Extensive heterogeneity in somatic mutation and selection in the human bladder

Controlling the False Discovery Rate: A Practical and Powerful Approach to Multiple Testing

Benjamini, Y., & Hochberg, Y. (1995) · Journal of the Royal Statistical Society Series B: Statistical Methodology · doi:10.1111/j.2517-6161.1995.tb02031.x · Cited by 109,482 · see citing works

Fast and accurate short read alignment with Burrows-Wheeler transform

Li, H., & Durbin, R. (2009) · Bioinformatics · doi:10.1093/bioinformatics/btp324 · Cited by 58,607 · see citing works

A global reference for human genetic variation

The 1000 Genomes Project Consortium, authors, C., Auton, A., Abecasis, G. R., Steering committee, Altshuler, D. M., Durbin, R. M., Abecasis, G. R., Bentley, D. R., Chakravarti, A., et al. (2015) · Nature · doi:10.1038/nature15393 · Cited by 18,247 · see citing works

Integrative genomics viewer

Robinson, J. T., Thorvaldsdóttir, H., Winckler, W., Guttman, M., Lander, E. S., Getz, G., & Mesirov, J. P. (2011) · Nature Biotechnology · doi:10.1038/nbt.1754 · Cited by 15,390 · see citing works

Signatures of mutational processes in human cancer

Initiative, A. P. C. G., Alexandrov, L. B., ICGC Breast Cancer Consortium, ICGC MMML-Seq Consortium, PedBrain, I., Nik-Zainal, S., Wedge, D. C., Aparicio, S. A. J. R., Behjati, S., Biankin, A. V., et al. (2013) · Nature · doi:10.1038/nature12477 · Cited by 9,660 · see citing works

Integrative Genomics Viewer (IGV): high-performance genomics data visualization and exploration

Thorvaldsdottir, H., Robinson, J. T., & Mesirov, J. P. (2013) · Briefings in Bioinformatics · doi:10.1093/bib/bbs017 · Cited by 9,049 · see citing works

Reference sequence (RefSeq) database at NCBI: current status, taxonomic expansion, and functional annotation

O'Leary, N. A., Wright, M. W., Brister, J. R., Ciufo, S., Haddad, D., McVeigh, R., Rajput, B., Robbertse, B., Smith-White, B., Ako-Adjei, D., et al. (2016) · Nucleic Acids Research · doi:10.1093/nar/gkv1189 · Cited by 6,357 · see citing works

Mutational heterogeneity in cancer and the search for new cancer-associated genes

Lawrence, M. S., Stojanov, P., Polak, P., Kryukov, G. V., Cibulskis, K., Sivachenko, A., Carter, S. L., Stewart, C., Mermel, C. H., Roberts, S. A., et al. (2013) · Nature · doi:10.1038/nature12213 · Cited by 5,461 · see citing works

Age-related clonal hematopoiesis associated with adverse outcomes

Jaiswal, S., Fontanillas, P., Flannick, J., Manning, A., Grauman, P. V., Mar, B. G., Lindsley, R. C., Mermel, C. H., Burtt, N., Chavez, A., et al. (2014) · New England Journal of Medicine · doi:10.1056/nejmoa1408617 · Cited by 4,841 · see citing works

phangorn: phylogenetic analysis in R

Schliep, K. P. (2010) · Bioinformatics · doi:10.1093/bioinformatics/btq706 · Cited by 3,678 · see citing works

The repertoire of mutational signatures in human cancer

Alexandrov, L. B., Kim, J., Haradhvala, N. J., Huang, M. N., Tian Ng, A. W., Wu, Y., Boot, A., Covington, K. R., Gordenin, D. A., Bergstrom, E. N., et al. (2020) · Nature · doi:10.1038/s41586-020-1943-3 · Cited by 3,496 · see citing works

Hierarchical Dirichlet Processes

Teh, Y. W., Jordan, M. I., Beal, M. J., & Blei, D. M. (2006) · Journal of the American Statistical Association · doi:10.1198/016214506000000302 · Cited by 3,445 · see citing works

Discovery and saturation analysis of cancer genes across 21 tumour types

Lawrence, M. S., Stojanov, P., Mermel, C. H., Robinson, J. T., Garraway, L. A., Golub, T. R., Meyerson, M., Gabriel, S. B., Lander, E. S., & Getz, G. (2014) · Nature · doi:10.1038/nature12912 · Cited by 3,096 · see citing works

Pan-cancer analysis of whole genomes

The ICGC/TCGA Pan-Cancer Analysis of Whole Genomes Consortium, Aaltonen, L. A., Abascal, F., Abeshouse, A., Aburatani, H., Adams, D. J., Agrawal, N., Ahn, K. S., Ahn, S.-M., Aikata, H., et al. (2020) · Nature · doi:10.1038/s41586-020-1969-6 · Cited by 3,064 · see citing works

Comprehensive molecular characterization of urothelial bladder carcinoma

Perou, C. M. (2019) · Carolina Digital Repository (University of North Carolina at Chapel Hill) · doi:10.17615/za09-dk57 · Cited by 2,992 · see citing works

Comprehensive Molecular Characterization of Muscle-Invasive Bladder Cancer

Robertson, A. G., Kim, J., Al‐Ahmadie, H. A., Joaquim Bellmunt, B., Guo, G., Cherniack, A. D., Hinoue, T., Laird, P. W., Hoadley, K. A., Akbani, R., et al. (2017) · Cell · doi:10.1016/j.cell.2017.09.007 · Cited by 2,435 · see citing works

High burden and pervasive positive selection of somatic mutations in normal human skin

Martincorena, I., Roshan, A., Gerstung, M., Ellis, P., Van Loo, P., McLaren, S., Wedge, D. C., Fullam, A., Alexandrov, L. B., Tubio, J. M., et al. (2015) · Science · doi:10.1126/science.aaa6806 · Cited by 1,770 · see citing works

The Parsimony Ratchet, a New Method for Rapid Parsimony Analysis

Nixon, K. C. (1999) · Cladistics · doi:10.1111/j.1096-0031.1999.tb00277.x · Cited by 1,748 · see citing works

The origin and evolution of mutations in acute myeloid leukemia

Welch, J. S., Ley, T. J., Link, D. C., Miller, C. A., Larson, D. E., Koboldt, D. C., Wartman, L. D., Lamprecht, T. L., Liu, F., Xia, J., et al. (2012) · Cell · doi:10.1016/j.cell.2012.06.023 · Cited by 1,575 · see citing works

The Age Distribution of Cancer and a Multi-stage Theory of Carcinogenesis

Armitage, P., & Doll, R. (1954) · British Journal of Cancer · doi:10.1038/bjc.1954.1 · Cited by 1,549 · see citing works

Universal Patterns of Selection in Cancer and Somatic Tissues

Martincorena, I., Raine, K. M., Gerstung, M., Dawson, K. J., Haase, K., Van Loo, P., Davies, H., Stratton, M. R., & Campbell, P. J. (2017) · Cell · doi:10.1016/j.cell.2017.09.042 · Cited by 1,523 · see citing works

The Life History of 21 Breast Cancers

Nik-Zainal, S., Van Loo, P., Wedge, D. C., Alexandrov, L. B., Greenman, C. D., Lau, K. W., Raine, K., Jones, D., Marshall, J., Ramakrishna, M., et al. (2012) · Cell · doi:10.1016/j.cell.2012.04.023 · Cited by 1,443 · see citing works

The age distribution of cancer and a multi-stage theory of carcinogenesis

Armitage, P., & Doll, R. (2004) · British Journal of Cancer · doi:10.1038/sj.bjc.6602297 · Cited by 1,309 · see citing works

Allele-specific copy number analysis of tumors

Loo, P. V., Nord, S., Lingjærde, O. C., Russnes, H. G., Rye, I. H., Sun, W., Weigman, V., Marynen, P., Zetterberg, A., Naume, B., et al. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1009843107 · Cited by 1,231 · see citing works

deconstructSigs: delineating mutational processes in single tumors distinguishes DNA repair deficiencies and patterns of carcinoma evolution

Rosenthal, R., McGranahan, N., Herrero, J., Taylor, B. S., & Swanton, C. (2016) · Genome biology · doi:10.1186/s13059-016-0893-4 · Cited by 1,217 · see citing works

Somatic mutant clones colonize the human esophagus with age

Martincorena, I., Fowler, J. C., Wabik, A., Lawson, A. R. J., Abascal, F., Hall, M. W. J., Cagan, A., Murai, K., Mahbubani, K., Stratton, M. R., et al. (2018) · Science · doi:10.1126/science.aau3879 · Cited by 1,113 · see citing works

Mutational signatures associated with tobacco smoking in human cancer

Alexandrov, L. B., Ju, Y. S., Haase, K., Van Loo, P., Martincorena, I., Nik-Zainal, S., Totoki, Y., Fujimoto, A., Nakagawa, H., Shibata, T., et al. (2016) · Science · doi:10.1126/science.aag0299 · Cited by 1,100 · see citing works

Microresonator soliton dual-comb spectroscopy

Suh, M.-G., Yang, Q.-F., Yang, K. Y., Yi, X., & Vahala, K. J. (2016) · Science · doi:10.1126/science.aah6516 · Cited by 991 · see citing works

Tissue-specific mutation accumulation in human adult stem cells during life

Blokzijl, F., de Ligt, J., Jager, M., Sasselli, V., Roerink, S., Sasaki, N., Huch, M., Boymans, S., Kuijk, E., Prins, P., et al. (2016) · Nature · doi:10.1038/nature19768 · Cited by 935 · see citing works

Prediction of acute myeloid leukaemia risk in healthy individuals

Abelson, S., Collord, G., Ng, S. W. K., Weissbrod, O., Mendelson Cohen, N., Niemeyer, E., Barda, N., Zuzarte, P. C., Heisler, L., Sundaravadanam, Y., et al. (2018) · Nature · doi:10.1038/s41586-018-0317-6 · Cited by 850 · see citing works

Identification of somatically acquired rearrangements in cancer using genome-wide massively parallel paired-end sequencing

Campbell, P. J., Stephens, P. J., Pleasance, E., O’Meara, S., Li, H., Santarius, T., Stebbings, L. A., Leroy, C., Edkins, S., Hardy, C. W., et al. (2008) · Nature Genetics · doi:10.1038/ng.128 · Cited by 812 · see citing works

Frequent mutations of chromatin remodeling genes in transitional cell carcinoma of the bladder

Gui, Y., Guo, G., Huang, Y., Hu, X., Tang, A., Gao, S., Wu, R., Chen, C., Li, X., Zhou, L., et al. (2011) · Nature Genetics · doi:10.1038/ng.907 · Cited by 748 · see citing works

The landscape of somatic mutation in normal colorectal epithelial cells

Lee-Six, H., Olafsson, S., Ellis, P., Osborne, R. J., Sanders, M. A., Moore, L., Georgakopoulos, N., Torrente, F., Noorani, A., Goddard, M., et al. (2019) · Nature · doi:10.1038/s41586-019-1672-7 · Cited by 747 · see citing works

Aging and neurodegeneration are associated with increased mutations in single human neurons

Lodato, M. A., Rodin, R. E., Bohrson, C. L., Coulter, M. E., Barton, A. R., Kwon, M., Sherman, M. A., Vitzthum, C. M., Luquette, L. J., Yandava, C. N., et al. (2018) · Science · doi:10.1126/science.aao4426 · Cited by 635 · see citing works

Age-related remodelling of oesophageal epithelia by mutated cancer drivers

Yokoyama, A., Kakiuchi, N., Yoshizato, T., Nannya, Y., Suzuki, H., Takeuchi, Y., Shiozawa, Y., Sato, Y., Aoki, K., Kim, S. K., et al. (2019) · Nature · doi:10.1038/s41586-018-0811-x · Cited by 628 · see citing works

Tobacco smoking and somatic mutations in human bronchial epithelium

Yoshida, K., Gowers, K. H. C., Lee-Six, H., Chandrasekharan, D. P., Coorens, T. H. H., Maughan, E. F., Beal, K. M., Menzies, A. H., Millar, F. R., Anderson, E. L., et al. (2020) · Nature · doi:10.1038/s41586-020-1961-1 · Cited by 532 · see citing works

RNA sequence analysis reveals macroscopic somatic clonal expansion across normal tissues

Yizhak, K., Aguet, F., Kim, J., Hess, J. M., Kübler, K., Grimsby, J., Frazer, R., Zhang, H., Haradhvala, N. J., Rosebrock, D., et al. (2019) · Science · doi:10.1126/science.aaw0726 · Cited by 500 · see citing works

The mutational landscape of normal human endometrial epithelium

Moore, L., Leongamornlert, D., Coorens, T. H. H., Sanders, M. A., Ellis, P., Dentro, S. C., Dawson, K. J., Butler, T., Rahbari, R., Mitchell, T. J., et al. (2020) · Nature · doi:10.1038/s41586-020-2214-z · Cited by 499 · see citing works

Detecting and Estimating Contamination of Human DNA Samples in Sequencing and Array-Based Genotype Data

Jun, G., Flickinger, M., Hetrick, K. N., Romm, J. M., Doheny, K. F., Abecasis, G. R., Boehnke, M., & Kang, H. M. (2012) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2012.09.004 · Cited by 484 · see citing works

Tumor-suppressor genes that escape from X-inactivation contribute to cancer sex bias

Dunford, A. J., Weinstock, D. M., Savova, V., Schumacher, S. E., Cleary, J. P., Yoda, A., Sullivan, T. J., Hess, J. M., Gimelbrant, A. A., Beroukhim, R., et al. (2016) · Nature Genetics · doi:10.1038/ng.3726 · Cited by 459 · see citing works

Pan-cancer analysis of whole genomes identifies driver rearrangements promoted by LINE-1 retrotransposition

Rodriguez-Martin, B., Alvarez, E. G., Baez-Ortega, A., Zamora, J., Supek, F., Demeulemeester, J., Santamarina, M., Ju, Y. S., Temes, J., Garcia-Souto, D., et al. (2020) · Nature Genetics · doi:10.1038/s41588-019-0562-0 · Cited by 451 · see citing works

Clonal Expansion and Diversification of Cancer-Associated Mutations in Endometriosis and Normal Endometrium

Suda, K., Nakaoka, H., Yoshihara, K., Ishiguro, T., Tamura, R., Mori, Y., Yamawaki, K., Adachi, S., Takahashi, T., Kase, H., et al. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.07.037 · Cited by 414 · see citing works

An APOBEC3A hypermutation signature is distinguishable from the signature of background mutagenesis by APOBEC3B in human cancers

Chan, K., Roberts, S. A., Klimczak, L. J., Sterling, J. F., Saini, N., Malc, E. P., Kim, J., Kwiatkowski, D. J., Fargo, D. C., Mieczkowski, P. A., et al. (2015) · Nature Genetics · doi:10.1038/ng.3378 · Cited by 414 · see citing works

Somatic ERCC2 mutations are associated with a distinct genomic signature in urothelial tumors

Kim, J., Mouw, K. W., Polak, P. P., Braunstein, L. Z., Kamburov, A., Tiao, G., Kwiatkowski, D. J., Rosenberg, J. E., Allen, E. M. V., D’Andrea, A. D., et al. (2016) · Nature Genetics · doi:10.1038/ng.3557 · Cited by 402 · see citing works

Only three driver gene mutations are required for the development of lung and colorectal cancers

Tomasetti, C., Marchionni, L., Nowak, M. A., Parmigiani, G., & Vogelstein, B. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1421839112 · Cited by 395 · see citing works

Somatic mutations and clonal dynamics in healthy and cirrhotic human liver

Brunner, S. F., Roberts, N. D., Wylie, L. A., Moore, L., Aitken, S. J., Davies, S. E., Sanders, M. A., Ellis, P., Alder, C., Hooks, Y., et al. (2019) · Nature · doi:10.1038/s41586-019-1670-9 · Cited by 393 · see citing works

Mutational Strand Asymmetries in Cancer Genomes Reveal Mechanisms of DNA Damage and Repair

Haradhvala, N. J., Polak, P. P., Stojanov, P., Covington, K. R., Shinbrot, E., Hess, J. M., Rheinbay, E., Kim, J., Maruvka, Y. E., Braunstein, L. Z., et al. (2016) · Cell · doi:10.1016/j.cell.2015.12.050 · Cited by 387 · see citing works

Prospective Study of FGFR3 Mutations As a Prognostic Factor in Nonmuscle Invasive Urothelial Bladder Carcinomas

Hernandez, S. F., López‐Knowles, E., Lloreta, J., Kogevinas, M., Amorós, À., Tardón, A., Carrato, A., Serra, C., Malats, N., & Real, F. X. (2006) · Journal of Clinical Oncology · doi:10.1200/jco.2005.05.1771 · Cited by 334 · see citing works

Genomic Subtypes of Non-invasive Bladder Cancer with Distinct Metabolic Profile and Female Gender Bias in KDM6A Mutation Frequency

Hurst, C. D., Alder, O., Platt, F. M., Droop, A., Stead, L. F., Burns, J. E., Burghel, G. J., Jain, S., Klimczak, L. J., Lindsay, H. A., et al. (2017) · Cancer Cell · doi:10.1016/j.ccell.2017.08.005 · Cited by 307 · see citing works

biobambam: tools for read pair collation based algorithms on BAM files

Tischler, G., & Leonard, S. R. (2014) · Source Code for Biology and Medicine · doi:10.1186/1751-0473-9-13 · Cited by 302 · see citing works

Bladder cancer, a review of the environmental risk factors

Letašiová, S., Medveďová, A., Šovčı́ková, A., Dušinská, M., Volkovová, K., Moșoiu, C., & Bartoňová, A. (2012) · Environmental Health · doi:10.1186/1476-069x-11-s1-s11 · Cited by 295 · see citing works

Telomerase Reverse Transcriptase Promoter Mutations in Bladder Cancer: High Frequency Across Stages, Detection in Urine, and Lack of Association with Outcome

Allory, Y., Beukers, W., Sagrera, A. M. A. D. P., Flández, M., Marqués, M., Márquez, M., van der Keur, K. A., Dyrskjøt, L., Lurkin, I., Vermeij, M., et al. (2013) · European Urology · doi:10.1016/j.eururo.2013.08.052 · Cited by 283 · see citing works

cgpCaVEManWrapper: Simple Execution of CaVEMan in Order to Detect Somatic Single Nucleotide Variants in NGS Data

Jones, D., Raine, K. M., Davies, H. R., Tarpey, P. S., Butler, A. P., Teague, J. W., Nik‐Zainal, S., & Campbell, P. J. (2016) · Current Protocols in Bioinformatics · doi:10.1002/cpbi.20 · Cited by 227 · see citing works

Macroscopic somatic clonal expansion in morphologically normal human urothelium

Li, R., Du, Y., Chen, Z., Xu, D., Lin, T., Jin, S., Wang, G., Liu, Z., Lu, M., Chen, X., et al. (2020) · Science · doi:10.1126/science.aba7300 · Cited by 206 · see citing works

Cellular origin of bladder neoplasia and tissue dynamics of its progression to invasive carcinoma

Shin, K., Lim, A. Y.-L., Odegaard, J. I., Honeycutt, J. D., Kawano, S., Hsieh, M. H., & Beachy, P. A. (2014) · Nature Cell Biology · doi:10.1038/ncb2956 · Cited by 200 · see citing works

ascatNgs: Identifying Somatically Acquired Copy‐Number Alterations from Whole‐Genome Sequencing Data

Raine, K. M., Loo, P. V., Wedge, D. C., Jones, D., Menzies, A. H., Butler, A. P., Teague, J. W., Tarpey, P. S., Nik‐Zainal, S., & Campbell, P. J. (2016) · Current Protocols in Bioinformatics · doi:10.1002/cpbi.17 · Cited by 170 · see citing works

Ultra-deep sequencing detects ovarian cancer cells in peritoneal fluid and reveals somatic TP53 mutations in noncancerous tissues

Krimmel‐Morrison, J. D., Schmitt, M. W., Harrell, M. I., Agnew, K. J., Kennedy, S. R., Emond, M. J., Loeb, L. A., Swisher, E. M., & Risques, R. A. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1601311113 · Cited by 155 · see citing works

Subclonal variant calling with multiple samples and prior knowledge

Gerstung, M., Papaemmanuil, E., & Campbell, P. J. (2014) · Bioinformatics · doi:10.1093/bioinformatics/btt750 · Cited by 154 · see citing works

cgpPindel: Identifying Somatically Acquired Insertion and Deletion Events from Paired End Sequencing

Raine, K. M., Hinton, J., Butler, A. P., Teague, J. W., Davies, H. R., Tarpey, P. S., Nik‐Zainal, S., & Campbell, P. J. (2015) · Current Protocols in Bioinformatics · doi:10.1002/0471250953.bi1507s52 · Cited by 141 · see citing works

Florid von Brunn Nests Mimicking Urothelial Carcinoma

Volmar, K. E., Chan, T. Y., Marzo, A. M. D., & Epstein, J. I. (2003) · The American Journal of Surgical Pathology · doi:10.1097/00000478-200309000-00008 · Cited by 140 · see citing works

Comprehensive multiregional analysis of molecular heterogeneity in bladder cancer

Thomsen, M. B. H., Nordentoft, I., Lamy, P., Vang, S., Reinert, L. S., Mapendano, C. K., Høyer, S., Orntoft, T. F., Jensen, J. B., & Dyrskjøt, L. (2017) · Scientific Reports · doi:10.1038/s41598-017-11291-0 · Cited by 135 · see citing works

Somatic mutagenesis in satellite cells associates with human skeletal muscle aging

Franco, I., Johansson, A., Olsson, K., Vrtačnik, P., Lundin, P., Helgadottir, H. T., Larsson, M., Revêchon, G., Bosia, C., Pagnani, A., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-03244-6 · Cited by 126 · see citing works

Recurrent urinary tract infection and risk of bladder cancer in the Nijmegen bladder cancer study

Vermeulen, S. H. H. M., Hanum, N., Grotenhuis, A. J., Castaño‐Vinyals, G., van der Heijden, A. G., Aben, K. K. H., Mysorekar, I. U., & Kiemeney, L. A. L. M. (2014) · British Journal of Cancer · doi:10.1038/bjc.2014.601 · Cited by 118 · see citing works

Mutation signatures implicate aristolochic acid in bladder cancer development

Poon, S. L., Huang, M. N., Choo, Y., McPherson, J. R., Yu, W., Heng, H. L., Gan, A., Myint, S. S., Siew, E. Y., Ler, L. D., et al. (2015) · Genome Medicine · doi:10.1186/s13073-015-0161-3 · Cited by 109 · see citing works

Negative selection in tumor genome evolution acts on essential cellular functions and the immunopeptidome

Zapata, L., Pich, O., Serrano, L. G., Kondrashov, F. A., Ossowski, S., & Schaefer, M. H. (2018) · Genome biology · doi:10.1186/s13059-018-1434-0 · Cited by 109 · see citing works

Passenger Hotspot Mutations in Cancer

Hess, J. M., Bernards, A., Kim, J., Miller, M. L., Taylor-Weiner, A. N., Haradhvala, N. J., Lawrence, M. S., & Getz, G. A. (2019) · Cancer Cell · doi:10.1016/j.ccell.2019.08.002 · Cited by 87 · see citing works

Lack of detectable neoantigen depletion signals in the untreated cancer genome

den Eynden, J. V., Jiménez-Sánchez, A., Miller, M. L., & Larsson, E. (2019) · Nature Genetics · doi:10.1038/s41588-019-0532-6 · Cited by 81 · see citing works

Tertiary lymphoid structures associate with tumour stage in urothelial bladder cancer

Koti, M., Xu, A. S., Ren, K. Y. M., Visram, K., Ren, R., Berman, D. M., & Siemens, D. R. (2017) · Bladder Cancer · doi:10.3233/blc-170120 · Cited by 78 · see citing works

The human urothelium consists of multiple clonal units, each maintained by a stem cell

Gaisa, N. T., Graham, T. A., McDonald, S. A. C., Cañadillas, S., Poulsom, R., Heidenreich, A., Jakse, G., Tadrous, P. J., Knuechel, R., & Wright, N. A. (2011) · The Journal of Pathology · doi:10.1002/path.2945 · Cited by 68 · see citing works

Urothelial generation and regeneration in development, injury, and cancer

Wang, C., Ross, W. T., & Mysorekar, I. U. (2017) · Developmental Dynamics · doi:10.1002/dvdy.24487 · Cited by 62 · see citing works

Genomics: data sharing needs an international code of conduct

Phillips, M. A., Molnár‐Gábor, F., Korbel, J. O., Thorogood, A., Joly, Y., Chalmers, D., Townend, D. M. R., & Knoppers, B. M. (2020) · Nature · doi:10.1038/d41586-020-00082-9 · Cited by 53 · see citing works

Whole-Organ Genomic Characterization of Mucosal Field Effects Initiating Bladder Carcinogenesis

Majewski, T., Yao, H., Bondaruk, J. E., Chung, W., Lee, S., Lee, J. G., Zhang, S., Cogdell, D. E., Yang, G., Choi, W., et al. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.01.095 · Cited by 50 · see citing works

Learning mutational signatures and their multidimensional genomic properties with TensorSignatures

Vöhringer, H., van Hoeck, A., Cuppen, E., & Gerstung, M. (2019) · Nature Communications · doi:10.1038/s41467-021-23551-9 · Cited by 48 · see citing works

V(D)J recombinase-mediated transposition of the BCL2gene to the IGH locus in follicular lymphoma

Vaandrager, J., Schuuring, E. M. D., Philippo, K., & Kluin, P. M. (2000) · Blood · doi:10.1182/blood.v96.5.1947 · Cited by 42 · see citing works

Determining the origin of synchronous multifocal bladder cancer by exome sequencing

Acar, Ö., Özkurt, E., Demir, G., Saraç, H., Alkan, C., Esen, T., Somel, M., & Lack, N. A. (2015) · BMC Cancer · doi:10.1186/s12885-015-1859-8 · Cited by 24 · see citing works

tRanslatome: an R/Bioconductor package to portray translational control

Tebaldi, T., Dassi, E., Kostoska, G., Viero, G., & Quattrone, A. (2013) · Bioinformatics · doi:10.1093/bioinformatics/btt634 · Cited by 20 · see citing works

Development: Liquid assets

Catley‐Carlson, M. (2014) · Nature · doi:10.1038/505288a · Cited by 4 · see citing works

Bladder cancer

Dyrskjøt, L., Hansel, D. E., Efstathiou, J. A., Knowles, M. A., Galsky, M. D., Teoh, J. Y., & Theodorescu, D. (2023) · Nature Reviews Disease Primers · doi:10.1038/s41572-023-00468-9 · Cited by 580 · see citing works

Somatic mutation landscapes at single-molecule resolution

Abascal, F., Harvey, L. M. R., Mitchell, E., Lawson, A. R. J., Lensing, S. V., Ellis, P., Russell, A. J. C., Alcantara, R. E., Baez‐Ortega, A., Wang, Y., et al. (2021) · Nature · doi:10.1038/s41586-021-03477-4 · Cited by 508 · see citing works

Tumor initiation and early tumorigenesis: molecular mechanisms and interventional targets

Zhang, S., Xiao, X., Yi, Y., Wang, X., Zhu, L., Shen, Y., Lin, D., & Wu, C. H. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-01848-7 · Cited by 440 · see citing works

The mutational landscape of human somatic and germline cells

Moore, L., Cagan, A., Coorens, T. H. H., Neville, M. D. C., Sanghvi, R., Sanders, M. A., Oliver, T. R. W., Leongamornlert, D., Ellis, P., Noorani, A., et al. (2021) · Nature · doi:10.1038/s41586-021-03822-7 · Cited by 379 · see citing works

Uncovering novel mutational signatures by de novo extraction with SigProfilerExtractor

Islam, S. M. A., Díaz‐Gay, M., Wu, Y., Barnes, M. D., Vangara, R., Bergstrom, E. N., He, Y., Vella, M., Wang, J., Teague, J. W., et al. (2022) · Cell Genomics · doi:10.1016/j.xgen.2022.100179 · Cited by 350 · see citing works

The evolution of lung cancer and impact of subclonal selection in TRACERx

Frankell, A. M., Dietzen, M., Bakir, M. A., Lim, E. L., Karasaki, T., Ward, S., Veeriah, S., Colliver, E., Huebner, A., Bunkum, A., et al. (2023) · Nature · doi:10.1038/s41586-023-05783-5 · Cited by 322 · see citing works

Genetic and non-genetic clonal diversity in cancer evolution

Black, J. R., & McGranahan, N. (2021) · Nature reviews. Cancer · doi:10.1038/s41568-021-00336-2 · Cited by 287 · see citing works

Mutational signatures: emerging concepts, caveats and clinical applications

Koh, C. C., Degasperi, A., Zou, X., Momen, S., & Nik‐Zainal, S. (2021) · Nature reviews. Cancer · doi:10.1038/s41568-021-00377-7 · Cited by 276 · see citing works

Substitution mutational signatures in whole-genome–sequenced cancers in the UK population

Degasperi, A., Zou, X., Amarante, T. D., Martinez-Martinez, A., Koh, C. C., Dias, J. M. L., Heskin, L., Chmelova, L., Rinaldi, G., Wang, V. Y. W., et al. (2022) · Science · doi:10.1126/science.abl9283 · Cited by 276 · see citing works

Rho GTPase signaling in cancer progression and dissemination

Crosas‐Molist, E., Samain, R., Kohlhammer, L., Orgaz, J. L., George, S. L., Maiques, Ó., Barcelo, J., & Sanz‐Moreno, V. (2021) · Physiological Reviews · doi:10.1152/physrev.00045.2020 · Cited by 277 · see citing works

The evolution of non-small cell lung cancer metastases in TRACERx

Bakir, M. A., Huebner, A., Martínez‐Ruiz, C., Grigoriadis, K., Watkins, T. B. K., Pich, O., Moore, D. A., Veeriah, S., Ward, S., Laycock, J., et al. (2023) · Nature · doi:10.1038/s41586-023-05729-x · Cited by 259 · see citing works

Clonal expansion in non-cancer tissues

Kakiuchi, N., & Ogawa, S. (2021) · Nature Reviews Cancer · doi:10.1038/s41568-021-00335-3 · Cited by 252 · see citing works

Spatial biology of cancer evolution

Seferbekova, Z., Lomakin, A., Yates, L. R., & Gerstung, M. (2022) · Nature Reviews Genetics · doi:10.1038/s41576-022-00553-x · Cited by 210 · see citing works

Macroscopic somatic clonal expansion in morphologically normal human urothelium

Li, R., Du, Y., Chen, Z., Xu, D., Lin, T., Jin, S., Wang, G., Liu, Z., Lu, M., Chen, X., et al. (2020) · Science · doi:10.1126/science.aba7300 · Cited by 206 · see citing works

Assigning mutational signatures to individual samples and individual somatic mutations with SigProfilerAssignment

Díaz‐Gay, M., Vangara, R., Barnes, M. D., Wang, X., Islam, S. M. A., Vermes, I., Duke, S. O., Narasimman, N. B., Yang, T., Jiang, Z., et al. (2023) · Bioinformatics · doi:10.1093/bioinformatics/btad756 · Cited by 196 · see citing works

Mutant clones in normal epithelium outcompete and eliminate emerging tumours

Colom, B., Herms, A., Hall, M. W. J., Dentro, S. C., King, C., Sood, R. K., Alcolea, M. P., Piedrafita, G., Fernandez-Antoran, D., Ong, S. H., et al. (2021) · Nature · doi:10.1038/s41586-021-03965-7 · Cited by 192 · see citing works

A body map of somatic mutagenesis in morphologically normal human tissues

Li, R., Di, L., Li, J., Fan, W., Liu, Y., Guo, W., Liu, W., Liu, L., Li, Q., Chen, L., et al. (2021) · Nature · doi:10.1038/s41586-021-03836-1 · Cited by 183 · see citing works

Molecular classification and diagnostics of upper urinary tract urothelial carcinoma

Fujii, Y. R., Sato, Y., Suzuki, H., Kakiuchi, N., Yoshizato, T., Lenis, A. T., Maekawa, S., Yokoyama, A., Takeuchi, Y., Inoue, Y., et al. (2021) · Cancer Cell · doi:10.1016/j.ccell.2021.05.008 · Cited by 180 · see citing works

Increased somatic mutation burdens in normal human cells due to defective DNA polymerases

Robinson, P. S., Coorens, T. H. H., Palles, C., Mitchell, E., Abascal, F., Olafsson, S., Lee, B. C. H., Lawson, A. R. J., Lee-Six, H., Moore, L., et al. (2021) · Nature Genetics · doi:10.1038/s41588-021-00930-y · Cited by 173 · see citing works

Somatic Mutations in “Benign” Disease

Mustjoki, S. M., & Young, N. S. (2021) · New England Journal of Medicine · doi:10.1056/nejmra2101920 · Cited by 160 · see citing works

Urine biomarkers in bladder cancer — current status and future perspectives

Maas, M., Todenhöfer, T., & Black, P. C. (2023) · Nature Reviews Urology · doi:10.1038/s41585-023-00773-8 · Cited by 159 · see citing works

Extensive phylogenies of human development inferred from somatic mutations

Coorens, T. H. H., Moore, L., Robinson, P. S., Sanghvi, R., Christopher, J., Hewinson, J., Przybilla, M. J., Lawson, A. R. J., Chapman, M. S., Cagan, A., et al. (2021) · Nature · doi:10.1038/s41586-021-03790-y · Cited by 147 · see citing works

Impact of risk factors on early cancer evolution

Weeden, C. E., Hill, W., Lim, E. L., Gronroos, E. C., & Swanton, C. (2023) · Cell · doi:10.1016/j.cell.2023.03.013 · Cited by 143 · see citing works

Whole-genome sequencing reveals progressive versus stable myeloma precursor conditions as two distinct entities

Oben, B., Froyen, G., Maclachlan, K. H., Leongamornlert, D., Abascal, F., Zheng-Lin, B., Yellapantula, V., Derkach, A., Geerdens, E., Diamond, B. T., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-22140-0 · Cited by 129 · see citing works

From DNA damage to mutations: All roads lead to aging

Vijg, J. (2021) · Ageing Research Reviews · doi:10.1016/j.arr.2021.101316 · Cited by 125 · see citing works

Integrated Urinalysis Devices Based on Interface‐Engineered Field‐Effect Transistor Biosensors Incorporated With Electronic Circuits

Yang, Y., Wang, J., Huang, W., Wan, G., Xia, M., Chen, D., Zhang, Y., Wang, Y., Guo, F., Tan, J., et al. (2022) · Advanced Materials · doi:10.1002/adma.202203224 · Cited by 120 · see citing works

Aristolochic acid-associated cancers: a public health risk in need of global action

Das, S., Thakur, S., Korenjak, M., Sidorenko, V. S., Chung, F. F., & Zavadil, J. (2022) · Nature reviews. Cancer · doi:10.1038/s41568-022-00494-x · Cited by 119 · see citing works

The translational challenges of precision oncology

Pich, O., Bailey, C., Watkins, T. B. K., Zaccaria, S., Jamal‐Hanjani, M., & Swanton, C. (2022) · Cancer Cell · doi:10.1016/j.ccell.2022.04.002 · Cited by 111 · see citing works

Clonal hematopoiesis, somatic mosaicism, and age-associated disease

Evans, M. A., & Walsh, K. (2022) · Physiological Reviews · doi:10.1152/physrev.00004.2022 · Cited by 105 · see citing works

MLL4 mediates differentiation and tumor suppression through ferroptosis

Egolf, S., Zou, J., Anderson, A., Simpson, C. L., Aubert, Y., Prouty, S., Ge, K., Seykora, J. T., & Capell, B. C. (2021) · Science Advances · doi:10.1126/sciadv.abj9141 · Cited by 88 · see citing works

Cell-Free Urine and Plasma DNA Mutational Analysis Predicts Neoadjuvant Chemotherapy Response and Outcome in Patients with Muscle-Invasive Bladder Cancer

Christensen, E., Nordentoft, I., Birkenkamp‐Demtröder, K., Elbæk, S. K., Lindskrog, S. V., Taber, A., Andreasen, T. G., Strandgaard, T., Knudsen, M., Lamy, P., et al. (2023) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-22-3250 · Cited by 85 · see citing works

Evolutionary histories of breast cancer and related clones

Nishimura, T., Kakiuchi, N., Yoshida, K., Sakurai, T., Kataoka, T. R., Kondoh, E., Chigusa, Y., Kawai, M., Sawada, M., Inoue, T., et al. (2023) · Nature · doi:10.1038/s41586-023-06333-9 · Cited by 85 · see citing works

Genetic mosaicism in the human brain: from lineage tracing to neuropsychiatric disorders

Bizzotto, S., & Walsh, C. A. (2022) · Nature reviews. Neuroscience · doi:10.1038/s41583-022-00572-x · Cited by 84 · see citing works

Cellular barcoding to decipher clonal dynamics in disease

Sankaran, V. G., Weissman, J. S., & Zon, L. I. (2022) · Science · doi:10.1126/science.abm5874 · Cited by 81 · see citing works

Genome-wide mapping of somatic mutation rates uncovers drivers of cancer

Sherman, M. A., Yaari, A. U., Priebe, O., Dietlein, F., Loh, P.-R., & Berger, B. (2022) · Nature Biotechnology · doi:10.1038/s41587-022-01353-8 · Cited by 80 · see citing works

Internal checkpoint regulates T cell neoantigen reactivity and susceptibility to PD1 blockade

Palmer, D. C., Webber, B. R., Patel, Y. K., Johnson, M. J., Kariya, C. M., Lahr, W. S., Parkhurst, M. R., Gartner, J. J., Prickett, T. D., Lowery, F. J., et al. (2022) · Med · doi:10.1016/j.medj.2022.07.008 · Cited by 81 · see citing works

Genomic heterogeneity as a barrier to precision oncology in urothelial cancer

Clinton, T. N., Chen, Z., Wise, H. C., Lenis, A. T., Chavan, S. S., Donoghue, M. T. A., Almassi, N., Chu, C. E., Dason, S., Rao, P., et al. (2022) · Cell Reports · doi:10.1016/j.celrep.2022.111859 · Cited by 78 · see citing works

Splicing Factor SRSF1 Promotes Pancreatitis and KRASG12D-Mediated Pancreatic Cancer

Wan, L., Lin, K., Rahman, M. A., Ishigami, Y., Wang, Z., Jensen, M. A., Wilkinson, J. E., Park, Y., Tuveson, D. A., & Krainer, A. R. (2023) · Cancer Discovery · doi:10.1158/2159-8290.cd-22-1013 · Cited by 73 · see citing works

Positive selection of somatically mutated clones identifies adaptive pathways in metabolic liver disease

Wang, Z., Zhu, S., Jia, Y., Wang, Y., Kubota, N., Fujiwara, N., Gordillo, R., Lewis, C., Zhu, M., Sharma, T., et al. (2023) · Cell · doi:10.1016/j.cell.2023.03.014 · Cited by 72 · see citing works

Somatic mutations provide important and unique insights into the biology of complex diseases

Ólafsson, S., & Anderson, C. A. (2021) · Trends in Genetics · doi:10.1016/j.tig.2021.06.012 · Cited by 69 · see citing works

Somatic mosaicism reveals clonal distributions of neocortical development

Breuss, M. W., Yang, X., Schlachetzki, J. C. M., Antaki, D., Lana, A. J., Xu, X., Chung, C., Chai, G., Stanley, V., Song, Q., et al. (2022) · Nature · doi:10.1038/s41586-022-04602-7 · Cited by 66 · see citing works

Normal Somatic Mutations in Cancer Transformation

Wijewardhane, N., Dreßler, L., & Ciccarelli, F. D. (2020) · Cancer Cell · doi:10.1016/j.ccell.2020.11.002 · Cited by 68 · see citing works

Emerging strategies to investigate the biology of early cancer

Zhou, R., Tang, X., & Wang, Y. (2024) · Nature reviews. Cancer · doi:10.1038/s41568-024-00754-y · Cited by 70 · see citing works

Genetic heterogeneity: Challenges, impacts, and methods through an associative lens

Woodward, A., Urbanowicz, R. J., Naj, A. C., & Moore, J. H. (2022) · Genetic Epidemiology · doi:10.1002/gepi.22497 · Cited by 69 · see citing works

The end of the genetic paradigm of cancer

Huang, S., Soto, A. M., & Sonnenschein, C. (2025) · PLoS Biology · doi:10.1371/journal.pbio.3003052 · Cited by 66 · see citing works

Inherited MUTYH mutations cause elevated somatic mutation rates and distinctive mutational signatures in normal human cells

Robinson, P. S., Thomas, L. E., Abascal, F., Jung, H., Harvey, L. M. R., West, H. D., Ólafsson, S., Lee, B. C. H., Coorens, T. H. H., Lee-Six, H., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-31341-0 · Cited by 63 · see citing works

The somatic mutation landscape of normal gastric epithelium

Coorens, T. H. H., Collord, G., Jung, H., Wang, Y., Moore, L., Hooks, Y., Mahbubani, K., Law, S. Y. K., Yan, H. H. N., Yuen, S. T., et al. (2025) · Nature · doi:10.1038/s41586-025-08708-6 · Cited by 57 · see citing works

The mutagenic forces shaping the genomes of lung cancer in never smokers

Díaz‐Gay, M., Zhang, T., Hoang, P. H., Leduc, C., Baine, M. K., Travis, W. D., Sholl, L. M., Joubert, P., Khandekar, A., Wei, Z., et al. (2025) · Nature · doi:10.1038/s41586-025-09219-0 · Cited by 81 · see citing works

Clonal dynamics after allogeneic haematopoietic cell transplantation

Spencer Chapman, M., Wilk, C. M., Boettcher, S., Mitchell, E., Dawson, K., Williams, N., Müller, J., Kovtonyuk, L., Jung, H., Caiado, F., et al. (2024) · Nature · doi:10.1038/s41586-024-08128-y · Cited by 60 · see citing works

Linking Tumor Microenvironment to Plasticity of Cancer Stem Cells: Mechanisms and Application in Cancer Therapy

Zheng, X., Yu, C., & Xu, M. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2021.678333 · Cited by 59 · see citing works

Stage-stratified molecular profiling of non-muscle-invasive bladder cancer enhances biological, clinical, and therapeutic insight

Hurst, C. D., Cheng, G., Platt, F. M., Castro, M. A. A., Marzouka, N., Eriksson, P., Black, E. V. I., Alder, O., Lawson, A. R. J., Lindskrog, S. V., et al. (2021) · Cell Reports Medicine · doi:10.1016/j.xcrm.2021.100472 · Cited by 59 · see citing works

Somatic mutation and selection at population scale

Lawson, A. R. J., Abascal, F., Nicola, P. A., Lensing, S. V., Roberts, A. L., Kalantzis, G., Baez‐Ortega, A., Brzozowska, N., Moustafa, J. S. E.-S., Vaitkute, D., et al. (2025) · Nature · doi:10.1038/s41586-025-09584-w · Cited by 72 · see citing works

Aneuploidy and complex genomic rearrangements in cancer evolution

Baker, T. M., Waise, S., Tarabichi, M., & Loo, P. V. (2024) · Nature Cancer · doi:10.1038/s43018-023-00711-y · Cited by 59 · see citing works

The interplay of mutagenesis and ecDNA shapes urothelial cancer evolution

Nguyen, D. D., Hooper, W. F., Liu, W., Chu, T. R., Geiger, H. M., Shelton, J. M., Shah, M. J., Goldstein, Z. R., Winterkorn, L. H., Helland, A., et al. (2024) · Nature · doi:10.1038/s41586-024-07955-3 · Cited by 62 · see citing works

APOBEC mutagenesis is a common process in normal human small intestine

Wang, Y., Robinson, P. S., Coorens, T. H. H., Moore, L., Lee-Six, H., Noorani, A., Sanders, M. A., Jung, H., Katainen, R., Heuschkel, R. B., et al. (2023) · Nature Genetics · doi:10.1038/s41588-022-01296-5 · Cited by 56 · see citing works

Field Cancerization Is Associated with Tumor Development, T-cell Exhaustion, and Clinical Outcomes in Bladder Cancer

Strandgaard, T., Nordentoft, I., Birkenkamp‐Demtröder, K., Salminen, L., Prip, F., Rasmussen, J., Andreasen, T. G., Lindskrog, S. V., Christensen, E., Lamy, P., et al. (2023) · European Urology · doi:10.1016/j.eururo.2023.07.014 · Cited by 56 · see citing works

Spatiotemporal dynamics of clonal selection and diversification in normal endometrial epithelium

Yamaguchi, M., Nakaoka, H., Suda, K., Yoshihara, K., Ishiguro, T., Yachida, N., Saito, K., Ueda, H., Sugino, K., Mori, Y., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-28568-2 · Cited by 54 · see citing works

Whole-genome Mutational Analysis for Tumor-informed Detection of Circulating Tumor DNA in Patients with Urothelial Carcinoma

Nordentoft, I., Lindskrog, S. V., Birkenkamp‐Demtröder, K., Gonzalez, S., Kuzman, M., Levatić, J., Glavaš, D., Ptashkin, R. N., Smadbeck, J. B., Afterman, D., et al. (2024) · European Urology · doi:10.1016/j.eururo.2024.05.014 · Cited by 54 · see citing works

The mutational landscape of human somatic and germline cells

Moore, L., Cagan, A., Coorens, T. H. H., Neville, M. D. C., Sanghvi, R., Sanders, M. A., Oliver, T. R. W., Leongamornlert, D. A., Ellis, P., Noorani, A., et al. (2022) · Yearbook of pediatric endocrinology · doi:10.1101/2020.11.25.398172 · Cited by 55 · see citing works

Rates and Patterns of Clonal Oncogenic Mutations in the Normal Human Brain

Ganz, J., Maury, E. A., Becerra, B., Bizzotto, S., Doan, R. N., Kenny, C. J., Shin, T., Kim, J., Zhou, Z., Ligon, K. L., et al. (2022) · Cancer Discovery · doi:10.1158/2159-8290.cd-21-0245 · Cited by 48 · see citing works

Induction of APOBEC3-mediated genomic damage in urothelium implicates BK polyomavirus (BKPyV) as a hit-and-run driver for bladder cancer

Baker, S. C., Mason, A. S., Slip, R. G., Skinner, K. T., Macdonald, A., Masood, O., Harris, R. S., Fenton, T. R., Periyasamy, M., Ali, S., et al. (2022) · Oncogene · doi:10.1038/s41388-022-02235-8 · Cited by 45 · see citing works

p53 mutation in normal esophagus promotes multiple stages of carcinogenesis but is constrained by clonal competition

Murai, K., Dentro, S. C., Ong, S. H., Sood, R. K., Fernández‐Antorán, D., Herms, A., Kostiou, V., Abnizova, I., Hall, B. A., Gerstung, M., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-33945-y · Cited by 51 · see citing works

Genetic variation across and within individuals

Yu, Z., Coorens, T. H. H., Uddin, M. M., Ardlie, K., Lennon, N. J., & Natarajan, P. (2024) · Nature Reviews Genetics · doi:10.1038/s41576-024-00709-x · Cited by 50 · see citing works

Steering research on mRNA splicing in cancer towards clinical translation

Anczuków, O., Allain, F. H. ‐., Angarola, B. L., Black, D. L., Brooks, A. N., Cheng, C., Conesa, A., Crosse, E. I., Eyras, E., Guccione, E., et al. (2024) · Nature reviews. Cancer · doi:10.1038/s41568-024-00750-2 · Cited by 48 · see citing works

Comprehensive Molecular Characterization Reveals Genomic and Transcriptomic Subtypes of Metastatic Urothelial Carcinoma

Nakauma‐González, J. A., Rijnders, M., van Riet, J., van der Heijden, M. S., Voortman, J., Cuppen, E. P. J. G., Mehra, N., van Wilpe, S., Oosting, S. F., Rijstenberg, L. L., et al. (2022) · European Urology · doi:10.1016/j.eururo.2022.01.026 · Cited by 48 · see citing works

SomaMutDB: a database of somatic mutations in normal human tissues

Sun, S., Wang, Y., Maslov, A. Y., Dong, X., & Vijg, J. (2021) · Nucleic Acids Research · doi:10.1093/nar/gkab914 · Cited by 49 · see citing works

Colorectal Cancer Is Associated with the Presence of Cancer Driver Mutations in Normal Colon

Matas, J., Kohrn, B., Fredrickson, J., Carter, K., Yu, M., Wang, T., Gui, X., Soussi, T., Moreno, V. R., Grady, W. M., et al. (2022) · Cancer Research · doi:10.1158/0008-5472.can-21-3607 · Cited by 49 · see citing works

Molecular biomarkers of progression in non-muscle-invasive bladder cancer — beyond conventional risk stratification

Olislagers, M., de Jong, F. C., Rutten, V. C., Boormans, J. L., Mahmoudi, T., & Zuiverloon, T. C. M. (2024) · Nature Reviews Urology · doi:10.1038/s41585-024-00914-7 · Cited by 48 · see citing works

Shared and distinct genetic etiologies for different types of clonal hematopoiesis

Brown, D. W., Cato, L. D., Zhao, Y., Nandakumar, S. K., Bao, E. L., Gardner, E. J., Hubbard, A. K., DePaulis, A., Rehling, T., Song, L., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-41315-5 · Cited by 45 · see citing works

How Does Endometriosis Lead to Ovarian Cancer? The Molecular Mechanism of Endometriosis-Associated Ovarian Cancer Development

Yachida, N., Yoshihara, K., Yamaguchi, M., Suda, K., Tamura, R., & Enomoto, T. (2021) · Cancers · doi:10.3390/cancers13061439 · Cited by 46 · see citing works

The Dynamics of Somatic Mutagenesis During Life in Humans

Manders, F., van Boxtel, R., & Middelkamp, S. (2021) · Frontiers in Aging · doi:10.3389/fragi.2021.802407 · Cited by 45 · see citing works

Emerging diversity in extracellular vesicles and their roles in cancer

Sohal, I. S., & Kasinski, A. L. (2023) · Frontiers in Oncology · doi:10.3389/fonc.2023.1167717 · Cited by 43 · see citing works

Preneoplastic somatic mutations including MYD88 L265P in lymphoplasmacytic lymphoma

Rodríguez, S., Celay, J., Goicoechea, I., Jiménez, C., Botta, C., Garcia-Barchino, M. J., Garcés, J., Larráyoz, M., Santos, S. A., Alignani, D., et al. (2022) · Science Advances · doi:10.1126/sciadv.abl4644 · Cited by 43 · see citing works

Clonal haematopoiesis, ageing and kidney disease

Vlasschaert, C., Lanktree, M. B., Rauh, M. J., Kelly, T. N., & Natarajan, P. (2023) · Nature Reviews Nephrology · doi:10.1038/s41581-023-00778-x · Cited by 41 · see citing works

Somatic variation in normal tissues: friend or foe of cancer early detection?

Acha‐Sagredo, A., Ganguli, P., & Ciccarelli, F. D. (2022) · Annals of Oncology · doi:10.1016/j.annonc.2022.09.156 · Cited by 39 · see citing works

Clonal hematopoiesis: Molecular and clinical implications

Kusne, Y. N., Xie, Z., & Patnaik, M. M. (2022) · Leukemia Research · doi:10.1016/j.leukres.2022.106787 · Cited by 41 · see citing works

Cell Competition in Carcinogenesis

Madan, E., Palma, A. M., Vudatha, V., Trevino, J. G., Natarajan, K. N., Winn, R. A., Won, K., Graham, T. A., Drapkin, R., McDonald, S. A. C., et al. (2022) · Cancer Research · doi:10.1158/0008-5472.can-22-2217 · Cited by 41 · see citing works

Clonal dynamics and somatic evolution of haematopoiesis in mouse

Kapadia, C. D., Williams, N., Dawson, K. J., Watson, C. J., Yousefzadeh, M. J., Le, D. T., Nyamondo, K., Kodavali, S., Cagan, A., Waldvogel, S. M., et al. (2025) · Nature · doi:10.1038/s41586-025-08625-8 · Cited by 41 · see citing works

Control-independent mosaic single nucleotide variant detection with DeepMosaic

Yang, X., Xu, X., Breuss, M. W., Antaki, D., Ball, L., Chung, C., Shen, J., Li, C., George, R. D., Wang, Y., et al. (2023) · Nature Biotechnology · doi:10.1038/s41587-022-01559-w · Cited by 40 · see citing works

The Mutagenic Impact of Environmental Exposures in Human Cells and Cancer: Imprints Through Time

Huber, A. R., van Hoeck, A., & van Boxtel, R. (2021) · Frontiers in Genetics · doi:10.3389/fgene.2021.760039 · Cited by 38 · see citing works

Somatic Mutation: What Shapes the Mutational Landscape of Normal Epithelia?

Fowler, J. C., & Jones, P. H. (2022) · Cancer Discovery · doi:10.1158/2159-8290.cd-22-0145 · Cited by 40 · see citing works

Sperm sequencing reveals extensive positive selection in the male germline

Neville, M., Lawson, A., Sanghvi, R., Abascal, F., Pham, M. H., Cagan, A., Nicola, P., Bayzetinova, T., Baez-Ortega, A., Roberts, K., et al. (2024) · Nature · doi:10.1038/s41586-025-09448-3 · Cited by 46 · see citing works

Decoding and rejuvenating human ageing genomes: Lessons from mosaic chromosomal alterations

Dai, X., & Guo, X. (2021) · Ageing Research Reviews · doi:10.1016/j.arr.2021.101342 · Cited by 37 · see citing works

Decoding the basis of histological variation in human cancer

Fujii, M., Sekine, S., & Sato, T. (2023) · Nature reviews. Cancer · doi:10.1038/s41568-023-00648-5 · Cited by 35 · see citing works

Alterations of Chromatin Regulators in the Pathogenesis of Urinary Bladder Urothelial Carcinoma

Hoffmann, M. J., & Schulz, W. A. (2021) · Cancers · doi:10.3390/cancers13236040 · Cited by 37 · see citing works

Cancer-Causative Mutations Occurring in Early Embryogenesis

Pareja, F. G., Ptashkin, R. N., Brown, D. N., Derakhshan, F. N., Selenica, P., da Silva, E. M., Gazzo, A. M., Paula, A. D. C., Breen, K. E., Shen, R., et al. (2021) · Cancer Discovery · doi:10.1158/2159-8290.cd-21-1110 · Cited by 33 · see citing works

Flavokawain A is a natural inhibitor of PRMT5 in bladder cancer

Liu, S., Liu, Z., Piao, C., Zhang, Z., Kong, C., Yin, L., & Liu, X. (2022) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-022-02500-4 · Cited by 33 · see citing works

Progesterone from ovulatory menstrual cycles is an important cause of breast cancer

Bennink, H. J. T. C., Schultz, I. J., Schmidt, M., Jordan, V. C., Briggs, P., Egberts, J. F. M., Gemzell‐Danielsson, K., Kiesel, L., Kluivers, K. B., Krijgh, J., et al. (2023) · Breast Cancer Research · doi:10.1186/s13058-023-01661-0 · Cited by 32 · see citing works

A Novel Ferroptosis-Related Prognostic Signature Reveals Macrophage Infiltration and EMT Status in Bladder Cancer

Yan, Y., Cai, J., Huang, Z., Cao, X., Tang, P., Wang, Z., Zhang, F., Xia, S., & Shen, B. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.712230 · Cited by 32 · see citing works

Non‐metabolic function of MTHFD2 activates CDK2 in bladder cancer

Liu, X., Liu, S., Piao, C., Zhang, Z., Zhang, X., Jiang, Y., & Kong, C. (2021) · Cancer Science · doi:10.1111/cas.15159 · Cited by 32 · see citing works

Cells with cancer‐associated mutations overtake our tissues as we age

Evans, E. J., & DeGregori, J. V. (2021) · Aging and Cancer · doi:10.1002/aac2.12037 · Cited by 34 · see citing works

Mutation rates and fitness consequences of mosaic chromosomal alterations in blood

Watson, C. J., & Blundell, J. R. (2023) · Nature Genetics · doi:10.1038/s41588-023-01490-z · Cited by 31 · see citing works

Cuproptosis: Mechanism, role, and advances in urological malignancies

Wu, J., He, J., Liu, Z., Zhu, X., Li, Z., Chen, A., & Lü, J. (2024) · Medicinal Research Reviews · doi:10.1002/med.22025 · Cited by 31 · see citing works

Progression‐associated molecular changes in basal/squamous and sarcomatoid bladder carcinogenesis

Fontugne, J., Wong, J., Cabel, L., Neyret‐Kahn, H., Karboul, N., Maillé, P., Rapinat, A., Gentien, D., Nicolas, A., Baulande, S., et al. (2023) · The Journal of Pathology · doi:10.1002/path.6060 · Cited by 30 · see citing works

A body map of somatic mutagenesis in morphologically normal human tissuesPreprint

Li, R., Di, L., Li, J., Fan, W., Liu, Y., Guo, W., Liu, W., Liu, L., Li, Q., Chen, L., et al. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.11.30.403436 · Cited by 30 · see citing works

Targeting histone modifiers in bladder cancer therapy — preclinical and clinical evidence

Zhang, S., Lin, T., Xiong, X., Chen, C., Tan, P., & Wei, Q. (2024) · Nature Reviews Urology · doi:10.1038/s41585-024-00857-z · Cited by 30 · see citing works

The Genetic Evolution of Metastasis

Rogiers, A., Lobón, I., Spain, L. A., & Turajlic, S. (2022) · Cancer Research · doi:10.1158/0008-5472.can-21-3863 · Cited by 28 · see citing works

The origin of bladder cancer from mucosal field effects

Bondaruk, J. E., Jaksik, R., Wang, Z., Cogdell, D. E., Lee, S., Chen, Y., Dinh, K. N., Majewski, T., Zhang, L., Cao, S., et al. (2022) · iScience · doi:10.1016/j.isci.2022.104551 · Cited by 27 · see citing works

The Lund Molecular Taxonomy Applied to Non–Muscle-Invasive Urothelial Carcinoma

Marzouka, N., Eriksson, P., Bernardo, C., Hurst, C. D., Knowles, M. A., Sjödahl, G., Liedberg, F., & Höglund, M. (2022) · Journal of Molecular Diagnostics · doi:10.1016/j.jmoldx.2022.05.006 · Cited by 28 · see citing works

Genetic and epigenetic alterations in aging and rejuvenation of human

Park, K., Jeon, M. C., Lee, D., Kim, J., & Im, S.-W. (2024) · Molecules and Cells · doi:10.1016/j.mocell.2024.100137 · Cited by 28 · see citing works

Genetic profiles of the bladder

Zahn, L. M. (2020) · Science · doi:10.1126/science.370.6512.70-k

Macroscopic somatic clonal expansion in morphologically normal human urothelium

Li, R., Du, Y., Chen, Z., Xu, D., Lin, T., Jin, S., Wang, G., Liu, Z., Lu, M., Chen, X., et al. (2020) · Science · doi:10.1126/science.aba7300 · Cited by 206 · see citing works

The mutational landscape of normal urothelium

Lawson, A. R. J. (2021) · Apollo (University of Cambridge) · doi:10.17863/cam.79577

Sex and smoking bias in the selection of somatic mutations in human bladder

Calvet, F., Martínez-Illescas, R. B., Muiños, F., Tretiakova, M., Latorre-Esteves, E. S., Fredrickson, J., Andrianova, M. A., Pellegrini, S., Huber, A. R., Ramis-Zaldivar, J. E., et al. (2025) · Nature · doi:10.1038/s41586-025-09521-x · Cited by 16 · see citing works

Bladder Cancer and Genetic Mutations

Zhang, X., & Zhang, Y. (2015) · Cell Biochemistry and Biophysics · doi:10.1007/s12013-015-0574-z · Cited by 95 · see citing works