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Cited by 6,080Cytokine Signaling Pathways and Interactionsinterferon and immune responsesNF-κB Signaling Pathways

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Jak-STAT Pathways and Transcriptional Activation in Response to IFNs and Other Extracellular Signaling Proteins

Darnell, James E., Kerr, lan M., Stark, George R.·1994·Science
DOI 10.1126/science.8197455
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Abstract

Through the study of transcriptional activation in response to interferon alpha (IFN-alpha) and interferon gamma (IFN-gamma), a previously unrecognized direct signal transduction pathway to the nucleus has been uncovered: IFN-receptor interaction at the cell surface leads to the activation of kinases of the Jak family that then phosphorylate substrate proteins called STATs (signal transducers and activators of transcription). The phosphorylated STAT proteins move to the nucleus, bind specific DNA elements, and direct transcription. Recognition of the molecules involved in the IFN-alpha and IFN-gamma pathway has led to discoveries that a number of STAT family members exist and that other polypeptide ligands also use the Jak-STAT molecules in signal transduction.

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Research works printed but not linked: 84

  1. AGUET, M, MOLECULAR-CLONING AND EXPRESSION OF THE HUMAN INTERFERON-GAMMA RECEPTOR, CELL 55: 273 (1988). · DOI
  2. ALMENDRAL, J.M., COMPLEXITY OF THE EARLY GENETIC RESPONSE TO GROWTH-FACTORS IN MOUSE FIBROBLASTS, MOLECULAR AND CELLULAR BIOLOGY 8: 2140 (1988).
  3. 10.1016/0092-8674(93)90415-M · DOI
  4. BEADLING, C, ISOLATION OF INTERLEUKIN-2-INDUCED IMMEDIATE-EARLY GENES, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 90: 2719 (1993).
  5. BLANAR, M.A., TRANSCRIPTIONAL ACTIVATION OF HLA-DR-ALPHA BY INTERFERON-GAMMA REQUIRES A TRANS-ACTING PROTEIN, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 85: 4672 (1988).
  6. 10.1126/science.7504325 · DOI
  7. COLAMONICI, O.R., MULTICHAIN STRUCTURE OF THE IFN-ALPHA RECEPTOR ON HEMATOPOIETIC-CELLS, JOURNAL OF IMMUNOLOGY 148: 2126 (1992). · DOI
  8. DALE, T.C., OVERLAPPING SITES FOR CONSTITUTIVE AND INDUCED DNA-BINDING FACTORS INVOLVED IN INTERFERON-STIMULATED TRANSCRIPTION, EMBO JOURNAL 8: 831 (1989). · DOI
  9. DALE, T.C., RAPID ACTIVATION BY INTERFERON-ALPHA OF A LATENT DNA-BINDING PROTEIN PRESENT IN THE CYTOPLASM OF UNTREATED CELLS, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 86: 1203 (1989).
  10. 10.1126/science.1496402 · DOI
  11. DECKER, T, INTERACTIONS OF ALPHA-INTERFERON AND GAMMA-INTERFERON IN THE TRANSCRIPTIONAL REGULATION OF THE GENE ENCODING A GUANYLATE-BINDING PROTEIN, EMBO JOURNAL 8: 2009 (1989). · DOI
  12. DECKER, T, CYTOPLASMIC ACTIVATION OF GAF, AN IFN-GAMMA-REGULATED DNA-BINDING FACTOR, EMBO JOURNAL 10: 927 (1991). · DOI
  13. FIRMBACHKRAFT, I, TYK2, PROTOTYPE OF A NOVEL CLASS OF NONRECEPTOR TYROSINE KINASE GENES, ONCOGENE 5: 1329 (1990).
  14. 10.1126/science.1650499 · DOI
  15. 10.1093/nar/9.23.6505 · DOI
  16. FRIEDMAN, R.L., TRANSCRIPTIONAL AND POSTTRANSCRIPTIONAL REGULATION OF INTERFERON-INDUCED GENE-EXPRESSION IN HUMAN-CELLS, CELL 38: 745 (1984). · DOI
  17. 10.1016/0092-8674(92)90106-M · DOI
  18. FU, X.Y., ISGF3, THE TRANSCRIPTIONAL ACTIVATOR INDUCED BY INTERFERON-ALPHA, CONSISTS OF MULTIPLE INTERACTING POLYPEPTIDE-CHAINS, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 87: 8555 (1990).
  19. FU, X.Y., THE PROTEINS OF ISGF-3, THE INTERFERON ALPHA-INDUCED TRANSCRIPTIONAL ACTIVATOR, DEFINE A GENE FAMILY INVOLVED IN SIGNAL TRANSDUCTION, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 89: 7840 (1992).
  20. GARRER, M.M., NUCLEIC ACIDS RES 9: 3047 (1981). · DOI
  21. 10.1126/science.1898992 · DOI
  22. GREENBERG, M.E., NERVE GROWTH-FACTOR AND EPIDERMAL GROWTH-FACTOR INDUCE RAPID TRANSIENT CHANGES IN PROTO-ONCOGENE TRANSCRIPTION IN PC12 CELLS, JOURNAL OF BIOLOGICAL CHEMISTRY 260: 14101 (1985). · DOI
  23. 10.1038/311433a0 · DOI
  24. HARADA, H, STRUCTURALLY SIMILAR BUT FUNCTIONALLY DISTINCT FACTORS, IRF-1 AND IRF-2, BIND TO THE SAME REGULATORY ELEMENTS OF IFN AND IFN-INDUCIBLE GENES, CELL 58: 729 (1989). · DOI
  25. HARPUR, A.G., ONCOGENE 7: 895 (1992).
  26. HEMMI, S, A NOVEL MEMBER OF THE INTERFERON RECEPTOR FAMILY COMPLEMENTS FUNCTIONALITY OF THE MURINE INTERFERON-GAMMA RECEPTOR IN HUMAN-CELLS, CELL 76: 803 (1994). · DOI
  27. IGARASHI, K, IN-VITRO ACTIVATION OF A TRANSCRIPTION FACTOR BY GAMMA-INTERFERON REQUIRES A MEMBRANE-ASSOCIATED TYROSINE KINASE AND IS MIMICKED BY VANADATE, MOLECULAR AND CELLULAR BIOLOGY 13: 3984 (1993).
  28. Improta, T., Proceedings of the National Academy of Sciences of the United States of America 91: 4776 (1994).
  29. JOHN, J, ISOLATION AND CHARACTERIZATION OF A NEW MUTANT HUMAN CELL-LINE UNRESPONSIVE TO ALPHA-INTERFERONS AND BETA-INTERFERONS, MOLECULAR AND CELLULAR BIOLOGY 11: 4189 (1991).
  30. KAHN, K.D., PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 90: 6806 (1993).
  31. KANNO, Y, THE GENOMIC STRUCTURE OF THE MURINE ICSBP GENE REVEALS THE PRESENCE OF THE GAMMA INTERFERON-RESPONSIVE ELEMENT, TO WHICH AN ISGF3-ALPHA SUBUNIT (OR SIMILAR) MOLECULE BINDS, MOLECULAR AND CELLULAR BIOLOGY 13: 3951 (1993).
  32. KESSLER, D.S., 2 INTERFERON-INDUCED NUCLEAR FACTORS BIND A SINGLE PROMOTER ELEMENT IN INTERFERON-STIMULATED GENES, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 85: 8521 (1988).
  33. 10.1126/science.1708916 · DOI
  34. 10.1126/science.7694370 · DOI
  35. 10.1126/science.8378773 · DOI
  36. LARNER, A.C., TRANSCRIPTIONAL INDUCTION BY INTERFERON - NEW PROTEIN(S) DETERMINE THE EXTENT AND LENGTH OF THE INDUCTION, JOURNAL OF BIOLOGICAL CHEMISTRY 261: 453 (1986). · DOI
  37. LARNER, A.C., TRANSCRIPTIONAL INDUCTION OF 2 GENES IN HUMAN-CELLS BY BETA-INTERFERON, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES 81: 6733 (1984).
  38. LEE, T.H., ISOLATION AND CHARACTERIZATION OF 8 TUMOR NECROSIS FACTOR-INDUCED GENE-SEQUENCES FROM HUMAN FIBROBLASTS, MOLECULAR AND CELLULAR BIOLOGY 10: 1982 (1990).
  39. LEVY, D, NEW BIOL 2: 923 (1990).
  40. LEVY, D.E., SYNERGISTIC INTERACTION BETWEEN INTERFERON-ALPHA AND INTERFERON-GAMMA THROUGH INDUCED SYNTHESIS OF ONE SUBUNIT OF THE TRANSCRIPTION FACTOR ISGF3, EMBO JOURNAL 9: 1105 (1990). · DOI
  41. LEVY, D.E., CYTOPLASMIC ACTIVATION OF ISGF3, THE POSITIVE REGULATOR OF INTERFERON-ALPHA-STIMULATED TRANSCRIPTION, RECONSTITUTED INVITRO, GENES & DEVELOPMENT 3: 1362 (1989). · DOI
  42. LEVY, D.E., INTERFERON-INDUCED NUCLEAR FACTORS THAT BIND A SHARED PROMOTER ELEMENT CORRELATE WITH POSITIVE AND NEGATIVE TRANSCRIPTIONAL CONTROL, GENES & DEVELOPMENT 2: 383 (1988). · DOI
  43. Levy, D. E., Interferon: Principles and Medical Applications: 161 (1992).
  44. LEW, D.J., ALPHA-INTERFERON AND GAMMA INTERFERON STIMULATE TRANSCRIPTION OF A SINGLE GENE THROUGH DIFFERENT SIGNAL TRANSDUCTION PATHWAYS, MOLECULAR AND CELLULAR BIOLOGY 9: 5404 (1989).
  45. LEW, D.J., OVERLAPPING ELEMENTS IN THE GUANYLATE-BINDING PROTEIN GENE PROMOTER MEDIATE TRANSCRIPTIONAL INDUCTION BY ALPHA AND GAMMA INTERFERONS, MOLECULAR AND CELLULAR BIOLOGY 11: 182 (1991).
  46. LUSTER, A.D., GAMMA-INTERFERON TRANSCRIPTIONALLY REGULATES AN EARLY-RESPONSE GENE CONTAINING HOMOLOGY TO PLATELET PROTEINS, NATURE 315: 672 (1985). · DOI
  47. MAO, C, MUTANT HUMAN-CELLS DEFECTIVE IN INDUCTION OF MAJOR HISTOCOMPATIBILITY COMPLEX CLASS-II GENES BY INTERFERON-GAMMA, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 90: 2880 (1993).
  48. MCKENDRY, R, HIGH-FREQUENCY MUTAGENESIS OF HUMAN-CELLS AND CHARACTERIZATION OF A MUTANT UNRESPONSIVE TO BOTH ALPHA INTERFERON AND GAMMA INTERFERON, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 88: 11455 (1991).
  49. MIRKOVITCH, J, MAPPING OF RNA-POLYMERASE ON MAMMALIAN GENES IN CELLS AND NUCLEI, MOLECULAR BIOLOGY OF THE CELL 3: 1085 (1992). · DOI
  50. MIYAMOTO, M, REGULATED EXPRESSION OF A GENE ENCODING A NUCLEAR FACTOR, IRF-1, THAT SPECIFICALLY BINDS TO IFN-BETA-GENE REGULATORY ELEMENTS, CELL 54: 903 (1988). · DOI
  51. MULLER, M, COMPLEMENTATION OF A MUTANT-CELL LINE - CENTRAL ROLE OF THE 91-KDA POLYPEPTIDE OF ISGF3 IN THE INTERFERON-ALPHA AND INTERFERON-GAMMA SIGNAL-TRANSDUCTION PATHWAYS, EMBO JOURNAL 12: 4221 (1993). · DOI · Paper page
  52. MULLER, M, THE PROTEIN-TYROSINE KINASE JAK1 COMPLEMENTS DEFECTS IN INTERFERON-ALPHA/BETA AND INTERFERON-GAMMA SIGNAL-TRANSDUCTION, NATURE 366: 129 (1993). · DOI
  53. MURDOCH, G.H., EPIDERMAL GROWTH-FACTOR RAPIDLY STIMULATES PROLACTIN GENE-TRANSCRIPTION, NATURE 300: 192 (1982). · DOI
  54. OVERDUIN, M, 3-DIMENSIONAL SOLUTION STRUCTURE OF THE SRC HOMOLOGY-2 DOMAIN OF C-ABL, CELL 70: 697 (1992). · DOI
  55. PEARSE, R.N., INTERFERON-GAMMA-INDUCED TRANSCRIPTION OF THE HIGH-AFFINITY FC RECEPTOR FOR IGG REQUIRES ASSEMBLY OF A COMPLEX THAT INCLUDES THE 91-KDA SUBUNIT OF TRANSCRIPTION FACTOR ISGF3, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 90: 4314 (1993).
  56. PELLEGRINI, S, USE OF A SELECTABLE MARKER REGULATED BY ALPHA INTERFERON TO OBTAIN MUTATIONS IN THE SIGNALING PATHWAY, MOLECULAR AND CELLULAR BIOLOGY 9: 4605 (1989).
  57. PINE, R, PURIFICATION AND CLONING OF INTERFERON-STIMULATED GENE FACTOR-2 (ISGF2) - ISGF2 (IRF-1) CAN BIND TO THE PROMOTERS OF BOTH BETA-INTERFERON-STIMULATED AND INTERFERON-STIMULATED GENES BUT IS NOT A PRIMARY TRANSCRIPTIONAL ACTIVATOR OF EITHER, MOLECULAR AND CELLULAR BIOLOGY 10: 2448 (1990).
  58. PORTER, ACG, INTERFERON RESPONSE ELEMENT OF THE HUMAN GENE-6-16, EMBO JOURNAL 7: 85 (1988). · DOI
  59. REICH, N, INTERFERON-INDUCED TRANSCRIPTION OF A GENE ENCODING A 15-KDA PROTEIN DEPENDS ON AN UPSTREAM ENHANCER ELEMENT, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 84: 6394 (1987).
  60. 10.1126/science.8378774 · DOI
  61. RUTHERFORD, M.N., INTERFERON-INDUCED BINDING OF NUCLEAR FACTORS TO PROMOTER ELEMENTS OF THE 2-5A SYNTHETASE GENE, EMBO JOURNAL 7: 751 (1988). · DOI
  62. 10.1126/science.8397445 · DOI
  63. SCHINDLER, C, PROTEINS OF TRANSCRIPTION FACTOR ISGF-3 - ONE GENE ENCODES THE 91-KDA AND 84-KDA ISGF-3 PROTEINS THAT ARE ACTIVATED BY INTERFERON-ALPHA, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 89: 7836 (1992).
  64. 10.1126/science.1496401 · DOI · Paper page
  65. SHIRAYOSHI, Y, INTERFERON-INDUCED TRANSCRIPTION OF A MAJOR HISTOCOMPATIBILITY CLASS-I GENE ACCOMPANIES BINDING OF INDUCIBLE NUCLEAR FACTORS TO THE INTERFERON CONSENSUS SEQUENCE, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 85: 5884 (1988).
  66. 10.1016/0092-8674(94)90357-3 · DOI · Paper page
  67. 10.1126/science.1281555 · DOI
  68. 10.1126/science.7690989 · DOI · Paper page
  69. SHUAL, K, POLYPEPTIDE SIGNALING TO THE NUCLEUS THROUGH TYROSINE PHOSPHORYLATION OF JAK AND STAT PROTEINS, NATURE 366: 580 (1993). · DOI
  70. SILVENNOINEN, O, INTERFERON-INDUCED NUCLEAR SIGNALING BY JAK PROTEIN-TYROSINE KINASES, NATURE 366: 583 (1993). · DOI
  71. SILVENNOINEN, O, STRUCTURE OF THE MURINE JAK2 PROTEIN-TYROSINE KINASE AND ITS ROLE IN INTERLEUKIN-3 SIGNAL-TRANSDUCTION, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 90: 8429 (1993).
  72. 10.1126/science.8378775 · DOI
  73. SIMS, S. H., MOLECULAR AND CELLULAR BIOLOGY 13: 690 (1993).
  74. SOH, J, IDENTIFICATION AND SEQUENCE OF AN ACCESSORY FACTOR REQUIRED FOR ACTIVATION OF THE HUMAN INTERFERON-GAMMA RECEPTOR, CELL 76: 793 (1994). · DOI
  75. UZE, G, GENETIC TRANSFER OF A FUNCTIONAL HUMAN INTERFERON-ALPHA RECEPTOR INTO MOUSE CELLS - CLONING AND EXPRESSION OF ITS CDNA, CELL 60: 225 (1990). · DOI
  76. VEALS, S.A., SUBUNIT OF AN ALPHA-INTERFERON-RESPONSIVE TRANSCRIPTION FACTOR IS RELATED TO INTERFERON REGULATORY FACTOR AND MYB FAMILIES OF DNA-BINDING PROTEINS, MOLECULAR AND CELLULAR BIOLOGY 12: 3315 (1992).
  77. 10.1016/0092-8674(92)90105-L · DOI
  78. Wakao, H., EMBO J. 13: 2182 (1994). · DOI
  79. WATLING, D, COMPLEMENTATION BY THE PROTEIN-TYROSINE KINASE JAK2 OF A MUTANT-CELL LINE DEFECTIVE IN THE INTERFERON-GAMMA SIGNAL-TRANSDUCTION PATHWAY, NATURE 366: 166 (1993). · DOI
  80. WILKS, A.F., 2 NOVEL PROTEIN-TYROSINE KINASES, EACH WITH A 2ND PHOSPHOTRANSFERASE-RELATED CATALYTIC DOMAIN, DEFINE A NEW CLASS OF PROTEIN-KINASE, MOLECULAR AND CELLULAR BIOLOGY 11: 2057 (1991).
  81. WILKS, A.F., 2 PUTATIVE PROTEIN-TYROSINE KINASES IDENTIFIED BY APPLICATION OF THE POLYMERASE CHAIN-REACTION, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 86: 1603 (1989).
  82. WITTHUHN, B.A., JAK2 ASSOCIATES WITH THE ERYTHROPOIETIN RECEPTOR AND IS TYROSINE-PHOSPHORYLATED AND ACTIVATED FOLLOWING STIMULATION WITH ERYTHROPOIETIN, CELL 74: 227 (1993). · DOI
  83. Yamamato K. Molecular and Cellular Biology in press.
  84. Zhong, Z., Proceedings of the National Academy of Sciences of the United States of America 91: 4806 (1994).

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Metadata

Authors
Darnell, J. E., Kerr, L. M., & Stark, G. R.
Affiliations
  • Rockefeller University (US)
  • Case Comprehensive Cancer Center (US)
ORCID
Stark, George R.
Venue
Science
Publisher
American Association for the Advancement of Science (AAAS)
Published
1994-06-03
Volume
264
Issue
5164
Pages
1415-1421
ISSN
  • 0036-8075 (ISSN-L)
  • 1095-9203
DOI
10.1126/science.8197455
OpenAlex
W2029275361
Cited by
6,080
References
85
Citations by year
2026: 84 · 2025: 139 · 2024: 175 · 2023: 170 · 2022: 183 · 2021: 177 · 2020: 162 · 2019: 155 · 2018: 121 · 2017: 166 · 2016: 148 · 2015: 152 · 2014: 160 · 2013: 207 · 2012: 188
FWCI
28.59
Type
journal article
Language
en
Open access
closed
Locations
  • Science (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Immunology and Microbiology › Immunology › Cytokine Signaling Pathways and Interactions
  • Life Sciences › Immunology and Microbiology › Immunology › interferon and immune responses
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › NF-κB Signaling Pathways
Keywords
JAK/STAT signaling, interferon-alpha, interferon-gamma, signal transduction, STAT proteins, transcriptional activation, JAK kinases, interferon receptor, nuclear translocation, DNA binding
MeSH terms
Amino Acid Sequence, Animals, Base Sequence, Cell Line, DNA-Binding Proteins, Genes, Genetic Complementation Test, Humans, Interferon-gamma, Molecular Sequence Data, Mutation, Protein-Tyrosine Kinases, Regulatory Sequences, Nucleic Acid, Transcription Factors, Signal Transduction, Transcriptional Activation, Interferon-alpha, Interferon-Stimulated Gene Factor 3, Interferon-Stimulated Gene Factor 3, gamma Subunit

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