Requirement for the Transcription Factor LSIRF/IRF4 for Mature B and T Lymphocyte Function

Differential T Cell Costimulatory Requirements in CD28-Deficient Mice

Shahinian, A., Pfeffer, K., Lee, K. P., Kündig, T. M., Kishihara, K., Wakeham, A. C., Kawai, K., Ohashi, P. S., Thompson, C. B., & Mak, T. W. (1993) · Science · doi:10.1126/science.7688139 · Cited by 1,258

Interleukin-2 receptor α chain regulates the size and content of the peripheral lymphoid compartment

Willerford, D. M., Chen, J., Ferry, J. A., Davidson, L., Ma, A. I., & Alt, F. W. (1995) · Immunity · doi:10.1016/1074-7613(95)90180-9 · Cited by 1,079

Requirement for Transcription Factor IRF-1 in NO Synthase Induction in Macrophages

Kamijo, R., Harada, H., Matsuyama, T., Bosland, M. C., Gerecitano, J. F., Shapiro, D., Le, J., Koh, S. I., Kimura, T., Green, S. J., et al. (1994) · Science · doi:10.1126/science.7510419 · Cited by 843

Cellular commitment to oncogene-induced transformation or apoptosis is dependent on the transcription factor IRF-1

Tanaka, N., Ishihara, M., Kitagawa, M., Harada, H., Kimura, T., Matsuyama, T., Lamphier, M. S., Aizawa, S., Mak, T. W., & Taniguchi, T. (1994) · Cell · doi:10.1016/0092-8674(94)90132-5 · Cited by 491

Pip, a novel IRF family member, is a lymphoid-specific, PU.1-dependent transcriptional activator.

Eisenbeis, C. F., Singh, H., & Storb, U. (1995) · Genes & Development · doi:10.1101/gad.9.11.1377 · Cited by 447

An IRF-1-dependent pathway of DNA damage-induced apoptosis in mitogen-activated T lymphocytes

Tamura, T., Ishihara, M., Lamphier, M. S., Tanaka, N., Oishi, I., Aizawa, S., Matsuyama, T., Mak, T. W., Taki, S., & Taniguchi, T. (1995) · Nature · doi:10.1038/376596a0 · Cited by 431

Elements regulating somatic hypermutation of an immunoglobulin κ gene: Critical role for the intron enhancer/matrix attachment region

Betz, A. G., Milstein, C., González‐Fernández, Á., Pannell, R., Larson, T., & Neuberger, M. S. (1994) · Cell · doi:10.1016/0092-8674(94)90316-6 · Cited by 379

An IRF-1-dependent pathway of DNA damage-induced apoptosis in mitogen-activated T lymphocytes

石原, 正. (1997) · Cited by 366

Transitional B cells are the target of negative selection in the B cell compartment.

Carsetti, R., Köhler, G., & Lamers, M. C. (1995) · The Journal of Experimental Medicine · doi:10.1084/jem.181.6.2129 · Cited by 358

Interferon-Induced Antiviral Actions and Their Regulation

Sen, G. C., & Ransohoff, R. M. (1993) · Advances in virus research · doi:10.1016/s0065-3527(08)60083-4 · Cited by 334

Stochastic modeling of a gene regulatory network driving B cell development in germinal centers

Koshkin, A., Herbach, U., Martínez, M. R., Gandrillon, O., & Fabien Crauste, A. (2024) · PLoS ONE · doi:10.1371/journal.pone.0301022 · Cited by 3

Distinct plasmablast developmental intermediates produce graded expression of IgM secretory transcripts

Sievert, E. P., Franke, M. C., Thomas, K., Yoon, Y., Shi, Y., & Sciammas, R. (2025) · Cell Reports · doi:10.1016/j.celrep.2025.115283 · Cited by 3

B-cell development and differentiation

Berek, C., Radbruch, A., & Schroeder, H. W. (2008) · Elsevier eBooks · doi:10.1016/b978-0-323-04404-2.10008-9 · Cited by 3

Interferon Research

Künzi, M. S., & Pitha, P. M. (2005) · Humana Press eBooks · doi:10.1385/1-59259-939-7:025 · Cited by 7

Multi-scale gene regulatory networks for resolving transcription factor and autoimmune variant impacts on human B cell fate dynamicsPreprint

Pease, N. A., Fan, J., Keshari, S., Stratton, J., Gierlack, S., Sachan, A., Rarani, Z. H., Swaminathan, T., McGinnis, C. S., Zhang, W., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.04.23.649973 · Cited by 4

IRF4 regulates myeloid-derived suppressor cells expansion and function in Schistosoma japonicum-infected mice

Zhou, L., Lin, P., Deng, G., Mo, L., Hong, C., Jiang, Z., Zhu, Y., Zhao, Y. D., Qi, Y., Hu, T., et al. (2024) · Parasites & Vectors · doi:10.1186/s13071-024-06543-8 · Cited by 2

IRF4 Mediates Immune Evasion to Facilitate EBV Transformation

Wang, L., Hensley, C. R., Rifat, J., Walker, A. D., Ning, K., Moorman, J. P., Yao, Z. Q., & Ning, S. (2025) · Viruses · doi:10.3390/v17070885 · Cited by 2

Clinicopathological and transcriptomic profiles of 101 patients with diffuse large B‐cell lymphoma/high‐grade B‐cell lymphoma with double‐hit MYC and BCL2 or BCL6 and triple hit

Miyaoka, M., Carreras, J., Kikuti, Y. Y., Ikoma, H., Nagase, S., Ito, A., Orita, M., Kawada, H., Sakai, R., Sato, Y., et al. (2026) · Histopathology · doi:10.1111/his.70117 · Cited by 2

Structural dynamics of the midnolin-proteasome during ubiquitin-independent substrate turnover

Zhu, C., Qin, L., Dai, Z., Zuo, P., Yang, A., Zhong, L., Lin, Z., & Liang, L. (2026) · Nature Communications · doi:10.1038/s41467-026-71002-0 · Cited by 2

Gene Expression during the Activation of Human B Cells

Zhang, Y. (2018) · InTech eBooks · doi:10.5772/intechopen.71863 · Cited by 2

Essential role of interferon-regulatory factor 4 in regulating diabetogenic CD4+ T and innate immune cells in autoimmune diabetes in NOD mice

Niri, T., Inoue, S.-I., Akazawa, S., Nishikido, S., Miwa, M., Kobayashi, M., Yui, K., Okita, M., Kawakami, A., & Abiru, N. (2024) · Clinical & Experimental Immunology · doi:10.1093/cei/uxae093 · Cited by 2

Neuropilin-2 functions as a coinhibitory receptor to regulate antigen-induced inflammation and allograft rejection

Wedel, J., Kochupurakkal, N. M., Kong, S. W., Bose, S., Lee, J.-W., Maslyar, M., Alsairafi, B., MacLeod, K., Liu, K., Zhang, H., et al. (2025) · Journal of Clinical Investigation · doi:10.1172/jci172218 · Cited by 2

Genomics in Multiple Myeloma

Cottini, F., Anderson, K. C., & Tonon, G. (2013) · Elsevier eBooks · doi:10.1016/b978-0-12-396967-5.00018-9 · Cited by 1

Immunoregulation of cytokines in infectious diseases (leprosy), future strategies.

Singh, R. P. (1998) · Japanese journal of leprosy · doi:10.5025/hansen.67.263 · Cited by 2

Immunodeficiencies Caused by B-Cell Defects

Bonilla, F. A., & Geha, R. S. (2004) · Elsevier eBooks · doi:10.1016/b978-012053641-2/50027-7 · Cited by 2

Identification and antiviral effect of Cherry Valley duck IRF4

Zhai, X., Hong, T., Zhang, T., Xing, B., Wang, J., Wang, X., Miao, R., Li, T., & Wei, L. (2021) · Poultry Science · doi:10.1016/j.psj.2021.101560 · Cited by 2

The Interferon Alpha Revival in CML

Talpaz, M., Mercer, J., & Hehlmann, R. (2016) · Hematologic malignancies · doi:10.1007/978-3-319-33198-0_14 · Cited by 2

Assessing the consequences of hurricane-induced fragmentation of mangrove forest on habitat and nekton in Big Sable Creek, Florida

Silverman, N. (2006) · Digital Commons - University of South Florida (University of South Florida) · Cited by 2

PROGNOSTIC MOLECULAR FACTORS AND ALGORITHMS IN DIFFUSE LARGE B-CELL LYMPHOMA

Nyman, H. (2010) · Työväentutkimus Vuosikirja · Cited by 2

Interferon Regulatory Factor 2 ( IRF2 ) Suppression Enhances Murine Cardiac Allograft Survival Through Immune Evasion

Tian, L., Zhang, M., Guo, Y., Chang, S., Chen, Z. K., & Zhou, H. (2025) · Immunology · doi:10.1111/imm.70082 · Cited by 1

IRF4 (interferon regulatory factor 4)

Rasi, S., & Gaïdano, G. (2011) · Atlas of Genetics and Cytogenetics in Oncology and Haematology · doi:10.4267/2042/44637 · Cited by 1

Quand les cellules cancéreuses sont accros à un gène normal

Lamy, L. (2009) · médecine/sciences · doi:10.1051/medsci/20092519 · Cited by 1

Regulatory Roles of B Cells in Allergy and Inflammation

Takatsu, K., Ikutani, M., & Nagai, Y. (2011) · doi:10.1002/9781444346688.ch6 · Cited by 1

Early divergent B cell differentiation during antibody responses

Marshall, J. L. (2009) · University of Birmingham Institutional Research Archive (University of Birmingham) · Cited by 1

Mechanisms of Transcriptional Regulation

Marecki, S., & Fenton, M. J. (2000) · Cited by 2

Erratum: How self-tolerance and the immunosuppressive drug FK506 prevent B-cell mitogenesis

Glynne, R. J., Akkaraju, S., Healy, J. I., Rayner, J., Goodnow, C. C., & Mack, D. H. (2000) · Nature · doi:10.1038/35030187 · Cited by 1

Osteolyse beim Multiplen Myelom : Untersuchungen am Zellmodell

Bergmann, M., & Lorenzen, J. (2005) · RWTH Publications (RWTH Aachen)

The role of lyp phosphatase in primary human macrophages AND cRel and its effect on class switch recombination, IRF4 induction and plasma cell differentiation during a T-independent immune response

Cawkwell, L. B. (2013) · University of Birmingham Institutional Research Archive (University of Birmingham)

Regulation of positive regulatory domain I-binding factor 1 and its role in mantle cell lymphoma

Desai, S. (2010) · Digital Commons - University of South Florida (University of South Florida)

Role of IRF4 in the Regulation of Cellular Interferon Stimulated Genes and KSHV Lytic Gene Expression in Primary Effusion Lymphoma

Rueda, A. F. (2013) · D-Scholarship@Pitt (University of Pittsburgh)

The role of the "Yaa (Y-linked autoimmune acceleration)" mutation and the Fc gamma receptor type IIB (FcγRIIB) in the control of lupus-like autoimmune responses in mice

Moll, T. (2004) · Archive ouverte UNIGE (University of Geneva) · doi:10.13097/archive-ouverte/unige:306

IRF- 1 and IRF-4 Regulate Target Gene Expression via Interaction with DMP 1

Yamamoto, Y., Yamamoto, K., Yoshida, K., Kohno, T., Nogi, Y., & Matsuyama, T. (2003) · Nagasaki University's Academic Output SITE (Nagasaki University)

Interferon Regulatory Factors

Pitha, P. M., & Alce, T. M. (2002) · Wiley Encyclopedia of Molecular Medicine · doi:10.1002/0471203076.emm0446

B Cell Growth, Differentiation and Malignancies

Tao, J., & Hu, C. A. (2012) · Springer eBooks · doi:10.1007/978-94-007-5028-9_1

Transcription Factors: Deciphering the Transcription Factor Network of Dendritic Cell Development

Hieronymus, T., & Zenke, M. (2006) · Wiley eBooks · doi:10.1002/9783527619696.ch4

Probing lymphocyte responses to modulation of the F0F1-ATPase by BZ-423

Wang, L. (2009) · Deep Blue (University of Michigan)

Regulation of transcription and analysis of drug targets in lymphoma and myeloma cells

Bolick, S. C. E. (2006) · Digital Commons - University of South Florida (University of South Florida)

Implication de la famille des facteurs de transcription IRF dans l’auto-immunité

Richez, C., Barnetche, T., Miceli‐Richard, C., Blanco, P., Moreau, J., Rifkin, I. R., & Schaeverbeke, T. (2010) · Revue du Rhumatisme · doi:10.1016/j.rhum.2010.04.031

IRF4 (interferon regulatory factor 4)

Shukla, V., & Lu, R. (2014) · Atlas of Genetics and Cytogenetics in Oncology and Haematology · doi:10.4267/2042/54034

Regulation of Humoral Immunity by Pim Kinases: A Dissertation

Willems, K. N. (2011) · eScholarship@UMassChan · doi:10.13028/w3jr-1r38

Effect of viral RNA mimics and ISA virus infection on expression of key genes ofthe Atlantic salmon interferon system

Kileng, Ø. (2008)

Expression and activation of STAT and IRF family transcription factors in mononuclear leukocytes

Lehtonen, A. (2005) · Työväentutkimus Vuosikirja

Prognostic Significance of Biomarkers of Diffuse Large B-cell Lymphomas

Park, S.-E., Park, S.-J., Park, N.-S., Chun, J.-M., Park, N.-H., Yang, Y.-J., Yun, K.-W., Yun, H., Kim, J., Jo, D., et al. (2005) · The Korean Journal of Hematology · doi:10.5045/kjh.2005.40.1.15

STUDIES ON THE EFFECTS OF ANTIGEN TYPE, APOPTOSIS AND AGE

Lindroth, K. (2004)

Background: A genome-wide SNP association study has linked low levels of IRF4 with the development of CLL. Results: Low levels of IRF4 disrupt homeostasis of B1 B cells and promote survival of CLL cell. Conclusion: Our results demonstrate a causal relationship between low levels of IRF4 and the development of CLL. Significance: We establish IRF4 as a critical regulator in the pathogenesis of CLL.

Ma, S., Shukla, V., Fang, L., Gould, K. A., Joshi, S. K., & Lu, R. (2013)

Pharmacogenomic modeling of bortezomib resistance in B cell malignancies

Stessman, H. A. F. (2013) · University of Minnesota Digital Conservancy (University of Minnesota)

Niedrigmaligne B-Zell-Lymphome

Mullerhermelink, H., & Ott, G. (2003) · Springer eBooks · doi:10.1007/978-3-642-59343-7_14

Regulation of B Cell Gene Expression and Function by Ikaros, Helios and Bcl6

Alinikula, J. (2010) · UTUPub (University of Turku)

Untersuchungen zur Rolle der mutierten Rezeptor-Tyrosinkinase FLT3 bei der Leukämogenese mit Hilfe humaner und muriner Transplantationsmodelle (Mus musculus (Linnaeus, 1758))

der Fakultät, B. (2009)

No evidence for a genetic association of IRF4 with systemic lupus erythematosus in a Chinese population

Müller‐Ladner, U. (2014)

Defining the role of Interferon Regulatory Factor 4 in Chronic Lymphocytic Leukemia.

Shukla, V. (2016) · DigitalCommons@UNMC

The roles of interferon regulatory factors in the murine models of colitis and sepsis

Yu, J. (2010) · Gutenberg Open Science · doi:10.25358/openscience-2232

Unique chromosome aberrations distinguish diffuse large B-cell lynphoma and Burkitt lymphoma

García, R. (2015) · doi:10.7282/t3qr4zzv

Protein 1 Transcription Factors by Multiple I-Binding Factor 1 and X Box-Binding Targeting Positive Regulatory Domain

Goldschmidt, H., Schneider, S., Strand, S., Ferreira, E. A., Moos, M., Lotz, M. C., Mutallib, S. A., & Oehlrich, N. (2013)

Sequenciamento de nova geração do gene IRF4: identificação de variações associadas a fenótipos de pigmentação na população brasileira

de Oliveira, M. L. G. (2017) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/d.17.2017.tde-05012017-120156

Principles of Treatment

Wilson, W. H. (2006) · Elsevier eBooks · doi:10.1016/b978-0-7216-0081-9.50017-0

The Role of Dendritic Cells in Promoting Adaptive Antiviral Immune Responses at the Intestinal Mucosa

Sun, T. (2017) · TSpace (University of Toronto)

Transcriptional control of tissue-resident memory T cell generation

Cvetkovski, F. (2019) · doi:10.7916/d8-n16c-b343

IRF4 deficiency vulnerates B progeny for leukemogenesis via Jak3 mutations resembling Ph-like B-ALL in humansPreprint

Gupta, D. D., Paul, C., Bollig, N., Bieringer, M., Staudenraus, D., Raifer, H., Menke, L., Camara, B., Roth, E. A., Daum, P., et al. (2021) · Research Square · doi:10.21203/rs.3.rs-271184/v1

New Insights into Neuropeptides Regulation of the Immune System and Hemopoiesis: Effects on Hematologic Malignancies

Allegra, A., Sant’Antonio, E., Musolino, C., & Ettari, R. (2021) · Current Medicinal Chemistry · doi:10.2174/0929867328666210914120228

Large B-cell lymphoma with IRF4 rearrangement

Васильевна, П. Л., Моисеева, Т. Н., Al-Radi, L. S., Kovrigina, A. M., Обухова, Т. Н., Goryacheva, S. R., Shupletsova, I. A., Магомедова, А. У., & Kravchenko, S. K. (2021) · Гематология и трансфузиология · doi:10.35754/0234-5730-2021-66-3-445-457

The Interferon-Alpha Revival in CML

Talpaz, M., Mercer, J., & Hehlmann, R. (2021) · Hematologic malignancies · doi:10.1007/978-3-030-71913-5_13

IRF4 deficiency vulnerates B cell progeny for leukemogenesis via somatically acquired Jak3 mutations conferring IL-7 hypersensitivityPreprint

Gupta, D. D., Paul, C., Samel, N., Bieringer, M., Staudenraus, D., Marini, F., Raifer, H., Menke, L., Hansal, L., Camara, B., et al. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.02.16.480573

Faculty Opinions recommendation of Regulatory T-cell suppressor program co-opts transcription factor IRF4 to control T(H)2 responses.

Keegan, A. D. (2009) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.1156915.616973

IRF-4

Mak, T. W., Penninger, J. M., Roder, J., Rossant, J., & Saunders, M. E. (1998) · Elsevier eBooks · doi:10.1016/b978-012466044-1/50357-4

Expression of the interferon regulatory factor 6 in non-small cell lung carcinoma distinguishes squamous cell lung carcinoma from adenocarcinoma.Preprint

Mamoor, S. (2020) · doi:10.31219/osf.io/dzw5p

Faculty Opinions recommendation of IRF4 haploinsufficiency in a family with Whipple's disease.

Lionakis, M. S. (2020) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.732842685.793572025

Faculty Opinions recommendation of CCL17 blockade as a therapy for osteoarthritis pain and disease.

Krawetz, R. J. (2018) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.732995466.793552567

Gene expression profiling reveals B cells are highly educated by the pancreatic environment during autoimmune diabetesPreprint

Boldison, J., Hopkinson, J. R., Davies, J. E., Pearson, J. A., Leete, P., Richardson, S. J., Morgan, N. G., & Wong, F. S. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.05.19.492647

Editorial: Mechanisms of dysregulated antibody responses in inborn errors of immunity

Min, Q., Walter, J. E., Schroeder, H. W., Burrows, P. D., & Wang, J. O. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1335217

The influence of IL-38 in the process of B cell differentiation

Wilmes, C. (2023) · doi:10.21248/gups.79591

A three-stage assembly program governing pancreatic, plasma, pituitary, and bone secretory cell differentiation: A strategy to augment protein delivery

Bidwell, J. P., Robling, A. G., & Wek, R. C. (2025) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2025.110562

Brugia malayi miRNAs and potential targets within the feline host (Felis catus)

Burkman, E. J., Tritten, L., Evans, C. C., Verocai, G. G., Sobotyk, C., Geary, T. G., & Moorhead, A. R. (2025) · Current Research in Parasitology and Vector-Borne Diseases · doi:10.1016/j.crpvbd.2025.100329

IRF4 (MUM1) in B-cell malignancies: molecular mechanisms, biological functions, and clinical implications

Wang, H., Chen, S., Tang, D., Chen, M., Peng, H., Zhang, G., & Wang, Y. (2025) · Pathology · doi:10.1016/j.pathol.2025.10.002 · Cited by 1

Bases moleculars de l’activitat antitumoral de la lenalidomida en el limfoma de cèl•lules del mantell

Sanz, A. M. (2014) · LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas)

FIGURE 40 in New species of Anillinus Casey (Carabidae: Trechinae: Bembidiini) from the Southern Appalachians and phylogeography of the A. loweae species group

Sokolov, I. M., & Carlton, C. E. (2010) · INFM-OAR (INFN Catania) · doi:10.5281/zenodo.195866

Additional file 1 of Novel maternal duplication of 6p22.3-p25.3 with subtelomeric 6p25.3 deletion: new clinical findings and genotype–phenotype correlations

Zhang, L., Tie, X., Che, F., Wang, G., Ge, Y., Li, B., & Yang, Y. (2024) · Figshare · doi:10.6084/m9.figshare.26596382

Caractérisation et modélisation des pathologies lymphoïdes présentant des gains du chromosome 21

Laurent, A. P. (2019) · theses.fr (ABES) · doi:10.70675/ed87382fza9bcz45fdz8589zd8c7fb99d3a9

A novel small-molecule inhibitor of IRF4 selectively suppresses multiple myeloma

Zhang, L., Ding, X., Wu, M., Zhang, J.-Z., Chen, H., Liu, M., Qiu, W.-W., & Yi, Z. (2026) · Genes & Diseases · doi:10.1016/j.gendis.2026.102176

Immunomodulatory and anti-inflammatory potential of S-nitrosoglutathione (GSNO) in multiple sclerosis: a review of mechanisms and therapeutic perspectives

Won, J., Kim, J., Singh, A. K., & Singh, I. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1797609

Distinct Gene Circuits Control the Differentiation of Innate Versus Adaptive IL-17 Producing T Cells: A Dissertation

Malhotra, N. (2012) · The Journal of the American Medical Association (JAMA) Network (American Medical Association) · doi:10.13028/p4kw-qf21

Identification and analysis of omentum derived suppressor cells in regards to Th17 inhibition

Huang, N. (2014) · Loyola eCommons (Loyola University of Chicago)

IRF4 Does the Balancing Act: A Dissertation

Nayar, R. (2015) · The Journal of the American Medical Association (JAMA) Network (American Medical Association) · doi:10.13028/m2302t

Pillars Article: Requirement for the Transcription Factor LSIRF/IRF4 for Mature B and T Lymphocyte Function. Science. 1997. 275: 540–543

Mittrücker, H., Matsuyama, T., Grossman, A., Kündig, T. M., Potter, J., Shahinian, A., Wakeham, A. C., Patterson, B. J., Ohashi, P. S., & Mak, T. W. (2017) · The Journal of Immunology · doi:10.1093/jimmunol/199.11.3717

IRF-4

Mak, T. W., Penninger, J. M., Roder, J., Rossant, J., & Saunders, M. E. (1998) · Elsevier eBooks · doi:10.1016/b978-012466044-1/50357-4

Critical Functions of IRF4 in B and T Lymphocytes

Hagman, J. R. (2017) · The Journal of Immunology · doi:10.4049/jimmunol.1701385 · Cited by 22

Review: The Role of IRF-4 in B and T Cell Activation and Differentiation

Pernis, A. B. (2002) · Journal of Interferon & Cytokine Research · doi:10.1089/107999002753452728 · Cited by 63

Aged IRF-4-deficient lupus-prone MRL/lpr mice show peripheral B-cell deficiency with elevated serum IFN-? levels and increased expression of IFN-?-receptor-1 on B cells

Machida, T., Natsumi, S., Honma, K., Matsuyama, T., Yui, K., & Sekine, H. (2013) · Frontiers in Immunology · doi:10.3389/conf.fimmu.2013.02.00861