The Phosphoinositide 3-Kinase Pathway

PHOSPHOINOSITIDE KINASES

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PKB/Akt

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Regulation of C. elegans Life-Span by Insulinlike Signaling in the Nervous System

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PTEN: a tumour suppressor that functions as a phospholipid phosphatase

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Constitutive and inducible Akt activity promotes resistance to chemotherapy, trastuzumab, or tamoxifen in breast cancer cells.

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The lipid phosphatase SHIP2 controls insulin sensitivity

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Activation of Mammalian Target of Rapamycin Signaling Promotes Cell Cycle Progression and Protects Cells from Apoptosis in Mantle Cell Lymphoma

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Uncoupling insulin signalling by serine/threonine phosphorylation: a molecular basis for insulin resistance

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Four MicroRNAs Promote Prostate Cell Proliferation with Regulation of PTEN and Its Downstream Signals In Vitro

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Gastrodin attenuation of the inflammatory response in H9c2 cardiomyocytes involves inhibition of NF-κB and MAPKs activation via the phosphatidylinositol 3-kinase signaling

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Toll-Like Receptors: New Players in Myocardial Ischemia/Reperfusion Injury

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NF-κB/STAT3/PI3K signaling crosstalk in iMycEμ B lymphoma

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Fucoxanthin Activates Apoptosis via Inhibition of PI3K/Akt/mTOR Pathway and Suppresses Invasion and Migration by Restriction of p38-MMP-2/9 Pathway in Human Glioblastoma Cells

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Targeting vascular endothelial growth receptor-2 (VEGFR-2): structural biology, functional insights, and therapeutic resistance

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Mechanisms of Disease: the PI3K–Akt–PTEN signaling node—an intercept point for the control of angiogenesis in brain tumors

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Nongenomic Androgen Activation of Phosphatidylinositol 3-Kinase/Akt Signaling Pathway in MC3T3-E1 Osteoblasts

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Endothelial cell integrins and COX-2: mediators and therapeutic targets of tumor angiogenesis

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Guanosine protects human neuroblastoma SH-SY5Y cells against mitochondrial oxidative stress by inducing heme oxigenase-1 via PI3K/Akt/GSK-3β pathway

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PI3K inhibitor LY294002, as opposed to wortmannin, enhances AKT phosphorylation in gemcitabine-resistant pancreatic cancer cells

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PtdIns(3,4,5)P3 Regulates Spindle Orientation in Adherent Cells

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PI3K activation by IGF-1 is essential for the regulation of membrane expansion at the nerve growth cone

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Melatonin attenuates sepsis-induced cardiac dysfunction via a PI3K/Akt-dependent mechanism

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PI3K/Akt/mTOR: A promising therapeutic target for non-medullary thyroid carcinoma

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Maternal and postweaning diet interaction alters hypothalamic gene expression and modulates response to a high-fat diet in male offspring

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Negative regulation of TLR signaling in myeloid cells—implications for autoimmune diseases

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The Roles of MicroRNA-141 in Human Cancers: From Diagnosis to Treatment

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Intimate connections: Inositol pyrophosphates at the interface of metabolic regulation and cell signaling

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PI3K signalling in the ventromedial hypothalamic nucleus is required for normal energy homeostasis

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Activation of IGF1R/p110β/AKT/mTOR confers resistance to α-specific PI3K inhibition

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Role of class II phosphoinositide 3-kinase in cell signalling

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An anti-inflammatory role for a phosphoinositide 3-kinase inhibitor LY294002 in a mouse asthma model

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Disulfiram Treatment Facilitates Phosphoinositide 3-Kinase Inhibition in Human Breast Cancer Cells In vitro and In vivo

Zhang, H., Chen, D., Ringler, J., Chen, W., Cui, Q. C., Ethier, S. P., Dou, Q. P., & Wu, G. (2010) · Cancer Research · doi:10.1158/0008-5472.can-09-3752 · Cited by 111

Deletion of the PDGFR-β Gene Affects Key Fibroblast Functions Important for Wound Healing

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The p85α Subunit of Phosphatidylinositol 3′-Kinase Binds to and Stimulates the GTPase Activity of Rab Proteins

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Essential role of PI3Kδ and PI3Kγ in thymocyte survival

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The Role of Signaling Pathways in Cervical Cancer and Molecular Therapeutic Targets

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Resolvins: Natural agonists for resolution of pulmonary inflammation

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Resveratrol inhibits high glucose-induced PI3K/Akt/ERK-dependent interleukin-17 expression in primary mouse cardiac fibroblasts

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TLR2 ligands induce cardioprotection against ischaemia/reperfusion injury through a PI3K/Akt-dependent mechanism

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The CXCR4 inhibitor BL-8040 induces the apoptosis of AML blasts by downregulating ERK, BCL-2, MCL-1 and cyclin-D1 via altered miR-15a/16-1 expression.

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Vascular smooth muscle cell proliferation as a therapeutic target. Part 1: molecular targets and pathways

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Decorin Suppresses Prostate Tumor Growth through Inhibition of Epidermal Growth Factor and Androgen Receptor Pathways

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Important Therapeutic Targets in Chronic Myelogenous Leukemia

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First-in-Human Phase I Study of GSK2126458, an Oral Pan-Class I Phosphatidylinositol-3-Kinase Inhibitor, in Patients with Advanced Solid Tumor Malignancies

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The guggul for chronic diseases: ancient medicine, modern targets.

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Gain of Interaction with IRS1 by p110α-Helical Domain Mutants Is Crucial for Their Oncogenic Functions

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Dynamics of the Phosphoinositide 3-Kinase p110δ Interaction with p85α and Membranes Reveals Aspects of Regulation Distinct from p110α

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Autophagic pathways as new targets for cancer drug development

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Moving towards personalised therapy in patients with hepatocellular carcinoma: the role of the microenvironment

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PTEN mediates Notch-dependent stalk cell arrest in angiogenesis

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Swimming exercise training-induced left ventricular hypertrophy involves microRNAs and synergistic regulation of the PI3K/AKT/mTOR signaling pathway

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Role of GSK3 Signaling in Neuronal Morphogenesis

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Neuroprotective Role of a Proline-Rich Akt Substrate in Apoptotic Neuronal Cell Death after Stroke: Relationships with Nerve Growth Factor

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Plant flavonoid apigenin inactivates Akt to trigger apoptosis in human prostate cancer: an in vitro and in vivo study

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Dihydrotestosterone Differentially Modulates the Mitogen-Activated Protein Kinase and the Phosphoinositide 3-Kinase/Akt Pathways through the Nuclear and Novel Membrane Androgen Receptor in C6 Cells

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Kinases as therapeutic targets for heart failure

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K63-Linked Ubiquitination in Kinase Activation and Cancer

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α-Lipoic acid inhibits liver fibrosis through the attenuation of ROS-triggered signaling in hepatic stellate cells activated by PDGF and TGF-β

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Protective effects of a green tea polyphenol, epigallocatechin-3-gallate, against sevoflurane-induced neuronal apoptosis involve regulation of CREB/BDNF/TrkB and PI3K/Akt/mTOR signalling pathways in neonatal mice

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RIPK3 promotes kidney fibrosis via AKT-dependent ATP citrate lyase

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Notch-1-PTEN-ERK1/2 signaling axis promotes HER2+ breast cancer cell proliferation and stem cell survival

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Pharmacological Inhibition of mTORC1 Prevents Over-Activation of the Primordial Follicle Pool in Response to Elevated PI3K Signaling

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The phosphatidylinositol‐3 kinase pathway regulates bladder cancer cell invasion

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Graded Mitogen-Activated Protein Kinase Activity Precedes Switch-Like c-Fos Induction in Mammalian Cells

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The roles of PI3K/Akt signaling pathway in regulating MC3T3‐E1 preosteoblast proliferation and differentiation on SLA and SLActive titanium surfaces

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Hepatitis C virus infection and type 1 and type 2 diabetes mellitus

Antonelli, A. (2014) · World Journal of Diabetes · doi:10.4239/wjd.v5.i5.586 · Cited by 113

PI3K/Akt activation is critical for early hepatic regeneration after partial hepatectomy

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Human variability in innate immunity

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Phosphatidylinositol 3′-Kinase Catalytic Subunit α Gene Amplification Contributes to the Pathogenesis of Mantle Cell Lymphoma

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Synthesis and Biological Evaluation of Novel Analogues of the Pan Class I Phosphatidylinositol 3-Kinase (PI3K) Inhibitor 2-(Difluoromethyl)-1-[4,6-di(4-morpholinyl)-1,3,5-triazin-2-yl]-1 H -benzimidazole (ZSTK474)

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PDK1: The Major Transducer of PI 3-Kinase Actions

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Gene Expression Profiles of I3C- and DIM-Treated PC3 Human Prostate Cancer Cells Determined by cDNA Microarray Analysis

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Emerging anti-inflammatory strategies for COPD

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Death Receptor-Induced Activation of Initiator Caspase 8 Is Antagonized by Serine/Threonine Kinase PAK4

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Stat3-induced apoptosis requires a molecular switch in PI(3)K subunit composition

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The Rational Design of Selective Benzoxazepin Inhibitors of the α-Isoform of Phosphoinositide 3-Kinase Culminating in the Identification of ( S )-2-((2-(1-Isopropyl-1 H -1,2,4-triazol-5-yl)-5,6-dihydrobenzo[ f ]imidazo[1,2- d ][1,4]oxazepin-9-yl)oxy)propanamide (GDC-0326)

Heffron, T. P., Heald, R. A., Ndubaku, C. O., Wei, B. Q., Augistin, M., Do, S., Edgar, K. A., Eigenbrot, C. W., Friedman, L. S., Gancia, E., et al. (2016) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.5b01483 · Cited by 107

Regulation of Cancer Metabolism by Oncogenes and Tumor Suppressors

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The deubiquitinase Otub1 controls the activation of CD8+ T cells and NK cells by regulating IL-15-mediated priming

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Reactive oxygen species produced by altered tumor metabolism impacts cancer stem cell maintenance

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Advances in the use of exosomes for the treatment of ALI/ARDS

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MUC1 Oncoprotein Activates the FOXO3a Transcription Factor in a Survival Response to Oxidative Stress

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Fluoxetine and olanzapine have synergistic effects in the modulation of fibroblast growth factor 2 expression within the rat brain

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Akt regulates skeletal development through GSK3, mTOR, and FoxOs

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