Epigenetic plasticity and the hallmarks of cancer

Hallmarks of Cancer: The Next Generation

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The hallmarks of cancer

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A 3D Map of the Human Genome at Kilobase Resolution Reveals Principles of Chromatin Looping

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Epigenetic Regulations of GABAergic Neurotransmission: Relevance for Neurological Disorders and Epigenetic Therapy

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Functions of DNA methylation: islands, start sites, gene bodies and beyond

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An Integrated Genomic Analysis of Human Glioblastoma Multiforme

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IDH1 and IDH2 Mutations in Gliomas

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A bivalent chromatin structure marks key developmental genes in embryonic stem cells

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The Epigenomics of Cancer

Jones, P. A., & Baylin, S. B. (2007) · Cell · doi:10.1016/j.cell.2007.01.029 · Cited by 4,515

EMT: 2016

Nieto, M. A., Huang, R. Y.-J., Jackson, R. A., & Thiery, J. P. (2016) · Cell · doi:10.1016/j.cell.2016.06.028 · Cited by 4,492

SETDB1 mediated histone H3 lysine 9 methylation suppresses MLL-fusion target expression and leukemic transformation

Ropa, J. P., Saha, N., Hu, H., Peterson, L. F., Talpaz, M., & Muntean, A. G. (2019) · Haematologica · doi:10.3324/haematol.2019.223883 · Cited by 41

Chromatin and Epigenetic Dysregulation of Prostate Cancer Development, Progression, and Therapeutic Response

Kukkonen, K., Taavitsainen, S., Huhtala, L., Uusi-Mäkelä, J., Granberg, K. J., Nykter, M., & Urbanucci, A. (2021) · Cancers · doi:10.3390/cancers13133325 · Cited by 47

Transcriptional alterations in glioma result primarily from DNA methylation–independent mechanismsPreprint

Court, F., Boiteux, E. L., Fogli, A., Müller-Barthélémy, M., Vaurs‐Barrière, C., Chautard, E., Pereira, B., Biau, J., Kémény, J., Khalil, T., et al. (2019) · Genome Research · doi:10.1101/gr.249219.119 · Cited by 49

A Review of Mathematical and Computational Methods in Cancer Dynamics

Uthamacumaran, A., & Zenil, H. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.850731 · Cited by 46

Spatial Transcriptomic Analysis of Ovarian Cancer Precursors Reveals Reactivation of IGFBP2 during Pathogenesis

Wang, Y., Huang, P., Wang, B. G., Murdock, T. A., Cope, L., Hsu, F., Wang, T., & Shih, I. (2022) · Cancer Research · doi:10.1158/0008-5472.can-22-1620 · Cited by 40

Cancer cell plasticity, stem cell factors, and therapy resistance: how are they linked?

Fatma, H., & Siddique, H. R. (2023) · Cancer and Metastasis Reviews · doi:10.1007/s10555-023-10144-9 · Cited by 40

MicroRNA-Mediated Regulation of Histone-Modifying Enzymes in Cancer: Mechanisms and Therapeutic Implications

Szczepanek, J., & Tretyn, A. (2023) · Biomolecules · doi:10.3390/biom13111590 · Cited by 43

Modularity of PRC1 composition and chromatin interaction define condensate properties

Niekamp, S., Marr, S. K., Oei, T. A., Subramanian, R., & Kingston, R. E. (2024) · Molecular Cell · doi:10.1016/j.molcel.2024.03.001 · Cited by 39

Endogenous retroviruses mediate transcriptional rewiring in response to oncogenic signaling in colorectal cancer

Ivancevic, A. M., Simpson, D. M., Joyner, O., Bagby, S. M., Nguyen, L. L., Bitler, B. G., Pitts, T. M., & Chuong, E. B. (2024) · Science Advances · doi:10.1126/sciadv.ado1218 · Cited by 42

Stem Cell Proliferation Is Kept in Check by the Chromatin Regulators Kismet/CHD7/CHD8 and Trr/MLL3/4

Gervais, L., van den Beek, M., Josserand, M., Sallé, J., Stefanutti, M., Perdigoto, C. N., Skorski, P., Mazouni, K., Marshall, O. J., Brand, A. H., et al. (2019) · Developmental Cell · doi:10.1016/j.devcel.2019.04.033 · Cited by 41

A three layered histone epigenetics in breast cancer metastasis

Nandy, D., Rajam, S. M., & Dutta, D. (2020) · Cell & Bioscience · doi:10.1186/s13578-020-00415-1 · Cited by 40

Super-Enhancer Redistribution as a Mechanism of Broad Gene Dysregulation in Repeatedly Drug-Treated Cancer Cells

Ma, Q., Yang, F., Mackintosh, C., Jayani, R. S., Oh, S., Jin, C., Nair, S. J., Merkurjev, D., Ma, W., Allen, S., et al. (2019) · Cell Reports · doi:10.1016/j.celrep.2020.107532 · Cited by 37

An Integrated Dual‐Functional Nanotool Capable of Studying Single‐Cell Epigenetics and Programmable Gene Regulation

Shi, X., Xu, Y., Wang, B., Li, Z., Yu, S., Dong, H., Zhao, W., Jiang, D., Chen, H., & Xu, J. (2023) · Angewandte Chemie International Edition · doi:10.1002/anie.202302930 · Cited by 39

Prognostic value of histone marks H3K27me3 and H3K9me3 and modifying enzymes EZH2, SETDB1 and LSD-1 in colorectal cancer

Carvalho, S. D., Freitas, M., Antunes, L., Monteiro‐Reis, S., Vieira‐Coimbra, M., Tavares, A., Paulino, S., Videira, J. F., Jerónimo, C., & Henrique, R. (2018) · Journal of Cancer Research and Clinical Oncology · doi:10.1007/s00432-018-2733-2 · Cited by 39

Binding of HMGN proteins to cell specific enhancers stabilizes cell identity

He, B., Deng, T., Zhu, I., Furusawa, T., Zhang, S., Tang, W., Postnikov, Y. V., Ambs, S., Li, C. C., Livák, F., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-07687-9 · Cited by 39

Ring1b-dependent epigenetic remodelling is an essential prerequisite for pancreatic carcinogenesis

Benitz, S., Straub, T., Mahajan, U. M., Mutter, J., Czemmel, S., Unruh, T., Wingerath, B., Deubler, S., Fahr, L., Cheng, T., et al. (2019) · Gut · doi:10.1136/gutjnl-2018-317208 · Cited by 39

Discovery of pyrazole derivatives as cellular active inhibitors of histone lysine specific demethylase 5B (KDM5B/JARID1B)

Zhao, B. Q., Liang, Q., Ren, H., Zhang, X., Wu, Y. J., Zhang, K., Ma, L., Zheng, Y., & Liu, H. (2020) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2020.112161 · Cited by 39

Hallmarks of cancer and hallmarks of aging

Blagosklonny, M. V. (2022) · Aging · doi:10.18632/aging.204082 · Cited by 43

PRMT5 Inhibitors Regulate DNA Damage Repair Pathways in Cancer Cells and Improve Response to PARP Inhibition and Chemotherapies

Carter, J., Hulse, M., Sivakumar, M., Burtell, J., Thodima, V., Wang, M., Agarwal, A., Vykuntam, K., Spruance, J., Bhagwat, N., et al. (2023) · Cancer Research Communications · doi:10.1158/2767-9764.crc-23-0070 · Cited by 38

The Warburg effect: The hacked mitochondrial-nuclear communication in cancer

Jiang, H., & Ye, J. (2025) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2025.03.006 · Cited by 40

Spatial and multiomics analysis of human and mouse lung adenocarcinoma precursors reveals TIM-3 as a putative target for precancer interception

Zhu, B., Chen, P., Aminu, M., Lǐ, J., Fujimoto, J., Tian, Y., Hong, L., Chen, H., Hu, X. Y., Li, C., et al. (2025) · Cancer Cell · doi:10.1016/j.ccell.2025.04.003 · Cited by 41

Epigenetic Regulation of p21cip1/waf1 in Human Cancer

Ocker, M., Bitar, S. A., Monteiro, A. C., Gali‐Muhtasib, H. U., & Schneider‐Stock, R. (2019) · Cancers · doi:10.3390/cancers11091343 · Cited by 40

Epigenetic Mechanisms of Escape from BRAF Oncogene Dependency

Khaliq, M., & Fallahi‐Sichani, M. (2019) · Cancers · doi:10.3390/cancers11101480 · Cited by 39

Context-Dependent Roles of Claudins in Tumorigenesis

Li, J. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2021.676781 · Cited by 37

Cell-Intrinsic Mechanisms of Drug Tolerance to Systemic Therapies in Cancer

Léonce, C., Saintigny, P., & Ortiz‐Cuaran, S. (2021) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-21-0038 · Cited by 41

METTL1 promotes neuroblastoma development through m7G tRNA modification and selective oncogenic gene translation

Huang, Y., Ma, J., Yang, C., Wei, P., Yang, M., Han, H., Chen, H. D., Yue, T., Xiao, S., Chen, X., et al. (2022) · Biomarker Research · doi:10.1186/s40364-022-00414-z · Cited by 38

Cancer cell states and emergent properties of the dynamic tumor systemPreprint

Barkley, D., Rao, A. N., Pour, M., França, G. S., & Yanai, I. (2021) · Genome Research · doi:10.1101/gr.275308.121 · Cited by 39

Combination of epidrugs with immune checkpoint inhibitors in cancer immunotherapy: From theory to therapy

Guo, R., Li, J., Hu, J., Fu, Q., Yan, Y., Xu, S., Wang, X., & Jiao, F. (2023) · International Immunopharmacology · doi:10.1016/j.intimp.2023.110417 · Cited by 37

EpigenCentral: Portal for DNA methylation data analysis and classification in rare diseases

Turinsky, A. L., Choufani, S., Lu, K., Liu, D., Mashouri, P., Min, D., Weksberg, R., & Brudno, M. (2020) · Human Mutation · doi:10.1002/humu.24076 · Cited by 39

D-Amino Acids and Cancer: Friends or Foes?

Murtas, G., & Pollegioni, L. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24043274 · Cited by 36

The State of Research and Weight of Evidence on the Epigenetic Effects of Bisphenol A

Nia, A. B. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24097951 · Cited by 40

Epigenetic Heritability of Cell Plasticity Drives Cancer Drug Resistance through a One-to-Many Genotype-to-Phenotype Paradigm

de Oliveira, E. A., Milite, S., Fernández-Mateos, J., Cresswell, G. D., Romero, E. Y., Vlachogiannis, G., Chen, B., James, C. T., Patruno, L., Ascolani, G., et al. (2025) · Cancer Research · doi:10.1158/0008-5472.can-25-0999 · Cited by 46

Dynamics of Cellular Plasticity in Prostate Cancer Progression

Tiwari, R., Manzar, N., & Ateeq, B. (2020) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2020.00130 · Cited by 40

Early Life Exposure to Aflatoxin B1 in Rats: Alterations in Lipids, Hormones, and DNA Methylation among the Offspring

Rotimi, O. A., Onuzulu, C. D., Dewald, A., Ehlinger, J. V., Adelani, I. B., Olasehinde, O. E., Rotimi, S. O., & Goodrich, J. M. (2021) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph18020589 · Cited by 36

EZH2 endorses cell plasticity to non-small cell lung cancer cells facilitating mesenchymal to epithelial transition and tumour colonization

Gallardo, A., Molina, A., Asenjo, H. G., López-Onieva, L., Martorell‐Marugán, J., Espinosa-Martínez, M., Griñán‐Lisón, C., Álvarez-Pérez, J. C., Cara, F. E., Navarro-Marchal, S. A., et al. (2022) · Oncogene · doi:10.1038/s41388-022-02375-x · Cited by 39

The multifaceted mechanisms of malignant glioblastoma progression and clinical implications

Sun, R., & Kim, A. H. (2022) · Cancer and Metastasis Reviews · doi:10.1007/s10555-022-10051-5 · Cited by 40

A prismatic view of the epigenetic-metabolic regulatory axis in breast cancer therapy resistance

Das, C., Bhattacharya, A., Adhikari, S., Mondal, A., Mondal, P., Adhikary, S., Roy, S., Ramos, K. S., Yadav, K. K., Tainer, J. A., et al. (2024) · Oncogene · doi:10.1038/s41388-024-03054-9 · Cited by 39

Oncogenic Hijacking of the PIN1 Signaling Network

Zannini, A., Rustighi, A., Campaner, E., & Sal, G. D. (2019) · Frontiers in Oncology · doi:10.3389/fonc.2019.00094 · Cited by 37

METTL3 Contributes to Osteosarcoma Progression by Increasing DANCR mRNA Stability via m6A Modification

Zhou, X., Yang, Y., Li, Y., Liang, G., Kang, D., Zhou, B., & Li, Q. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.784719 · Cited by 35

Opportunities for Early Cancer Detection: The Rise of ctDNA Methylation-Based Pan-Cancer Screening Technologies

Constantin, N., Sina, A. A. I., Korbie, D. J., & Trau, M. (2022) · Epigenomes · doi:10.3390/epigenomes6010006 · Cited by 36

Superenhancer activation of KLHDC8A drives glioma ciliation and hedgehog signaling

Lee, D., Gimple, R. C., Wu, X., Prager, B. C., Qiu, Z., Wu, Q., Daggubati, V., Mariappan, A., Gopalakrishnan, J., Sarkisian, M. R., et al. (2022) · Journal of Clinical Investigation · doi:10.1172/jci163592 · Cited by 36

Melanoma RBPome identification reveals PDIA6 as an unconventional RNA-binding protein involved in metastasis

Mestre-Farràs, N., Guerrero, S. X., Bley, N., Rivero, E., Coll, O., Borràs, E., Sabidó, E., Indacochea, A., Casillas-Serra, C., Järvelin, A. I., et al. (2022) · Nucleic Acids Research · doi:10.1093/nar/gkac605 · Cited by 34

PHLPP1 counter-regulates STAT1-mediated inflammatory signaling

Cohen‐Katsenelson, K., Stender, J. D., Kawashima, A. T., Lordén, G., Uchiyama, S., Nizet, V., Glass, C. K., & Newton, A. C. (2019) · eLife · doi:10.7554/elife.48609 · Cited by 33

Neonatal Lead (Pb) Exposure and DNA Methylation Profiles in Dried Bloodspots

Montrose, L. B., Goodrich, J. M., Morishita, M., Kochmanski, J. J., Klaver, Z. M., Cavalcante, R. G., Lumeng, J. C., Peterson, K. E., & Dolinoy, D. C. (2020) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph17186775 · Cited by 33

Primary effusion lymphoma enhancer connectome links super-enhancers to dependency factors

Wang, C., Zhang, L., Ke, L., Ding, W., Jiang, S., Li, D., Narita, Y., Hou, I., Liang, J., Li, S., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-20136-w · Cited by 35

Variations in oral microbiome and its predictive functions between tumorous and healthy individuals

Yang, J., He, P., Zhou, M., Li, S., Zhang, J., Tao, X., Wang, A., & Wu, X. (2022) · Journal of Medical Microbiology · doi:10.1099/jmm.0.001568 · Cited by 34

Single-Cell Chromatin Accessibility Analysis Reveals the Epigenetic Basis and Signature Transcription Factors for the Molecular Subtypes of Colorectal Cancers

Liu, Z., Hu, Y., Xie, H., Chen, K., Wen, L., Fu, W., Zhou, X., & Tang, F. (2024) · Cancer Discovery · doi:10.1158/2159-8290.cd-23-1445 · Cited by 32

Dual-Responsive Core Crosslinking Glycopolymer-Drug Conjugates Nanoparticles for Precise Hepatocarcinoma Therapy

Wu, J., Yuan, J., Ye, B., Wu, Y., Xu, Z., Chen, J., & Chen, J. (2018) · Frontiers in Pharmacology · doi:10.3389/fphar.2018.00663 · Cited by 33

RAB37 Hypermethylation Regulates Metastasis and Resistance to Docetaxel-Based Induction Chemotherapy in Nasopharyngeal Carcinoma

Li, Y.-Q., Yang, X.-J., Du, X., Lei, Y., He, Q., Hong, X., Tang, X.-R., Wen, X., Zhang, P., Sun, Y. H., et al. (2018) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-18-0532 · Cited by 35

Probiotic lactobacilli mediated changes in global epigenetic signatures of human intestinal epithelial cells during Escherichia coli challenge

Bhat, M. I., Kumari, A., Kapila, S., & Kapila, R. (2019) · Annals of Microbiology · doi:10.1007/s13213-019-01451-0 · Cited by 33

Genome-wide DNA methylation and hydroxymethylation analysis reveal human menstrual blood-derived stem cells inhibit hepatocellular carcinoma growth through oncogenic pathway suppression via regulating 5-hmC in enhancer elements

Wu, Y., Chen, X., Zhao, Y., Wang, Y., Li, Y., & Xiang, C. (2019) · Stem Cell Research & Therapy · doi:10.1186/s13287-019-1243-8 · Cited by 33

Recent Advances in the Targeting of Epigenetic Regulators in B-Cell Non-Hodgkin Lymphoma

Ribeiro, M. L., Reyes-Garau, D., Armengol, M., Fernández-Serrano, M., & Roué, G. (2019) · Frontiers in Genetics · doi:10.3389/fgene.2019.00986 · Cited by 34

Hypoxia-induced changes in intragenic DNA methylation correlate with alternative splicing in breast cancer

Pant, D., Narayanan, S. P., Vijay, N., & Shukla, S. (2020) · Journal of Biosciences · doi:10.1007/s12038-019-9977-0 · Cited by 32

BRMS1: a multifunctional signaling molecule in metastasis

Zimmermann, R. C., & Welch, D. R. (2020) · Cancer and Metastasis Reviews · doi:10.1007/s10555-020-09871-0 · Cited by 35

A functional LSD1 coregulator screen reveals a novel transcriptional regulatory cascade connecting R-loop homeostasis with epigenetic regulation

Pinter, S., Knodel, F., Choudalakis, M., Schnee, P., Kroll, C., Fuchs, M., Broehm, A., Weirich, S., Roth, M., Eisler, S. A., et al. (2021) · Nucleic Acids Research · doi:10.1093/nar/gkab180 · Cited by 32

The MAL Protein, an Integral Component of Specialized Membranes, in Normal Cells and Cancer

Rubio-Ramos, A., Labat‐de‐Hoz, L., Correas, I., & Alonso, M. A. (2021) · Cells · doi:10.3390/cells10051065 · Cited by 35

Cancer progression as a learning process

Shomar, A., Barak, O., & Brenner, N. (2022) · iScience · doi:10.1016/j.isci.2022.103924 · Cited by 33

Cancer: slaying the nine-headed Hydra

Adashek, J. J., Subbiah, V., Westphalen, C. B., Naing, A., Kato, S., & Kurzrock, R. (2022) · Annals of Oncology · doi:10.1016/j.annonc.2022.07.010 · Cited by 33

SUZ 12 is a novel putative oncogene promoting tumorigenesis in head and neck squamous cell carcinoma

Wu, Y., Hu, H., Zhang, W., Li, Z., Diao, P., Wang, D., Zhang, W., Wang, Y., Yang, J., & Cheng, J. (2018) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.13638 · Cited by 41

EZH2/G9a interact to mediate drug resistance in non-small-cell lung cancer by regulating the SMAD4/ERK/c-Myc signaling axis

Zhang, Q., Shi, Y., Liu, S., Yang, W., Chen, H., Guo, N., Sun, W., Zhao, Y., Ren, Y., Ren, Y., et al. (2024) · Cell Reports · doi:10.1016/j.celrep.2024.113714 · Cited by 32

Targeting amino acid-metabolizing enzymes for cancer immunotherapy

Grobben, Y. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1440269 · Cited by 35

Exploring viral mimicry combined with epigenetics and tumor immunity: new perspectives in cancer therapy

Wang, R., Dong, X., Zhang, X., Liao, J., Cui, W., & Li, W. (2025) · International Journal of Biological Sciences · doi:10.7150/ijbs.103877 · Cited by 37

The Rho GTPase Rnd1 inhibits epithelial–mesenchymal transition in hepatocellular carcinoma and is a favorable anti-metastasis target

Qin, C., Ma, D.-N., Zhang, S.-Z., Zhang, N., Ren, Z., Zhu, X., Jia, Q., Chai, Z., Wang, C., Sun, H., et al. (2018) · Cell Death and Disease · doi:10.1038/s41419-018-0517-x · Cited by 32

LncRNA PVT1 promotes malignant progression in squamous cell carcinoma of the head and neck

Yu, C., Wang, Y., Guo, L., She, L., Zhang, D., Chen, X., Zhang, X., Qin, Z., Cao, H., & Liu, Y. (2018) · Journal of Cancer · doi:10.7150/jca.26465 · Cited by 32

Potent antitumor activity of Laccaic acid and Phenethyl isothiocyanate combination in colorectal cancer via dual inhibition of DNA methyltransferase-1 and Histone deacetylase-1

Gupta, R., Bhatt, L. K., & Momin, M. M. (2019) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2019.114631 · Cited by 32

DNA G‐Quadruplexes (G4s) Modulate Epigenetic (Re)Programming and Chromatin Remodeling

Varizhuk, A. M., Isaakova, E. A., & Pozmogova, G. E. (2019) · BioEssays · doi:10.1002/bies.201900091 · Cited by 33

Loss of TET2 Affects Proliferation and Drug Sensitivity through Altered Dynamics of Cell-State Transitions

Morinishi, L. S., Kochanowski, K., Levine, R. L., Wu, L. F., & Altschuler, S. J. (2020) · Cell Systems · doi:10.1016/j.cels.2020.06.003 · Cited by 32

Aberrant Activity of Histone–Lysine N-Methyltransferase 2 (KMT2) Complexes in Oncogenesis

Poręba, E., Leśniewicz, K., & Durzyńska, J. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21249340 · Cited by 31

Group phenotypic composition in cancer

Capp, J., DeGregori, J. V., Nedelcu, A. M., Dujon, A. M., Boutry, J., Pujol, P., Alix‐Panabières, C., Hamede, R., Roche, B., Újvári, B., et al. (2021) · eLife · doi:10.7554/elife.63518 · Cited by 32

Diverse, Potent, and Efficacious Inhibitors That Target the EED Subunit of the Polycomb Repressive Complex 2 Methyltransferase

Bagal, S. K., Gregson, C. L., O’Donovan, D. H., Pike, K. G., Bloecher, A., Barton, P., Borodovsky, A., Code, E. L., Fillery, S. M., Hsu, J. H.-R., et al. (2021) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.1c01161 · Cited by 32

H3K4me3 recognition by the COMPASS complex facilitates the restoration of this histone mark following DNA replication

Serra‐Cardona, A., Duan, S., Yu, C., & Zhang, Z. (2022) · Science Advances · doi:10.1126/sciadv.abm6246 · Cited by 33

Cell-intrinsic survival signals. The role of autophagy in metastatic dissemination and tumor cell dormancy

Ramírez, L. V. (2019) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2019.07.027 · Cited by 35

DNA methylation correlates of chronological age in diverse human tissue types

Jain, N., Li, J., Lin, T., Jasmine, F., Kibriya, M. G., Demanelis, K., Oliva, M., Chen, L., & Pierce, B. L. (2024) · Epigenetics & Chromatin · doi:10.1186/s13072-024-00546-6 · Cited by 33

Epigenetic memory of colitis promotes tumour growth

Nagaraja, S., Ojeda-Miron, L., Zhang, R., Oreskovic, E., Hock, C., Yan, H., Zeve, D., Sharma, K., Hyman, R. R., Zhang, Q., et al. (2026) · Nature · doi:10.1038/s41586-026-10258-4 · Cited by 36

Chromatin Stability as a Target for Cancer Treatment

Gurova, K. V. (2018) · BioEssays · doi:10.1002/bies.201800141 · Cited by 31

EHMT2 Inhibition Induces Cell Death in Human Non-Small Cell Lung Cancer by Altering the Cholesterol Biosynthesis Pathway

Kim, H., Choi, S. Y., Lim, J., Lindroth, A. M., & Park, Y. J. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21031002 · Cited by 32

Targeting the histone demethylase PHF8-mediated PKCα-Src-PTEN axis in HER2-negative gastric cancer

Tseng, L.-L., Cheng, H.-H., Yeh, T., Huang, S., Syu, Y.-Y., Chuu, C., Yuh, C., Kung, H.-J., & Wang, W. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1919766117 · Cited by 31

Polycomb-group proteins in the initiation and progression of cancer

Zhao, X., & Wu, X. (2021) · Journal of genetics and genomics/Journal of Genetics and Genomics · doi:10.1016/j.jgg.2021.03.013 · Cited by 34

Induced pluripotency in the context of stem cell expansion bioprocess development, optimization, and manufacturing: a roadmap to the clinic

Colter, J., Murari, K., Biernaskie, J. A., & Kallos, M. S. (2021) · npj Regenerative Medicine · doi:10.1038/s41536-021-00183-7 · Cited by 31

Alternative Splicing, Epigenetic Modifications and Cancer: A Dangerous Triangle, or a Hopeful One?

Gimeno-Valiente, F., López‐Rodas, G., Castillo, J., & Franco, L. (2022) · Cancers · doi:10.3390/cancers14030560 · Cited by 33

Epigenetic plasticity, selection, and tumorigenesis

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Phenotypic heterogeneity and plasticity in colorectal cancer metastasis

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