The Phosphoinositide 3-Kinase Pathway

PHOSPHOINOSITIDE KINASES

Fruman, D. A., Meyers, R. E., & Cantley, L. C. (1998) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.67.1.481 · Cited by 1,382

Transcription-dependent and -independent control of neuronal survival by the PI3K–Akt signaling pathway

Brunet, A., Datta, S. R., & Greenberg, M. E. (2001) · Current Opinion in Neurobiology · doi:10.1016/s0959-4388(00)00211-7 · Cited by 1,208

PKB/Akt

Lawlor, M. A., & Alessi, D. R. (2001) · Journal of Cell Science · doi:10.1242/jcs.114.16.2903 · Cited by 1,068

Regulation of C. elegans Life-Span by Insulinlike Signaling in the Nervous System

Wolkow, C. A., Kimura, K. D., Lee, M. S., & Ruvkun, G. (2000) · Science · doi:10.1126/science.290.5489.147 · Cited by 681

PTEN: a tumour suppressor that functions as a phospholipid phosphatase

Maehama, T. (1999) · Trends in Cell Biology · doi:10.1016/s0962-8924(99)01519-6 · Cited by 599

Constitutive and inducible Akt activity promotes resistance to chemotherapy, trastuzumab, or tamoxifen in breast cancer cells.

Clark, A. S., West, K. A., Streicher, S. A., & Dennis, P. A. (2002) · PubMed · Cited by 589

The lipid phosphatase SHIP2 controls insulin sensitivity

Clément, S., Krause, U., Desmedt, F., Tanti, J., Behrends, J., Pesesse, X., Sasaki, T., Penninger, J. M., Doherty, M., Malaisse, W. J., et al. (2001) · Nature · doi:10.1038/35051094 · Cited by 377

Identification of CISK, a new member of the SGK kinase family that promotes IL-3-dependent survival

Liu, D., Xiao-hong, Y., & Songyang, Z. (2000) · Current Biology · doi:10.1016/s0960-9822(00)00733-8 · Cited by 135

Focal adhesion kinase signaling activities and their implications in the control of cell survival and motility

Hanks, S. K. (2003) · Frontiers in bioscience · doi:10.2741/1114 · Cited by 371

Restraining PI3K: mTOR signalling goes back to the membrane

Harrington, L. S., Findlay, G. M., & Lamb, R. F. (2004) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2004.11.003 · Cited by 369

Cell-free therapy based on adipose tissue stem cell-derived exosomes promotes wound healing via the PI3K/Akt signaling pathway

Zhang, W., Bai, X., Zhao, B., Li, Y., Zhang, Y., Li, Z., Wang, X., Luo, L., Han, F., Zhang, J., et al. (2018) · Experimental Cell Research · doi:10.1016/j.yexcr.2018.06.035 · Cited by 361

Identification of a Proline-rich Akt Substrate as a 14-3-3 Binding Partner

Kovacina, K. S., Park, G. Y., Bae, S. S., Guzzetta, A. W., Schaefer, E., Birnbaum, M. J., & Roth, R. A. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m210837200 · Cited by 374

Selective requirement of PI3K/PDK1 signaling for Kras oncogene-driven pancreatic cell plasticity and cancer

Eser, S., Reiff, N., Messer, M., Seidler, B., Gottschalk, K., Dobler, M., Hieber, M., Arbeiter, A., Klein, S., Kong, B., et al. (2013) · Cancer Cell · doi:10.1016/j.ccr.2013.01.023 · Cited by 360

Oncogenic EGFR Signaling Networks in Glioma

Huang, P. H., Xu, A. M., & White, F. M. (2009) · Science Signaling · doi:10.1126/scisignal.287re6 · Cited by 371

Ras Conformational Ensembles, Allostery, and Signaling

Lu, S., Jang, H., Muratcioglu, S., Gursoy, A., Keskin, O., Nussinov, R., & Zhang, J. (2016) · Chemical Reviews · doi:10.1021/acs.chemrev.5b00542 · Cited by 355

Non-Alcoholic Fatty Liver Disease and the Metabolic Syndrome

Najjar, S. M. (2010) · Springer eBooks · doi:10.1007/978-1-4419-1607-5_12 · Cited by 354

Targeting the PI3K/Akt/mTOR Pathway - Beyond Rapalogs

Markman, B., Dienstmann, R., & Tabernero, J. M. (2010) · Oncotarget · doi:10.18632/oncotarget.188 · Cited by 357

Activation of Akt signaling is sufficient to maintain pluripotency in mouse and primate embryonic stem cells

Watanabe, S., Umehara, H., Murayama, K., Okabe, M., Kimura, T., & Nakano, T. (2005) · Oncogene · doi:10.1038/sj.onc.1209307 · Cited by 357

The regulation of cell motility and chemotaxis by phospholipid signaling

Kölsch, V., Charest, P. G., & Firtel, R. (2008) · Journal of Cell Science · doi:10.1242/jcs.023333 · Cited by 351

Neutrophil apoptosis pathways and their modifications in inflammation

Simon, H. (2003) · Immunological Reviews · doi:10.1034/j.1600-065x.2003.00038.x · Cited by 350

Pharmacologic Characterization of a Potent Inhibitor of Class I Phosphatidylinositide 3-Kinases

Raynaud, F. I., Eccles, S. A., Clarke, P. A., Hayes, A., Nutley, B. P., Alix, S., Henley, A. T., Di-Stefano, F., Ahmad, Z., Guillard, S., et al. (2007) · Cancer Research · doi:10.1158/0008-5472.can-06-4615 · Cited by 354

Recent advances in the protein kinase B signaling pathway

Woodgett, J. R. (2005) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2005.02.010 · Cited by 352

Feedback upregulation of HER3 (ErbB3) expression and activity attenuates antitumor effect of PI3K inhibitors

Chakrabarty, A., Sanchez, V. M., Kuba, M. G., Rinehart, C., & Arteaga, C. L. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1018001108 · Cited by 353

Chemical modulators of autophagy as biological probes and potential therapeutics

Fleming, A., Noda, T., Yoshimori, T., & Rubinsztein, D. C. (2010) · Nature Chemical Biology · doi:10.1038/nchembio.500 · Cited by 358

PI3K/PTEN signaling in tumorigenesis and angiogenesis

Jiang, B., & Liu, L.-Z. (2007) · Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics · doi:10.1016/j.bbapap.2007.09.008 · Cited by 352

Untitled work

(2010) · PubMed Central

Shear stress–induced endothelial cell polarization is mediated by Rho and Rac but not Cdc42 or PI 3-kinases

Wójciak‐Stothard, B., & Ridley, A. J. (2003) · The Journal of Cell Biology · doi:10.1083/jcb.200210135 · Cited by 348

MYC and metabolism on the path to cancer

Hsieh, A. L., Walton, Z. E., Altman, B. J., Stine, Z. E., & Dang, C. V. (2015) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2015.08.003 · Cited by 347

Mutations of PIK3CA in Anaplastic Oligodendrogliomas, High-Grade Astrocytomas, and Medulloblastomas

Broderick, D. K., Di, C., Parrett, T. J., Samuels, Y., Cummins, J. M., McLendon, R. E., Fults, D. W., Velculescu, V. E., Bigner, D. D., & Yan, H. (2004) · Cancer Research · doi:10.1158/0008-5472.can-04-1170 · Cited by 336

Impaired IRS-1/PI3-kinase signaling in patients with HCV: A mechanism for increased prevalence of type 2 diabetes

Aytug, S., Reich, D. L., Sapiro, L. E., Bernstein, D., & Begum, N. (2003) · Hepatology · doi:10.1016/j.hep.2003.09.012 · Cited by 342

Identification of a PTEN-regulated STAT3 brain tumor suppressor pathway

de la Iglesia, N., Konopka, G., Puram, S. V., Chan, J. A., Bachoo, R. M., You, M. J., Levy, D. E., DePinho, R. A., & Bonni, A. (2008) · Genes & Development · doi:10.1101/gad.1606508 · Cited by 336

Nanopreparations to overcome multidrug resistance in cancer

Patel, N. R., Pattni, B. S., Abouzeid, A. H., & Torchilin, V. P. (2013) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2013.08.004 · Cited by 340

Influenza A Virus NS1 Protein Activates the PI3K/Akt Pathway To Mediate Antiapoptotic Signaling Responses

Ehrhardt, C., Wolff, T., Pleschka, S., Planz, O., Beermann, W., Bode, J. G., Schmolke, M., & Ludwig, S. (2007) · Journal of Virology · doi:10.1128/jvi.02082-06 · Cited by 333

17β-Estradiol Reduces Cardiomyocyte Apoptosis In Vivo and In Vitro via Activation of Phospho-Inositide-3 Kinase/Akt Signaling

Patten, R. D., Pourati, I., Aronovitz, M. J., Baur, J., Celestin, F., Chen, X., Michael, A., Haq, S., Nuedling, S., Grohé, C., et al. (2004) · Circulation Research · doi:10.1161/01.res.0000144126.57786.89 · Cited by 333

mTORC1 Inhibition Is Required for Sensitivity to PI3K p110α Inhibitors in PIK3CA -Mutant Breast Cancer

Elkabets, M., Vora, S., Juric, D., Morse, N., Mino-Kenudson, M., Muranen, T., Tao, J., Campos, A. B., Rodon, J., Ibrahim, Y. H., et al. (2013) · Science Translational Medicine · doi:10.1126/scitranslmed.3005747 · Cited by 332

Inhibition of Mammalian Target of Rapamycin or Apoptotic Pathway Induces Autophagy and Radiosensitizes PTEN Null Prostate Cancer Cells

Cao, C., Subhawong, T. K., Albert, J. M., Kim, K. W., Geng, L., Sekhar, K. R., Gi, Y. J., & Lu, J. (2006) · Cancer Research · doi:10.1158/0008-5472.can-06-0802 · Cited by 332

Akt negatively regulates the in vitro lifespan of human endothelial cells via a p53/p21‐dependent pathway

Miyauchi, H., Minamino, T., Tateno, K., Kunieda, T., Toko, H., & Komuro, I. (2004) · The EMBO Journal · doi:10.1038/sj.emboj.7600045 · Cited by 335

Targeting the PI3-kinase pathway in triple-negative breast cancer

Pascual, J., & Turner, N. C. (2019) · Annals of Oncology · doi:10.1093/annonc/mdz133 · Cited by 339

Activation of the PI3-K/AKT pathway and implications for radioresistance mechanisms in head and neck cancer

Bussink, J., van der Kogel, A. J., & Kaanders, J. H. A. M. (2008) · The Lancet Oncology · doi:10.1016/s1470-2045(08)70073-1 · Cited by 327

New drug targets in depression: inflammatory, cell-mediated immune, oxidative and nitrosative stress, mitochondrial, antioxidant, and neuroprogressive pathways. And new drug candidates—Nrf2 activators and GSK-3 inhibitors

Maes, M., Fišar, Z., Medina, M., Scapagnini, G., Nowak, G., & Berk, M. (2012) · Inflammopharmacology · doi:10.1007/s10787-011-0111-7 · Cited by 325

A Secreted PTEN Phosphatase That Enters Cells to Alter Signaling and Survival

Hopkins, B. D., Fine, B. M., Steinbach, N., Dendy, M., Rapp, Z., Shaw, J. M., Pappas, K., Yu, J. S., Hodakoski, C., Mense, S. M., et al. (2013) · Science · doi:10.1126/science.1234907 · Cited by 325

Signaling pathways and therapeutic interventions in gastric cancer

Lei, Z., Teng, Q., Qin, T. L., Chen, W., Xie, Y., Wu, K., Zeng, Q., Zeng, L., Pan, Y., Chen, Z., et al. (2022) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-022-01190-w · Cited by 338

PI3K is a key molecule in the Nrf2‐mediated regulation of antioxidative proteins by hemin in human neuroblastoma cells

Nakaso, K., Yano, H., Fukuhara, Y., Takeshima, T., Wada‐Isoe, K., & Nakashima, K. (2003) · FEBS Letters · doi:10.1016/s0014-5793(03)00517-9 · Cited by 324

Protein-lipid interactions and phosphoinositide metabolism in membrane traffic: Insights from vesicle recycling in nerve terminals

Wenk, M. R., & Camilli, P. V. D. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0401874101 · Cited by 327

Optogenetic control of phosphoinositide metabolism

Idevall‐Hagren, O., Dickson, E. J., Hille, B., Toomre, D. K., & Camilli, P. V. D. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1211305109 · Cited by 337

Renin-angiotensin-aldosterone system and oxidative stress in cardiovascular insulin resistance

Cooper, S. A., Whaley-Connell, A., Habibi, J., Wei, Y., Lastra, G., Manrique, C., Stas, S., & Sowers, J. R. (2007) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00522.2007 · Cited by 317

Molecular pharmacology and antitumor activity of PX-866, a novel inhibitor of phosphoinositide-3-kinase signaling

Ihle, N. T., Williams, R. R., Chow, S., Chew, W. M., Berggren, M. I., Paine-Murrieta, G. D., Minion, D. J., Halter, R. J., Wipf, P., Abraham, R. T., et al. (2004) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.763.3.7 · Cited by 317

Transforming growth factor-β2 promotes Snail-mediated endothelial–mesenchymal transition through convergence of Smad-dependent and Smad-independent signalling

Medici, D., Potenta, S. E., & Kalluri, R. (2011) · Biochemical Journal · doi:10.1042/bj20101500 · Cited by 315

Outcome and molecular landscape of patients with PIK3CA-mutated metastatic breast cancer

Mosele, F., Stefanovska, B., Lusque, A., Dien, A. T., Garberis, I., Droin, N. M., Tourneau, C. L., Sablin, M., Lacroix, L., Enrico, D. H., et al. (2020) · Annals of Oncology · doi:10.1016/j.annonc.2019.11.006 · Cited by 316

Drug resistance in cancer: mechanisms and tackling strategies

Haider, T., Pandey, V., Banjare, N., Gupta, P. N., & Soni, V. (2020) · Pharmacological Reports · doi:10.1007/s43440-020-00138-7 · Cited by 282

Phosphoinositides regulate ion channels

Hille, B., Dickson, E. J., Kruse, M., Vivas, O., & Suh, B.-C. (2015) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2014.09.010 · Cited by 312

Electrostatic Sequestration of PIP2 on Phospholipid Membranes by Basic/Aromatic Regions of Proteins

Gambhir, A., Hangyás-Mihályné, G., Zaitseva, I., Cafiso, D. S., Wang, J., Murray, D., Pentyala, S., Smith, S. O., & McLaughlin, S. (2004) · Biophysical Journal · doi:10.1016/s0006-3495(04)74278-2 · Cited by 318

T cell anergy and costimulation

Appleman, L. J., & Boussiotis, V. A. (2003) · Immunological Reviews · doi:10.1034/j.1600-065x.2003.00009.x · Cited by 315

Characterization of VPS34-IN1, a selective inhibitor of Vps34, reveals that the phosphatidylinositol 3-phosphate-binding SGK3 protein kinase is a downstream target of class III phosphoinositide 3-kinase

Bago, R., Malik, N., Munson, M. J., Prescott, A. R., Davies, P., Sommer, E., Shpiro, N., Ward, R., Cross, D., Ganley, I. G., et al. (2014) · Biochemical Journal · doi:10.1042/bj20140889 · Cited by 308

Aiding and abetting roles of NOX oxidases in cellular transformation

Block, K. L., & Gorin, Y. C. (2012) · Nature reviews. Cancer · doi:10.1038/nrc3339 · Cited by 308

Proliferating Cholangiocytes: A Neuroendocrine Compartment in the Diseased Liver

Alvaro, D., Mancino, M. G., Glaser, S. S., Gaudio, E., Marzioni, M., Francis, H., & Alpini, G. D. (2006) · Gastroenterology · doi:10.1053/j.gastro.2006.07.023 · Cited by 300

PIK3CA Mutation H1047R Is Associated with Response to PI3K/AKT/mTOR Signaling Pathway Inhibitors in Early-Phase Clinical Trials

Jankú, F., Wheler, J. J., Naing, A., Falchook, G. S., Hong, D. S., Stepanek, V. M. T., Fu, S., Piha-Paul, S. A., Lee, J. J., Luthra, R., et al. (2012) · Cancer Research · doi:10.1158/0008-5472.can-12-1726 · Cited by 303

Probing the Probes: Fitness Factors For Small Molecule Tools

Workman, P., & Collins, I. (2010) · Chemistry & Biology · doi:10.1016/j.chembiol.2010.05.013 · Cited by 304

Renewing the conspiracy theory debate: does Raf function alone to mediate Ras oncogenesis?

Repasky, G. A., Chenette, E. J., & Der, C. J. (2004) · Trends in Cell Biology · doi:10.1016/j.tcb.2004.09.014 · Cited by 299

Emerging mechanisms of neutrophil recruitment across endothelium

Williams, M. R., Azcutia, V., Newton, G. A., Alcaide, P., & Luscinskas, F. W. (2011) · Trends in Immunology · doi:10.1016/j.it.2011.06.009 · Cited by 310

Emerging common themes in regulation of PIKKs and PI3Ks

Lempiäinen, H., & Halazonetis, T. D. (2009) · The EMBO Journal · doi:10.1038/emboj.2009.281 · Cited by 312

A frequent kinase domain mutation that changes the interaction between PI3Kα and the membrane

Mandelker, D. L., Gabelli, S. B., Schmidt‐Kittler, O., Zhu, J., Cheong, I., Huang, C., Kinzler, K. W., Vogelstein, B., & Amzel, L. M. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0908444106 · Cited by 304

The p110δ structure: mechanisms for selectivity and potency of new PI(3)K inhibitors

Berndt, A., Miller, S., Williams, O., Le, D. D., Houseman, B. T., Pacold, J. I., Gorrec, F., Hon, W., Ren, P., Liu, Y., et al. (2010) · Nature Chemical Biology · doi:10.1038/nchembio.293 · Cited by 301

Targeting Apoptosis Pathways in Cancer Therapy

Fulda, S., & Debatin, K. (2004) · Current Cancer Drug Targets · doi:10.2174/1568009043332763 · Cited by 297

Frequent activation of AKT in non-small cell lung carcinomas and preneoplastic bronchial lesions

Balsara, B. (2004) · Carcinogenesis · doi:10.1093/carcin/bgh226 · Cited by 293

PIK3CA Mutations Are Not a Major Determinant of Resistance to the Epidermal Growth Factor Receptor Inhibitor Cetuximab in Metastatic Colorectal Cancer

Prenen, H., De Schutter, J., Jacobs, B., De Roock, W., Biesmans, B., Claes, B., Lambrechts, D., Van Cutsem, E., & Tejpar, S. (2009) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-08-2961 · Cited by 291

Oncogenic Mutations of PIK3CA in Human Cancers

Samuels, Y., & Waldman, T. (2010) · Current Topics in Microbiology and Immunology · doi:10.1007/82_2010_68 · Cited by 291

Oncogenic PIK3CA mutations reprogram glutamine metabolism in colorectal cancer

Hao, Y., Samuels, Y., Li, Q., Krokowski, D., Guan, B.-J., Wang, C., Jin, Z., Dong, B., Cao, B., Feng, X., et al. (2016) · Nature Communications · doi:10.1038/ncomms11971 · Cited by 290

Quantification of PtdInsP3 molecular species in cells and tissues by mass spectrometry

Clark, J. P., Anderson, K. E., Juvin, V., Smith, T., Karpe, F., Wakelam, M. J. O., Stephens, L., & Hawkins, P. T. (2011) · Nature Methods · doi:10.1038/nmeth.1564 · Cited by 290

PI3k/Akt signalling pathway plays a crucial role in the anti-inflammatory effects of curcumin in LPS-activated microglia

Cianciulli, A., Calvello, R., Porro, C., Trotta, T., Salvatore, R., & Panaro, M. A. (2016) · International Immunopharmacology · doi:10.1016/j.intimp.2016.05.007 · Cited by 290

Hydrocarbon Stapled Peptides as Modulators of Biological Function

Cromm, P. M., Spiegel, J., & Grossmann, T. N. (2015) · ACS Chemical Biology · doi:10.1021/cb501020r · Cited by 294

Temporal regulation of EGF signalling networks by the scaffold protein Shc1

Zheng, Y., Zhang, C., Croucher, D. R., Soliman, M. A., St‐Denis, N., Pasculescu, A., Taylor, L., Tate, S. A., Hardy, W. R., Colwill, K., et al. (2013) · Nature · doi:10.1038/nature12308 · Cited by 289

Somatic Mutations in p85α Promote Tumorigenesis through Class IA PI3K Activation

Jaiswal, B. S., Janakiraman, V., Kljavin, N. M., Chaudhuri, S., Stern, H. M., Wang, W., Kan, Z., Dbouk, H. A., Peters, B. A., Waring, P., et al. (2009) · Cancer Cell · doi:10.1016/j.ccr.2009.10.016 · Cited by 295

The PI3K/AKT signaling pathway in regulatory T-cell development, stability, and function

Pompura, S. L., & Dominguez‐Villar, M. (2018) · Journal of Leukocyte Biology · doi:10.1002/jlb.2mir0817-349r · Cited by 291

Oncogenic Ras in tumour progression and metastasis

Giehl, K. (2005) · Biological Chemistry · doi:10.1515/bc.2005.025 · Cited by 292

Insulin action on glucose transporters through molecular switches, tracks and tethers

Zaid, H., Antonescu, C. N., Randhawa, V. K., & Klip, A. (2008) · Biochemical Journal · doi:10.1042/bj20080723 · Cited by 294

Phosphatidylinositol 3-phosphates—at the interface between cell signalling and membrane traffic

Marat, A. L., & Haucke, V. (2016) · The EMBO Journal · doi:10.15252/embj.201593564 · Cited by 299

Influenza A virus NS1 protein binds p85β and activates phosphatidylinositol-3-kinase signaling

Hale, B. G., Jackson, D., Chen, Y.-H., Lamb, R. A., & Randall, R. E. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0606109103 · Cited by 284

Loss of Akt1 Leads to Severe Atherosclerosis and Occlusive Coronary Artery Disease

Fernandez-Hernando, C. F., Ackah, E., Yu, J., Suárez, Y., Murata, T., Iwakiri, Y., Prendergast, J., Miao, R. Q., Birnbaum, M. J., & Sessa, W. C. (2007) · Cell Metabolism · doi:10.1016/j.cmet.2007.10.007 · Cited by 292

The Upstream Pathway of mTOR-Mediated Autophagy in Liver Diseases

Wang, H., Liu, Y., Wang, D., Xu, Y., Dong, R., Yang, Y., Lv, Q., Chen, X., & Zhang, Z. (2019) · Cells · doi:10.3390/cells8121597 · Cited by 286

Structural Evolution of the Protein Kinase-Like Superfamily

Scheeff, E. D., & Bourne, P. E. (2005) · PLoS Computational Biology · doi:10.1371/journal.pcbi.0010049 · Cited by 286

Reactive oxygen species-dependent signaling regulates cancer

Weinberg, F. D., & Chandel, N. S. (2009) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-009-0099-y · Cited by 279

Constitutive activation of Akt contributes to the pathogenesis and survival of mantle cell lymphoma

Rudelius, M., Pittaluga, S., Nishizuka, S., Pham, T. H.-T., Fend, F., Jaffe, E. S., Quintanilla‐Martínez, L., & Raffeld, M. A. (2006) · Blood · doi:10.1182/blood-2006-04-015586 · Cited by 281

Phospholipase D Signaling Pathways and Phosphatidic Acid as Therapeutic Targets in Cancer

Bruntz, R. C., Lindsley, C. W., & Brown, H. A. (2014) · Pharmacological Reviews · doi:10.1124/pr.114.009217 · Cited by 286

Mutations in the Phosphatidylinositol-3-Kinase Pathway Predict for Antitumor Activity of the Inhibitor PX-866 whereas Oncogenic Ras Is a Dominant Predictor for Resistance

Ihle, N. T., Lemos, R., Wipf, P., Yacoub, A., Mitchell, C., Siwak, D. R., Mills, G. B., Dent, P., Kirkpatrick, D. L., & Powis, G. (2008) · Cancer Research · doi:10.1158/0008-5472.can-07-6656 · Cited by 275

Mammalian phosphoinositide kinases and phosphatases

Sasaki, T., Takasuga, S., Sasaki, J., Kofuji, S., Eguchi, S., Yamazaki, M., & Suzuki, A. (2009) · Progress in Lipid Research · doi:10.1016/j.plipres.2009.06.001 · Cited by 283

Bioactivity of genistein: A review of in vitro and in vivo studies

Ganai, A. A., & Farooqi, H. (2015) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2015.10.026 · Cited by 274

TLR2 Is Constitutively Expressed within the Kidney and Participates in Ischemic Renal Injury through Both MyD88-Dependent and -Independent Pathways

Shigeoka, A. A., Holscher, T. D., King, A. J., Hall, F. W., Kiosses, W. B., Tobias, P. S., Mackman, N., & McKay, D. B. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.178.10.6252 · Cited by 273

The Key Regulatory Roles of the PI3K/Akt Signaling Pathway in the Functionalities of Mesenchymal Stem Cells and Applications in Tissue Regeneration

Chen, J., Crawford, R., Chen, C., & Xiao, Y. (2013) · Tissue Engineering Part B Reviews · doi:10.1089/ten.teb.2012.0672 · Cited by 273

Biological properties of potent inhibitors of class I phosphatidylinositide 3-kinases: from PI-103 through PI-540, PI-620 to the oral agent GDC-0941

Raynaud, F. I., Eccles, S. A., Patel, S. K., Alix, S., Box, G., Chuckowree, I., Folkes, A. J., Gowan, S. M., Brandon, A. D. H., Stefano, F. D., et al. (2009) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-08-1200 · Cited by 273

Genetic Analysis of the Role of the PI3K-Akt Pathway in Lipopolysaccharide-Induced Cytokine and Tissue Factor Gene Expression in Monocytes/Macrophages

Luyendyk, J. P., Schabbauer, G., Tencati, M., Holscher, T. D., Pawliński, R., & Mackman, N. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.180.6.4218 · Cited by 274

Insulin signalling mechanisms for triacylglycerol storage

Czech, M., Tencerová, M., Pedersen, D. J., & Aouadi, M. (2013) · Diabetologia · doi:10.1007/s00125-013-2869-1 · Cited by 289

Leptin Treatment Induces Loss of Bone Marrow Adipocytes and Increases Bone Formation in Leptin-Deficient ob/ob Mice

Hamrick, M. W., Della-Fera, M. A., Choi, Y.-H., Pennington, C., Hartzell, D., & Baile, C. A. (2005) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.050103 · Cited by 268

The Phosphoinositide 3-Kinase Pathway in Human Cancer: Genetic Alterations and Therapeutic Implications

Arcaro, A., & Stücklin, A. G. (2007) · Current Genomics · doi:10.2174/138920207782446160 · Cited by 274

Mechanisms maintaining the dormancy and survival of mammalian primordial follicles

Reddy, P., Zheng, W., & Liu, K. (2009) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2009.10.001 · Cited by 276

Phosphoinositide profiling in complex lipid mixtures using electrospray ionization mass spectrometry

Wenk, M. R., Lucast, L. J., Paolo, G. D., Romanelli, A. J., Suchy, S. F., Nussbaum, R. L., Cline, G. W., Shulman, G. I., McMurray, W. J., & Camilli, P. V. D. (2003) · Nature Biotechnology · doi:10.1038/nbt837 · Cited by 268

The interactions of flavonoids within neuronal signalling pathways

Spencer, J. P. E. (2007) · Genes & Nutrition · doi:10.1007/s12263-007-0056-z · Cited by 268

Essential Roles of the PI3 Kinase/Akt Pathway in Regulating Nrf2-Dependent Antioxidant Functions in the RPE

Wang, L., Chen, Y., Sternberg, P., & Cai, J. (2008) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.07-1099 · Cited by 271

The Role of mTOR Signaling as a Therapeutic Target in Cancer

Popova, N. V., & Jücker, M. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22041743 · Cited by 273

Pathobiology of ALK+ anaplastic large-cell lymphoma

Amin, H. M., & Lai, R. L. (2007) · Blood · doi:10.1182/blood-2007-04-060715 · Cited by 267

PI3K/ Akt/ mTOR Pathway as a Therapeutic Target for Colorectal Cancer: A Review of Preclinical and Clinical Evidence

Narayanankutty, A. (2019) · Current Drug Targets · doi:10.2174/1389450120666190618123846 · Cited by 267

Biology of common β receptor–signaling cytokines

Shearer, W. T., Rosenwasser, L. J., Bochner, B. S., Martinez-Moczygemba, M., & Huston, D. P. (2003) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2003.08.015 · Cited by 263

BAY 80-6946 Is a Highly Selective Intravenous PI3K Inhibitor with Potent p110α and p110δ Activities in Tumor Cell Lines and Xenograft Models

Liu, N., Rowley, B. R., Bull, C. O., Schneider, C., Haegebarth, A., Schatz, C. A., Fracasso, P. R., Wilkie, D. P., Hentemann, M. F., Wilhelm, S. M., et al. (2013) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-12-0993-t · Cited by 263

Glioblastoma Therapy: Past, Present and Future

Obrador, E., Moreno-Murciano, P., Oriol-Caballo, M., López-Blanch, R., Pineda, B., Gutiérrez-Arroyo, J., Loras, A., Gonzalez-Bonet, L., Martinez-Cadenas, C., Estrela, J., et al. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25052529 · Cited by 271

Drugging the PI3 Kinome: From Chemical Tools to Drugs in the Clinic

Workman, P., Clarke, P., Raynaud, F., & van Montfort, R. (2010) · Cancer Research · doi:10.1158/0008-5472.can-09-4355 · Cited by 287

Convergent signal transduction pathways controlling cardiomyocyte survival and function: the role of PI 3-kinase and Akt

Matsui, T., & Rosenzweig, A. (2004) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2004.11.005 · Cited by 264

Binding of phosphatidylinositol 3,4,5-trisphosphate to the pleckstrin homology domain of protein kinase B induces a conformational change

Milburn, C. C., Deák, M., Kelly, S. M., Price, N. C., Alessi, D. R., & van Aalten, D. M. F. (2003) · Biochemical Journal · doi:10.1042/bj20031229 · Cited by 262

Research Progress on Structure and Function of PI3K

Li, X. (2013) · Journal of Chengdu University

Phosphoinositide 3-Kinase signaling pathway: the key to cell proliferation and death

Peacock, J. G. (2007) · PubMed Central

Phosphatidylinositol-4,5-bisphosphate 3-kinase family in GtoPdb v.2023.1

Uddin, M. (2023) · IUPHAR/BPS Guide to Pharmacology CITE · doi:10.2218/gtopdb/f673/2023.1

Phosphoinositide 3-kinase: A new effector in signal transduction?

Downes, C. P., & Carter, A. N. (1991) · Cellular Signalling · doi:10.1016/0898-6568(91)90027-r · Cited by 160

Protein Kinases as Mediators of Phosphoinositide 3-Kinase Signaling

Toker, A. (2000) · Molecular Pharmacology · doi:10.1124/mol.57.4.652 · Cited by 302