Cited by 6,080Cytokine Signaling Pathways and Interactionsinterferon and immune responsesNF-κB Signaling Pathways

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Jak-STAT Pathways and Transcriptional Activation in Response to IFNs and Other Extracellular Signaling Proteins

Darnell, James E., Kerr, lan M., Stark, George R.·1994·Science

DOI 10.1126/science.8197455

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Abstract

Through the study of transcriptional activation in response to interferon alpha (IFN-alpha) and interferon gamma (IFN-gamma), a previously unrecognized direct signal transduction pathway to the nucleus has been uncovered: IFN-receptor interaction at the cell surface leads to the activation of kinases of the Jak family that then phosphorylate substrate proteins called STATs (signal transducers and activators of transcription). The phosphorylated STAT proteins move to the nucleus, bind specific DNA elements, and direct transcription. Recognition of the molecules involved in the IFN-alpha and IFN-gamma pathway has led to discoveries that a number of STAT family members exist and that other polypeptide ligands also use the Jak-STAT molecules in signal transduction.

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Mogensen, T. H. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2018.03047 · Cited by 235
“The identification of the JAKSTAT pathway was the result of seminal work performed by several scientists, including Darnell, Stark, and Kerr in the search for molecules mediating IFN-induced signaling (29).”
BackgroundInfluential
STAT3 and epithelial–mesenchymal transitions in carcinomas
Wendt, M. K., Balanis, N. G., Carlin, C. R., & Schiemann, W. P. (2014) · JAK-STAT · doi:10.4161/jkst.28975 · Cited by 206
“Indeed, gp130 dimerization results in the activation of members the Janus family (JAK1, JAK2, or TYK2) of receptor-associated protein tyrosine kinases, which readily phosphorylate gp130 at intracellular SH2-domain docking sites that not only promote the activation of STAT3 (and STAT1), but also that of the MAP kinase…”
Background
Neurons under T Cell Attack Coordinate Phagocyte-Mediated Synaptic Stripping
Di Liberto, G., Pantelyushin, S., Kreutzfeldt, M., Page, N., Musardo, S., Coras, R., Steinbach, K., Vincenti, I., Klimek, B., Lingner, T., et al. (2018) · Cell · doi:10.1016/j.cell.2018.07.049 · Cited by 195
“IFNGR signaling involves the Janus kinases JAK1 and JAK2, which phosphorylate STAT1 and enable its transcription factor activity (Darnell et al., 1994).”
Phospholipid scramblases: An overview
Sahu, S. K., Gummadi, S. N., Manoj, N., & Aradhyam, G. K. (2007) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2007.04.002 · Cited by 211
Hepcidin mediates transcriptional changes that modulate acute cytokine-induced inflammatory responses in mice
De Domenico, I., Zhang, T. Y., Koening, C. L., Branch, R. W., London, N., Lo, E., Daynes, R. A., Kushner, J. P., Li, D., Ward, D. M., et al. (2010) · Journal of Clinical Investigation · doi:10.1172/jci42011 · Cited by 197
Signaling pathways involved in MDSC regulation
Trikha, P., & Carson, W. E. (2014) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2014.04.003 · Cited by 207
“Gene knockout studies have helped elucidate various components of this pathway, which was originally discovered as part of the IFN signaling system [84].”
Background
A nuclear protein tyrosine phosphatase is required for the inactivation of Stat1
Haspel, R. L., & Darnell, J. E. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.18.10188 · Cited by 203
How cells respond to interferons revisited: From early history to current complexity
Stark, G. R. (2007) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2007.06.013 · Cited by 182
“Please see reviews [6,7] for descriptions and results of these experiments.”
BackgroundSelf-citation
White Spot Syndrome Virus Annexes a Shrimp STAT To Enhance Expression of the Immediate-Early Gene ie1
Liu, W.-J., Chang, Y.-S., Wang, A. H. ‐., Kou, G., & Lo, C. (2007) · Journal of Virology · doi:10.1128/jvi.01880-06 · Cited by 205
“Tyrosine-phosphorylated STATs form dimers or multimers, are transported into the nucleus, bind to the cognate DNA sequences, and activate gene expression (7, 10, 15, 31, 44).”
Background
Pregnancy recognition signaling mechanisms in ruminants and pigs
Bazer, F. (2013) · Journal of Animal Science and Biotechnology · doi:10.1186/2049-1891-4-23 · Cited by 200
“(TYK2) pathway [1,7,8].”
Hepatitis C Virus Core Protein Blocks Interferon Signaling by Interaction with the STAT1 SH2 Domain
Lin, W., Kim, S. S., Yeung, E., Kamegaya, Y., Blackard, J., Kim, K. A., Holtzman, M., & Chung, R. (2006) · Journal of Virology · doi:10.1128/jvi.00459-06 · Cited by 200
“... previously demonstrated to be essential for STAT1 signaling, we examined the effect of HCV core transfection in STAT1-deficient U3A cells cotransfected with wild-type STAT1 construct pST1-Full (aa 1 to 750) or point mutant STAT1 constructs pST1- 428/9 M (putative DNA binding site), pST1-701 M (JAK kinase phosphory…”
BackgroundMethod
Protein kinase inhibitors in the treatment of inflammatory and autoimmune diseases
Patterson, H., Nibbs, R., McInnes, I., & Siebert, S. (2014) · Clinical and Experimental Immunology · doi:10.1111/cei.12248 · Cited by 199
Contribution of STAT3 to inflammatory and fibrotic diseases and prospects for its targeting for treatment
Kasembeli, M. M., Bharadwaj, U., Robinson, P., & Tweardy, D. J. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19082299 · Cited by 199
“Signal transducer and activator of transcription (STAT) 3 is one of a seven-member family of proteins that transduce peptide hormone signals from the cell surface to the nucleus [1].”
Background
Interferons: Signaling, antiviral and viral evasion
Bonjardim, C. A., Ferreira, P. C. P., & Kroon, E. G. (2009) · Immunology Letters · doi:10.1016/j.imlet.2008.11.002 · Cited by 196
“However, a recent report revealed that ISGF3 formation and translocation to the nucleus in response to IFN-␣ is dependent on the acetylation of all components of the heterotrimeric complex.”
Background
Redox Regulation of STAT1 and STAT3 Signaling
Butturini, E., de Prati, A. C., & Mariotto, S. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21197034 · Cited by 214
Evaluation of potential Stat3-regulated genes in human breast cancer
Hsieh, F.-C., Cheng, G., & Lin, J. (2005) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2005.07.075 · Cited by 180
Virus Infection Triggers SUMOylation of IRF3 and IRF7, Leading to the Negative Regulation of Type I Interferon Gene Expression
Kubota, T., Matsuoka, M., Chang, T.-H., Tailor, P. B., Sasaki, T., Tashiro, M., Kato, A., & Ozato, K. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m804479200 · Cited by 174
Loss of Androgen Receptor Expression Promotes a Stem-like Cell Phenotype in Prostate Cancer through STAT3 Signaling
Schroeder, A., Herrmann, A., Cherryholmes, G. A., Kowolik, C. M., Buettner, R., Pal, S. K., Yu, H., Müller‐Newen, G., & Jove, R. (2013) · Cancer Research · doi:10.1158/0008-5472.can-13-0594 · Cited by 192
“Upon STAT3 phosphorylation at Y705, STAT3 forms stable dimers and translocates to the nucleus, where it binds to its specific promoter sequences to induce target gene expression (9, 24).”
Background
The Common Cytokine Receptor γ Chain Family of CytokinesPreprint
Lin, J., & Leonard, W. J. (2017) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a028449 · Cited by 215
Novel STAT1 Alleles in Otherwise Healthy Patients with Mycobacterial Disease
Chapgier, A. L. A., Boisson‐Dupuis, S., Jouanguy, E., Vogt, G., Feinberg, J. M., Prochnicka‐Chalufour, A., Casrouge, A., Yang, K., Soudais, C., Fieschi, C., et al. (2006) · PLoS Genetics · doi:10.1371/journal.pgen.0020131 · Cited by 200
Targeting the JAK/STAT Signaling Pathway Using Phytocompounds for Cancer Prevention and Therapy
Bose, S., Banerjee, S., Mondal, A., Chakraborty, U., Pumarol, J., Croley, C. R., & Bishayee, A. (2020) · Cells · doi:10.3390/cells9061451 · Cited by 219
“The dimer then translocates into the nucleus wherein the dimer gets attached to DNA and stimulates the expression of genes that are responsive to cytokines [33,34].”
Background
Life-threatening influenza pneumonitis in a child with inherited IRF9 deficiency
Hernandez, N., Melki, I., Jing, H., Habib, T., Huang, S. S. Y., Danielson, J. J., Kula, T., Drutman, S. B., Belkaya, S., Rattina, V., et al. (2018) · The Journal of Experimental Medicine · doi:10.1084/jem.20180628 · Cited by 215
“IRF9 also enables binding of the trimer to DNA, after its translocation to the nucleus (Veals et al., 1993; Darnell et al., 1994; Taniguchi et al., 2001; Stark and Darnell, 2012).”
Background
A genetic and developmental pathway from STAT3 to the OCT4–NANOG circuit is essential for maintenance of ICM lineages in vivoPreprint
Do, D. V., Ueda, J., Messerschmidt, D. M., Lorthongpanich, C., Zhou, Y., Feng, B., Guo, G., Lin, P. J., Hossain, M. Z., Zhang, W., et al. (2013) · Genes & Development · doi:10.1101/gad.221176.113 · Cited by 184
“…recruitment of the Src homology-2 (SH2) domain and phosphorylation on Tyr705 residues of signal transducers and activators of transcription (STAT), a gene family originally described in the interferon-induced regulatory pathways (Fu et al. 1990, 1992; Schindler et al. 1992; Darnell et al. 1994).”
Background
BDNF Selectively Regulates GABA A Receptor Transcription by Activation of the JAK/STAT Pathway
Lund, I. V., Hu, Y., Raol, Y. H., Benham, R. S., Faris, R., Russek, S. J., & Brooks‐Kayal, A. R. (2008) · Science Signaling · doi:10.1126/scisignal.1162396 · Cited by 181
Interplay between interferon and other cytokine systems in bone metabolism
Takayanagi, H., Sato, K., Takaoka, A., & Taniguchi, T. (2005) · Immunological Reviews · doi:10.1111/j.0105-2896.2005.00337.x · Cited by 192
Understanding the therapeutic toolkit for inflammatory bowel disease
Vieujean, S., Jairath, V., Peyrin‐Biroulet, L., Dubinsky, M. C., Iacucci, M., Magro, F., & Danese, S. (2025) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-024-01035-7 · Cited by 210
“JAK, including JAK1, JAK2, JAK3 and TYK2, are enzymes linked to the intracellular domains of cytokine receptors 169 .”
Differential Regulation of Type I and Type III Interferon Signaling
Stanifer, M. L., Pervolaraki, K., & Boulant, S. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20061445 · Cited by 214
“Beside the canonical ISGF3 transcriptional complex made of STAT1:STAT2 heterodimer and of IRF9, almost all combination of STAT homo- and heterodimers can be found: STAT1:STAT1, STAT3:STAT3, STAT4:STAT4, STAT5:STAT5, STAT6:STAT6, STAT1:STAT2, STAT1:STAT3, STAT1:STAT4, STAT1:STAT5, STAT2:STAT3 STAT5:STAT6 [12,30,92,100,…”
Background
BRD4 Coordinates Recruitment of Pause Release Factor P-TEFb and the Pausing Complex NELF/DSIF To Regulate Transcription Elongation of Interferon-Stimulated Genes
Patel, M. C., Debrosse, M., Smith, M. D., Dey, A., Huynh, W., Sarai, N., Heightman, T. D., Tamura, T., & Ozato, K. (2013) · Molecular and Cellular Biology · doi:10.1128/mcb.01180-12 · Cited by 182
“Given that a wide range of genes are stimulated by JAK/STAT pathways in addition to ISGs, regulating cell growth, development, and responses to various external signals, it is reasonable to assume that the pattern of NELF/DSIF occupancy revealed in this study may represent a fairly common feature (30, 31, 33, 51).”
Background
Distinct Induction Patterns and Functions of Two Closely Related Interferon-inducible Human Genes, ISG54 and ISG56
Terenzi, F., Hui, D. J., Merrick, W. C., & Sen, G. C. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m605771200 · Cited by 177
Antisense therapy for cancer
Gleave, M. E., & Monia, B. P. (2005) · Nature reviews. Cancer · doi:10.1038/nrc1631 · Cited by 384
“Following specific receptor stimulation and dimerization, activation of the Janus tyrosine kinases or SRC family members results in the phosphorylation and activation of STAT family member”
Background
The complex STATes of astrocyte reactivity: How are they controlled by the JAK-STAT3 pathway?
Ceyzériat, K., Abjean, L., Carrillo-de Sauvage, M.-A., Ben Haim, L., & Escartin, C. (2016) · Neuroscience · doi:10.1016/j.neuroscience.2016.05.043 · Cited by 185
Review: ICSBP/IRF-8: Its Regulatory Roles in the Development of Myeloid Cells
Tamura, T., & Ozato, K. (2002) · Journal of Interferon & Cytokine Research · doi:10.1089/107999002753452755 · Cited by 183
JAK-Inhibitors for the Treatment of Rheumatoid Arthritis: A Focus on the Present and an Outlook on the Future
Angelini, J., Talotta, R., Roncato, R., Fornasier, G., Barbiero, G., Cin, L. D., Brancati, S. B., & Scaglione, F. (2020) · Biomolecules · doi:10.3390/biom10071002 · Cited by 224
“IFN-α/β Type II JAK1 TYK2 STAT1 STAT2 STAT4 STAT3 naïve T lymphocytes, Th1 lymphocytes alopecia, rheumatoid arthritis, atopic dermatitis, systemic lupus erythematosus, ulcerative colitis, Crohn’s disease, ankylosing spondylitis [11,38,39,59,60]”
Background
Pharmacology and therapeutic potential of interferons
George, P. M., Badiger, R., Alazawi, W., Foster, G. R., & Mitchell, J. A. (2012) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2012.03.006 · Cited by 182
E3 ubiquitin ligase RNF128 promotes innate antiviral immunity through K63-linked ubiquitination of TBK1
Song, G., Liu, B., Li, Z., Wu, H. M., Wang, P., Zhao, K., Jiang, G., Zhang, L., & Gao, C. (2016) · Nature Immunology · doi:10.1038/ni.3588 · Cited by 201
Alpha Interferon Induces Long-Lasting Refractoriness of JAK-STAT Signaling in the Mouse Liver through Induction of USP18/UBP43
Sinnreich, M. F., Wang, X., Yan, M., Duong, F. H. T., Poli, V., Hilton, D. J., Zhang, D., & Heim, M. H. (2009) · Molecular and Cellular Biology · doi:10.1128/mcb.00224-09 · Cited by 177
IFN-λ: Novel Antiviral Cytokines
Ank, N., West, H., & Paludan, S. R. (2006) · Journal of Interferon & Cytokine Research · doi:10.1089/jir.2006.26.373 · Cited by 193
“36 To some extent, the use of Stats explains the activities of a given cytokine.”
Expression of p-STAT3 in human colorectal adenocarcinoma and adenoma; correlation with clinicopathological factors
Kusaba, T., Nakayama, T., Yamazumi, K., Yakata, Y., Yoshizaki, A., Nagayasu, T., & Sekine, I. (2005) · Journal of Clinical Pathology · doi:10.1136/jcp.2004.023416 · Cited by 169
Potential therapeutic targets for inflammation in toll-like receptor 4 (TLR4)-mediated signaling pathways
Roy, A., Srivastava, M., Saqib, U., Liu, D., Faisal, S. M., Sugathan, S., Bishnoi, S., & Baig, M. S. (2016) · International Immunopharmacology · doi:10.1016/j.intimp.2016.08.026 · Cited by 196
IFN Induces miR-21 through a Signal Transducer and Activator of Transcription 3–Dependent Pathway as a Suppressive Negative Feedback on IFN-Induced Apoptosis
Yang, C. H., Yue, J., Fan, M., & Pfeffer, L. M. (2010) · Cancer Research · doi:10.1158/0008-5472.can-10-2579 · Cited by 179
Involvement of STAT3 in the Granulocyte Colony-stimulating Factor-induced Differentiation of Myeloid Cells
Shimozaki, K., Nakajima, K., Hirano, T., & Nagata, S. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.40.25184 · Cited by 169
Signaling by vitamin A and retinol-binding protein regulates gene expression to inhibit insulin responses
Berry, D. C., Jin, H., Majumdar, A., & Noy, N. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1011115108 · Cited by 204
Respiratory syncytial virus nonstructural protein 2 specifically inhibits type I interferon signal transduction
Ramaswamy, M., Shi, L., Varga, S. M., Barik, S., Behlke, M. A., & Look, D. C. (2005) · Virology · doi:10.1016/j.virol.2005.09.009 · Cited by 165
Regulation of TNF-related apoptosis-inducing ligand on primary CD4 + T cells by HIV-1: Role of type I IFN-producing plasmacytoid dendritic cells
Herbeuval, J., Hardy, A. W., Boasso, A., Anderson, S. A., Dolan, M. J., Dy, M., & Shearer, G. M. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0505251102 · Cited by 164
ISG15 and immune diseases
Jeon, Y. J., Yoo, H. M., & Chung, C. H. (2010) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2010.02.006 · Cited by 175
“activator of transcription (STAT) signaling pathway [3].”
IL‐23‐mediated regulation of IL‐17 production in Helicobacter pylori‐infected gastric mucosa
Caruso, R., Fina, D., Paoluzi, O. A., Blanco, G. D. V., Stolfi, C., Rizzo, A., Caprioli, F., Sarra, M., Andrei, F., Fantini, M. C., et al. (2008) · European Journal of Immunology · doi:10.1002/eji.200737635 · Cited by 164
Galectin-3 Exerts Cytokine-Like Regulatory Actions through the JAK–STAT Pathway
Jeon, S., Yoon, H. J., Chang, C. Y., Koh, H. S., Jeon, S.-H., & Park, E. J. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.1000154 · Cited by 176
“Because IFN-g receptor 1 (IFNGR1) has been shown to be responsible for ligand binding and activation of the JAK–STAT pathway (36), we questioned whether IFNGR1 could be associated with galectin-3–triggered phosphorylation of the JAK2-STAT cascade.”
Background
The Role of JAK/STAT Pathway in Fibrotic Diseases: Molecular and Cellular Mechanisms
Liu, J., Wang, F., & Luo, F. (2023) · Biomolecules · doi:10.3390/biom13010119 · Cited by 188
“The JAK/signal transducer and activator of transcription (STAT) signaling pathway is a cascade of responses critical for the signal transduction of multiple cytokines and growth factors in vivo [6,7].”
Background
Stat3 activation in human endometrial and cervical cancers
Chen, C.-L., Hsieh, F.-C., Lieblein, J., Brown, J., Chan, C., Wallace, J. A., Cheng, G., Hall, B. M., & Lin, J. (2007) · British Journal of Cancer · doi:10.1038/sj.bjc.6603597 · Cited by 171
“…www.bjcancer.com & 2007 Cancer Research UK Keywords: Stat3; endometrial cancer; cervical cancer; tissue microarray Signal transducer and activator of transcription signaling pathways are activated in response to cytokines and growth factors (Darnell et al, 1994; Zhong et al, 1994).”
Background
The Pathogenic NY-1 Hantavirus G1 Cytoplasmic Tail Inhibits RIG-I- and TBK-1-Directed Interferon Responses
Alff, P. J., Gavrilovskaya, I. N., Gorbunova, E. E., Endriss, K., Chong, Y., Geimonen, E., Sen, N., Reich, N. C., & Mackow, E. R. (2006) · Journal of Virology · doi:10.1128/jvi.00508-06 · Cited by 152
“In response to IFN, IFN receptors activate JAK/STAT signaling pathways and direct transcription of interferon-stimulated genes (ISGs), which amplify the IFN response and disrupt viral transcription and translation (8, 9, 54).”
Background
The Long Form of the Leptin Receptor Regulates STAT5 and Ribosomal Protein S6 via Alternate Mechanisms
Gong, Y., Ishida-Takahashi, R., Villanueva, E. C., Fingar, D. C., Münzberg, H., & Myers, M. G. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m702838200 · Cited by 173
Activation of p38 MAPK in CD4 T cells controls IL-17 production and autoimmune encephalomyelitis
Noubade, R., Krementsov, D. N., del Río, R., Thornton, T. M., Nagaleekar, V. K., Saligrama, N., Spitzack, A., Spach, K. M., Sabio, G., Davis, R. J., et al. (2011) · Blood · doi:10.1182/blood-2011-02-336552 · Cited by 167
Porcine Reproductive and Respiratory Syndrome Virus Inhibits Type I Interferon Signaling by Blocking STAT1/STAT2 Nuclear Translocation
Patel, D., Nan, Y., Shen, M., Ritthipichai, K., Zhu, X., & Zhang, Y. (2010) · Journal of Virology · doi:10.1128/jvi.00655-10 · Cited by 163
“Overexpression of NSP1 of PRRSV VR2385 inhibited expression of ISG15 and ISG56 and blocked nuclear translocation of STAT1, which suggests that NSP1 might be the viral protein responsible for the inhibition of IFN signaling.”
BackgroundInfluential
A Genomic Approach to Human Autoimmune Diseases
Pascual, V., Chaussabel, D., & Banchereau, J. (2010) · Annual Review of Immunology · doi:10.1146/annurev-immunol-030409-101221 · Cited by 152
“All nucleated cells express the type I IFN receptor (IFNAR) and respond to type I IFN with phosphorylation of STAT1 and STAT2, which ultimately leads to the transcription of interferon-responsive genes (83).”
Background
Toxoplasma Effector Recruits the Mi-2/NuRD Complex to Repress STAT1 Transcription and Block IFN-γ-Dependent Gene Expression
Olias, P., Etheridge, R. D., Zhang, Y., Holtzman, M. J., & Sibley, L. D. (2016) · Cell Host & Microbe · doi:10.1016/j.chom.2016.06.006 · Cited by 187
“…trafficking, and binding to a conserved motif known as the gamma-activated sequence (GAS), resulting in the transcription of many genes, including those important for immunity (Darnell et al., 1994; 72 Cell Host & Microbe 20, 72–82, July 13, 2016 ª 2016 Elsevier Inc. Schindler and Darnell, 1995).”
Vitamin C Is an Essential Factor on the Anti-viral Immune Responses through the Production of Interferon-α/β at the Initial Stage of Influenza A Virus (H3N2) Infection
Kim, Y., Kim, H., Bae, S., Choi, J., Lim, S., Lee, N., Kong, J. M., Hwang, Y.-I., Kang, J. S., & Lee, W. J. (2013) · Immune Network · doi:10.4110/in.2013.13.2.70 · Cited by 186
“The phosphorylation of signal transducers and activators of transcription (STATs) is the critical signaling process after the dimerization of its receptors, when type I IFNs are increased (17,18).”
STAT proteins – Key regulators of anti-viral responses, inflammation, and tumorigenesis in the liver
Gao, B., Wang, H., Lafdil, F., & Feng, D. (2012) · Journal of Hepatology · doi:10.1016/j.jhep.2012.01.029 · Cited by 180
“The JAK–STAT pathway was identified in the early 1990s as a key signaling cascade mediating cytokine receptor-derived signals in mammals [1,2].”
Background
Regulation of JAK2 by miR-135a: prognostic impact in classic Hodgkin lymphoma
Navarro, A., Díaz, T., Martı́nez, A., Gayà, A., Pons, A., Gel, B., Codony, C., Ferrer, G., Martı́nez, C., Montserrat, E., et al. (2009) · Blood · doi:10.1182/blood-2009-02-204842 · Cited by 171
MyD88-mediated stabilization of interferon-γ-induced cytokine and chemokine mRNA
Sun, D., & Ding, A. H. (2006) · Nature Immunology · doi:10.1038/ni1308 · Cited by 210
“These inflammatory mediators are also induced by IFN-γ, which uses a signaling pathway involving Janus kinases and signal transducers and activators of transcription (STATs”
Melatonin in macrophage biology: Current understanding and future perspectives
Xia, Y., Chen, S., Zeng, S., Zhao, Y., Zhu, C., Deng, B., Zhu, G., Yin, Y., Wang, W., Hardeland, R., et al. (2018) · Journal of Pineal Research · doi:10.1111/jpi.12547 · Cited by 191
MicroRNA miR-21 Regulates the Metastatic Behavior of B16 Melanoma Cells
Yang, C. H., Yue, J., Pfeffer, S. R., Handorf, C. R., & Pfeffer, L. M. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.285098 · Cited by 186
JAK1 and Tyk2 Activation by the Homologous Polycythemia Vera JAK2 V617F Mutation
Staerk, J., Kallin, A., Demoulin, J., Vainchenker, W., & Constantinescu, S. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.c500358200 · Cited by 169
STAT3 and apoptosis challenges in cancer
Fathi, N., Rashidi, G., Khodadadi, A., Shahi, S., & Sharifi, S. (2018) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2018.05.121 · Cited by 191
Mechanisms of Fish Macrophage Antimicrobial Immunity
Grayfer, L., Kerimoğlu, B., Yaparla, A., Hodgkinson, J. W., Xie, J., & Belosevic, M. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.01105 · Cited by 191
“The assembly of this signaling complex (IFNγ:IFNGR1:IFNGR2) activates Janus kinases (Jak)-1 and -2 (124), upon which phosphorylation activates signal transducer of activation-1 (Stat1) transcription factor (125).”
Background
Cancer Prevention with Promising Natural Products: Mechanisms of Action and Molecular Targets
Pratheeshkumar, P., Sreekala, C., Zhang, Z., Budhraja, A., Ding, S., Son, Y., Wang, X., Hitron, J. A., Hyun-Jung, K., Wang, L., et al. (2012) · Anti-Cancer Agents in Medicinal Chemistry · doi:10.2174/187152012803833035 · Cited by 180
Signal transducer and activator of transcription (STAT) signalling and T‐cell lymphomas
Mitchell, T. J., & John, S. (2005) · Immunology · doi:10.1111/j.1365-2567.2005.02091.x · Cited by 172
PD-L1/PD-1 Axis in Glioblastoma Multiforme
Litak, J., Mazurek, M., Grochowski, C., Kamieniak, P., & Roliński, J. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20215347 · Cited by 187
Hepatitis C virus expression suppresses interferon signaling by degrading STAT1.
Lin, W., Choe, W., Hiasa, Y., Kamegaya, Y., Blackard, J., Schmidt, E., & Chung, R. (2005) · Gastroenterology · doi:10.1053/j.gastro.2005.02.006 · Cited by 165
STAT1 and Its Crucial Role in the Control of Viral Infections
Tolomeo, M., Cavalli, A., & Cascio, A. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23084095 · Cited by 187
Importance of Type I and III Interferons at Respiratory and Intestinal Barrier Surfaces
Stanifer, M. L., Guo, C., Doldan, P., & Boulant, S. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.608645 · Cited by 195
“Following type I IFN binding, STAT1–6 have all been shown to participate in the antiviral and anti-proliferative actions of these IFNs (65, 66).”
Background
STAT5 in Cancer and Immunity
Rani, A., & Murphy, J. J. (2015) · Journal of Interferon & Cytokine Research · doi:10.1089/jir.2015.0054 · Cited by 179
“The first STATs to be cloned by Darnell and co-workers were the IFN-inducible 91-kDa STAT1and the 113-kDa STAT2 proteins [3, 7].”
Phosphorylation Events Modulate the Ability of Interferon Consensus Sequence Binding Protein to Interact with Interferon Regulatory Factors and to Bind DNA
Sharf, R., Meraro, D., Azriel, A., Thornton, A. M., Ozato, K., Petricoin, E. F., Larner, A. C., Schaper, F., Hauser, H., & Levi, B.-Z. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.15.9785 · Cited by 162
Interferon (IFN) Consensus Sequence-binding Protein, a Transcription Factor of the IFN Regulatory Factor Family, Regulates Immune Responses In Vivo through Control of Interleukin 12 Expression
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Authors: Darnell, J. E., Kerr, L. M., & Stark, G. R.
Affiliations: Rockefeller University (US)
Case Comprehensive Cancer Center (US)
ORCID: Stark, George R.
Venue: Science
Publisher: American Association for the Advancement of Science (AAAS)
Published: 1994-06-03
Volume: 264
Issue: 5164
Pages: 1415-1421
ISSN: 0036-8075 (ISSN-L)
1095-9203
DOI: 10.1126/science.8197455
OpenAlex: W2029275361
Cited by: 6,080
References: 85
Citations by year: 2026: 84 · 2025: 139 · 2024: 175 · 2023: 170 · 2022: 183 · 2021: 177 · 2020: 162 · 2019: 155 · 2018: 121 · 2017: 166 · 2016: 148 · 2015: 152 · 2014: 160 · 2013: 207 · 2012: 188
FWCI: 28.59
Type: journal article
Language: en
Open access: closed
Locations: Science (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Immunology and Microbiology › Immunology › Cytokine Signaling Pathways and Interactions
Life Sciences › Immunology and Microbiology › Immunology › interferon and immune responses
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › NF-κB Signaling Pathways
Keywords: JAK/STAT signaling, interferon-alpha, interferon-gamma, signal transduction, STAT proteins, transcriptional activation, JAK kinases, interferon receptor, nuclear translocation, DNA binding
MeSH terms: Amino Acid Sequence, Animals, Base Sequence, Cell Line, DNA-Binding Proteins, Genes, Genetic Complementation Test, Humans, Interferon-gamma, Molecular Sequence Data, Mutation, Protein-Tyrosine Kinases, Regulatory Sequences, Nucleic Acid, Transcription Factors, Signal Transduction, Transcriptional Activation, Interferon-alpha, Interferon-Stimulated Gene Factor 3, Interferon-Stimulated Gene Factor 3, gamma Subunit

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Jak-STAT Pathways and Transcriptional Activation in Response to IFNs and Other Extracellular Signaling Proteins

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