The DOI matches its Crossref record; 16 of the 16 references it cites were found in a registry or an index.
Binding of a Cytosolic Protein to the Iron-Responsive Element of Human Ferritin Messenger RNA
Abstract
The human ferritin H chain messenger RNA contains a specific iron-responsive element (IRE) in its 5′ untranslated region, which mediates regulation by iron of ferritin translation. An RNA gel retardation assay was used to demonstrate the affinity of a specific cytosolic binding protein for the IRE. A single-base deletion in the IRE eliminated both the interaction of the cytoplasmic protein with the IRE and translational regulation. Thus, the regulatory potential of the IRE correlates with its capacity to specifically interact with proteins. Titration curves of binding activity after treatment of cells with an iron chelator suggest that the factor acts as a repressor of ferritin translation.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Cultured neurons from mice deficient in PERK (PKR-like ER kinase), which have an impaired UPR, exhibited enhanced sensitivity to 6-OHDA treatment (266).”
From Intracellular iron transport and storage: from molecular mechanisms to health implications (2008) · cites this paper as [266]
Citations
Cites
Dignam, J. D., Lebovitz, R. M., & Roeder, R. G. (1983) · Nucleic Acids Research · doi:10.1093/nar/11.5.1475 · Cited by 11,262
Optimal computer folding of large RNA sequences using thermodynamics and auxiliary information
Zuker, M., & Stiegler, P. (1981) · Nucleic Acids Research · doi:10.1093/nar/9.1.133 · Cited by 3,604
Iron-Responsive Elements: Regulatory RNA Sequences That Control mRNA Levels and Translation
Casey, J. L., Hentze, M. W., Koeller, D. M., Caughman, S. W., Rouault, T. A., Klausner, R. D., & Harford, J. B. (1988) · Science · doi:10.1126/science.2452485 · Cited by 709
Self-citationLeibold, E. A., & Munro, H. N. (1988) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.85.7.2171 · Cited by 671
Normal and mutant human β-globin pre-mRNAs are faithfully and efficiently spliced in vitro
Krainer, A. R., Maniatis, T., Ruskin, B., & Green, M. R. (1984) · Cell · doi:10.1016/0092-8674(84)90049-7 · Cited by 637
Hentze, M. W., Caughman, S. W., Rouault, T. A., Barriocanal, J. G., Dancis, A., Harford, J. B., & Klausner, R. D. (1987) · Science · doi:10.1126/science.3685996 · Cited by 571
Self-citationNovel mechanism for translational control in regulation of ferritin synthesis by iron.
Zähringer, J., Baliga, B. S., & Munro, H. N. (1976) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.73.3.857 · Cited by 318
Hentze, M. W., Rouault, T. A., Caughman, S. W., Dancis, A., Harford, J. B., & Klausner, R. D. (1987) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.84.19.6730 · Cited by 249
Self-citationRogers, J. T., & Munro, H. N. (1987) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.84.8.2277 · Cited by 162
Both subunits of rat liver ferritin are regulated at a translational level by iron induction
Aziz, N., & Munro, H. N. (1986) · Nucleic Acids Research · doi:10.1093/nar/14.2.915 · Cited by 161
Flagged first, then by citations
Research works printed but not linked: 2
- Brown, A. J., Proceedings of the National Academy of Sciences of the United States of America 80: 1265 (1983).
- CAREY, J, BIOCHEMISTRY 24: 4239 (1983).
Cited by
Sorted by citations
The scanning model for translation: an update.
Kozak, M. (1989) · The Journal of Cell Biology · doi:10.1083/jcb.108.2.229 · Cited by 3,485
The ferritins: molecular properties, iron storage function and cellular regulation
Harrison, P. M., & Arosio, P. (1996) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/0005-2728(96)00022-9 · Cited by 2,667
Metals in Neurobiology: Probing Their Chemistry and Biology with Molecular Imaging
Que, E. L., Domaille, D. W., & Chang, C. J. (2008) · Chemical Reviews · doi:10.1021/cr078203u · Cited by 2,077
Hentze, M. W., & Kühn, L. C. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.16.8175 · Cited by 1,292
Self-citationRegulating the fate of mRNA: the control of cellular iron metabolism
Klausner, R. D., Rouault, T. A., & Harford, J. B. (1993) · Cell · doi:10.1016/0092-8674(93)90046-s · Cited by 1,210
Self-citation
Metadata
- Authors
- Rouault, T. A., Hentze, M. W., Caughman, S. W., Harford, J. B., & Klausner, R. D.
- Affiliations
- National Institutes of Health (US)
- Venue
- Science
- Published
- 1988-09-02
- Volume
- 241
- Issue
- 4870
- Pages
- 1207-1210
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2023361302
- Cited by
- 351
- References
- 16
- Citations by year
- 2026: 2 · 2025: 4 · 2024: 4 · 2023: 2 · 2022: 2 · 2021: 2 · 2019: 2 · 2018: 2 · 2017: 4 · 2016: 3 · 2015: 3 · 2014: 6 · 2013: 3 · 2012: 3
- FWCI
- 24.50
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Hematology › Iron Metabolism and Disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA and protein synthesis mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Research and Splicing
- Keywords
- iron-responsive element, iron-responsive element-binding protein, translational regulation, 5' untranslated region, single-base deletion, iron chelators
- MeSH terms
- Base Composition, Binding, Competitive, Carrier Proteins, Cytosol, Deferoxamine, Ferritins, Globins, Humans, Iron, Liver, RNA, Messenger, Protein Biosynthesis, RNA-Binding Proteins, Nucleocytoplasmic Transport Proteins
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
