Science (AAAS)
Published: 1997-01-24
Volume: 275
Issue: 5299
Pages: 540-543
ISSN: 0036-8075 (ISSN-L)
1095-9203
DOI: 10.1126/science.275.5299.540
OpenAlex: W2022687427
Cited by: 583
References: 21
Citations by year: 2026: 7 · 2025: 15 · 2024: 12 · 2023: 20 · 2022: 23 · 2021: 23 · 2020: 17 · 2019: 15 · 2018: 16 · 2017: 20 · 2016: 15 · 2015: 18 · 2014: 25 · 2013: 32 · 2012: 20
FWCI: 8.58
Type: journal article
Language: en
Open access: closed
Locations: Science (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
Life Sciences › Immunology and Microbiology › Immunology › Immunodeficiency and Autoimmune Disorders
Life Sciences › Immunology and Microbiology › Immunology › interferon and immune responses
Keywords: IRF4, transcription factors, B cells, T cells, lymphocyte homeostasis, lymphadenopathy, antibody deficiency, antibody response, cytotoxic T lymphocytes, antitumor immunity
MeSH terms: Lymphadenopathy, Interferon Regulatory Factor-4, Animals, Antibody Formation, B-Lymphocytes, Cell Differentiation, Cells, Cultured, Homeostasis, Mice, Inbred BALB C, T-Lymphocytes, Cytotoxic, Transcription, Genetic, Mice, SCID, Mice, Knockout, Cell Proliferation, Interferon Regulatory Factors, Mice

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Requirement for the Transcription Factor LSIRF/IRF4 for Mature B and T Lymphocyte Function

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