A prudent path forward for genomic engineering and germline gene modification

Cited by (733)

Items 101–200 of 733

  1. Precision epigenetic editing: Technological advances, enduring challenges, and therapeutic applications
    Goldie V. Roth, Isabella R. Gengaro, Lei S. Qi · 2024 · Cell chemical biology
  2. The Nazi Physicians as Leaders in Eugenics and “Euthanasia”: Lessons for Today
    Michael A. Grodin, Erin L. Miller, Johnathan I. Kelly · 2017 · American Journal of Public Health
  3. Embryo editing sparks epic debate
    Cyranoski, David, Reardon, Sara · 2015 · Nature
  4. Germline Modification and the Burden of Human Existence
    HARRIS, JOHN · 2016 · Cambridge Quarterly of Healthcare Ethics
  5. Engineering therapeutic protein disaggregases
    James Shorter · 2016 · Molecular Biology of the Cell
  6. The rise of the ethical license
    Christi J. Guerrini, Margaret Curnutte, Jacob S. Sherkow, Christopher Thomas Scott · 2017 · Nature Biotechnology
  7. Improving medical students' knowledge of genetic disease: a review of current and emerging pedagogical practices
    Michael J. Wolyniak, Lynne Bemis, Amy J. Prunuske · 2015 · Advances in Medical Education and Practice
  8. Gene therapy and editing: Novel potential treatments for neuronal channelopathies
    Robert C. Wykes, Gabriele Lignani · 2017 · Neuropharmacology
  9. Anti-CRISPR AcrIIA5 Potently Inhibits All Cas9 Homologs Used for Genome Editing
    Bianca García, Jooyoung Lee, Alireza Edraki, Yurima Hidalgo-Reyes, Steven Erwood, Aamir Mir, Chantel N. Trost, Uri Seroussi, Sabrina Y. Stanley, Ronald D. Cohn et al. · 2019 · Cell Reports
  10. Germline Manipulation and Our Future Worlds
    John Harris · 2015 · The American Journal of Bioethics
  11. Genome-editing revolution: My whirlwind year with CRISPR
    Jennifer A. Doudna · 2015 · Nature
  12. Future of rAAV Gene Therapy: Platform for RNAi, Gene Editing, and Beyond
    Paul N. Valdmanis, Mark A. Kay · 2017 · Human Gene Therapy
  13. Disruptive reproductive technologies
    Ivan Glenn Cohen, George Q. Daley, Eli Y. Adashi · 2017 · Science Translational Medicine
  14. Genome engineering in ophthalmology: Application of CRISPR/Cas to the treatment of eye disease
    Sandy S. C. Hung, Tristan McCaughey, Olivia G. Swann, Alice Pébay, Alex William Hewitt · 2016 · Progress in Retinal and Eye Research
  15. Investigation of the functional role of human Interleukin-8 gene haplotypes by CRISPR/Cas9 mediated genome editing
    Manjunatha R. Benakanakere, Lívia Sertori Finoti, Urara Tanaka, Gregory R. Grant, Raquel Mantuaneli Scarel‐Caminaga, Denis F. Kinane · 2016 · Scientific Reports
  16. Addressing challenges in the clinical applications associated with CRISPR/Cas9 technology and ethical questions to prevent its misuse
    Xiangjin Kang, Chiong Isabella Noelle Caparas, Boon-Seng Soh, Yong Fan · 2017 · Protein & Cell
  17. Systems healthcare: a holistic paradigm for tomorrow
    Massimo S. Fiandaca, Mark E. Mapstone, Elenora E. Connors, Mireille Jacobson, Edwin S. Monuki, Shaista Malik, Fabio M. Macciardi, Howard J. Federoff · 2017 · BMC Systems Biology
  18. Limits of Responsibility: Genome Editing, Asilomar, and the Politics of Deliberation
    J. Benjamin Hurlbut · 2015 · The Hastings Center Report
  19. CRISPR Critters and CRISPR Cracks
    R. Alta Charo, Henry T. Greely · 2015 · The American Journal of Bioethics
  20. Gene Editing and Genetic Lung Disease. Basic Research Meets Therapeutic Application
    Deepthi Alapati, Edward E. Morrisey · 2016 · American Journal of Respiratory Cell and Molecular Biology
  21. Compelling Reasons for Repairing Human Germlines
    George McDonald Church · 2017 · New England Journal of Medicine
  22. The functional properties and structural characteristics of deamidated and succinylated wheat gluten
    Yanhong Liu, Lingling Zhang, Yongxiang Li, Yang Yang, Fei Yang, Shuo Wang · 2017 · International Journal of Biological Macromolecules
  23. Is CRISPR an Ethical Game Changer?
    Marcus Schultz-Bergin · 2018 · Journal of Agricultural and Environmental Ethics
  24. Next Generation Precision Medicine: CRISPR-mediated Genome Editing for the Treatment of Neurodegenerative Disorders
    Sudhanshu P. Raikwar, Nidhi Shankar Kikkeri, Ragha Chaitanya Sakuru, Daniyal Saeed, Haris Zahoor, Keerthivaas Premkumar, Shireen Mentor, Ramasamy Thangavel, Iuliia Dubova, Mohammad Ejaz Ahmed et al. · 2019 · Journal of Neuroimmune Pharmacology
  25. Homology-based repair induced by CRISPR-Cas nucleases in mammalian embryo genome editing
    Xiya Zhang, Tao Li, Jianping Ou, Junjiu Huang, Puping Liang · 2021 · Protein & Cell
  26. The ethics of clinical applications of germline genome modification: a systematic review of reasons
    Ivy van Dijke, Lance Bosch, Annelien L. Bredenoord, Martina Cornelia Cornel, Sjoerd Repping, Saskia Hendriks · 2018 · Human Reproduction
  27. The Human Right to Science and the Regulation of Human Germline Engineering
    Andrea Boggio, Bartha Maria Knoppers, Jessica Almqvist, Cesare P.R. Romano · 2019 · The CRISPR Journal
  28. A Need for Better Understanding Is the Major Determinant for Public Perceptions of Human Gene Editing
    Tristan McCaughey, David Budden, Paul Gerard Sanfilippo, George E.C. Gooden, Fan Li, Eva Fenwick, Gwyneth Rees, Casimir MacGregor, Lei Si, Christine Chen et al. · 2018 · Human Gene Therapy
  29. Reasons for being in favour of or against genome modification: a survey of the Dutch general public
    Saskia Hendriks, Noor A. A. Giesbertz, Annelien L. Bredenoord, Sjoerd Repping · 2018 · Human Reproduction Open
  30. Contribution of bacterial extracellular polymeric substances (EPS) in surface water purification
    Weihua Li, Mengjie Liu, Muhammad Saboor Siddique, Nigel J. D. Graham, Wenzheng Yu · 2021 · Environmental Pollution
  31. Genetic manipulation for inherited neurodegenerative diseases: myth or reality?
    Patrick Yu‐Wai‐Man · 2016 · British Journal of Ophthalmology
  32. Human enhancement
    Mara Almeida, Rui Diogo · 2019 · Evolution Medicine and Public Health
  33. The ethics of biosafety considerations in gain-of-function research resulting in the creation of potential pandemic pathogens: Table 1
    Nicholas Greig Evans, Marc Lipsitch, Meira Levinson · 2015 · Journal of Medical Ethics
  34. The Future of Cardiovascular Regenerative Medicine
    Richard Theodore Lee, Kenneth X. Walsh · 2016 · Circulation
  35. CRISPR‐Cas: From the Bacterial Adaptive Immune System to a Versatile Tool for Genome Engineering
    Marion Kirchner, Sabine Schneider · 2015 · Angewandte Chemie International Edition
  36. CRISPR, un système qui permet de corriger ou de modifier l’expression de gènes responsables de maladies héréditaires
    Jacques P. Tremblay · 2015 · médecine/sciences
  37. Drugs: Regulate 'home-brew' opiates
    Kenneth A. Oye, J. Chappell H. Lawson, Tania M. Bubela · 2015 · Nature
  38. The FDA is prohibited from going germline
    Ivan Glenn Cohen, Eli Y. Adashi · 2016 · Science
  39. Dreading Crispr: GMOs, Honest Brokers, And Mertonian Transgressions
    Glenn Davis Stone · 2017 · Geographical Review
  40. Trust in Science: CRISPR–Cas9 and the Ban on Human Germline Editing
    Stephan Güttinger · 2017 · Science and Engineering Ethics
  41. Non-viral delivery of CRISPR/Cas cargo to the retina using nanoparticles: current possibilities, challenges, and limitations
    Salman, Ahmed, Kantor, Ariel, McClements, Michelle E., Marfany, Gemma, Trigueros, Sonia, MacLaren, Robert E. · 2022 · Pharmaceutics
  42. On the Road (to a Cure?) — Stem-Cell Tourism and Lessons for Gene Editing
    R. Alta Charo · 2016 · New England Journal of Medicine
  43. Ethical issues in genetic modification and why application matters
    Megan Munsie, Christopher Gyngell · 2018 · Current Opinion in Genetics & Development
  44. Understanding attitudes on new technologies to manage invasive species
    Nicholas Kirk, Robyn L. Kannemeyer, Alison J. Greenaway, Edy MacDonald, Dean C. Stronge · 2019 · Pacific Conservation Biology
  45. CRISPR-Cas9: A Revolutionary Tool for Cancer Modelling
    Raúl Torres-Ruiz, Sandra Rodríguez · 2015 · International Journal of Molecular Sciences
  46. Researching the future: scenarios to explore the future of human genome editing
    Cynthia L. Selin, Lauren M. Lambert, Stephanie R. Morain, John P. Nelson, Dorit Barlevy, Mahmud Farooque, Haley Manley, Christopher Thomas Scott · 2023 · BMC Medical Ethics
  47. Revising, Correcting, and Transferring Genes
    Bryan Cwik · 2020 · The American Journal of Bioethics
  48. CRISPR and the Rebirth of Synthetic Biology
    Raheleh Heidari, David Shaw, Bernice S. Elger · 2016 · Science and Engineering Ethics
  49. Antiviral Defenses in Plants through Genome Editing
    Gustavo Romay, Claude Bragard · 2017 · Frontiers in Microbiology
  50. Global Governance of Human Genome Editing: What Are the Rules?
    Gary E. Marchant · 2021 · Annual Review of Genomics and Human Genetics
  51. Germline gene editing and the precautionary principle
    Julian J. Koplin, Christopher Gyngell, Julian Savulescu · 2019 · Bioethics
  52. Obstacles and future of gene therapy for hemophilia
    Arruda, Valder R, Samelson-Jones, Ben J · 2015 · Expert Opinion on Orphan Drugs
  53. Human Germline Interventions–Think First
    Elisabeth Hildt · 2016 · Frontiers in Genetics
  54. Experimental Models to Study Autism Spectrum Disorders: hiPSCs, Rodents and Zebrafish
    Alba Pensado‐López, Sara Veiga-Rúa, Ángel Carracedo, Catarina Allegue, Laura E. Sanchez · 2020 · Genes
  55. Emerging Ethical Perspectives in The Clustered Regularly Interspaced Short Palindromic Repeats Genome-Editing Debate
    Silvia Camporesi, Giulia Cavaliere · 2016 · Personalized Medicine
  56. Anomaly handling and the politics of gene drives
    Sam Weiss Evans, Megan Joan Palmer · 2017 · Journal of Responsible Innovation
  57. Genome Editing of the Germline: Broadening the Discussion
    Matthew Hebden Porteus, Christina Tenenhaus Dann · 2015 · Molecular Therapy
  58. Controlling CRISPR Through Law: Legal Regimes as Precautionary Principles
    Jacob S. Sherkow · 2019 · The CRISPR Journal
  59. The Off-Targets of Clustered Regularly Interspaced Short Palindromic Repeats Gene Editing
    Manuel M. Vicente, Miguel Chaves‐Ferreira, João M. P. Jorge, João T. Proença, Vasco M. Barreto · 2021 · Frontiers in Cell and Developmental Biology
  60. Ethics and Genomic Editing Using the Crispr-Cas9 Technique: Challenges and Conflicts
    David Lorenzo, Montse Esquerda, Francesc Palau, Francisco José Cambra Lasaosa, Grup Interdisciplinari de Bioètica · 2022 · NanoEthics
  61. CRISPR-Cas9: From a bacterial immune system to genome-edited human cells in clinical trials
    Leonhard M. Kick, Marion Kirchner, Sabine Schneider · 2017 · Bioengineered
  62. Prophet of a new modernity: Ulrich Beck’s legacy for sociology
    Dan Woodman, Steven Threadgold, Alphia Possamai‐Inesedy · 2015 · Journal of Sociology
  63. Genomic translational research: Paving the way to individualized cardiac functional analyses and personalized cardiology
    Ares D. Pasipoularides · 2016 · International Journal of Cardiology
  64. Moving Beyond ‘Therapy’ and ‘Enhancement’ in the Ethics of Gene Editing
    Bryan Cwik · 2019 · Cambridge Quarterly of Healthcare Ethics
  65. Genetics experience impacts attitudes towards germline gene editing: a survey of over 1500 members of the public
    Abbie JEDWAB, Danya F. Vears, Cheryl Tse, Christopher Gyngell · 2020 · Journal of Human Genetics
  66. Public and Stakeholder Engagement in Developing Human Heritable Genome Editing Policies: What Does it Mean and What Should it Mean?
    Ana S. Iltis, Sarah Hoover, Kirstin R.W. Matthews · 2021 · Frontiers in Political Science
  67. Yellow lights for emerging technologies
    R. Alta Charo · 2015 · Science
  68. High content analysis platform for optimization of lipid mediated CRISPR-Cas9 delivery strategies in human cells
    Benjamin Steyer, Jared Carlson-Stevermer, Nicolas Angenent-Mari, Andrew S. Khalil, Ty Harkness, Krishanu Saha · 2015 · Acta Biomaterialia
  69. Genome editing: the dynamics of continuity, convergence, and change in the engineering of life
    Paul A. Martin, Michael C. Morrison, Ilke Turkmendag, Brigitte Nerlich, Aisling M. McMahon, Stevienna de Saille, Andrew Bartlett · 2020 · New Genetics and Society
  70. Increased awareness and decreased acceptance of genome-editing technology: The impact of the Chinese twin babies
    Daiki Watanabe, Yoko Saito, Mai Tsuda, Ryo Ohsawa · 2020 · PLoS ONE
  71. The evolution of CRISPR/Cas9 and their cousins: hope or hype?
    Kul Bhushan, Anirudha Chattopadhyay, Dharmendra Pratap · 2018 · Biotechnology Letters
  72. Attitudes of Members of Genetics Professional Societies Toward Human Gene Editing
    Alyssa J. Armsby, Yvonne Bombard, Nanibaa’ A. Garrison, Bonnie L. Halpern‐Felsher, Kelly E. Ormond · 2019 · The CRISPR Journal
  73. Transforming Scientists’ Understanding of Science–Society Relations. Stimulating Double-Loop Learning when Teaching RRI
    Maria Bårdsen Hesjedal, Heidrun Åm, Knut Holtan Sørensen, Roger Strand · 2020 · Science and Engineering Ethics
  74. You can't keep a bad idea down: Dark history, death, and potential rebirth of eugenics
    Mannie Liscum, Michael L. Garcia · 2021 · The Anatomical Record
  75. The CRISPR-Cas system of Streptococcus pyogenes: function and applications
    Luciano A. Marraffini · 2016 · Europe PMC (PubMed Central)
  76. Assessing Public Opinion on CRISPR-Cas9: Combining Crowdsourcing and Deep Learning
    Martin Müller, Manuel Schneider, Marcel Salathé, Effy Vayena · 2020 · Journal of Medical Internet Research
  77. Effects of Advancing Gestation and Non-Caucasian Race on Ductus Arteriosus Gene Expression
    Nahid S. Waleh, Anne Marie Barrette, John M. Dagle, Allison M. Momany, Chengshi Jin, Nancy K. Hills, Elaine L. Shelton, Jeff Reese, Ronald I. Clyman · 2015 · The Journal of Pediatrics
  78. High-Content Analysis of CRISPR-Cas9 Gene-Edited Human Embryonic Stem Cells
    Jared Carlson-Stevermer, Madelyn Goedland, Benjamin Steyer, Arezoo Movaghar, Meng Lou, Lucille K. Kohlenberg, Ryan Prestil, Krishanu Saha · 2016 · Stem Cell Reports
  79. Synthetic biology and occupational risk
    John Howard, Vladimir V. Murashov, Paul A. Schulte · 2016 · Journal of Occupational and Environmental Hygiene
  80. Advances in CRISPR-Cas systems for gut microbiome
    Namra Ali, Chaitali Vora, Anshu Mathuria, Naina Kataria, Indra Mani · 2024 · Progress in molecular biology and translational science
  81. Brain tumor modeling using the CRISPR/Cas9 system: state of the art and view to the future
    Xiao‐Yuan Mao, Jinxiang Dai, Hong‐Hao Zhou, Zhaoqian Liu, Weilin Jin · 2016 · Oncotarget
  82. Gene Editing: Powerful New Tools for Nephrology Research and Therapy
    Ayano Miyagi, Aiwu Lu, Benjamin D. Humphreys · 2016 · Journal of the American Society of Nephrology
  83. Attitudes Toward Hypothetical Uses of Gene-Editing Technologies in Parents of People with Autosomal Aneuploidies
    Erika Snure Beckman, Natalie T Deuitch, Marsha Michie, Megan A. Allyse, Kirsten A. Riggan, Kelly E. Ormond · 2019 · The CRISPR Journal
  84. Ethics in embryo research: a position statement by the ASRM Ethics in Embryo Research Task Force and the ASRM Ethics Committee
    Paula Amato, Judith Daar, Leslie Francis, Sigal Klipstein, David Ball, Paolo Rinaudo, Alexandar Rajovic, Marissa Palmore, Sean Tipton, Christos Coutifaris et al. · 2020 · Fertility and Sterility
  85. US Competitiveness in Synthetic Biology
    Gigi Kwik Grönvall · 2015 · Health Security
  86. Legal Issues Regarding Gene Editing at the Beginning of Life: An EU Perspective
    Íñigo de Miguel Beriaín · 2017 · Regenerative Medicine
  87. AAN position statement: Ethical issues in clinical research in neurology
    Benjamin David Tolchin, ROBIN A. CONWIT, Leon G. Epstein, James A. Russell · 2020 · Neurology
  88. Thinking the unthinkable: how did human germline genome editing become ethically acceptable?
    Paul A. Martin, Ilke Turkmendag · 2021 · New Genetics and Society
  89. Heritable genome editing: ethical aspects of a developing domain
    Seppe Segers · 2023 · Human Reproduction
  90. Heritable Genome Editing and the Downsides of a Global Moratorium
    Kerry Lynn Macintosh · 2019 · The CRISPR Journal
  91. Genome Editing in Neurosciences
    Rudolf Jaenisch, Fred H. Gage, Feng Zhang · 2017 · Research and perspectives in neurosciences
  92. Human germline editing: Legal-ethical guidelines for South Africa
    Donrich Willem Thaldar, Marietjie Botes, Bonginkosi Shozi, Beverley Townsend, Julian Kinderlerer · 2020 · South African Journal of Science
  93. Application of CRISPR-Cas9 gene editing for congenital heart disease
    Heeyoung Seok, Rui Deng, Douglas B. Cowan, Da‐Zhi Wang · 2021 · Korean Journal of Pediatrics
  94. CRISPR gene editing
    Amber Dance · 2015 · Proceedings of the National Academy of Sciences
  95. Investigating Leber's hereditary optic neuropathy: Cell models and future perspectives
    Elona Jankauskaitė, Ewa Bartnik, Agata Kodroń · 2016 · Mitochondrion
  96. Ethical Issues in Genome Editing for Non-Human Organisms Using CRISPR/ Cas9 System
    Eduardo Rodrı́guez · 2017 · Journal of Clinical Research & Bioethics
  97. Modeling Microbial Communities: A Call for Collaboration between Experimentalists and Theorists
    Marco Zaccaria, Sandra Dedrick, Babak Momeni · 2017 · Processes
  98. Ethical principles for the use of human cellular biotechnologies
    the Drafting and Reviewing Delegates of the BEINGS Working Groups, Paul Root Wolpe, Karen S. Rommelfanger · 2017 · Nature Biotechnology
  99. Chromosome therapy: Potential strategies for the correction of severe chromosome aberrations
    Kathleen L. Plona, Tae Hyun Kim, Katherine Halloran, Anthony J. Wynshaw-Boris · 2016 · American Journal of Medical Genetics Part C Seminars in Medical Genetics
  100. Edição genética: riscos e benefícios da modificação do DNA humano
    Rafael Nogueira Furtado · 2019 · Revista Bioética