A prudent path forward for genomic engineering and germline gene modification
Baltimore, David, Berg, Paul, Botchan, Michael, Carroll, Dana, Charo, R. Alta, Church, George, Corn, Jacob E., Daley, George Q., Doudna, Jennifer A., Fenner, Marsha, Greely, Henry T., Jinek, Martin, Martin, G. Steven, Penhoet, Edward, Puck, Jennifer, Sternberg, Samuel H., Weissman, Jonathan S., Yamamoto, Keith R.·2015·Science
Cited by (733)
Items 101–200 of 733
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- Embryo editing sparks epic debateCyranoski, David, Reardon, Sara · 2015 · Nature
- Germline Modification and the Burden of Human ExistenceHARRIS, JOHN · 2016 · Cambridge Quarterly of Healthcare Ethics
- Engineering therapeutic protein disaggregasesJames Shorter · 2016 · Molecular Biology of the Cell
- The rise of the ethical licenseChristi J. Guerrini, Margaret Curnutte, Jacob S. Sherkow, Christopher Thomas Scott · 2017 · Nature Biotechnology
- Improving medical students' knowledge of genetic disease: a review of current and emerging pedagogical practicesMichael J. Wolyniak, Lynne Bemis, Amy J. Prunuske · 2015 · Advances in Medical Education and Practice
- Gene therapy and editing: Novel potential treatments for neuronal channelopathiesRobert C. Wykes, Gabriele Lignani · 2017 · Neuropharmacology
- Anti-CRISPR AcrIIA5 Potently Inhibits All Cas9 Homologs Used for Genome EditingBianca García, Jooyoung Lee, Alireza Edraki, Yurima Hidalgo-Reyes, Steven Erwood, Aamir Mir, Chantel N. Trost, Uri Seroussi, Sabrina Y. Stanley, Ronald D. Cohn et al. · 2019 · Cell Reports
- Germline Manipulation and Our Future WorldsJohn Harris · 2015 · The American Journal of Bioethics
- Genome-editing revolution: My whirlwind year with CRISPRJennifer A. Doudna · 2015 · Nature
- Future of rAAV Gene Therapy: Platform for RNAi, Gene Editing, and BeyondPaul N. Valdmanis, Mark A. Kay · 2017 · Human Gene Therapy
- Disruptive reproductive technologiesIvan Glenn Cohen, George Q. Daley, Eli Y. Adashi · 2017 · Science Translational Medicine
- Genome engineering in ophthalmology: Application of CRISPR/Cas to the treatment of eye diseaseSandy S. C. Hung, Tristan McCaughey, Olivia G. Swann, Alice Pébay, Alex William Hewitt · 2016 · Progress in Retinal and Eye Research
- Investigation of the functional role of human Interleukin-8 gene haplotypes by CRISPR/Cas9 mediated genome editingManjunatha R. Benakanakere, Lívia Sertori Finoti, Urara Tanaka, Gregory R. Grant, Raquel Mantuaneli Scarel‐Caminaga, Denis F. Kinane · 2016 · Scientific Reports
- Addressing challenges in the clinical applications associated with CRISPR/Cas9 technology and ethical questions to prevent its misuseXiangjin Kang, Chiong Isabella Noelle Caparas, Boon-Seng Soh, Yong Fan · 2017 · Protein & Cell
- Systems healthcare: a holistic paradigm for tomorrowMassimo S. Fiandaca, Mark E. Mapstone, Elenora E. Connors, Mireille Jacobson, Edwin S. Monuki, Shaista Malik, Fabio M. Macciardi, Howard J. Federoff · 2017 · BMC Systems Biology
- Limits of Responsibility: Genome Editing, Asilomar, and the Politics of DeliberationJ. Benjamin Hurlbut · 2015 · The Hastings Center Report
- CRISPR Critters and CRISPR CracksR. Alta Charo, Henry T. Greely · 2015 · The American Journal of Bioethics
- Gene Editing and Genetic Lung Disease. Basic Research Meets Therapeutic ApplicationDeepthi Alapati, Edward E. Morrisey · 2016 · American Journal of Respiratory Cell and Molecular Biology
- Compelling Reasons for Repairing Human GermlinesGeorge McDonald Church · 2017 · New England Journal of Medicine
- The functional properties and structural characteristics of deamidated and succinylated wheat glutenYanhong Liu, Lingling Zhang, Yongxiang Li, Yang Yang, Fei Yang, Shuo Wang · 2017 · International Journal of Biological Macromolecules
- Is CRISPR an Ethical Game Changer?Marcus Schultz-Bergin · 2018 · Journal of Agricultural and Environmental Ethics
- Next Generation Precision Medicine: CRISPR-mediated Genome Editing for the Treatment of Neurodegenerative DisordersSudhanshu P. Raikwar, Nidhi Shankar Kikkeri, Ragha Chaitanya Sakuru, Daniyal Saeed, Haris Zahoor, Keerthivaas Premkumar, Shireen Mentor, Ramasamy Thangavel, Iuliia Dubova, Mohammad Ejaz Ahmed et al. · 2019 · Journal of Neuroimmune Pharmacology
- Homology-based repair induced by CRISPR-Cas nucleases in mammalian embryo genome editingXiya Zhang, Tao Li, Jianping Ou, Junjiu Huang, Puping Liang · 2021 · Protein & Cell
- The ethics of clinical applications of germline genome modification: a systematic review of reasonsIvy van Dijke, Lance Bosch, Annelien L. Bredenoord, Martina Cornelia Cornel, Sjoerd Repping, Saskia Hendriks · 2018 · Human Reproduction
- The Human Right to Science and the Regulation of Human Germline EngineeringAndrea Boggio, Bartha Maria Knoppers, Jessica Almqvist, Cesare P.R. Romano · 2019 · The CRISPR Journal
- A Need for Better Understanding Is the Major Determinant for Public Perceptions of Human Gene EditingTristan McCaughey, David Budden, Paul Gerard Sanfilippo, George E.C. Gooden, Fan Li, Eva Fenwick, Gwyneth Rees, Casimir MacGregor, Lei Si, Christine Chen et al. · 2018 · Human Gene Therapy
- Reasons for being in favour of or against genome modification: a survey of the Dutch general publicSaskia Hendriks, Noor A. A. Giesbertz, Annelien L. Bredenoord, Sjoerd Repping · 2018 · Human Reproduction Open
- Contribution of bacterial extracellular polymeric substances (EPS) in surface water purificationWeihua Li, Mengjie Liu, Muhammad Saboor Siddique, Nigel J. D. Graham, Wenzheng Yu · 2021 · Environmental Pollution
- Genetic manipulation for inherited neurodegenerative diseases: myth or reality?Patrick Yu‐Wai‐Man · 2016 · British Journal of Ophthalmology
- Human enhancementMara Almeida, Rui Diogo · 2019 · Evolution Medicine and Public Health
- The ethics of biosafety considerations in gain-of-function research resulting in the creation of potential pandemic pathogens: Table 1Nicholas Greig Evans, Marc Lipsitch, Meira Levinson · 2015 · Journal of Medical Ethics
- The Future of Cardiovascular Regenerative MedicineRichard Theodore Lee, Kenneth X. Walsh · 2016 · Circulation
- CRISPR‐Cas: From the Bacterial Adaptive Immune System to a Versatile Tool for Genome EngineeringMarion Kirchner, Sabine Schneider · 2015 · Angewandte Chemie International Edition
- CRISPR, un système qui permet de corriger ou de modifier l’expression de gènes responsables de maladies héréditairesJacques P. Tremblay · 2015 · médecine/sciences
- Drugs: Regulate 'home-brew' opiatesKenneth A. Oye, J. Chappell H. Lawson, Tania M. Bubela · 2015 · Nature
- The FDA is prohibited from going germlineIvan Glenn Cohen, Eli Y. Adashi · 2016 · Science
- Dreading Crispr: GMOs, Honest Brokers, And Mertonian TransgressionsGlenn Davis Stone · 2017 · Geographical Review
- Trust in Science: CRISPR–Cas9 and the Ban on Human Germline EditingStephan Güttinger · 2017 · Science and Engineering Ethics
- Non-viral delivery of CRISPR/Cas cargo to the retina using nanoparticles: current possibilities, challenges, and limitationsSalman, Ahmed, Kantor, Ariel, McClements, Michelle E., Marfany, Gemma, Trigueros, Sonia, MacLaren, Robert E. · 2022 · Pharmaceutics
- On the Road (to a Cure?) — Stem-Cell Tourism and Lessons for Gene EditingR. Alta Charo · 2016 · New England Journal of Medicine
- Ethical issues in genetic modification and why application mattersMegan Munsie, Christopher Gyngell · 2018 · Current Opinion in Genetics & Development
- Understanding attitudes on new technologies to manage invasive speciesNicholas Kirk, Robyn L. Kannemeyer, Alison J. Greenaway, Edy MacDonald, Dean C. Stronge · 2019 · Pacific Conservation Biology
- CRISPR-Cas9: A Revolutionary Tool for Cancer ModellingRaúl Torres-Ruiz, Sandra Rodríguez · 2015 · International Journal of Molecular Sciences
- Researching the future: scenarios to explore the future of human genome editingCynthia L. Selin, Lauren M. Lambert, Stephanie R. Morain, John P. Nelson, Dorit Barlevy, Mahmud Farooque, Haley Manley, Christopher Thomas Scott · 2023 · BMC Medical Ethics
- Revising, Correcting, and Transferring GenesBryan Cwik · 2020 · The American Journal of Bioethics
- CRISPR and the Rebirth of Synthetic BiologyRaheleh Heidari, David Shaw, Bernice S. Elger · 2016 · Science and Engineering Ethics
- Antiviral Defenses in Plants through Genome EditingGustavo Romay, Claude Bragard · 2017 · Frontiers in Microbiology
- Global Governance of Human Genome Editing: What Are the Rules?Gary E. Marchant · 2021 · Annual Review of Genomics and Human Genetics
- Germline gene editing and the precautionary principleJulian J. Koplin, Christopher Gyngell, Julian Savulescu · 2019 · Bioethics
- Obstacles and future of gene therapy for hemophiliaArruda, Valder R, Samelson-Jones, Ben J · 2015 · Expert Opinion on Orphan Drugs
- Human Germline Interventions–Think FirstElisabeth Hildt · 2016 · Frontiers in Genetics
- Experimental Models to Study Autism Spectrum Disorders: hiPSCs, Rodents and ZebrafishAlba Pensado‐López, Sara Veiga-Rúa, Ángel Carracedo, Catarina Allegue, Laura E. Sanchez · 2020 · Genes
- Emerging Ethical Perspectives in The Clustered Regularly Interspaced Short Palindromic Repeats Genome-Editing DebateSilvia Camporesi, Giulia Cavaliere · 2016 · Personalized Medicine
- Anomaly handling and the politics of gene drivesSam Weiss Evans, Megan Joan Palmer · 2017 · Journal of Responsible Innovation
- Genome Editing of the Germline: Broadening the DiscussionMatthew Hebden Porteus, Christina Tenenhaus Dann · 2015 · Molecular Therapy
- Controlling CRISPR Through Law: Legal Regimes as Precautionary PrinciplesJacob S. Sherkow · 2019 · The CRISPR Journal
- The Off-Targets of Clustered Regularly Interspaced Short Palindromic Repeats Gene EditingManuel M. Vicente, Miguel Chaves‐Ferreira, João M. P. Jorge, João T. Proença, Vasco M. Barreto · 2021 · Frontiers in Cell and Developmental Biology
- Ethics and Genomic Editing Using the Crispr-Cas9 Technique: Challenges and ConflictsDavid Lorenzo, Montse Esquerda, Francesc Palau, Francisco José Cambra Lasaosa, Grup Interdisciplinari de Bioètica · 2022 · NanoEthics
- CRISPR-Cas9: From a bacterial immune system to genome-edited human cells in clinical trialsLeonhard M. Kick, Marion Kirchner, Sabine Schneider · 2017 · Bioengineered
- Prophet of a new modernity: Ulrich Beck’s legacy for sociologyDan Woodman, Steven Threadgold, Alphia Possamai‐Inesedy · 2015 · Journal of Sociology
- Genomic translational research: Paving the way to individualized cardiac functional analyses and personalized cardiologyAres D. Pasipoularides · 2016 · International Journal of Cardiology
- Moving Beyond ‘Therapy’ and ‘Enhancement’ in the Ethics of Gene EditingBryan Cwik · 2019 · Cambridge Quarterly of Healthcare Ethics
- Genetics experience impacts attitudes towards germline gene editing: a survey of over 1500 members of the publicAbbie JEDWAB, Danya F. Vears, Cheryl Tse, Christopher Gyngell · 2020 · Journal of Human Genetics
- Public and Stakeholder Engagement in Developing Human Heritable Genome Editing Policies: What Does it Mean and What Should it Mean?Ana S. Iltis, Sarah Hoover, Kirstin R.W. Matthews · 2021 · Frontiers in Political Science
- Yellow lights for emerging technologiesR. Alta Charo · 2015 · Science
- High content analysis platform for optimization of lipid mediated CRISPR-Cas9 delivery strategies in human cellsBenjamin Steyer, Jared Carlson-Stevermer, Nicolas Angenent-Mari, Andrew S. Khalil, Ty Harkness, Krishanu Saha · 2015 · Acta Biomaterialia
- Genome editing: the dynamics of continuity, convergence, and change in the engineering of lifePaul A. Martin, Michael C. Morrison, Ilke Turkmendag, Brigitte Nerlich, Aisling M. McMahon, Stevienna de Saille, Andrew Bartlett · 2020 · New Genetics and Society
- Increased awareness and decreased acceptance of genome-editing technology: The impact of the Chinese twin babiesDaiki Watanabe, Yoko Saito, Mai Tsuda, Ryo Ohsawa · 2020 · PLoS ONE
- The evolution of CRISPR/Cas9 and their cousins: hope or hype?Kul Bhushan, Anirudha Chattopadhyay, Dharmendra Pratap · 2018 · Biotechnology Letters
- Attitudes of Members of Genetics Professional Societies Toward Human Gene EditingAlyssa J. Armsby, Yvonne Bombard, Nanibaa’ A. Garrison, Bonnie L. Halpern‐Felsher, Kelly E. Ormond · 2019 · The CRISPR Journal
- Transforming Scientists’ Understanding of Science–Society Relations. Stimulating Double-Loop Learning when Teaching RRIMaria Bårdsen Hesjedal, Heidrun Åm, Knut Holtan Sørensen, Roger Strand · 2020 · Science and Engineering Ethics
- You can't keep a bad idea down: Dark history, death, and potential rebirth of eugenicsMannie Liscum, Michael L. Garcia · 2021 · The Anatomical Record
- The CRISPR-Cas system of Streptococcus pyogenes: function and applicationsLuciano A. Marraffini · 2016 · Europe PMC (PubMed Central)
- Assessing Public Opinion on CRISPR-Cas9: Combining Crowdsourcing and Deep LearningMartin Müller, Manuel Schneider, Marcel Salathé, Effy Vayena · 2020 · Journal of Medical Internet Research
- Effects of Advancing Gestation and Non-Caucasian Race on Ductus Arteriosus Gene ExpressionNahid S. Waleh, Anne Marie Barrette, John M. Dagle, Allison M. Momany, Chengshi Jin, Nancy K. Hills, Elaine L. Shelton, Jeff Reese, Ronald I. Clyman · 2015 · The Journal of Pediatrics
- High-Content Analysis of CRISPR-Cas9 Gene-Edited Human Embryonic Stem CellsJared Carlson-Stevermer, Madelyn Goedland, Benjamin Steyer, Arezoo Movaghar, Meng Lou, Lucille K. Kohlenberg, Ryan Prestil, Krishanu Saha · 2016 · Stem Cell Reports
- Synthetic biology and occupational riskJohn Howard, Vladimir V. Murashov, Paul A. Schulte · 2016 · Journal of Occupational and Environmental Hygiene
- Advances in CRISPR-Cas systems for gut microbiomeNamra Ali, Chaitali Vora, Anshu Mathuria, Naina Kataria, Indra Mani · 2024 · Progress in molecular biology and translational science
- Brain tumor modeling using the CRISPR/Cas9 system: state of the art and view to the futureXiao‐Yuan Mao, Jinxiang Dai, Hong‐Hao Zhou, Zhaoqian Liu, Weilin Jin · 2016 · Oncotarget
- Gene Editing: Powerful New Tools for Nephrology Research and TherapyAyano Miyagi, Aiwu Lu, Benjamin D. Humphreys · 2016 · Journal of the American Society of Nephrology
- Attitudes Toward Hypothetical Uses of Gene-Editing Technologies in Parents of People with Autosomal AneuploidiesErika Snure Beckman, Natalie T Deuitch, Marsha Michie, Megan A. Allyse, Kirsten A. Riggan, Kelly E. Ormond · 2019 · The CRISPR Journal
- Ethics in embryo research: a position statement by the ASRM Ethics in Embryo Research Task Force and the ASRM Ethics CommitteePaula Amato, Judith Daar, Leslie Francis, Sigal Klipstein, David Ball, Paolo Rinaudo, Alexandar Rajovic, Marissa Palmore, Sean Tipton, Christos Coutifaris et al. · 2020 · Fertility and Sterility
- US Competitiveness in Synthetic BiologyGigi Kwik Grönvall · 2015 · Health Security
- Legal Issues Regarding Gene Editing at the Beginning of Life: An EU PerspectiveÍñigo de Miguel Beriaín · 2017 · Regenerative Medicine
- AAN position statement: Ethical issues in clinical research in neurologyBenjamin David Tolchin, ROBIN A. CONWIT, Leon G. Epstein, James A. Russell · 2020 · Neurology
- Thinking the unthinkable: how did human germline genome editing become ethically acceptable?Paul A. Martin, Ilke Turkmendag · 2021 · New Genetics and Society
- Heritable genome editing: ethical aspects of a developing domainSeppe Segers · 2023 · Human Reproduction
- Heritable Genome Editing and the Downsides of a Global MoratoriumKerry Lynn Macintosh · 2019 · The CRISPR Journal
- Genome Editing in NeurosciencesRudolf Jaenisch, Fred H. Gage, Feng Zhang · 2017 · Research and perspectives in neurosciences
- Human germline editing: Legal-ethical guidelines for South AfricaDonrich Willem Thaldar, Marietjie Botes, Bonginkosi Shozi, Beverley Townsend, Julian Kinderlerer · 2020 · South African Journal of Science
- Application of CRISPR-Cas9 gene editing for congenital heart diseaseHeeyoung Seok, Rui Deng, Douglas B. Cowan, Da‐Zhi Wang · 2021 · Korean Journal of Pediatrics
- CRISPR gene editingAmber Dance · 2015 · Proceedings of the National Academy of Sciences
- Investigating Leber's hereditary optic neuropathy: Cell models and future perspectivesElona Jankauskaitė, Ewa Bartnik, Agata Kodroń · 2016 · Mitochondrion
- Ethical Issues in Genome Editing for Non-Human Organisms Using CRISPR/ Cas9 SystemEduardo Rodrı́guez · 2017 · Journal of Clinical Research & Bioethics
- Modeling Microbial Communities: A Call for Collaboration between Experimentalists and TheoristsMarco Zaccaria, Sandra Dedrick, Babak Momeni · 2017 · Processes
- Ethical principles for the use of human cellular biotechnologiesthe Drafting and Reviewing Delegates of the BEINGS Working Groups, Paul Root Wolpe, Karen S. Rommelfanger · 2017 · Nature Biotechnology
- Chromosome therapy: Potential strategies for the correction of severe chromosome aberrationsKathleen L. Plona, Tae Hyun Kim, Katherine Halloran, Anthony J. Wynshaw-Boris · 2016 · American Journal of Medical Genetics Part C Seminars in Medical Genetics
- Edição genética: riscos e benefícios da modificação do DNA humanoRafael Nogueira Furtado · 2019 · Revista Bioética