Epigenetic (re)programming of caste-specific behavior in the ant Camponotus floridanus
Open accessAbstract
Epigenetic control of caste-specific foraging: In carpenter ants, separate behavioral classes, known as castes, are determined by the epigenetic regulation of genes. Simola et al. treated ants of different castes with drugs that affected histone acetylation. Reducing histone acetylation stimulated scouting and foraging behavior. The foraging and scouting behaviors of young ants were permanently changed by directly injecting their brains with histone acetylation inhibitors. Science , this issue p. 10.1126/science.aac6633
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In the carpenter ant Camponotus floridanus, the balance between morphologically distinct worker castes depends on histone acetylation levels, which may be influenced by feeding behaviour.
“Another form of environmentally induced chromatin regulation is found in social insects such as the carpenter ant Camponotus floridanus, in which the balance between morphologically distinct worker castes depends on the levels of histone acetylation, which may be influenced by feeding behaviour 82 .”
From Advances in epigenetics link genetics to the environment and disease (2019) · cites this paper as [82]
Ant and bee castes have caste-specific DNA methylation and H3K27ac patterns functionally important for behavior.
“Comparisons between individuals from different castes have revealed that they have caste-specific DNA methylation and H3K27ac patterns that are functionally important for their behavior (Simola et al., 2016; Yan et al., 2015).”
From The Aging Epigenome (2016) · cites this paper as Simola et al., 2016
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Fast gapped-read alignment with Bowtie 2
Langmead, B., & Salzberg, S. L. (2012) · Nature Methods · doi:10.1038/nmeth.1923 · Cited by 56,400 · see citing works
Trapnell, C., Williams, B. A., Pertea, G., Mortazavi, A., Kwan, G., van Baren, M. J., Salzberg, S. L., Wold, B. J., & Pachter, L. (2010) · Nature Biotechnology · doi:10.1038/nbt.1621 · Cited by 15,556 · see citing works
Hölldobler, B., & Wilson, E. O. (1990) · Springer eBooks · doi:10.1007/978-3-662-10306-7 · Cited by 5,531 · see citing works
Valproic acid defines a novel class of HDAC inhibitors inducing differentiation of transformed cells
Göttlicher, M., Minucci, S., Zhu, P., Krämer, O. H., Schimpf, A., Giavara, S., Sleeman, J. P., Coco, F. L., Nervi, C., Pelicci, P. G., et al. (2001) · The EMBO Journal · doi:10.1093/emboj/20.24.6969 · Cited by 1,889 · see citing works
Recovery of learning and memory is associated with chromatin remodelling
Fischer, A., Sananbenesi, F., Wang, X., Dobbin, M., & Tsai, L.-H. (2007) · Nature · doi:10.1038/nature05772 · Cited by 1,227 · see citing works
Nutritional Control of Reproductive Status in Honeybees via DNA Methylation
Kucharski, R., Maleszka, J., Forêt, S., & Maleszka, R. (2008) · Science · doi:10.1126/science.1153069 · Cited by 1,146 · see citing works
Regulation of Division of Labor in Insect Societies
Robinson, G. E. (1992) · Annual Review of Entomology · doi:10.1146/annurev.en.37.010192.003225 · Cited by 1,111 · see citing works
Regulation Of Division Of Labor In Insect Societies
Robinson, G. E. (1992) · Annual Review of Entomology · doi:10.1146/annurev.ento.37.1.637 · Cited by 902 · see citing works
Chromatin Acetylation, Memory, and LTP Are Impaired in CBP+/− Mice
Alarcón, J. M., Malleret, G., Touzani, K., Vronskaya, S., Ishii, S., Kandel, E. R., & Barco, A. (2004) · Neuron · doi:10.1016/j.neuron.2004.05.021 · Cited by 892 · see citing works
Jin, Q., Yu, L., Wang, L., Zhang, Z., Kasper, L. H., Lee, J., Wang, C., Brindle, P. K., Dent, S. Y. R., & Ge, K. (2011) · The EMBO Journal · doi:10.1038/emboj.2010.318 · Cited by 877 · see citing works
Vecsey, C. G., Hawk, J. D., Lattal, K. M., Stein, J. M., Fabian, S., Attner, M. A., Cabrera, S. M., McDonough, C. B., Brindle, P. K., Abel, T. G., et al. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.0296-07.2007 · Cited by 828 · see citing works
CBP Histone Acetyltransferase Activity Is a Critical Component of Memory Consolidation
Korzus, E., Rosenfeld, M. G., & Mayford, M. (2004) · Neuron · doi:10.1016/j.neuron.2004.06.002 · Cited by 823 · see citing works
Bowers, E. M., Yan, G., Mukherjee, C., Orry, A., Wang, L., Holbert, M. A., Crump, N. T., Hazzalin, C. A., Liszczak, G., Yuan, H., et al. (2010) · Chemistry & Biology · doi:10.1016/j.chembiol.2010.03.006 · Cited by 666 · see citing works
CBP-mediated acetylation of histone H3 lysine 27 antagonizesDrosophilaPolycomb silencing
Tie, F., Banerjee, R., Stratton, C. A., Prasad-Sinha, J., Stepanik, V. A., Zlobin, A., Dı́az, M. O., Scacheri, P. C., & Harte, P. J. (2009) · Development · doi:10.1242/dev.037127 · Cited by 575 · see citing works
Artificial Diet for Rearing Various Species of Ants
Bhatkar, A. P., & Whitcomb, W. H. (1970) · Florida Entomologist · doi:10.2307/3493193 · Cited by 544 · see citing works
Quantitative ChIP-Seq normalization reveals global modulation of the epigenome
Orlando, D. A., Chen, M. W., Brown, V. E., Solanki, S., Choi, Y. J., Olson, E. R., Fritz, C. C., Bradner, J. E., & Guenther, M. G. (2014) · Cell Reports · doi:10.1016/j.celrep.2014.10.018 · Cited by 503 · cited 1× · see citing works
“5% by volume based on Qubit protein quantitation [ChIP-Rx (36)].”
High-Throughput Illumina Strand-Specific RNA Sequencing Library PreparationPreprint
Zhong, S., Joung, J., Zheng, Y., Chen, Y.-R., Liu, B., Shao, Y., Xiang, J., Fei, Z., & Giovannoni, J. J. (2011) · Cold Spring Harbor Protocols · doi:10.1101/pdb.prot5652 · Cited by 471 · see citing works
Sociogenomics: social life in molecular terms
Robinson, G. E., Grozinger, C. M., & Whitfield, C. W. (2005) · Nature Reviews Genetics · doi:10.1038/nrg1575 · Cited by 456 · see citing works
Genomic Comparison of the Ants Camponotus floridanus and Harpegnathos saltator
Bonasio, R., Zhang, G., Ye, C., Mutti, N. S., Fang, X., Qin, N., Donahue, G., Yang, P., Li, Q., Li, C., et al. (2010) · Science · doi:10.1126/science.1192428 · Cited by 453 · see citing works
Self-citationA Y-like social chromosome causes alternative colony organization in fire ants
Wang, J., Wurm, Y., Nipitwattanaphon, M., Riba‐Grognuz, O., Huang, Y., Shoemaker, D., & Keller, L. (2013) · Nature · doi:10.1038/nature11832 · Cited by 424 · see citing works
Tracking Individuals Shows Spatial Fidelity Is a Key Regulator of Ant Social Organization
Mersch, D. P., Crespi, A., & Keller, L. (2013) · Science · doi:10.1126/science.1234316 · Cited by 418 · see citing works
Selective neuroanatomical plasticity and division of labour in the honeybee
Withers, G. S., Fahrbach, S. E., & Robinson, G. E. (1993) · Nature · doi:10.1038/364238a0 · Cited by 408 · see citing works
Bonasio, R., Li, Q., Lian, J., Mutti, N. S., Jin, L., Zhao, H., Zhang, P., Wen, P., Xiang, H., Ding, Y., et al. (2012) · Current Biology · doi:10.1016/j.cub.2012.07.042 · Cited by 398 · see citing works
Self-citationTschinkel, W. R. (2006) · Medical Entomology and Zoology · Cited by 372 · see citing works
Genetic and genomic analyses of the division of labour in insect societies
Smith, C. R., Toth, A. L., Suarez, A. V., & Robinson, G. E. (2008) · Nature Reviews Genetics · doi:10.1038/nrg2429 · Cited by 371 · see citing works
Reversible switching between epigenetic states in honeybee behavioral subcastes
Herb, B. R., Wolschin, F., Hansen, K. D., Aryee, M. J., Langmead, B., Irizarry, R. A., Amdam, G. V., & Feinberg, A. P. (2012) · Nature Neuroscience · doi:10.1038/nn.3218 · Cited by 335 · see citing works
Brain function and chromatin plasticity
Dulac, C. G. (2010) · Nature · doi:10.1038/nature09231 · Cited by 299 · see citing works
Genome-wide identification and characterization of functional neuronal activity–dependent enhancers
Malik, A. N., Vierbuchen, T., Hemberg, M., Rubin, A. A., Ling, E., Couch, C. H., Stroud, H., Spiegel, I., Farh, K. K., Harmin, D. A., et al. (2014) · Nature Neuroscience · doi:10.1038/nn.3808 · Cited by 267 · see citing works
Simola, D. F., Wissler, L., Donahue, G., Waterhouse, R. M., Helmkampf, M., Roux, J., Nygaard, S., Glastad, K. M., Hagen, D. E., Viljakainen, L., et al. (2013) · Genome Research · doi:10.1101/gr.155408.113 · Cited by 247 · see citing works
Self-citationZhou, X., Slone, J. D., Rokas, A., Berger, S. L., Liebig, J., Ray, A., Reinberg, D., & Zwiebel, L. J. (2012) · PLoS Genetics · doi:10.1371/journal.pgen.1002930 · Cited by 241 · see citing works
Self-citationNMDA Receptors Mediate Olfactory Learning and Memory in Drosophila
Xia, S., Miyashita, T., Fu, T., Lin, W., Wu, C., Pyzocha, L., Lin, I.-R., Saitoe, M., Tully, T., & Chiang, A. (2005) · Current Biology · doi:10.1016/j.cub.2005.02.059 · Cited by 226 · see citing works
Gronenberg, W., Heeren, S., & Hölldobler, B. (1996) · Journal of Experimental Biology · doi:10.1242/jeb.199.9.2011 · Cited by 221 · see citing works
Behavioral discretization and the number of castes in an ant species
Wilson, E. O. (1976) · Behavioral Ecology and Sociobiology · doi:10.1007/bf00299195 · Cited by 214 · see citing works
Histone deacetylase inhibitor activity in royal jelly might facilitate caste switching in bees
Spannhoff, A., Kim, Y. K., Raynal, N. J. ‐., Gharibyan, V., Su, M., Zhou, Y., Li, J. X., Castellano, S., Sbardella, G., Issa, J. J., et al. (2011) · EMBO Reports · doi:10.1038/embor.2011.9 · Cited by 213 · see citing works
Eusocial insects as emerging models for behavioural epigenetics
Yan, H., Simola, D. F., Bonasio, R., Liebig, J., Berger, S. L., & Reinberg, D. (2014) · Nature Reviews Genetics · doi:10.1038/nrg3787 · Cited by 198 · see citing works
Self-citationATAC is a double histone acetyltransferase complex that stimulates nucleosome sliding
Suganuma, T., Gutiérrez, J. L., Li, B., Florens, L. A., Swanson, S. K., Washburn, M. P., Abmayr, S. M., & Workman, J. L. (2008) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.1397 · Cited by 191 · see citing works
Molecular Determinants of Scouting Behavior in Honey Bees
Liang, Z., Nguyen, T. T., Mattila, H. R., Rodriguez‐Zas, S. L., Seeley, T. D., & Robinson, G. E. (2012) · Science · doi:10.1126/science.1213962 · Cited by 156 · see citing works
A chromatin link to caste identity in the carpenter ant Camponotus floridanusPreprint
Simola, D. F., Ye, C., Mutti, N. S., Dolezal, K., Bonasio, R., Liebig, J., Reinberg, D., & Berger, S. L. (2012) · Genome Research · doi:10.1101/gr.148361.112 · Cited by 145 · see citing works
Self-citationThe Evolution of Worker Caste Diversity in Social Insects
Fjerdingstad, E. J., & Crozier, R. H. (2006) · The American Naturalist · doi:10.1086/499545 · Cited by 135 · see citing works
Molecular basis for changes in behavioral state in ant social behaviors
Lucas, C., & Sokolowski, M. B. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0809463106 · Cited by 125 · see citing works
Recruitment behavior in Camponotus socius (Hym. Formicidae)
Hölldobler, B. (1971) · Zeitschrift für Vergleichende Physiologie · doi:10.1007/bf00335259 · Cited by 124 · see citing works
Epigenetic variation in the Egfr gene generates quantitative variation in a complex trait in ants
Alvarado, S. G., Rajakumar, R., Abouheif, E., & Moshe Szyf, A. (2015) · Nature Communications · doi:10.1038/ncomms7513 · Cited by 123 · see citing works
Crump, N., Hazzalin, C. A., Bowers, E. M., Alani, R., Cole, P., & Mahadevan, L. C. (2011) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.1100099108 · Cited by 104 · see citing works
Knowledgeable individuals lead collective decisions in ants
Stroeymeyt, N., Franks, N. R., & Giurfa, M. (2011) · Journal of Experimental Biology · doi:10.1242/jeb.059188 · Cited by 78 · see citing works
Behavioral flexibility in age castes of the antPheidole dentata
Calabi, P., & Traniello, J. F. A. (1989) · Journal of Insect Behavior · doi:10.1007/bf01065785 · Cited by 76 · see citing works
Individual histone deacetylases in Drosophila modulate transcription of distinct genes
Cho, Y., Griswold, A., Campbell, C., & Min, K.-T. (2005) · Genomics · doi:10.1016/j.ygeno.2005.07.007 · Cited by 71 · see citing works
Mushroom body volumes and visual interneurons in ants: Comparison between sexes and castes
Ehmer, B., & Gronenberg, W. (2003) · The Journal of Comparative Neurology · doi:10.1002/cne.11014 · Cited by 71 · see citing works
Iyer, S. C., Wang, D. Y. Q., Iyer, E. P. R., Trunnell, S. A., Meduri, R., Shinwari, R., Sulkowski, M. J., & Cox, D. N. (2012) · PLoS ONE · doi:10.1371/journal.pone.0033634 · Cited by 64 · see citing works
Population and colony structure of the carpenter ant Camponotus floridanus
Gadau, J. R., Heınze, J., Hölldobler, B., & Schmid, M. (1996) · Molecular Ecology · doi:10.1111/j.1365-294x.1996.tb00374.x · Cited by 61 · see citing works
Milite, C., Feoli, A., Sasaki, K., Pietra, V. L., Balzano, A. L., Marinelli, L., Mai, A., Novellino, E., Castellano, S., Tosco, A., et al. (2015) · Journal of Medicinal Chemistry · doi:10.1021/jm5019687 · Cited by 54 · see citing works
Tschinkel, W. R. (2013) · Harvard University Press eBooks · doi:10.2307/j.ctv1dp0txz · Cited by 52 · see citing works
Schrader, L., Simola, D. F., Heınze, J., & Oettler, J. (2015) · Molecular Biology and Evolution · doi:10.1093/molbev/msv039 · Cited by 48 · see citing works
Self-citationGenetic Modulation of Rpd3 Expression Impairs Long-Term Courtship Memory in Drosophila
Fitzsimons, H. L., & Scott, M. J. (2011) · PLoS ONE · doi:10.1371/journal.pone.0029171 · Cited by 41 · see citing works
Single-tube linear DNA amplification for genome-wide studies using a few thousand cells
Shankaranarayanan, P., Mendoza-Parra, M. A., Gool, W. V., Trindade, L. M., & Gronemeyer, H. (2012) · Nature Protocols · doi:10.1038/nprot.2011.447 · Cited by 37 · see citing works
Sniper: improved SNP discovery by multiply mapping deep sequenced reads
Simola, D. F., & Kim, J. (2011) · Genome biology · doi:10.1186/gb-2011-12-6-r55 · Cited by 31 · see citing works
Self-citation
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- [1]Hölldobler B Wilson EO The Ants 1990 Belknap/Harvard Univ. Press Cambridge, MA
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Sorted by citations
Advances in epigenetics link genetics to the environment and disease
Cavalli, G., & Heard, E. (2019) · Nature · doi:10.1038/s41586-019-1411-0 · Cited by 1,509 · see citing works
Epigenetic mechanisms of longevity and aging
Sen, P., Shah, P. P., Nativio, R., & Berger, S. L. (2016) · Cell · doi:10.1016/j.cell.2016.07.050 · Cited by 956 · see citing works
Self-citationMathers, T. C., Chen, Y., Kaithakottil, G., Legeai, F., Mugford, S. T., Bâa-Puyoulet, P., Bretaudeau, A., Clavijo, B., Colella, S., Collin, O., et al. (2017) · Genome biology · doi:10.1186/s13059-016-1145-3 · Cited by 825 · see citing works
Booth, L. N., & Brunet, A. (2016) · Molecular Cell · doi:10.1016/j.molcel.2016.05.013 · Cited by 499 · see citing works
Biological embedding of experience: a primer on epigenetics
Aristizabal, M. J., Anreiter, I., Halldorsdottir, T., Odgers, C. L., McDade, T. W., Goldenberg, A., Mostafavi, S., Kobor, M. S., Binder, E. B., Sokolowski, M. B., et al. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1820838116 · Cited by 268 · see citing works
The Neuropeptide Corazonin Controls Social Behavior and Caste Identity in Ants
Gospočić, J., Shields, E. J., Glastad, K. M., Lin, Y., Penick, C. A., Yan, H., Mikheyev, A. S., Linksvayer, T. A., Garcia, B. A., Berger, S. L., et al. (2017) · Cell · doi:10.1016/j.cell.2017.07.014 · Cited by 189 · see citing works
Self-citationThe Dynamic Regulatory Genome of Capsaspora and the Origin of Animal Multicellularity
Sebé-Pedrós, A., Ballaré, C., Parra-Acero, H., Chiva, C., Tena, J. J., Sabidó, E., Gómez-Skármeta, J. L., Croce, L. D., & Ruiz‐Trillo, I. (2016) · Cell · doi:10.1016/j.cell.2016.03.034 · Cited by 183 · see citing works
Epigenetics in Insects: Genome Regulation and the Generation of Phenotypic Diversity
Glastad, K. M., Hunt, B. G., & Goodisman, M. A. D. (2018) · Annual Review of Entomology · doi:10.1146/annurev-ento-011118-111914 · Cited by 169 · see citing works
Plant microRNAs in larval food regulate honeybee caste development
Zhu, K., Liu, M., Fu, Z., Zhou, Z., Kong, Y., Liang, H., Lin, Z., Luo, J., Zheng, H., Wan, P., et al. (2017) · PLoS Genetics · doi:10.1371/journal.pgen.1006946 · Cited by 161 · see citing works
Genomics of Developmental Plasticity in Animals
Lafuente, E., & Beldade, P. (2019) · Frontiers in Genetics · doi:10.3389/fgene.2019.00720 · Cited by 147 · see citing works
Molecular Evolution of Insect Sociality: An Eco-Evo-Devo Perspective
Toth, A. L., & Rehan, S. M. (2016) · Annual Review of Entomology · doi:10.1146/annurev-ento-031616-035601 · Cited by 122 · see citing works
Bengston, S. E., Dahan, R. A., Donaldson, Z. R., Phelps, S. M., van Oers, K., Sih, A., & Bell, A. M. (2018) · Nature Ecology & Evolution · doi:10.1038/s41559-017-0411-4 · Cited by 114 · see citing works
Wojciechowski, M., Lowe, R., Maleszka, J., Conn, D. A., Maleszka, R., & Hurd, P. J. (2018) · Genome Research · doi:10.1101/gr.236497.118 · Cited by 108 · see citing works
Lea, A. J., Tung, J., Archie, E. A., & Alberts, S. C. (2017) · Evolution Medicine and Public Health · doi:10.1093/emph/eox019 · Cited by 107 · see citing works
The social nature of mitochondria: Implications for human health
Picard, M. A., & Sandi, C. (2020) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2020.04.017 · Cited by 102 · see citing works
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Romiguier, J., Borowiec, M. L., Weyna, A., Helleu, Q., Loire, É., Mendola, C. L., Rabeling, C., Fisher, B. L., Ward, P. S., & Keller, L. (2022) · Current Biology · doi:10.1016/j.cub.2022.05.001 · Cited by 102 · see citing works
Current Insights into Sublethal Effects of Pesticides on Insects
Bartling, M. T., Brandt, A., Hollert, H., & Vilcinskas, A. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25116007 · Cited by 96 · see citing works
Origins of Aminergic Regulation of Behavior in Complex Insect Social Systems
Kamhi, J. F., Arganda, S., Moreau, C. S., & Traniello, J. F. A. (2017) · Frontiers in Systems Neuroscience · doi:10.3389/fnsys.2017.00074 · Cited by 94 · see citing works
Warner, M. R., Qiu, L., Holmes, M. J., Mikheyev, A. S., & Linksvayer, T. A. (2019) · Nature Communications · doi:10.1038/s41467-019-10546-w · Cited by 88 · see citing works
High-Quality Genome Assemblies Reveal Long Non-coding RNAs Expressed in Ant Brains
Shields, E. J., Sheng, L., Weiner, A. K., Garcia, B. A., & Bonasio, R. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.05.014 · Cited by 84 · see citing works
Self-citationGospočić, J., Glastad, K. M., Sheng, L., Shields, E. J., Berger, S. L., & Bonasio, R. (2021) · Cell · doi:10.1016/j.cell.2021.10.006 · Cited by 81 · see citing works
Self-citationEnvironmental influence on Pristionchus pacificus mouth form through different culture methods
Werner, M. S., Sieriebriennikov, B., Loschko, T., Namdeo, S., Lenuzzi, M., Dardiry, M., Renahan, T., Sharma, D. R., & Sommer, R. J. (2017) · Scientific Reports · doi:10.1038/s41598-017-07455-7 · Cited by 72 · see citing works
The genomewide transcriptional response underlying the pea aphid wing polyphenism
Vellichirammal, N. N., Madayiputhiya, N., & Brisson, J. A. (2016) · Molecular Ecology · doi:10.1111/mec.13749 · Cited by 76 · see citing works
Shigenobu, S., Hayashi, Y., Watanabe, D., Tokuda, G., Hojo, M., Toga, K., Saiki, R., Yaguchi, H., Masuoka, Y., Suzuki, R., et al. (2022) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2110361119 · Cited by 72 · see citing works
Methylation and gene expression differences between reproductive and sterile bumblebee workers
Marshall, H., Lonsdale, Z. N., & Mallon, E. B. (2019) · Evolution Letters · doi:10.1002/evl3.129 · Cited by 63 · see citing works
Behavioral, transcriptomic and epigenetic responses to social challenge in honey bees
Shpigler, H. Y., Saul, M. C., Murdoch, E. E., Cash-Ahmed, A. C., Seward, C. H., Sloofman, L. G., Chandrasekaran, S., Sinha, S., Stubbs, L. J., & Robinson, G. E. (2017) · Genes Brain & Behavior · doi:10.1111/gbb.12379 · Cited by 72 · see citing works
Epigenetic code and insect behavioural plasticity.
Maleszka, R. (2016) · Current Opinion in Insect Science · doi:10.1016/j.cois.2016.03.003 · Cited by 54 · see citing works
Roy, A., & Palli, S. R. (2018) · BMC Genomics · doi:10.1186/s12864-018-5323-4 · Cited by 63 · see citing works
Will, I., Das, B., Trinh, T., Brachmann, A., Ohm, R. A., & de Bekker, C. (2020) · G3 Genes Genomes Genetics · doi:10.1534/g3.120.401290 · Cited by 63 · see citing works
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Yang, C.-H., & Pospisilik, J. A. (2019) · Frontiers in Genetics · doi:10.3389/fgene.2019.00132 · Cited by 61 · see citing works
Gibert, J., Mouchel‐Vielh, E., Castro, S. D., & Peronnet, F. (2016) · PLoS Genetics · doi:10.1371/journal.pgen.1006218 · Cited by 59 · see citing works
Recent Advances in Behavioral (Epi)Genetics in Eusocial Insects
Opachaloemphan, C., Yan, H., Leibholz, A., Desplan, C., & Reinberg, D. (2018) · Annual Review of Genetics · doi:10.1146/annurev-genet-120116-024456 · Cited by 57 · see citing works
Self-citationIndividual differences in honey bee behavior enabled by plasticity in brain gene regulatory networks
Jones, B. M., Rao, V. D., Gernat, T., Jagla, T., Cash-Ahmed, A. C., Rubin, B. E. R., Comi, T. J., Bhogale, S. G., Husain, S. S., Blatti, C. A., et al. (2020) · eLife · doi:10.7554/elife.62850 · Cited by 54 · see citing works
Genetics and Evolution of Social Behavior in Insects
Weitekamp, C. A., Libbrecht, R., & Keller, L. (2017) · Annual Review of Genetics · doi:10.1146/annurev-genet-120116-024515 · Cited by 56 · see citing works
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Glastad, K. M., Graham, R. J., Ju, L., Roessler, J. M., Brady, C. M., & Berger, S. L. (2019) · Molecular Cell · doi:10.1016/j.molcel.2019.10.012 · Cited by 56 · see citing works
Self-citationAnt behavioral maturation is mediated by a stochastic transition between two fundamental states
Richardson, T. O., Kay, T., Braunschweig, R., Journeau, O. A., Rüegg, M., McGregor, S., Rios, P. D. L., & Keller, L. (2021) · Current Biology · doi:10.1016/j.cub.2020.05.038 · Cited by 54 · see citing works
Defense in Social Insects: Diversity, Division of Labor, and Evolution
Abbot, P. (2022) · Annual Review of Entomology · doi:10.1146/annurev-ento-082521-072638 · Cited by 53 · see citing works
Adaptive radiation and social evolution of the ants
Vizueta, J., Xiong, Z., Ding, G., Larsen, R., Ran, H., Gao, Q., Stiller, J., Dai, W., Jiang, W., Zhao, J., et al. (2025) · Cell · doi:10.1016/j.cell.2025.05.030 · Cited by 52 · see citing works
Genome Architecture Facilitates Phenotypic Plasticity in the Honeybee (Apis mellifera)
Duncan, E. J., Leask, M., & Dearden, P. K. (2020) · Molecular Biology and Evolution · doi:10.1093/molbev/msaa057 · Cited by 47 · see citing works
The genetics of phenotypic plasticity in nematode feeding structures
Sommer, R. J., Dardiry, M., Lenuzzi, M., Namdeo, S., Renahan, T., Sieriebriennikov, B., & Werner, M. S. (2017) · Open Biology · doi:10.1098/rsob.160332 · Cited by 49 · see citing works
The flexible stem hypothesis: evidence from genetic data
Gibert, J. (2017) · Development Genes and Evolution · doi:10.1007/s00427-017-0589-0 · Cited by 49 · see citing works
Lewis, J. J., van der Burg, K. R. L., Mazo‐Vargas, A., & Reed, R. D. (2016) · Cell Reports · doi:10.1016/j.celrep.2016.08.042 · Cited by 47 · see citing works
The Role of Dopamine in the Collective Regulation of Foraging in Harvester Ants
Friedman, D., Pilko, A., Skowronska‐Krawczyk, D., Krasinska, K. M., Parker, J. W., Hirsh, J., & Gordon, D. M. (2018) · iScience · doi:10.1016/j.isci.2018.09.001 · Cited by 47 · see citing works
Comparative transcriptomics of social insect queen pheromones
Holman, L., Helanterä, H., Trontti, K., & Mikheyev, A. S. (2019) · Nature Communications · doi:10.1038/s41467-019-09567-2 · Cited by 47 · see citing works
Epigenetic Molecular Mechanisms in Insects
Villagra, C., & Frías-Lasserre, D. (2020) · Neotropical Entomology · doi:10.1007/s13744-020-00777-8 · Cited by 46 · see citing works
The molecular basis of socially mediated phenotypic plasticity in a eusocial paper wasp
Taylor, B. A., Cini, A., Wyatt, C. D. R., Reuter, M., & Sumner, S. (2021) · Nature Communications · doi:10.1038/s41467-021-21095-6 · Cited by 46 · see citing works
Hormonal gatekeeping via the blood-brain barrier governs caste-specific behavior in ants
Ju, L., Glastad, K. M., Sheng, L., Gospočić, J., Kingwell, C. J., Davidson, S. M., Kocher, S. D., Bonasio, R., & Berger, S. L. (2023) · Cell · doi:10.1016/j.cell.2023.08.002 · Cited by 46 · see citing works
Self-citationChak, S. T. C., Harris, S. E., Hultgren, K. M., Jeffery, N. W., & Rubenstein, D. R. (2021) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2025051118 · Cited by 42 · see citing works
Epigenetic regulation of post-embryonic development
Palli, S. R. (2020) · Current Opinion in Insect Science · doi:10.1016/j.cois.2020.09.011 · Cited by 41 · see citing works
Independent phenotypic plasticity axes define distinct obesity sub-types
Yang, C.-H., Fagnocchi, L., Apostle, S., Wegert, V., Casaní-Galdón, S., Landgraf, K., Panzeri, I., Dror, E., Heyne, S., Wörpel, T., et al. (2022) · Nature Metabolism · doi:10.1038/s42255-022-00629-2 · Cited by 39 · see citing works
Rate variation in the evolution of non-coding DNA associated with social evolution in bees
Rubin, B. E. R., Jones, B. M., Hunt, B. G., & Kocher, S. D. (2019) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2018.0247 · Cited by 40 · see citing works
Single-cell dissection of aggression in honeybee colonies
Traniello, I. M., Bukhari, S. A., Dibaeinia, P., Serrano, G., Avalos, A., Cash-Ahmed, A. C., Sankey, A. L., Hernáez, M., Sinha, S., Zhao, S. D., et al. (2023) · Nature Ecology & Evolution · doi:10.1038/s41559-023-02090-0 · Cited by 39 · see citing works
(Epi)Genetic Mechanisms Underlying the Evolutionary Success of Eusocial Insects
Sieber, K. R., Dorman, T., Newell, N., & Yan, H. (2021) · Insects · doi:10.3390/insects12060498 · Cited by 38 · see citing works
Early behavioral and molecular events leading to caste switching in the ant HarpegnathosPreprint
Opachaloemphan, C., Mancini, G., Konstantinides, N., Parikh, A., Mlejnek, J., Yan, H., Reinberg, D., & Desplan, C. (2021) · Genes & Development · doi:10.1101/gad.343699.120 · Cited by 38 · see citing works
Self-citationHistone 4 lysine 5/12 acetylation enables developmental plasticity of Pristionchus mouth form
Werner, M. S., Loschko, T., King, T., Reich, S., Theska, T., Franz‐Wachtel, M., Maček, B., & Sommer, R. J. (2023) · Nature Communications · doi:10.1038/s41467-023-37734-z · Cited by 39 · see citing works
Ingram, K. K., Gordon, D. M., Friedman, D., Greene, M., Kahler, J., & Peteru, S. (2016) · Proceedings of the Royal Society B Biological Sciences · doi:10.1098/rspb.2016.0841 · Cited by 37 · see citing works
Hamilton, A. R., Traniello, I. M., Ray, A. M., Caldwell, A. S., Wickline, S. A., & Robinson, G. E. (2019) · Journal of Experimental Biology · doi:10.1242/jeb.200196 · Cited by 37 · see citing works
Self-citationGenetic basis of chemical communication in eusocial insectsPreprint
Yan, H., & Liebig, J. (2021) · Genes & Development · doi:10.1101/gad.346965.120 · Cited by 33 · see citing works
Self-citationThe Budding Neuroscience of Ant Social Behavior
Frank, D. D., & Kronauer, D. J. C. (2024) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-083023-102101 · Cited by 36 · see citing works
Epigenetics in Insects: Mechanisms, Phenotypes and Ecological and Evolutionary Implications
Burggren, W. W. (2017) · Advances in insect physiology · doi:10.1016/bs.aiip.2017.04.001 · Cited by 36 · see citing works
Monarch Butterfly Migration Moving into the Genetic Era
Merlin, C., Iiams, S. E., & Lugena, A. B. (2020) · Trends in Genetics · doi:10.1016/j.tig.2020.06.011 · Cited by 36 · see citing works
Ant Genetics: Reproductive Physiology, Worker Morphology, and Behavior
Friedman, D., & Gordon, D. M. (2016) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-070815-013927 · Cited by 35 · see citing works
A molecular concept of caste in insect societies
Sumner, S., Bell, E. F., & Taylor, D. A. (2017) · Current Opinion in Insect Science · doi:10.1016/j.cois.2017.11.010 · Cited by 34 · see citing works
Hearn, J., Plenderleith, F. A., & Little, T. J. (2021) · Epigenetics & Chromatin · doi:10.1186/s13072-020-00379-z · Cited by 33 · see citing works
Genetic accommodation and the role of ancestral plasticity in the evolution of insect eusociality
Jones, B. M., & Robinson, G. E. (2018) · Journal of Experimental Biology · doi:10.1242/jeb.153163 · Cited by 33 · see citing works
Kirfel, P. P., Vilcinskas, A., & Škaljac, M. (2020) · Insects · doi:10.3390/insects11050265 · Cited by 33 · see citing works
Das, B., & de Bekker, C. (2022) · BMC Genomics · doi:10.1186/s12864-021-08282-x · Cited by 32 · see citing works
Functional Heterogeneity in Superorganisms: Emerging Trends and Concepts
O’Shea-Wheller, T. A., Hunt, E. R., & Sasaki, T. (2020) · Annals of the Entomological Society of America · doi:10.1093/aesa/saaa039 · Cited by 31 · see citing works
Insect Epigenetic Mechanisms Facing Anthropogenic-Derived Contamination, an Overview
Olivares-Castro, G., Cáceres-Jensen, L., Guerrero‐Bosagna, C., & Villagra, C. (2021) · Insects · doi:10.3390/insects12090780 · Cited by 32 · see citing works
Chandra, G. S., Albishi, N. M., Dhandapani, R. K., & Palli, S. R. (2022) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2118871119 · Cited by 29 · see citing works
Histone methylation regulates reproductive diapause in Drosophila melanogaster
Evans, A. D., Fairbanks, R. A., SCHMIDT, P. S., & Levine, M. T. (2023) · PLoS Genetics · doi:10.1371/journal.pgen.1010906 · Cited by 30 · see citing works
Choppin, M., Feldmeyer, B., & Foitzik, S. (2021) · BMC Genomics · doi:10.1186/s12864-021-08196-8 · Cited by 28 · see citing works
Do social insects support Haig's kin theory for the evolution of genomic imprinting?
Pegoraro, M., Marshall, H., Lonsdale, Z. N., & Mallon, E. B. (2017) · Epigenetics · doi:10.1080/15592294.2017.1348445 · Cited by 26 · see citing works
From Egg to Adult: A Developmental Table of the Ant Monomorium pharaonis
Rajakumar, A., Pontieri, L., Li, R., Larsen, R. S., Vásquez‐Correa, A., Frandsen, J. K. L., Rafiqi, A. M., Zhang, G., & Abouheif, E. (2024) · Journal of Experimental Zoology Part B Molecular and Developmental Evolution · doi:10.1002/jez.b.23278 · Cited by 27 · see citing works
Endocrine Influences on Insect Societies
Hamilton, A. R., Shpigler, H. Y., Bloch, G., Wheeler, D. E., & Robinson, G. E. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-803592-4.00037-7 · Cited by 27 · see citing works
Phenotypic Plasticity in Locusts: Trade-Off Between Migration and Reproduction
Guo, X., & Kang, L. (2024) · Annual Review of Entomology · doi:10.1146/annurev-ento-013124-124333 · Cited by 26 · see citing works
Histone H4 acetylation regulates behavioral inter-individual variability in zebrafish
Román, A.-C., Vicente-Page, J., Pérez-Escudero, A., Carvajal-González, J. M., Fernández-Salguero, P., & de Polavieja, G. D. (2017) · Genome Biology · doi:10.1186/s13059-018-1428-y · Cited by 27 · see citing works
Gaddelapati, S. C., Dhandapani, R. K., & Palli, S. R. (2020) · Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms · doi:10.1016/j.bbagrm.2020.194576 · Cited by 26 · see citing works
Seasonal plasticity: how do butterfly wing pattern traits evolve environmental responsiveness?
van der Burg, K. R. L., & Reed, R. D. (2021) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2021.02.009 · Cited by 26 · see citing works
Gordon, D. G., Ilieş, I., & Traniello, J. F. A. (2017) · Behavioral Ecology and Sociobiology · doi:10.1007/s00265-017-2396-z · Cited by 26 · see citing works
A Role of Histone Acetylation in the Regulation of Circadian Rhythm in Ants
Libbrecht, R., Nadrau, D., & Foitzik, S. (2020) · iScience · doi:10.1016/j.isci.2020.100846 · Cited by 26 · see citing works
Friedman, D., York, R. A., Hilliard, A. T., & Gordon, D. M. (2020) · Communications Biology · doi:10.1038/s42003-020-0813-8 · Cited by 26 · see citing works
Advances in the Study of Olfaction in Eusocial Ants
Ferguson, S. T., Bakis, I., & Zwiebel, L. J. (2021) · Insects · doi:10.3390/insects12030252 · Cited by 25 · see citing works
Self-citationBehavior Individuality: A Focus on Drosophila melanogaster
Mollá-Albaladejo, R., & Sánchez‐Alcañiz, J. A. (2021) · Frontiers in Physiology · doi:10.3389/fphys.2021.719038 · Cited by 30 · see citing works
Faulk, C. D. (2022) · Nucleic Acids Research · doi:10.1093/nar/gkac510 · Cited by 24 · see citing works
Kaur, R., Stoldt, M., Jongepier, E., Feldmeyer, B., Menzel, F., Bornberg‐Bauer, E., & Foitzik, S. (2019) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2018.0192 · Cited by 24 · see citing works
The foraging gene as a modulator of division of labour in social insects
Lucas, C., & Ben‐Shahar, Y. (2021) · Journal of Neurogenetics · doi:10.1080/01677063.2021.1940173 · Cited by 24 · see citing works
Zhang, L., Wang, M.-Y., Li, X., Wang, X., Jia, C., Yang, X., Feng, R.-Q., & Yuan, M. (2018) · Gene · doi:10.1016/j.gene.2018.01.079 · Cited by 24 · see citing works
Kay, J., Menegazzi, P., Mildner, S., Roces, F., & Helfrich‐Förster, C. (2018) · Journal of Biological Rhythms · doi:10.1177/0748730418764738 · Cited by 23 · see citing works
de Bekker, C. (2019) · Current Opinion in Insect Science · doi:10.1016/j.cois.2019.01.005 · Cited by 23 · see citing works
Why behavioral neuroscience still needs diversity?: A curious case of a persistent need
Mathuru, A. S., Libersat, F., Vyas, A., & Teseo, S. (2020) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2020.06.021 · Cited by 23 · see citing works
Vogt, G. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-817996-3.00010-4 · Cited by 17 · see citing works
Special Significance of Non-Drosophila Insects in Aging
Guo, S., Wang, X., & Kang, L. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.576571 · Cited by 21 · see citing works
Ants’ Personality and Its Dependence on Foraging Styles: Research Perspectives
Reznikova, Z. I. (2021) · Frontiers in Ecology and Evolution · doi:10.3389/fevo.2021.661066 · Cited by 21 · see citing works
Epigenetic inheritance is gated by naïve pluripotency and Dppa2
Carlini, V., Policarpi, C., & Hackett, J. A. (2022) · The EMBO Journal · doi:10.15252/embj.2021108677 · Cited by 20 · see citing works
Epigenetic regulation and division of labor in social insects
Okwaro, L. A., & Korb, J. (2023) · Current Opinion in Insect Science · doi:10.1016/j.cois.2023.101051 · Cited by 21 · see citing works
Characteristics and expression patterns of histone-modifying enzyme systems in the migratory locust
Guo, S., Jiang, F., Yang, P., Liu, Q. F., Wang, X., & Kang, L. (2016) · Insect Biochemistry and Molecular Biology · doi:10.1016/j.ibmb.2016.06.010 · Cited by 21 · see citing works
Long‐term sperm storage in eusocial H ymenoptera
Degueldre, F., & Aron, S. (2022) · Biological reviews/Biological reviews of the Cambridge Philosophical Society · doi:10.1111/brv.12919 · Cited by 18 · see citing works
Jiang, F., Liu, Q. F., Wang, Y., Zhang, J., Wang, H., Song, T., Yang, M., Wang, X., & Kang, L. (2017) · GigaScience · doi:10.1093/gigascience/gix031 · Cited by 20 · see citing works
The Sustained Impact of Model Organisms—in Genetics and Epigenetics
Bonini, N. M., & Berger, S. L. (2017) · Genetics · doi:10.1534/genetics.116.187864 · Cited by 20 · see citing works
Self-citation
- Authors
- Simola, D. F., Graham, R. J., Brady, C. M., Enzmann, B. L., Desplan, C., Ray, A., Zwiebel, L. J., Bonasio, R., Reinberg, D., Liebig, J., & Berger, S. L.
- Affiliations
- University of Pennsylvania (US)
- Arizona State University (US)
- New York University (US)
- University of California, Riverside (US)
- Vanderbilt University (US)
- Corresponding author
- Simola, Daniel F.
- Graham, Riley J.
- Reinberg, Danny
- Liebig, Jürgen
- Berger, Shelley L.
- ORCID
- Venue
- Science
- Published
- 2016-01
- Volume
- 351
- Issue
- 6268
- Pages
- aac6633-aac6633
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- PMC
- PMC5057185
- OpenAlex
- W2207623969
- Cited by
- 242
- References
- 55
- Citations by year
- 2026: 10 · 2025: 18 · 2024: 24 · 2023: 22 · 2022: 21 · 2021: 30 · 2020: 31 · 2019: 21 · 2018: 19 · 2017: 27 · 2016: 19
- FWCI
- 14.81
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Funders
- Howard Hughes Medical Institute (2009005)
- NIH (T32HD083185, DP2MH107055)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Insect and Arachnid Ecology and Behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurobiology and Insect Physiology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
- Keywords
- epigenetic reprogramming, Camponotus floridanus, carpenter ants, histone acetylation, histone deacetylase, Rpd3, foraging behavior, worker caste, eusocial insects, behavioral plasticity, brain transcriptome, chromatin
- MeSH terms
- Acetylation, Animals, Ants, Behavior, Animal, Chromatin, Protein Processing, Post-Translational, Social Behavior, Epigenesis, Genetic, Histone Deacetylase 2, Histone Deacetylase Inhibitors, Transcriptome
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