The Phosphoinositide 3-Kinase Pathway

PHOSPHOINOSITIDE KINASES

Fruman, D. A., Meyers, R. E., & Cantley, L. C. (1998) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.67.1.481 · Cited by 1,382

Transcription-dependent and -independent control of neuronal survival by the PI3K–Akt signaling pathway

Brunet, A., Datta, S. R., & Greenberg, M. E. (2001) · Current Opinion in Neurobiology · doi:10.1016/s0959-4388(00)00211-7 · Cited by 1,208

PKB/Akt

Lawlor, M. A., & Alessi, D. R. (2001) · Journal of Cell Science · doi:10.1242/jcs.114.16.2903 · Cited by 1,068

Regulation of C. elegans Life-Span by Insulinlike Signaling in the Nervous System

Wolkow, C. A., Kimura, K. D., Lee, M. S., & Ruvkun, G. (2000) · Science · doi:10.1126/science.290.5489.147 · Cited by 681

PTEN: a tumour suppressor that functions as a phospholipid phosphatase

Maehama, T. (1999) · Trends in Cell Biology · doi:10.1016/s0962-8924(99)01519-6 · Cited by 599

Constitutive and inducible Akt activity promotes resistance to chemotherapy, trastuzumab, or tamoxifen in breast cancer cells.

Clark, A. S., West, K. A., Streicher, S. A., & Dennis, P. A. (2002) · PubMed · Cited by 589

The lipid phosphatase SHIP2 controls insulin sensitivity

Clément, S., Krause, U., Desmedt, F., Tanti, J., Behrends, J., Pesesse, X., Sasaki, T., Penninger, J. M., Doherty, M., Malaisse, W. J., et al. (2001) · Nature · doi:10.1038/35051094 · Cited by 377

Identification of CISK, a new member of the SGK kinase family that promotes IL-3-dependent survival

Liu, D., Xiao-hong, Y., & Songyang, Z. (2000) · Current Biology · doi:10.1016/s0960-9822(00)00733-8 · Cited by 135

Pharmaceuticals targeting signaling pathways of endometriosis as potential new medical treatment: A review

Hung, S. W., Zhang, R., Tan, Z., Chung, J. P. W., Zhang, T., & Wang, C. C. (2021) · Medicinal Research Reviews · doi:10.1002/med.21802 · Cited by 175

Celastrol inhibits tumor cell proliferation and promotes apoptosis through the activation of c-Jun N-terminal kinase and suppression of PI3 K/Akt signaling pathways

Kannaiyan, R., Manu, K. A., Chen, L., Li, F., Rajendran, P., Subramaniam, A., Lam, P. Y. P., Kumar, A. P., & Sethi, G. (2011) · APOPTOSIS · doi:10.1007/s10495-011-0629-6 · Cited by 171

Pten controls lung morphogenesis, bronchioalveolar stem cells, and onset of lung adenocarcinomas in mice

Yanagi, S., Kishimoto, H., Kawahara, K., Sasaki, T., Sasaki, M., Nishio, M., Yajima, N., Hamada, K., Horie, Y., Kubo, H., et al. (2007) · Journal of Clinical Investigation · doi:10.1172/jci31854 · Cited by 172

Mechanism of Apoptosis Induced by Curcumin in Colorectal Cancer

Ismail, N. I., Othman, I., Abas, F., Lajis, N. H., & Naidu, R. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20102454 · Cited by 180

Opportunities and challenges in the development of kinase inhibitor therapy for cancerPreprint

Sawyers, C. L. (2003) · Genes & Development · doi:10.1101/gad.1152403 · Cited by 170

Functional roles of the phosphatidylinositol 3-kinases (PI3Ks) signaling in the mammalian ovary

Zheng, W., Gorre, N., Liu, Z., & Liu, K. (2011) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2011.05.027 · Cited by 175

Gβγs and the Ras binding domain of p110γ are both important regulators of PI3Kγ signalling in neutrophils

Suire, S., Condliffe, A. M., Ferguson, G., Ellson, C. D., Guillou, H., Davidson, K., Welch, H. C. E., Coadwell, J., Turner, M., Chilvers, E. R., et al. (2006) · Nature Cell Biology · doi:10.1038/ncb1494 · Cited by 177

MicroRNA‐21 protects from mesangial cell proliferation induced by diabetic nephropathy in db/db mice

Zhang, Z., Peng, H., Chen, J., Chen, X., Han, F., Xu, X., He, X.-Y., & Yan, N. (2009) · FEBS Letters · doi:10.1016/j.febslet.2009.05.021 · Cited by 170

Analysis of the genome to personalize therapy for melanoma

Davies, M. A., & Samuels, Y. (2010) · Oncogene · doi:10.1038/onc.2010.323 · Cited by 190

Class II phosphoinositide 3-kinase defines a novel signaling pathway in cell migration

Maffucci, T., Cooke, F. T., Foster, F. M., Traer, C. J., Fry, M., & Falasca, M. (2005) · The Journal of Cell Biology · doi:10.1083/jcb.200408005 · Cited by 167

mTOR signaling in tumorigenesis

Xu, K. L., Liu, P., & Wei, W. (2014) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2014.10.007 · Cited by 167

Pertuzumab: new hope for patients with HER2-positive breast cancer

Capelán, M., Pugliano, L., de Azambuja, E., Bozovic, I., Saini, K. S., Sotiriou, C. P., Loi, S., & Piccart, M. J. (2012) · Annals of Oncology · doi:10.1093/annonc/mds328 · Cited by 174

Stability of Phosphoprotein as a Biological Marker of Tumor Signaling

Baker, A. F., Dragovich, T., Ihle, N. T., Williams, R. R., Fenoglio‐Preiser, C. M., & Powis, G. (2005) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-05-0422 · Cited by 167

Epigallocatechin gallate protects nerve growth factor differentiated PC12 cells from oxidative-radical-stress-induced apoptosis through its effect on phosphoinositide 3-kinase/Akt and glycogen synthase kinase-3

Koh, S., Kim, S. H., Kwon, H., Park, Y., Kim, K. S., Song, C. W., Kim, J., Kim, M., Yu, H., Henkel-Tigges, J., et al. (2003) · Molecular Brain Research · doi:10.1016/j.molbrainres.2003.07.003 · Cited by 167

The Role of Phosphoinositide 3-Kinase C2α in Insulin Signaling

Falasca, M., Hughes, W. E., Dominguez, V., Sala, G., Fostira, F., Fang, M. Q., Cazzolli, R., Shepherd, P. R., James, D. E., & Maffucci, T. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m704357200 · Cited by 176

Class II Phosphoinositide 3-Kinase Regulates Exocytosis of Insulin Granules in Pancreatic β Cells

Dominguez, V., Raimondi, C., Somanath, S., Bugliani, M., Loder, M. K., Edling, C. E., Divecha, N., Xavier, G. D. S., Marselli, L., Persaud, S. J., et al. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.200295 · Cited by 166

Phosphatidylinositol 3-kinase (PI3K) pathway activation in bladder cancer

Knowles, M. A., Platt, F. M., Ross, R. L., & Hurst, C. D. (2009) · Cancer and Metastasis Reviews · doi:10.1007/s10555-009-9198-3 · Cited by 168

Discovery of GDC-0077 (Inavolisib), a Highly Selective Inhibitor and Degrader of Mutant PI3Kα

Hanan, E. J., Braun, M., Heald, R. A., MacLeod, C., Chan, C. C. C., Clausen, S., Edgar, K. A., Eigenbrot, C. W., Elliott, R. L., Endres, N., et al. (2022) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.2c01422 · Cited by 171

Protein kinases and transcription factors activation in response to UV-radiation of skin: implications for carcinogenesis

López-Camarillo, C., Aréchaga Ocampo, E., López Casamichana, M., Pérez-Plasencia, C., Álvarez-Sánchez, E., & Marchat, L. A. (2011) · International Journal of Molecular Sciences · doi:10.3390/ijms13010142 · Cited by 165

The role of intracellular signaling in insulin-mediated regulation of drug metabolizing enzyme gene and protein expression

Kim, S. K., & NOVAK, R. F. (2006) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2006.07.004 · Cited by 167

Lipopolysaccharide-induced myocardial protection against ischaemia/reperfusion injury is mediated through a PI3K/Akt-dependent mechanism

Ha, T., Hua, F., Liu, X., Ma, J., McMullen, J. R., Shioi, T., Izumo, S., Kelley, J., Gao, X., Browder, W., et al. (2008) · Cardiovascular Research · doi:10.1093/cvr/cvn037 · Cited by 166

Regulation of Akt signaling activation by ubiquitination

Yang, W.-L., Wu, C.-Y., Wu, J., & Lin, H.-K. (2010) · Cell Cycle · doi:10.4161/cc.9.3.10508 · Cited by 164

Comprehensive two-dimensional gas chromatography–time-of-flight mass spectrometry (GC × GC-TOF) for high resolution metabolomics: biomarker discovery on spleen tissue extracts of obese NZO compared to lean C57BL/6 mice

Welthagen, W., Shellie, R. A., Spranger, J., Ristow, M., Zimmermann, R., & Fiehn, O. (2005) · Metabolomics · doi:10.1007/s11306-005-1108-2 · Cited by 164

Cell survival and metastasis regulation by Akt signaling in colorectal cancer

Agarwal, E., Brattain, M. G., & Chowdhury, S. (2013) · Cellular Signalling · doi:10.1016/j.cellsig.2013.03.025 · Cited by 164

PF-04691502, a Potent and Selective Oral Inhibitor of PI3K and mTOR Kinases with Antitumor Activity

Yuan, J., Mehta, P. P., Yin, M.-J., Sun, S., Zou, A., Chen, J. W., Rafidi, K., Feng, Z., Nickel, J., Engebretsen, J., et al. (2011) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-11-0185 · Cited by 168

Hepatitis C Virus Upregulates Beclin1 for Induction of Autophagy and Activates mTOR Signaling

Shrivastava, S., Bhanja Chowdhury, J., Steele, R., Ray, R., & Ray, R. B. (2012) · Journal of Virology · doi:10.1128/jvi.00616-12 · Cited by 163

Targeting the PI3K/Akt pathway in prostate cancer: Challenges and opportunities (Review)

Toren, P., & Zoubeidi, A. (2014) · International Journal of Oncology · doi:10.3892/ijo.2014.2601 · Cited by 165

Modular evolution of phosphorylation-based signalling systems

Jin, J., & Pawson, T. J. (2012) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2012.0106 · Cited by 167

PI3K/Akt pathway-mediated HO-1 induction regulates mitochondrial quality control and attenuates endotoxin-induced acute lung injury

Shi, J., Yu, J., Zhang, Y., Wu, L., Dong, S., Wu, L., Wu, L., Du, S., Zhang, Y., & Ma, D. (2019) · Laboratory Investigation · doi:10.1038/s41374-019-0286-x · Cited by 162

The Interleukin (IL)‐2 Family Cytokines: Survival and Proliferation Signaling Pathways in T Lymphocytes

Benczik, M., & Gaffen, S. L. (2004) · Immunological Investigations · doi:10.1081/imm-120030732 · Cited by 165

Dysregulation of HIF and VEGF is a unifying feature of the familial hamartoma syndromes

Brugarolas, J., & Kaelin, W. G. (2004) · Cancer Cell · doi:10.1016/j.ccr.2004.06.020 · Cited by 165

Disrupted neuronal trafficking in amyotrophic lateral sclerosis

Burk, K., & Pasterkamp, R. J. (2019) · Acta Neuropathologica · doi:10.1007/s00401-019-01964-7 · Cited by 162

Inhibition of PI3K Prevents the Proliferation and Differentiation of Human Lung Fibroblasts into Myofibroblasts: The Role of Class I P110 Isoforms

Conte, E., Fruciano, M., Fagone, E., Gili, E., Caraci, F., Iemmolo, M., Crimi, N., & Vancheri, C. (2011) · PLoS ONE · doi:10.1371/journal.pone.0024663 · Cited by 161

Insulin deficiency exacerbates cerebral amyloidosis and behavioral deficits in an Alzheimer transgenic mouse model

Wang, X., Zheng, W. H., Xie, J., Wang, T., Wang, S., Teng, W., & Wang, Z. (2010) · Molecular Neurodegeneration · doi:10.1186/1750-1326-5-46 · Cited by 161

Phase I Dose-Escalation Study of Taselisib, an Oral PI3K Inhibitor, in Patients with Advanced Solid Tumors

Juric, D., Krop, I. E., Ramanathan, R. K., Wilson, T. R., Ware, J. A., Bohorquez, S. M. S., Savage, H. M., Sampath, D., Salphati, L., Lin, R., et al. (2017) · Cancer Discovery · doi:10.1158/2159-8290.cd-16-1080 · Cited by 161

ERYTHROPOIETIN ATTENUATES THE TISSUE INJURY ASSOCIATED WITH HEMORRHAGIC SHOCK AND MYOCARDIAL ISCHEMIA

Abdelrahman, M., Sharples, E. J., McDonald, M. C., Collin, M., Patel, N. S. A., Yaqoob, M. M., & Thiemermann, C. (2004) · Shock · doi:10.1097/01.shk.00001276869.21260.9d · Cited by 160

A Central Role for mTOR Kinase in Homeostatic Proliferation Induced CD8+ T Cell Memory and Tumor Immunity

Li, Q., Rao, R. R., Araki, K., Pollizzi, K. N., Odunsi, K. O., Powell, J. D., & Shrikant, P. A. (2011) · Immunity · doi:10.1016/j.immuni.2011.04.006 · Cited by 166

Graphene‒Regulated Cardiomyogenic Differentiation Process of Mesenchymal Stem Cells by Enhancing the Expression of Extracellular Matrix Proteins and Cell Signaling Molecules

Park, J., Park, S., Ryu, S., Bhang, S. H., Kim, J., Yoon, J., Park, Y. H., Cho, S., Lee, S., Hong, B. H., et al. (2013) · Advanced Healthcare Materials · doi:10.1002/adhm.201300177 · Cited by 160

Molecular evidences for the chemosensitizing efficacy of liposomal curcumin in paclitaxel chemotherapy in mouse models of cervical cancer

Sreekanth, C. N., Bava, S. V., Sreekumar, E., & Anto, R. J. (2011) · Oncogene · doi:10.1038/onc.2011.23 · Cited by 160

Lengthened G1 Phase Indicates Differentiation Status in Human Embryonic Stem Cells

Calder, A. N., Roth-Albin, I., Bhatia, S., Pilquil, C., Lee, J., Bhatia, M., Levadoux‐Martin, M., McNicol, J. D., Russell, J., Collins, T., et al. (2012) · Stem Cells and Development · doi:10.1089/scd.2012.0168 · Cited by 160

Widespread changes in transcriptome profile of human mesenchymal stem cells induced by two-dimensional nanosilicates

Carrow, J. K., Cross, L., Reese, R. W., Jaiswal, M. K., Gregory, C. A., Kaunas, R. R., Singh, I., & Gaharwar, A. K. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1716164115 · Cited by 160

Management of breast cancer with targeted agents: importance of heterogenicity

Cosimo, S. D., & Baselga, J. M. (2010) · Nature Reviews Clinical Oncology · doi:10.1038/nrclinonc.2009.234 · Cited by 159

Status of PI3K inhibition and biomarker development in cancer therapeutics

Markman, B., Atzori, F., Pérez-García, J. M., Tabernero, J. M., & Baselga, J. M. (2009) · Annals of Oncology · doi:10.1093/annonc/mdp347 · Cited by 160

Resveratrol and breast cancer chemoprevention: Molecular mechanisms

Corre, L. L., Chalabi, N., Delort, L., Bignon, Y., & Bernard-Gallon, D. J. (2005) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.200400094 · Cited by 162

The NHE1 Na+/H+ Exchanger Recruits Ezrin/Radixin/Moesin Proteins to Regulate Akt-dependent Cell Survival

Wu, K. L., Khan, S., Lakhe-Reddy, S., Jarad, G., Mukherjee, A., Obejero‐Paz, C. A., Konieczkowski, M., Sedor, J. R., & Schelling, J. R. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m400814200 · Cited by 160

The balance between IL-17 and IL-22 produced by liver-infiltrating T-helper cells critically controls NASH development in mice

Rolla, S., Alchera, E., Imarisio, C., Bardina, V., Valente, G., Cappello, P., Mombello, C., Follenzi, A., Novelli, F., & Carini, R. (2016) · Clinical Science · doi:10.1042/cs20150405 · Cited by 158

Endocytic Mechanisms of Graphene Oxide Nanosheets in Osteoblasts, Hepatocytes and Macrophages

Linares, J., Matesanz, M. C., Vila, M., Feito, M. J., Gonçalves, G., Vallet‐Regí, M., Marques, P. A. A. P., & Portolés, M. T. (2014) · ACS Applied Materials & Interfaces · doi:10.1021/am5031598 · Cited by 158

PIP3 controls synaptic function by maintaining AMPA receptor clustering at the postsynaptic membrane

Arendt, K. L., Royo, M., Fernández‐Monreal, M., Knafo, S., Petrok, C. N., Martens, J. R., & Esteban, J. A. (2009) · Nature Neuroscience · doi:10.1038/nn.2462 · Cited by 168

MicroRNA‐205 promotes keratinocyte migration via the lipid phosphatase SHIP2

Yu, J., Peng, H., Ruan, Q., Fatima, A., Getsios, S., & Lavker, R. M. (2010) · The FASEB Journal · doi:10.1096/fj.10-157404 · Cited by 164

Hydrogen sulfide and ischemia–reperfusion injury

Nicholson, C. K., & Calvert, J. W. (2010) · Pharmacological Research · doi:10.1016/j.phrs.2010.06.002 · Cited by 158

The role of PI3K/AKT/FOXO signaling in psoriasis

Zhang, M., & Zhang, X. (2018) · Archives of Dermatological Research · doi:10.1007/s00403-018-1879-8 · Cited by 159

Finding a better drug for epilepsy: The mTOR pathway as an antiepileptogenic target

Galanopoulou, A. S., Gorter, J. A., & Cepeda, C. (2012) · Epilepsia · doi:10.1111/j.1528-1167.2012.03506.x · Cited by 158

Protection against Myocardial Ischemia/Reperfusion Injury in TLR4-Deficient Mice Is Mediated through a Phosphoinositide 3-Kinase-Dependent Mechanism

Hua, F., Ha, T., Ma, J., Li, Y., Kelley, J., Gao, X., Browder, I. W., Kao, R. L., Williams, D. L., & Li, C. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.178.11.7317 · Cited by 158

Resveratrol Inhibits LPS-Induced MAPKs Activation via Activation of the Phosphatidylinositol 3-Kinase Pathway in Murine RAW 264.7 Macrophage Cells

Zong, Y., Sun, L., Liu, B., Deng, Y., Zhan, D., Chen, Y., He, Y., Liu, J., Zong-ji, Z., Sun, J., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0044107 · Cited by 163

Regulating the acrosome reaction

Florman, H. M., Jungnickel, M. K., & Sutton, K. A. (2008) · The International Journal of Developmental Biology · doi:10.1387/ijdb.082696hf · Cited by 157

Changes in adipose tissue gene expression with energy-restricted diets in obese women1–4,

Dahlman, I. A., Linder, K., Nordström, E. A., Andersson, I., Lidén, J., Verdich, C., Sørensen, T. I. A., & Arner, P. (2005) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/81.6.1275 · Cited by 158

Signaling Pathways in Leiomyoma: Understanding Pathobiology and Implications for Therapy

Borahay, M. A., Al-Hendy, A. A., Kilic, G. S., & Boehning, D. F. (2015) · Molecular Medicine · doi:10.2119/molmed.2014.00053 · Cited by 157

Adaptive and maladaptive hypertrophic pathways: points of convergence and divergence

Selvetella, G. (2004) · Cardiovascular Research · doi:10.1016/j.cardiores.2004.04.031 · Cited by 159

Transport of PIP3 by GAKIN, a kinesin-3 family protein, regulates neuronal cell polarity

Horiguchi, K., Hanada, T., Fukui, Y., & Chishti, A. H. (2006) · The Journal of Cell Biology · doi:10.1083/jcb.200604031 · Cited by 161

Regulation of autophagy by protein post-translational modification

Wani, W. Y., Boyer‐Guittaut, M., Dodson, M. B., Chatham, J. C., Darley-Usmar, V. M., & Zhang, J. (2014) · Laboratory Investigation · doi:10.1038/labinvest.2014.131 · Cited by 160

The PI3-K/AKT-Pathway and Radiation Resistance Mechanisms in Non-small Cell Lung Cancer

Schuurbiers, O. C. J., Kaanders, J. H. A. M., van der Heijden, E. H. F. M., Dekhuijzen, R. P. N., Oyen, W. J. G., & Bussink, J. (2009) · Journal of Thoracic Oncology · doi:10.1097/jto.0b013e3181a1084f · Cited by 160

Functions of lipoprotein receptors in neurons

Beffert, U., Stolt-Bergner, P. C., & Herz, J. (2004) · Journal of Lipid Research · doi:10.1194/jlr.r300017-jlr200 · Cited by 164

Vitamin D Inhibits COX-2 Expression and Inflammatory Response by Targeting Thioesterase Superfamily Member 4

Wang, Q., He, Y., Shen, Y., Zhang, Q., Chen, C., Zuo, C., Qin, J., Wang, H., Wang, J., & Yu, Y. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.517581 · Cited by 158

Phosphatidylinositol 3-Kinase Is a Key Mediator of Central Sensitization in Painful Inflammatory Conditions

Pezet, S., Marchand, F., D’Mello, R., Grist, J., Clark, A. K., Malcangio, M., Dickenson, A. H., Williams, R. J., & McMahon, S. B. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.5392-07.2008 · Cited by 156

Hydrogels preserve native phenotypes of valvular fibroblasts through an elasticity-regulated PI3K/AKT pathway

Wang, H., Tibbitt, M. W., Langer, S. J., Leinwand, L. A., & Anseth, K. S. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1306369110 · Cited by 159

The phosphatidylinositol-3-kinase inhibitor PX-866 overcomes resistance to the epidermal growth factor receptor inhibitor gefitinib in A-549 human non–small cell lung cancer xenografts

Ihle, N. T., Paine-Murrieta, G. D., Berggren, M. I., Baker, A. F., Tate, W. R., Wipf, P., Abraham, R. T., Kirkpatrick, D. L., & Powis, G. (2005) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-05-0149 · Cited by 154

A selective inhibitor of the p110δ isoform of PI 3-kinase inhibits AML cell proliferation and survival and increases the cytotoxic effects of VP16

Billottet, C., Grandage, V., Gale, R. E., Quattropani, A., Rommel, C., Vanhaesebroeck, B., & Khwaja, A. (2006) · Oncogene · doi:10.1038/sj.onc.1209670 · Cited by 155

Reactive oxygen species regulation of autophagy in cancer: Implications for cancer treatment

Li, L., Ishdorj, G., & Gibson, S. B. (2012) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2012.07.011 · Cited by 154

Proline-rich Akt substrate of 40 kDa (PRAS40): A novel downstream target of PI3k/Akt signaling pathway

Wang, H., Zhang, Q., Wen, Q. J., Zheng, Y., Lazarovici, P., Jiang, H., Lin, J., & Zheng, W. (2011) · Cellular Signalling · doi:10.1016/j.cellsig.2011.08.010 · Cited by 156

PIK3CA mutations in breast cancer: reconciling findings from preclinical and clinical data

Zardavas, D., Phillips, W. A., & Loi, S. (2014) · Breast Cancer Research · doi:10.1186/bcr3605 · Cited by 161

Discovery of a Selective Phosphoinositide-3-Kinase (PI3K)-γ Inhibitor (IPI-549) as an Immuno-Oncology Clinical Candidate

Evans, C. A., Liu, T., Lescarbeau, A., Nair, S. J., Grenier, L., Pradeilles, J. A., Glenadel, Q., Tibbitts, T. T., Rowley, A. M., DiNitto, J. P., et al. (2016) · ACS Medicinal Chemistry Letters · doi:10.1021/acsmedchemlett.6b00238 · Cited by 153

Key signaling pathways in thyroid cancer

Zaballos, M. A., & Santisteban, P. (2017) · Journal of Endocrinology · doi:10.1530/joe-17-0266 · Cited by 153

Biomechanics and mechanical signaling in the ovary: a systematic review

Shah, J. S., Sabouni, R., Vaught, K. C. C., Owen, C. M., Albertini, D. F., & Segars, J. H. (2018) · Journal of Assisted Reproduction and Genetics · doi:10.1007/s10815-018-1180-y · Cited by 157

AKT methylation by SETDB1 promotes AKT kinase activity and oncogenic functions

Guo, J., Dai, X., Laurent, B., Zheng, N., Gan, W., Zhang, J., Guo, A., Yuan, M., Liu, P., Asara, J. M., et al. (2019) · Nature Cell Biology · doi:10.1038/s41556-018-0261-6 · Cited by 156

Host Lipids in Positive-Strand RNA Virus Genome Replication

Zhang, Z., He, G., Filipowicz, N., Randall, G. C., Belov, G. A., Kopek, B. G., & Wang, X. (2019) · Frontiers in Microbiology · doi:10.3389/fmicb.2019.00286 · Cited by 159

Kaposi's Sarcoma-Associated Herpesvirus/Human Herpesvirus 8 Envelope Glycoprotein gB Induces the Integrin-Dependent Focal Adhesion Kinase-Src-Phosphatidylinositol 3-Kinase-Rho GTPase Signal Pathways and Cytoskeletal Rearrangements

Sharma-Walia, N., Naranatt, P. P., Krishnan, H. H., Zeng, L., & Chandran, B. (2004) · Journal of Virology · doi:10.1128/jvi.78.8.4207-4223.2004 · Cited by 153

mTOR regulates cell survival after etoposide treatment in primary AML cells

Xu, Q., Thompson, J. E., & Carroll, M. P. (2005) · Blood · doi:10.1182/blood-2004-11-4468 · Cited by 153

Phase I Safety, Pharmacokinetic, and Pharmacodynamic Study of SAR245408 (XL147), an Oral Pan-Class I PI3K Inhibitor, in Patients with Advanced Solid Tumors

Shapiro, G. I., Rodon, J., Bedell, C., Kwak, E. L., Baselga, J., Braña, I., Pandya, S. S., Scheffold, C., Laird, A. D., Nguyen, L. T., et al. (2014) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-13-1777 · Cited by 152

Plumbagin induces apoptotic and autophagic cell death through inhibition of the PI3K/Akt/mTOR pathway in human non-small cell lung cancer cells

Li, Y.-C., He, S.-M., He, Z.-X., Li, M., Yang, Y., Jian-xin, P., Zhang, X., Chow, K., Zhou, Q. S., Duan, W., et al. (2013) · Cancer Letters · doi:10.1016/j.canlet.2013.11.001 · Cited by 152

Regulation and cellular functions of class II phosphoinositide 3-kinases

Falasca, M., & Maffucci, T. (2012) · Biochemical Journal · doi:10.1042/bj20120008 · Cited by 158

Membrane and juxtamembrane targeting by PH and PTB domains

DiNitto, J. P., & Lambright, D. G. (2006) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2006.04.008 · Cited by 154

Diphenyl Difluoroketone: A Curcumin Derivative with Potent In vivo Anticancer Activity

Subramaniam, D., May, R. J., Sureban, S. M., Lee, K. B., George, R., Kuppusamy, P., Ramanujam, R. P., Hideg, K., Dieckgraefe, B. K., Houchen, C. W., et al. (2008) · Cancer Research · doi:10.1158/0008-5472.can-07-6011 · Cited by 151

Cyclooxygenase-2 Inhibitor Induces Apoptosis in Breast Cancer Cells in an In vivo Model of Spontaneous Metastatic Breast Cancer

Basu, G. D., Pathangey, L. B., Tinder, T. L., LaGioia, M., Gendler, S. J., & Mukherjee, P. (2004) · Molecular Cancer Research · doi:10.1158/1541-7786.632.2.11 · Cited by 151

Estrogen Receptors and Signaling in Fibroids: Role in Pathobiology and Therapeutic Implications

Borahay, M. A., Asoğlu, M. R., Mas, A., Adam, S., Kilic, G. S., & Al-Hendy, A. A. (2016) · Reproductive Sciences · doi:10.1177/1933719116678686 · Cited by 151

DNA microarray analysis of gene expression in eutopic endometrium from patients with deep endometriosis using laser capture microdissection

Matsuzaki, S., Canis, M. J., Vaurs‐Barrière, C., Boespflug‐Tanguy, O., Dastugue, B., & Mage, G. (2005) · Fertility and Sterility · doi:10.1016/j.fertnstert.2005.04.041 · Cited by 151

Stimulation of phosphoinositide 3-kinase/Akt signaling by copper and zinc ions: Mechanisms and consequences

Barthel, A., Ostrakhovitch, E. A., Walter, P. L., Kampkötter, A., & Klotz, L. (2007) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2007.04.015 · Cited by 152

Sodium-dependent bile salt transporters of the SLC10A transporter family: more than solute transporters

Anwer, M. S., & Stieger, B. (2013) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-013-1367-0 · Cited by 156

Resveratrol modulates the phosphoinositide 3‐kinase pathway through an estrogen receptor α‐dependent mechanism: Relevance in cell proliferation

Pozo‐Guisado, E., Lorenzo‐Benayas, M. J., & Fernández‐Salguero, P. M. (2003) · International Journal of Cancer · doi:10.1002/ijc.11720 · Cited by 150

Mammalian Target of Rapamycin Complex 2 (mTORC2) Negatively Regulates Toll-like Receptor 4-mediated Inflammatory Response via FoxO1

Brown, J. R., Wang, H., Suttles, J., Graves, D. T., & Martin, M. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.258053 · Cited by 154

Membrane targeting and activation of the Lowe syndrome protein OCRL1 by rab GTPases

Hyvola, N., Diao, A., McKenzie, E., Skippen, A. J., Cockcroft, S., & Lowe, M. (2006) · The EMBO Journal · doi:10.1038/sj.emboj.7601274 · Cited by 150

Downregulation of miR-133a-3p promotes prostate cancer bone metastasis via activating PI3K/AKT signaling

Tang, Y., Pan, J., Huang, S., Peng, X., Zou, X., Luo, Y., Ren, D., Zhang, X., Li, R., He, P., et al. (2018) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-018-0813-4 · Cited by 150

Peroxidase Activity of Human Hemoproteins: Keeping the Fire under Control

Vlasova, I. I. (2018) · Molecules · doi:10.3390/molecules23102561 · Cited by 150

Punicalagin Induces Nrf2/HO‐1 Expression via Upregulation of PI3K/AKT Pathway and Inhibits LPS‐Induced Oxidative Stress in RAW264.7 Macrophages

Xu, X., Li, H., Hou, X., Li, D., He, S., Wan, C., Yin, P., Liu, M., Liu, F., & Xu, J. (2015) · Mediators of Inflammation · doi:10.1155/2015/380218 · Cited by 149

Statins Prevent Oxidized LDL-Induced Injury of Glomerular Podocytes by Activating the Phosphatidylinositol 3-Kinase/AKT-Signaling Pathway

Bussolati, B., Deregibus, M. C., Fonsato, V., Doublier, S., Spatola, T., Procida, S., Carlo, F. D., & Camussi, G. (2005) · Journal of the American Society of Nephrology · doi:10.1681/asn.2004080629 · Cited by 149

Small Molecules Drive Big Improvements in Immuno‐Oncology Therapies

Huck, B. R., Kötzner, L., & Urbahns, K. (2017) · Angewandte Chemie International Edition · doi:10.1002/anie.201707816 · Cited by 154

MODULATION OF THE PHOSPHOINOSITIDE 3-KINASE SIGNALING PATHWAY ALTERS HOST RESPONSE TO SEPSIS, INFLAMMATION, AND ISCHEMIA/REPERFUSION INJURY

Williams, D. L., Ozment-Skelton, T. R., & Li, C. (2006) · Shock · doi:10.1097/01.shk.0000209542.76305.55 · Cited by 148

The insulin-like growth factor-I receptor as a target for cancer therapy

Baserga, R. (2005) · Expert Opinion on Therapeutic Targets · doi:10.1517/14728222.9.4.753 · Cited by 148

FoxO Transcription Factors Promote AKT Ser473 Phosphorylation and Renal Tumor Growth in Response to Pharmacologic Inhibition of the PI3K–AKT Pathway

Lin, A., Piao, H.-L., Li, Z., Sarbassov, D. D., Ma, L., & Gan, B. (2014) · Cancer Research · doi:10.1158/0008-5472.can-13-1729 · Cited by 152

Loss of insulin-induced activation of TRPM6 magnesium channels results in impaired glucose tolerance during pregnancy

Nair, A. V., Hocher, B., Verkaart, S., van Zeeland, F., Pfab, T., Slowinski, T., Chen, Y., Schlingmann, K. P., Schaller, A., Gallati, S., et al. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1113811109 · Cited by 148

Kinase and Histone Deacetylase Hybrid Inhibitors for Cancer Therapy

Luan, Y., Li, J., Bernatchez, J. A., & Li, R. (2018) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.8b00189 · Cited by 148

Research Progress on Structure and Function of PI3K

Li, X. (2013) · Journal of Chengdu University

Phosphoinositide 3-Kinase signaling pathway: the key to cell proliferation and death

Peacock, J. G. (2007) · PubMed Central

Phosphatidylinositol-4,5-bisphosphate 3-kinase family in GtoPdb v.2023.1

Uddin, M. (2023) · IUPHAR/BPS Guide to Pharmacology CITE · doi:10.2218/gtopdb/f673/2023.1

Phosphoinositide 3-kinase: A new effector in signal transduction?

Downes, C. P., & Carter, A. N. (1991) · Cellular Signalling · doi:10.1016/0898-6568(91)90027-r · Cited by 160

Protein Kinases as Mediators of Phosphoinositide 3-Kinase Signaling

Toker, A. (2000) · Molecular Pharmacology · doi:10.1124/mol.57.4.652 · Cited by 302