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A Member of the Frizzled Protein Family Mediating Axis Induction by Wnt-5A
Abstract
In Xenopus laevis embryos, the Wingless/Wnt-1 subclass of Wnt molecules induces axis duplication, whereas the Wnt-5A subclass does not. This difference could be explained by distinct signal transduction pathways or by a lack of one or more Wnt-5A receptors during axis formation. Wnt-5A induced axis duplication and an ectopic Spemann organizer in the presence of hFz5, a member of the Frizzled family of seven-transmembrane receptors. Wnt-5A/hFz5 signaling was antagonized by glycogen synthase kinase-3 and by the amino-terminal ectodomain of hFz5. These results identify hFz5 as a receptor for Wnt-5A.
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Citations
Cited by
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Veeman, M. T., Axelrod, J. D., & Moon, R. T. (2003) · Developmental Cell · doi:10.1016/s1534-5807(03)00266-1 · Cited by 1,359
LDL-receptor-related proteins in Wnt signal transduction
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Lengfeld, J. E., Lutz, S. E., Smith, J. R., Diaconu, C., Scott, C., Kofman, S. B., Choi, C., Walsh, C. M., Raine, C. S., Agalliu, I., et al. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1609905114 · Cited by 152
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Metadata
- Authors
- He, X., Saint-Jeannet, J.-P., Wang, Y., Nathans, J., Dawid, I., & Varmus, H.
- Venue
- Science
- Published
- 1997-03-14
- Volume
- 275
- Issue
- 5306
- Pages
- 1652-1654
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2071397057
- Cited by
- 492
- References
- 0
- FWCI
- 9.22
- Type
- journal article
- Language
- en
- Open access
- closed
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