The Phosphoinositide 3-Kinase Pathway

PHOSPHOINOSITIDE KINASES

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PKB/Akt

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Regulation of C. elegans Life-Span by Insulinlike Signaling in the Nervous System

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PTEN: a tumour suppressor that functions as a phospholipid phosphatase

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Constitutive and inducible Akt activity promotes resistance to chemotherapy, trastuzumab, or tamoxifen in breast cancer cells.

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The lipid phosphatase SHIP2 controls insulin sensitivity

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Metabolic Reprogramming by the PI3K-Akt-mTOR Pathway in Cancer

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PtdIns(5)P activates the host cell PI3‐kinase/Akt pathway during Shigella flexneri infection

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PI3K/AKT/mTOR signaling pathway: an important driver and therapeutic target in triple-negative breast cancer

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Oxytocin revisited: Its role in cardiovascular regulation

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Platelet receptor signaling in thrombus formation

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PIM kinase (and Akt) biology and signaling in tumors

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Role of epithelial-mesenchymal transition in gastric cancer initiation and progression

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Molecular mechanisms underlying IGF‐I‐induced attenuation of the growth‐inhibitory activity of trastuzumab (Herceptin) on SKBR3 breast cancer cells

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Oncogenic PIK3CA mutations occur in epidermal nevi and seborrheic keratoses with a characteristic mutation pattern

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Involvement of Ras Activation in Human Breast Cancer Cell Signaling, Invasion, and Anoikis

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Putting the Rap on Akt

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The Monoclonal Antibody nBT062 Conjugated to Cytotoxic Maytansinoids Has Selective Cytotoxicity Against CD138-Positive Multiple Myeloma Cells In vitro and In vivo

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Advances in human primordial follicle activation and premature ovarian insufficiency

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Knockdown of STAT3 Expression by RNA Interference Inhibits the Induction of Breast Tumors in Immunocompetent Mice

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PINCH-1 Is an Obligate Partner of Integrin-linked Kinase (ILK) Functioning in Cell Shape Modulation, Motility, and Survival

Fukuda, T., Chen, K., Shi, X., & Wu, C. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m309122200 · Cited by 202

Mechanisms regulating GLUT4 glucose transporter expression and glucose transport in skeletal muscle

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The Signaling Pathways Involved in Ovarian Follicle Development

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The multifaceted roles of the receptor tyrosine kinase ROS in development and cancer

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Mechanisms and implications of phosphoinositide 3-kinase δ in promoting neutrophil trafficking into inflamed tissue

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A Polybasic Motif Allows N-WASP to Act as a Sensor of PIP2 Density

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Activation of Toll-like receptor 4 signaling contributes to hippocampal neuronal death following global cerebral ischemia/reperfusion

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EphA2 receptor tyrosine kinase regulates endothelial cell migration and vascular assembly through phosphoinositide 3-kinase-mediated Rac1 GTPase activation

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Mitofusin 2 Triggers Vascular Smooth Muscle Cell Apoptosis via Mitochondrial Death Pathway

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Mechanism of resistance to endocrine therapy in breast cancer: the important role of PI3K/Akt/mTOR in estrogen receptor-positive, HER2-negative breast cancer

Araki, K., & Miyoshi, Y. (2017) · Breast Cancer · doi:10.1007/s12282-017-0812-x · Cited by 201

Carbon monoxide differentially modulates STAT1 and STAT3 and inhibits apoptosis via a phosphatidylinositol 3-kinase/Akt and p38 kinase-dependent STAT3 pathway during anoxia-reoxygenation injury

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Flavivirus Activates Phosphatidylinositol 3-Kinase Signaling To Block Caspase-Dependent Apoptotic Cell Death at the Early Stage of Virus Infection

Lee, C.-J., Liao, C., & Lin, Y. (2005) · Journal of Virology · doi:10.1128/jvi.79.13.8388-8399.2005 · Cited by 200

Class I A Phosphoinositide 3-Kinase Regulates Heart Size and Physiological Cardiac Hypertrophy

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Synthesis and biological evaluation of 4-morpholino-2-phenylquinazolines and related derivatives as novel PI3 kinase p110α inhibitors

Hayakawa, M., Kaizawa, H., Moritomo, H., Koizumi, T., Ohishi, T., Okada, M., Ohta, M., Tsukamoto, S., Parker, P. J., Workman, P., et al. (2006) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2006.06.046 · Cited by 197

The Akt of translational control

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Depletion of a Putatively Druggable Class of Phosphatidylinositol Kinases Inhibits Growth of p53-Null Tumors

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Cancer cachexia prevention via physical exercise: molecular mechanisms

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Tyrosine kinase receptors as attractive targets of cancer therapy

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Role of the phosphoinositide 3-kinase-Akt-mammalian target of the rapamycin signaling pathway in long-term potentiation and trace fear conditioning memory in rat medial prefrontal cortexPreprint

Sui, L., Wang, J., & Li, B.-M. (2008) · Learning & Memory · doi:10.1101/lm.1067808 · Cited by 195

Akt-mediated phosphorylation of CDK2 regulates its dual role in cell cycle progression and apoptosis

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The Importance of the PI3K/AKT/MTOR Pathway in the Progression of Ovarian Cancer

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Kinase signalling pathways in endometriosis: potential targets for non-hormonal therapeutics

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Regulation of mRNA Translation by Signaling PathwaysPreprint

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Cooperative Activation of PI3K by Ras and Rho Family Small GTPases

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The Role of STAT3 in Non-Small Cell Lung Cancer

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The Regulation of Ovarian Granulosa Cell Death by Pro- and Anti-apoptotic Molecules

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Perturbation Biology: Inferring Signaling Networks in Cellular Systems

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Mutations in Phosphoinositide Metabolizing Enzymes and Human Disease

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Nephrin mediates actin reorganization via phosphoinositide 3-kinase in podocytes

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Leptin signaling and circuits in puberty and fertility

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Sox9 sustains chondrocyte survival and hypertrophy in part through Pik3ca-Akt pathways

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The Efficacy of the Novel Dual PI3-Kinase/mTOR Inhibitor NVP-BEZ235 Compared with Rapamycin in Renal Cell Carcinoma

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Hepatocyte Growth Factor-induced Ras Activation Requires ERM Proteins Linked to Both CD44v6 and F-Actin

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The p110δ isoform of the kinase PI(3)K controls the subcellular compartmentalization of TLR4 signaling and protects from endotoxic shock

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Insulin Hypersensitivity and Resistance to Streptozotocin-Induced Diabetes in Mice Lacking PTEN in Adipose Tissue

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Integrin traffic

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LKB1, a protein kinase regulating cell proliferation and polarity

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PI3K/p110δ is a novel therapeutic target in multiple myeloma

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Effect of nano-structured bioceramic surface on osteogenic differentiation of adipose derived stem cells

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Crosstalk Between Epidermal Growth Factor Receptor- and Insulin-Like Growth Factor-1 Receptor Signaling: Implications for Cancer Therapy

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Epidermal growth factor receptor

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Inositol Pyrophosphates Mediate Chemotaxis in Dictyostelium via Pleckstrin Homology Domain-PtdIns(3,4,5)P3 Interactions

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TGF-β: the connecting link between nephropathy and fibrosis

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The role of electrostatics in protein–membrane interactions

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SETDB1-mediated methylation of Akt promotes its K63-linked ubiquitination and activation leading to tumorigenesis

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Estrogen Receptor (ER)α and ERβ Are Both Expressed in Human Ejaculated Spermatozoa: Evidence of Their Direct Interaction with Phosphatidylinositol-3-OH Kinase/Akt Pathway

Aquila, S., Sisci, D., Gentile, M., Middea, E., Catalano, S., Carpino, A., Rago, V., & Andò, S. (2004) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2003-031681 · Cited by 184

Ethnic Differences and Functional Analysis of MET Mutations in Lung Cancer

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The critical role of AMPK in driving Akt activation under stress, tumorigenesis and drug resistance

Han, F., Li, C., Cai, Z., Zhang, X., Jin, G., Zhang, W.-N., Xu, C. S., Wang, C., Morrow, J. K., Zhang, S., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-07188-9 · Cited by 189

Mesenchymal stem cells as a double-edged sword in tumor growth: focusing on MSC-derived cytokines

Liang, W., Chen, X., Zhang, S., Fang, J., Chen, M., Xu, Y., & Chen, X. (2021) · Cellular & Molecular Biology Letters · doi:10.1186/s11658-020-00246-5 · Cited by 192

The ubiquitin ligase Nedd4-1 is dispensable for the regulation of PTEN stability and localization

Fouladkou, F., Landry, T., Kawabe, H., Neeb, A., Chen, L., Brose, N., Stambolic, V., & Rotin, D. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0803233105 · Cited by 189

PHLiPPing the switch on Akt and protein kinase C signaling

Brognard, J., & Newton, A. C. (2008) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2008.04.001 · Cited by 186

Conserved insulin signaling in the regulation of oocyte growth, development, and maturation

Das, D., & Arur, S. (2017) · Molecular Reproduction and Development · doi:10.1002/mrd.22806 · Cited by 183

Pioglitazone Prevents Hypertension and Reduces Oxidative Stress in Diet-Induced Obesity

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Discovery of 2-{3-[2-(1-Isopropyl-3-methyl-1H-1,2–4-triazol-5-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepin-9-yl]-1H-pyrazol-1-yl}-2-methylpropanamide (GDC-0032): A β-Sparing Phosphoinositide 3-Kinase Inhibitor with High Unbound Exposure and Robust in Vivo Antitumor Activity

Ndubaku, C. O., Heffron, T. P., Staben, S. T., Baumgardner, M., Blaquière, N., Bradley, E. K., Bull, R., Do, S., Dotson, J., Dudley, D. A., et al. (2013) · Journal of Medicinal Chemistry · doi:10.1021/jm4003632 · Cited by 182

Regulation of Autophagy by Kinases

Sridharan, S., Jain, K., & Basu, A. (2011) · Cancers · doi:10.3390/cancers3022630 · Cited by 189

PI3K and Akt as molecular targets for cancer therapy: current clinical outcomes

Pal, I., & Mandal, M. (2012) · Acta Pharmacologica Sinica · doi:10.1038/aps.2012.72 · Cited by 183

The Biology Behind mTOR Inhibition in Sarcoma

Wan, X., & Helman, L. J. (2007) · The Oncologist · doi:10.1634/theoncologist.12-8-1007 · Cited by 181

Endocrine Protection of Ischemic Myocardium by FGF21 from the Liver and Adipose Tissue

Liu, S. Q., Roberts, D., Kharitonenkov, A., Zhang, B., Hanson, S., Li, Y. C., Zhang, L., & Wu, Y. (2013) · Scientific Reports · doi:10.1038/srep02767 · Cited by 179

Signaling inputs to invadopodia and podosomes

Hoshino, D., Branch, K. M., & Weaver, A. M. (2013) · Journal of Cell Science · doi:10.1242/jcs.079475 · Cited by 188

EGF Increases TRPM6 Activity and Surface Expression

Thébault, S. C., Alexander, R. T., Groenestege, W. M. T., Hoenderop, J. G. J., & Bindels, R. A. A. J. (2008) · Journal of the American Society of Nephrology · doi:10.1681/asn.2008030327 · Cited by 178

PTEN-opathies: from biological insights to evidence-based precision medicine

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Vascular integrins: pleiotropic adhesion and signaling molecules in vascular homeostasis and angiogenesis

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Androgen Receptor Mediates Non-genomic Activation of Phosphatidylinositol 3-OH Kinase in Androgen-sensitive Epithelial Cells

Baron, S., Manin, M., Beaudoin, C., Léotoing, L., Communal, Y., VEYSSIERE, G., & Morel, L. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m306143200 · Cited by 178

Strategies for co-targeting the PI3K/AKT/mTOR pathway in NSCLC

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Akt2 overexpression plays a critical role in the establishment of colorectal cancer metastasis

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Constitutive activation of phosphatidyl‐inositide 3 kinase contributes to the survival of Hodgkin's lymphoma cells through a mechanism involving Akt kinase and mTOR

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The FoxO transcription factors and metabolic regulation

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Both PI3K/Akt and ERK1/2 pathways participate in the protection by dexmedetomidine against transient focal cerebral ischemia/reperfusion injury in rats

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Cardioprotection induced by hydrogen sulfide preconditioning involves activation of ERK and PI3K/Akt pathways

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