The Phosphoinositide 3-Kinase Pathway

PHOSPHOINOSITIDE KINASES

Fruman, D. A., Meyers, R. E., & Cantley, L. C. (1998) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.67.1.481 · Cited by 1,382

Transcription-dependent and -independent control of neuronal survival by the PI3K–Akt signaling pathway

Brunet, A., Datta, S. R., & Greenberg, M. E. (2001) · Current Opinion in Neurobiology · doi:10.1016/s0959-4388(00)00211-7 · Cited by 1,208

PKB/Akt

Lawlor, M. A., & Alessi, D. R. (2001) · Journal of Cell Science · doi:10.1242/jcs.114.16.2903 · Cited by 1,068

Regulation of C. elegans Life-Span by Insulinlike Signaling in the Nervous System

Wolkow, C. A., Kimura, K. D., Lee, M. S., & Ruvkun, G. (2000) · Science · doi:10.1126/science.290.5489.147 · Cited by 681

PTEN: a tumour suppressor that functions as a phospholipid phosphatase

Maehama, T. (1999) · Trends in Cell Biology · doi:10.1016/s0962-8924(99)01519-6 · Cited by 599

Constitutive and inducible Akt activity promotes resistance to chemotherapy, trastuzumab, or tamoxifen in breast cancer cells.

Clark, A. S., West, K. A., Streicher, S. A., & Dennis, P. A. (2002) · PubMed · Cited by 589

The lipid phosphatase SHIP2 controls insulin sensitivity

Clément, S., Krause, U., Desmedt, F., Tanti, J., Behrends, J., Pesesse, X., Sasaki, T., Penninger, J. M., Doherty, M., Malaisse, W. J., et al. (2001) · Nature · doi:10.1038/35051094 · Cited by 377

Identification of CISK, a new member of the SGK kinase family that promotes IL-3-dependent survival

Liu, D., Xiao-hong, Y., & Songyang, Z. (2000) · Current Biology · doi:10.1016/s0960-9822(00)00733-8 · Cited by 135

Liraglutide attenuates high glucose-induced abnormal cell migration, proliferation, and apoptosis of vascular smooth muscle cells by activating the GLP-1 receptor, and inhibiting ERK1/2 and PI3K/Akt signaling pathways

Shi, L., Ji, Y., Jiang, X., Zhou, L., Xu, Y., Li, Y., Jiang, W., Meng, P., & Liu, X. (2015) · Cardiovascular Diabetology · doi:10.1186/s12933-015-0177-4 · Cited by 91

Nitric oxide and protein phosphatase 2A provide novel therapeutic opportunities in ER-negative breast cancer

Switzer, C. H., Glynn, S. A., Ridnour, L. A., Cheng, R. Y.-S., Vitek, M. P., Ambs, S., & Wink, D. A. (2011) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2011.07.001 · Cited by 74

Activation of autophagy in macrophages by pro-resolving lipid mediators

Prieto, P., Rosales-Mendoza, C. E., TerrÓn, V., Toledano, V., Cuadrado, A., LÓpez-Collazo, E., Bannenberg, G., Martín-Sanz, P., FernÁndez-Velasco, M., & BoscÁ, L. (2015) · Autophagy · doi:10.1080/15548627.2015.1078958 · Cited by 71

Exendin-4, a glucagon-like peptide 1 receptor agonist, protects cholangiocytes from apoptosis

Marzioni, M., Alpini, G., Saccomanno, S., Candelaresi, C., Venter, J., Rychlicki, C., Fava, G., Francis, H., Trozzi, L., & Benedetti, A. (2009) · Gut · doi:10.1136/gut.2008.150870 · Cited by 73

Induction of prolonged early G1arrest by CDK4/CDK6 inhibition reprograms lymphoma cells for durable PI3Kδ inhibition through PIK3IP1

Chiron, D., Martin, P., Di Liberto, M., Huang, X., Ely, S., Lannutti, B. J., Leonard, J. P., Mason, C. E., & Chen-Kiang, S. (2013) · Cell Cycle · doi:10.4161/cc.24928 · Cited by 71

Signaling Pathway Mediating Myeloma Cell Growth and Survival

Hideshima, T., & Anderson, K. C. (2021) · Cancers · doi:10.3390/cancers13020216 · Cited by 70

Monomeric Targeted Protein Degraders

Hanan, E. J., Liang, J., Wang, X., Blake, R. A., Blaquiere, N., & Staben, S. T. (2020) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.0c00093 · Cited by 69

Sulfhydration of AKT triggers Tau-phosphorylation by activating glycogen synthase kinase 3β in Alzheimer’s disease

Sen, T., Saha, P., Jiang, T., & Sen, N. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1916895117 · Cited by 68

Dual Pharmacological Targeting of the MAP Kinase and PI3K/mTOR Pathway in Preclinical Models of Colorectal Cancer

Pitts, T. M., Newton, T. P., Bradshaw-Pierce, E. L., Addison, R., Arcaroli, J. J., Klauck, P. J., Bagby, S. M., Hyatt, S. L., Purkey, A., Tentler, J. J., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0113037 · Cited by 54

Insulin Regulation of Hepatic Lipid Homeostasis

Uehara, K., Santoleri, D., Whitlock, A. E. G., & Titchenell, P. M. (2023) · Comprehensive Physiology · doi:10.1002/cphy.c220015 · Cited by 49

Mammalian cells internalize bacteriophages and use them as a resource to enhance cellular growth and survival

Bichet, M. C., Adderley, J., Avellaneda-Franco, L., Magnin-Bougma, I., Torriero-Smith, N., Gearing, L. J., Deffrasnes, C., David, C., Pepin, G., Gantier, M. P., et al. (2023) · PLOS Biology · doi:10.1371/journal.pbio.3002341 · Cited by 47

Nogo Receptor Inhibition Enhances Functional Recovery following Lysolecithin-Induced Demyelination in Mouse Optic Chiasm

Pourabdolhossein, F., Mozafari, S., Morvan-Dubois, G., Mirnajafi-Zadeh, J., Lopez-Juarez, A., Pierre-Simons, J., Demeneix, B. A., & Javan, M. (2014) · PLoS ONE · doi:10.1371/journal.pone.0106378 · Cited by 47

Programming of macrophages by UV-irradiated apoptotic cancer cells inhibits cancer progression and lung metastasis

Kim, Y.-B., Ahn, Y.-H., Jung, J.-H., Lee, Y.-J., Lee, J.-H., & Kang, J. L. (2019) · Cellular & Molecular Immunology · doi:10.1038/s41423-019-0209-1 · Cited by 45

Inhibition of mTOR radiosensitizes soft tissue sarcoma and tumor vasculature

Murphy, J. D., Spalding, A. C., Somnay, Y. R., Markwart, S., Ray, M. E., & Hamstra, D. A. (2009) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-08-1019 · Cited by 44

Structure-Based Design of a Potent and Selective Covalent Inhibitor for SRC Kinase That Targets a P-Loop Cysteine

Du, G., Rao, S., Gurbani, D., Henning, N. J., Jiang, J., Che, J., Yang, A., Ficarro, S. B., Marto, J. A., Aguirre, A. J., et al. (2020) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.9b01502 · Cited by 39

The role of protein kinase B/Akt in insulin-induced inactivation of phosphorylase in rat hepatocytes

Aiston, S., Hampson, L. J., Arden, C., Iynedjian, P. B., & Agius, L. (2006) · Diabetologia · doi:10.1007/s00125-005-0068-4 · Cited by 38

Osmotin Protects H9c2 Cells from Simulated Ischemia-Reperfusion Injury through AdipoR1/PI3K/AKT Signaling Pathway

Liu, J., Sui, H., Zhao, J., & Wang, Y. (2017) · Frontiers in Physiology · doi:10.3389/fphys.2017.00611 · Cited by 38

Modulation of immune checkpoint molecule expression in mantle cell lymphoma

Harrington, B. K., Wheeler, E., Hornbuckle, K., Shana’ah, A. Y., Youssef, Y., Smith, L., Hassan II, Q., Klamer, B., Zhang, X., Long, M., et al. (2019) · Leukemia & Lymphoma · doi:10.1080/10428194.2019.1569231 · Cited by 31

A purified Feverfew extract protects from oxidative damage by inducing DNA repair in skin cells via a PI3-kinase-dependent Nrf2/ARE pathway

Rodriguez, K. J., Wong, H.-K., Oddos, T., Southall, M., Frei, B., & Kaur, S. (2013) · Journal of Dermatological Science · doi:10.1016/j.jdermsci.2013.08.004 · Cited by 34

γδT-cell function in sepsis is modulated by C5a receptor signalling

Han, G., Geng, S., Li, Y., Chen, G., Wang, R., Li, X., Ma, Y., Shen, B., & Li, Y. (2011) · Immunology · doi:10.1111/j.1365-2567.2011.03445.x · Cited by 32

A PTEN-related 5-Phosphatidylinositol Phosphatase Localized in the Golgi

Merlot, S., Meili, R., Pagliarini, D. J., Maehama, T., Dixon, J. E., & Firtel, R. A. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m306318200 · Cited by 32

Sex-dependent differences in rat brown adipose tissue mitochondrial biogenesis and insulin signaling parameters in response to an obesogenic diet

Nadal-Casellas, A., Bauzá-Thorbrügge, M., Proenza, A. M., Gianotti, M., & Lladó, I. (2013) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-012-1481-x · Cited by 31

Signal transduction pathways mediating the effect of adrenomedullin on osteoblast survival

Lausson, S., & Cressent, M. (2011) · Journal of Cellular Biochemistry · doi:10.1002/jcb.23311 · Cited by 26

Phosphoinositide 3-kinase signaling in retinal rod photoreceptors

Ivanovic, I., Allen, D. T., Dighe, R., Le, Y. Z., Anderson, R. E., & Rajala, R. V. S. (2011) · Investigative Opthalmology & Visual Science · doi:10.1167/iovs.10-7138 · Cited by 25

Regulation of the Src Homology 2 Domain-containing Inositol 5′-Phosphatase (SHIP1) by the Cyclic AMP-dependent Protein Kinase

Zhang, J., Walk, S. F., Ravichandran, K. S., & Garrison, J. C. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.016865 · Cited by 18

miR-27a promotes osteogenic differentiation in glucocorticoid-treated human bone marrow mesenchymal stem cells by targeting PI3K

Tang, J., Yu, H., Wang, Y., Duan, G., Wang, B., Li, W., & Zhu, Z. (2021) · Journal of Molecular Histology · doi:10.1007/s10735-020-09947-9 · Cited by 16

Treatments on the Horizon: Breast Cancer Patients with Central Nervous System Metastases

Kaplan, A., Li, M. J., & Malani, R. (2022) · Current Oncology Reports · doi:10.1007/s11912-022-01206-2 · Cited by 4

Research Progress on Structure and Function of PI3K

Li, X. (2013) · Journal of Chengdu University

Phosphoinositide 3-Kinase signaling pathway: the key to cell proliferation and death

Peacock, J. G. (2007) · PubMed Central

Phosphatidylinositol-4,5-bisphosphate 3-kinase family in GtoPdb v.2023.1

Uddin, M. (2023) · IUPHAR/BPS Guide to Pharmacology CITE · doi:10.2218/gtopdb/f673/2023.1

Phosphoinositide 3-kinase: A new effector in signal transduction?

Downes, C. P., & Carter, A. N. (1991) · Cellular Signalling · doi:10.1016/0898-6568(91)90027-r · Cited by 160

Protein Kinases as Mediators of Phosphoinositide 3-Kinase Signaling

Toker, A. (2000) · Molecular Pharmacology · doi:10.1124/mol.57.4.652 · Cited by 302