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The Phosphoinositide 3-Kinase Pathway
Abstract
Phosphorylated lipids are produced at cellular membranes during signaling events and contribute to the recruitment and activation of various signaling components. The role of phosphoinositide 3-kinase (PI3K), which catalyzes the production of phosphatidylinositol-3,4,5-trisphosphate, in cell survival pathways; the regulation of gene expression and cell metabolism; and cytoskeletal rearrangements are highlighted. The PI3K pathway is implicated in human diseases including diabetes and cancer, and understanding the intricacies of this pathway may provide new avenues for therapuetic intervention.
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“Activation of phosphoinositide-3-kinase (PI3K) by ligation of growth factors to their cellular receptors promotes recruitment of Akt to the plasma membrane and its subsequent activation 28.”
From Mitochondrial reactive oxygen species regulate cellular signaling and dictate biological outcomes (2010) · cites this paper as [28]
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Metadata
- Authors
- Cantley, L. C.
- Affiliations
- Beth Israel Deaconess Medical Center (US)
- Corresponding author
- Cantley, Lewis C.
- ORCID
- Cantley, Lewis C.
- Venue
- Science
- Published
- 2002-05-31
- Volume
- 296
- Issue
- 5573
- Pages
- 1655-1657
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2070732456
- Cited by
- 5,621
- References
- 9
- Citations by year
- 2026: 87 · 2025: 137 · 2024: 134 · 2023: 182 · 2022: 200 · 2021: 203 · 2020: 216 · 2019: 215 · 2018: 232 · 2017: 276 · 2016: 243 · 2015: 297 · 2014: 292 · 2013: 306 · 2012: 325
- FWCI
- 76.33
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of General Medical Sciences (R01GM041890)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › PI3K/AKT/mTOR signaling in cancer
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Kinase Regulation and GTPase Signaling
- Keywords
- phosphatidylinositol 3-kinase, PI3K signaling, phosphatidylinositol 3,4,5-trisphosphate, cell survival signaling, gene expression regulation, cellular metabolism, cytoskeletal rearrangement, diabetes mellitus, cancer, therapeutic target
- MeSH terms
- Animals, Cell Membrane, Cell Physiological Phenomena, Diabetes Mellitus, Type 2, Humans, Models, Biological, Neoplasms, Phosphorylation, Protein Kinases, Proto-Oncogene Proteins, Signal Transduction, Protein Serine-Threonine Kinases, Phosphatidylinositol Phosphates, Phosphatidylinositol 4,5-Diphosphate, Phosphatidylinositol 3-Kinases, Proto-Oncogene Proteins c-akt, 3-Phosphoinositide-Dependent Protein Kinases
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