Cited by 5,621PI3K/AKT/mTOR signaling in cancerMetabolism, Diabetes, and CancerProtein Kinase Regulation and GTPase Signaling

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The Phosphoinositide 3-Kinase Pathway

Cantley, Lewis C.·2002·Science

DOI 10.1126/science.296.5573.1655

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Abstract

Phosphorylated lipids are produced at cellular membranes during signaling events and contribute to the recruitment and activation of various signaling components. The role of phosphoinositide 3-kinase (PI3K), which catalyzes the production of phosphatidylinositol-3,4,5-trisphosphate, in cell survival pathways; the regulation of gene expression and cell metabolism; and cytoskeletal rearrangements are highlighted. The PI3K pathway is implicated in human diseases including diabetes and cancer, and understanding the intricacies of this pathway may provide new avenues for therapuetic intervention.

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PHOSPHOINOSITIDE KINASES
Fruman, D. A., Meyers, R. E., & Cantley, L. C. (1998) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.67.1.481 · Cited by 1,382
Self-citation
Transcription-dependent and -independent control of neuronal survival by the PI3K–Akt signaling pathway
Brunet, A., Datta, S. R., & Greenberg, M. E. (2001) · Current Opinion in Neurobiology · doi:10.1016/s0959-4388(00)00211-7 · Cited by 1,208
PKB/Akt
Lawlor, M. A., & Alessi, D. R. (2001) · Journal of Cell Science · doi:10.1242/jcs.114.16.2903 · Cited by 1,068
Regulation of C. elegans Life-Span by Insulinlike Signaling in the Nervous System
Wolkow, C. A., Kimura, K. D., Lee, M. S., & Ruvkun, G. (2000) · Science · doi:10.1126/science.290.5489.147 · Cited by 681
PTEN: a tumour suppressor that functions as a phospholipid phosphatase
Maehama, T. (1999) · Trends in Cell Biology · doi:10.1016/s0962-8924(99)01519-6 · Cited by 599
Constitutive and inducible Akt activity promotes resistance to chemotherapy, trastuzumab, or tamoxifen in breast cancer cells.
Clark, A. S., West, K. A., Streicher, S. A., & Dennis, P. A. (2002) · PubMed · Cited by 589
The lipid phosphatase SHIP2 controls insulin sensitivity
Clément, S., Krause, U., Desmedt, F., Tanti, J., Behrends, J., Pesesse, X., Sasaki, T., Penninger, J. M., Doherty, M., Malaisse, W. J., et al. (2001) · Nature · doi:10.1038/35051094 · Cited by 377
Identification of CISK, a new member of the SGK kinase family that promotes IL-3-dependent survival
Liu, D., Xiao-hong, Y., & Songyang, Z. (2000) · Current Biology · doi:10.1016/s0960-9822(00)00733-8 · Cited by 135

Show all 9 references

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Liao, R. S., Ma, S., Lu, M., Li, R., Yin, Y., & Raj, G. V. (2013) · PubMed Central · doi:10.3978/j.issn.2223-4683.2013.09.07 · Cited by 103
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Pachori, A. S., Smith, A. M., McDonald, P. H., Zhang, L., Dzau, V. J., & Melo, L. G. (2007) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2007.08.003 · Cited by 103
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Sumitomo, M., Shen, R., & Nanus, D. M. (2004) · Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics · doi:10.1016/j.bbapap.2004.11.001 · Cited by 106
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Conte, E., Gili, E., Fruciano, M., Korfei, M., Fagone, E., Iemmolo, M., Furno, D. L., Giuffrida, R., Crimi, N., Günther, A., et al. (2013) · Laboratory Investigation · doi:10.1038/labinvest.2013.6 · Cited by 97
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Massari, F., Ciccarese, C., Santoni, M., Brunelli, M., Piva, F., Modena, A., Bimbatti, D., Fantinel, E., Santini, D., Liang Cheng, C., et al. (2015) · Cancer Treatment Reviews · doi:10.1016/j.ctrv.2015.07.002 · Cited by 99
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Yu, C., Rahmani, M., Dai, Y., Conrad, D. H., Krystal, G. W., Dent, P., & Grant, S. (2003) · PubMed · Cited by 97
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Zhao, Y., Cheng, X., Wei, F., Xiao, X., Sun, W.-J., Zhang, Y., & Lin, R. (2011) · Biomarkers · doi:10.3109/1354750x.2011.637180 · Cited by 96
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Cheng, B., Bai, B., Shao, Z., Dou, S., Zhu, J., Wang, H., & Wang, C. (2020) · Neural Regeneration Research · doi:10.4103/1673-5374.300725 · Cited by 95
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Aleskandarany, M. A., Rakha, E. A., Ahmed, M. A. H., Powe, D. G., Paish, E. C., Macmillan, R. D., Ellis, I. O., & Green, A. R. (2009) · Breast Cancer Research and Treatment · doi:10.1007/s10549-009-0508-9 · Cited by 99
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Hartmann, C. J., Bartels, G., Gehlhaar, C., Holtkamp, N., & von Deimling, A. (2005) · Acta Neuropathologica · doi:10.1007/s00401-005-1000-1 · Cited by 95
Dual Inhibition of PI3K/Akt and mTOR by the Dietary Antioxidant, Delphinidin, Ameliorates Psoriatic Features In Vitro and in an Imiquimod-Induced Psoriasis-Like Disease in Mice
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Authors: Cantley, L. C.
Affiliations: Beth Israel Deaconess Medical Center (US)
Corresponding author: Cantley, Lewis C.
ORCID: Cantley, Lewis C.
Venue: Science
Publisher: American Association for the Advancement of Science (AAAS)
Published: 2002-05-31
Volume: 296
Issue: 5573
Pages: 1655-1657
ISSN: 0036-8075 (ISSN-L)
1095-9203
DOI: 10.1126/science.296.5573.1655
OpenAlex: W2070732456
Cited by: 5,621
References: 9
Citations by year: 2026: 87 · 2025: 137 · 2024: 134 · 2023: 182 · 2022: 200 · 2021: 203 · 2020: 216 · 2019: 215 · 2018: 232 · 2017: 276 · 2016: 243 · 2015: 297 · 2014: 292 · 2013: 306 · 2012: 325
FWCI: 76.33
Type: journal article
Language: en
Open access: closed
Locations: Science (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute of General Medical Sciences (R01GM041890)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › PI3K/AKT/mTOR signaling in cancer
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Kinase Regulation and GTPase Signaling
Keywords: phosphatidylinositol 3-kinase, PI3K signaling, phosphatidylinositol 3,4,5-trisphosphate, cell survival signaling, gene expression regulation, cellular metabolism, cytoskeletal rearrangement, diabetes mellitus, cancer, therapeutic target
MeSH terms: Animals, Cell Membrane, Cell Physiological Phenomena, Diabetes Mellitus, Type 2, Humans, Models, Biological, Neoplasms, Phosphorylation, Protein Kinases, Proto-Oncogene Proteins, Signal Transduction, Protein Serine-Threonine Kinases, Phosphatidylinositol Phosphates, Phosphatidylinositol 4,5-Diphosphate, Phosphatidylinositol 3-Kinases, Proto-Oncogene Proteins c-akt, 3-Phosphoinositide-Dependent Protein Kinases

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The Phosphoinositide 3-Kinase Pathway

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