The DOI matches its Crossref record; 275 of the 275 references it cites were found in a registry or an index.
Spermidine in health and disease
Abstract
Having your longevity and eating too: Although caloric restriction has clear benefits for maximizing health span and life span, it is sufficiently unpleasant that few humans stick to it. Madeo et al. review evidence that increased intake of the polyamine spermidine appears to reproduce many of the healthful effects of caloric restriction, and they explain its cellular actions, which include enhancement of autophagy and protein deacetylation. Spermidine is found in foods such as wheat germ, soybeans, nuts, and some fruits and vegetables and produced by the microbiota. Increased uptake of spermidine has protective effects against cancer, metabolic disease, heart disease, and neurodegeneration. Science , this issue p. eaan2788
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Several CR-associated genes, including GPX3, HMGN2, NQO1 and ODC1 (encoding a rate-limiting enzyme of polyamine biosynthesis), possess or promote antioxidant activities61–66 (Fig. 5c–f and Supplementary Fig. 43a–d).”
From Single-cell multiregion dissection of Alzheimer’s disease (2024) · cites this paper as [66]
In the citing paper
“Similarly, dietary supplementation with the polyamine spermidine prolongs life span and health span in several animal models66, and spermidine has also been shown to enhance memory performance and counteract age-related cognitive decline79–81.”
From Single-cell multiregion dissection of Alzheimer’s disease (2024) · cites this paper as [66]
In the citing paper
“Polyamines are autophagy inducers33 that are implicated in immune regulation and have been shown to improve anti-cancer immunity in mice, synergizing with anti-PD ligand 1 immunotherapy22,34.”
From Longitudinal gut microbiome changes in immune checkpoint blockade-treated advanced melanoma (2024) · cites this paper as [33]
In the citing paper
“Thus, aging is linked to the decline of circulating spermidine and a-ketoglutarate, which are both endowed with anti-aging and anticancer properties.233,234”
From Meta-hallmarks of aging and cancer (2023) · cites this paper as [233]
In the citing paper
“Disabled autophagy due to progressive depletion of spermidine in aging tissues 233 can be expected to interfere with the immune recognition of cancer cells due the incapacity of dendritic cells to recognize autophagy-deficient cancer cells, as well as due to defective T lymphocyte and NK cell responses.163,252”
From Meta-hallmarks of aging and cancer (2023) · cites this paper as [233]
In the citing paper
“In particular, metabolites of the spermidine and kynurenine pathways are associated with the gut microbiota as well as the physiology of the host231,232.”
From The gut microbiota and the brain–gut–kidney axis in hypertension and chronic kidney disease (2018) · cites this paper as [232]
Citations
Cites
López-Otín, C., Blasco, M. A., Partridge, L., Serrano, M., & Kroemer, G. (2013) · Cell · doi:10.1016/j.cell.2013.05.039 · Cited by 14,982
Self-citationMitochondrial Dysfunction and Oxidative Stress in Neurodegenerative Diseases
Lin, M. T., & Beal, M. F. (2006) · Nature · doi:10.1038/nature05292 · Cited by 6,455
Inflamm‐aging: An Evolutionary Perspective on Immunosenescence
FRANCESCHI, C., BONAFÈ, M., VALENSIN, S., OLIVIERI, F., DE LUCA, M., OTTAVIANI, E., & DE BENEDICTIS, G. (2000) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2000.tb06651.x · Cited by 5,358
Resveratrol improves health and survival of mice on a high-calorie diet
Baur, J. A., Pearson, K. J., Price, N. L., Jamieson, H. A., Lerin, C., Kalra, A., Prabhu, V. V., Allard, J. S., Lopez-Lluch, G., Lewis, K., et al. (2006) · Nature · doi:10.1038/nature05354 · Cited by 4,290
Rapamycin fed late in life extends lifespan in genetically heterogeneous mice
Harrison, D. E., Strong, R., Sharp, Z. D., Nelson, J. F., Astle, C. M., Flurkey, K., Nadon, N. L., Wilkinson, J. E., Frenkel, K., Carter, C. S., et al. (2009) · Nature · doi:10.1038/nature08221 · Cited by 3,766
Immunogenic cell death in cancer and infectious disease
Galluzzi, L., Buqué, A., Kepp, O., Zitvogel, L., & Kroemer, G. (2017) · Nature Reviews Immunology · doi:10.1038/nri.2016.107 · Cited by 3,119
Self-citationExtending Healthy Life Span—From Yeast to Humans
Fontana, L., Partridge, L., & Longo, V. D. (2010) · Science · doi:10.1126/science.1172539 · Cited by 3,023
Autophagy in Human Health and Disease
Choi, A. M. K., Ryter, S. W., & Levine, B. (2013) · New England Journal of Medicine · doi:10.1056/nejmra1205406 · Cited by 2,583
Rubinsztein, D. C., Mariño, G., & Kroemer, G. (2011) · Cell · doi:10.1016/j.cell.2011.07.030 · Cited by 2,107
Self-citationFoxO3 Controls Autophagy in Skeletal Muscle In Vivo
Mammucari, C., Milan, G., Romanello, V., Masiero, E., Rudolf, R., Del Piccolo, P., Burden, S. J., Di Lisi, R., Sandri, C., Zhao, J., et al. (2007) · Cell Metabolism · doi:10.1016/j.cmet.2007.11.001 · Cited by 1,953
Cited by
Sorted by citations
Items 901–1,000 of 1,002
Mitophagy Impairments as Culprit of Alzheimer’s Disease
Mani, S., Swargiary, G., Singh, M., & Rawal, M. (2022) · Springer eBooks · doi:10.1007/978-981-16-7606-2_5 · Cited by 1
The therapeutic role of microbial metabolites in human health and diseases
Manoharan, N., Parasuraman, R., Jayamurali, D., & Govindarajulu, S. N. (2023) · Elsevier eBooks · doi:10.1016/b978-0-323-90113-0.00002-x · Cited by 1
Li, C., Zhang, W., Chang, X., Di, X., Xie, Q., Lin, B., Zhang, H., Ye, Z., Lan, M., Lian, J., et al. (2023) · Translational Pediatrics · doi:10.21037/tp-23-41 · Cited by 1
Impact of Cellular Senescence on Cellular Clocks
Nakahata, Y. (2023) · Healthy ageing and longevity · doi:10.1007/978-3-031-22468-3_5 · Cited by 1
The Research Progress of Vascular Aging Related Diseases
Wang, S., Liu, J., Cui, Z., Yu, W., Hu, S., & Mao, Y. (2023) · Journal of Innovations in Medical Research · doi:10.56397/jimr/2023.06.06 · Cited by 1
Stereodivergent synthesis of 2-oxo-oligopyrrolidines by an iterative coupling strategy
Soda, Y., Tatsumi, K., Forner, M., Sato, S., Shibuya, K., Matagawa, T., Simizu, S., Chida, N., Okamura, T., & Sato, T. (2024) · Organic & Biomolecular Chemistry · doi:10.1039/d4ob00350k · Cited by 1
Ren, H., Wang, P., Huang, H., Huang, J., Lu, Y., Wu, Y., Xie, Z., Tang, Y., Cai, Z., & Shen, H. (2024) · Biomaterials Science · doi:10.1039/d4bm00061g · Cited by 1
Exploring juventology: unlocking the secrets of youthspan and longevity programs
Brandhorst, S., & Longo, V. D. (2024) · Frontiers in Aging · doi:10.3389/fragi.2024.1379289 · Cited by 2
Guo, Z., Zhang, Z. M., Huang, W., Xia, H., Huang, S., Lan, X., Ning, Y., Zhou, Y., & Shang, D. (2024) · Metabolic Brain Disease · doi:10.1007/s11011-024-01427-3 · Cited by 1
Wang, Z., Zuo, C., Fei, J., Chen, H., Wang, L., Xie, Y., Zhang, J., Min, S., Wang, X., & Lian, C. (2024) · Discover Oncology · doi:10.1007/s12672-024-01615-8 · Cited by 1
Natural Polyamine Spermidine Inhibits the In Vitro Oxidation of LDL
Rossmann, C. R., Darko, A., Kager, G., Ledinski, G., Wonisch, W., Wagner, T., Hallström, S., Reibnegger, G. J., Paar, M., & Cvirn, G. (2025) · Molecules · doi:10.3390/molecules30040955 · Cited by 1
Polyamine dynamics and transcriptomic changes in honey bees (Apis mellifera, L.) during aging
Purać, J. S., Vukašinović, E. L., Kebert, M., Čelić, T. V., Đorđievski, S., Spremo, J., Pihler, I. I., & Kojić, D. K. (2025) · Comparative Biochemistry and Physiology Part A Molecular & Integrative Physiology · doi:10.1016/j.cbpa.2025.111870 · Cited by 1
Potential targets of protecting podocyte in glomerular aging and injury
Zhong, Z. (2025) · Discover Medicine · doi:10.1007/s44337-025-00384-9 · Cited by 1
Parweez, F., Palou, R., Li, R., Kadhim, L., MacMillan, H. A., Tyers, M., & Liu, X. J. (2025) · Frontiers in Neuroscience · doi:10.3389/fnins.2025.1628160 · Cited by 1
Litvinov, D. Y., Savushkin, E. V., & Dergunov, A. D. (2019) · Pharmaceutical Medicine · doi:10.1007/s40290-019-00308-w · Cited by 1
Colucci, F., & Carbone, E. (2019) · European Journal of Immunology · doi:10.1002/eji.201970125 · Cited by 1
Aging, Calorie Restriction and Calorie Restriction Mimetics
Čepelak, I., Dodig, S., & Dodig, D. Č. (2019) · Rad Hrvatske akademije znanosti i umjetnosti Medicinske znanosti · doi:10.21857/9e31lhnddm · Cited by 2
Vilgis, T. A. (2020) · Springer eBooks · doi:10.1007/978-3-662-61151-7_6 · Cited by 1
Health and Pro-Longevity Interventions
Vaiserman, A. M., & Lushchak, O. V. (2020) · Healthy ageing and longevity · doi:10.1007/978-3-030-52663-4_27 · Cited by 1
Higashi, K. (2020) · Trends in Glycoscience and Glycotechnology · doi:10.4052/tigg.1979.7e · Cited by 1
Case Study 10: A Case to Investigate Acetyl Transferase Kinetics
Dumouchel, J. L., & Kramlinger, V. M. (2021) · Methods in molecular biology · doi:10.1007/978-1-0716-1554-6_29 · Cited by 1
Vilgis, T. A. (2022) · Springer eBooks · doi:10.1007/978-3-662-65108-7_6 · Cited by 1
Gut Microbiota in Elderly Onset Rheumatoid Arthritis
Kushugulova, A. R., Kunz, J., Poddighe, D., & Ainabekova, B. A. (2023) · Healthy ageing and longevity · doi:10.1007/978-3-031-14023-5_9 · Cited by 1
Polyamines of Kyoto vegetables and Uji tea
Suzuki, H., Fujiwara, Y., & Kinoshita, I. (2023) · NIPPON SHOKUHIN KOGYO GAKKAISHI · doi:10.3136/nskkk.nskkk-d-22-00096 · Cited by 1
Translational Control of TFEB and Autophagy via eIF5A Rejuvenates B Cell ImmunityPreprint
Zhang, H., Alsaleh, G., Feltham, J., Sun, Y., Riffelmacher, T., Charles, P. D., Frau, L., Yu, Z., Mohammed, S., Balabanov, S., et al. (2018) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/360503 · Cited by 1
Pechlaner, R., Madeo, F., Eisenberg, T., Kroemer, G., Tilg, H., Willeit, J., & Kiechl, S. J. (2018) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/nqy222 · Cited by 1
Self-citationMetabolic Engineering of Bacillus Amyloliquefaciens as A Novel Cell Factory to Produce SpermidinePreprint
Zou, D., Li, L., Min, Y., Ji, A., Liu, Y., Wei, X., Wang, J., & Wen, Z. (2020) · Research Square · doi:10.21203/rs.3.rs-66197/v1 · Cited by 1
Kennedy, B. K., Goh, J., & Wong, E. S. P. (2021) · Springer eBooks · doi:10.1007/978-3-030-22009-9_1074 · Cited by 1
Palikaras, K., & Tavernarakis, N. (2020) · Springer eBooks · doi:10.1007/978-3-030-21573-6_10027-1 · Cited by 1
Inflammation primes the kidney for recovery by activating AZIN1 A-to-I editingPreprint
Heruye, S., Myslinski, J., Zeng, C., Zollman, A., Makino, S., Nanamatsu, A., Mir, Q., Janga, S. C., Doud, E. H., Eadon, M. T., et al. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.11.09.566426 · Cited by 1
Cellular senescence and aging at the crossroad between immunity and cancer
Kepp, O., Galluzzi, L., & Petroni, G. (2024) · Methods in cell biology · doi:10.1016/s0091-679x(24)00009-8 · Cited by 1
Endogenous nucleophilic scavengers of reactive acyl-species neutralize carbon stressPreprint
Lee, M.-K., Kim, S. M., Lee, S., Yang, J. H., Choi, C.-R., Miao, T., Kim, J.-S., Perrimon, N., Kang, Y. P., & Rhee, H. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.04.06.716549 · Cited by 1
Ohta, R., Oguro, A., Nishimura, K., Murai, K., Fujioka, H., & Arisawa, M. (2018) · Organic & Biomolecular Chemistry · doi:10.1039/c8ob02900h
Dietary restriction in the epigenomic regulation of cardiovascular diseases
Shinmura, K. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-816843-1.00017-5
Carbotoxicity-noxious effects of carbohydrates
Kroemer, G., López-Otı́n, C., Madeo, F., & de Cabo, R. (2019) · Yearbook of pediatric endocrinology · doi:10.1530/ey.16.12.8
Self-citationKleimaier, F., Klatte, C., Stange, R., & Koppold, D. A. (2019) · Bundesgesundheitsblatt - Gesundheitsforschung - Gesundheitsschutz · doi:10.1007/s00103-019-03030-9
The role of polyamines in activation of macrophages
de Souza, D., Moraes‐Vieira, P. M., & Davanzo, G. G. (2019) · Resumos do... · doi:10.20396/revpibic2720192602
Madeo, F., & Eisenberg, T. (2020) · Zeitschrift für Komplementärmedizin · doi:10.1055/a-1228-2009
Self-citationDas, M., & Devi, K. P. (2020) · Reference series in phytochemistry · doi:10.1007/978-3-030-45299-5_31-1
Regulation der Homöostase – die Rolle der Autophagie
Milczynski, C., Mahler, A., & Schmidt, K. (2020) · Ernährung & Medizin · doi:10.1055/a-1115-9687
SUPLEMENTOS POTENCIALMENTE ALTERNATIVOS PARA O TRATAMENTO DA DESNUTRIÇÃO EM CRIANÇAS
Abreu, C. D. D., Pereira, J. A., Caldas, B. V., Neves, T. S., Rocha, B. P. C., Silveira, A. C. A., Nascimento, A. L., Antunes, A. L. M., Almeida, L. M., de Carvalho, D. M. A., et al. (2021) · Editora Omnis Scietia eBooks · doi:10.47094/978-65-88958-19-3/23-35
Vascular aging and cardiovascular diseases
Zhao, Y., Wu, A., LiYong, L. I. A. O., Liu, M., XueTing, G. O. N. G., & Tian, X. (2021) · Scientia Sinica Vitae · doi:10.1360/ssv-2020-0344
Плосконос, М. В. (2021) · Russian Clinical Laboratory Diagnostics · doi:10.51620/0869-2084-2021-66-4-197-204
Effects of physiologic inputs on autophagy
Eisenberg, T., Abdellatif, M., Ljubojević-Holzer, S., & Sedej, S. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-822003-0.00001-2
Self-citationPalikaras, K., & Tavernarakis, N. (2021) · Springer eBooks · doi:10.1007/978-3-030-57401-7_10027
An, Y., Zhu, J., Wang, X., Huang, L., Huang, W., Sun, X., Luo, C., Dang, Y., Huang, B., Zhang, B., et al. (2021) · SSRN Electronic Journal · doi:10.2139/ssrn.3979179
Shangzhi, G., Long, B., Lan, Y., Liang, Y., Li, G., Yang, X., He, M., Zheng, L. X., & Zhong, J. (2022) · Research Square · doi:10.21203/rs.3.rs-1285382/v1
Gebhardt, U. (2019) · Springer eBooks · doi:10.1007/978-3-662-57990-9_11
Johnston, M. (2018) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.733755177.793552274
Ingram, D. K. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-801238-3.62139-6
Han, J. J. (2020) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.737578806.793574219
Ongoing Research on Microgreens
Paradiso, V. M., & Renna, M. (2021) · MDPI eBooks · doi:10.3390/books978-3-03943-207-3
Das, M., & Devi, K. P. (2020) · Reference series in phytochemistry · doi:10.1007/978-3-030-45299-5_31-2
Saas, P., & Perruche, S. (2020) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.737578806.793575237
Kennedy, B. K., Goh, J., & Wong, E. S. P. (2020) · Springer eBooks · doi:10.1007/978-3-319-69892-2_1074-1
Faculty Opinions recommendation of Carbotoxicity-Noxious Effects of Carbohydrates.
Kapahi, P. (2018) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.734245524.793552366
Higashi, K. (2020) · Trends in Glycoscience and Glycotechnology · doi:10.4052/tigg.1979.7j
CONCENTRATION OF POLYAMINES IN THE RAT LIVER DURING POSTNATAL PERIOD
Bjelaković, M., Sokolovic, D. T., & Bjelaković, M. (2022) · Facta Universitatis Series Medicine and Biology · doi:10.22190/fumb210414007b
Choi, H. M., Kim, S.-G., Kim, H. Y., Woo, S. O., Kim, S.-M., Moon, H.-J., & Han, S. M. (2022) · Journal of Apiculture · doi:10.17519/apiculture.2022.04.37.1.51
Huang, S., Piao, C., Beuschel, C. B., & Sigrist, S. J. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.06.29.498204
Various forms of glaucoma and their treatments
Sharif, N. A. (2022) · Elsevier eBooks · doi:10.1016/b978-0-12-819291-7.00032-0
Lebensverlängernde Substanzen und Lebensmittel für ein gesundes Altern
Kratky, W., Weidinger, L., & Goldgruber, J. (2022) · PRO CARE · doi:10.1007/s00735-022-1609-5
Dietary modulation and mitochondrial DNA damage
Freire, T. D. S., & de Souza-Pinto, N. C. (2022) · Elsevier eBooks · doi:10.1016/b978-0-323-90256-4.00020-5
Efeitos da poliamina espermidina no metabolismo e na longevidade
Pereira, J. A., Abreu, C. D. D., Abreu, L. D., Magalhães, P. G. D. A., Almeida, D. D. S., Antunes, A. L. M., Rocha, B. P. C., Andrade, F. M. P., Machado, M. S. V., Machado, M. S. V., et al. (2022) · Research Society and Development · doi:10.33448/rsd-v11i14.32266
Matsumoto, M. (2021) · KAGAKU TO SEIBUTSU · doi:10.1271/kagakutoseibutsu.59.598
Faùndes, V. (2023) · Journal of Medicinal Food · doi:10.1089/jmf.2022.0078
Xu, M., Legradi, J., & Leonards, P. E. G. (2023) · SSRN Electronic Journal · doi:10.2139/ssrn.4351067
Paulino, A. H. D. S., Todescato, A. P., Paula, B. M. D., Rodrigues, K. L., Silva, M. Z., Teodoro, M. A., Júnior, S. I. D. S., de Brito, T. R. P., & da Silva, W. R. (2023) · ARCHIVES OF HEALTH INVESTIGATION · doi:10.21270/archi.v12i.6097
Tomato: Genetics, Genomics, and Breeding of Health Related Traits
Çelik, İ., Çolak, N. G., Doğanlar, S., & Frary, A. (2023) · Springer eBooks · doi:10.1007/978-981-19-3627-2_49-1
Sharif, N. A. (2023) · Elsevier eBooks · doi:10.1016/b978-0-323-85841-0.00018-3
Exploring Autophagy in Treating Spike Protein-related PathologyPreprint
Halma, M. T. J., Marik, P. E., & Saleeby, Y. M. (2023) · Preprints.org · doi:10.20944/preprints202306.1903.v1
Youssef, M. M., Mohamed, T. M., Bakry, A. M., & El-Keiy, M. M. (2023) · Research Square · doi:10.21203/rs.3.rs-3238520/v1
Vilgis, T. A. (2023) · Springer eBooks · doi:10.1007/978-3-662-67597-7_6
Kurihara, S. (2022) · Japanese Journal of Lactic Acid Bacteria · doi:10.4109/jslab.33.186
Biology of cognitive aging across species
Kakizawa, S., Park, J., & Tonoki, A. (2023) · Geriatrics and gerontology international/Geriatrics & gerontology international · doi:10.1111/ggi.14782
Liu, W., Hu, X., Yan, Y., & Cai, Y. (2024) · SSRN Electronic Journal · doi:10.2139/ssrn.4670676
Lee, E. J., Park, D. G., Kang, W., Shin, I.-J., Chalita, M., Oh, H., Hyun, D., Kim, H., Chun, J., An, Y., et al. (2024) · Research Square · doi:10.21203/rs.3.rs-3742244/v1
Controlling immune cell functions by biofunctionalized biopolymer
Nishiguchi, A., & Taguchi, T. (2023) · Drug Delivery System · doi:10.2745/dds.38.379
Xu, Y., & Wan, W. (2024) · Chinese Science Bulletin (Chinese Version) · doi:10.1360/tb-2024-0037
Neuwirth, T., Malzl, D., Knapp, K., Tsokkou, P., Kleißl, L., Redl, A., Freystätter, C., Marella, N., Kutschat, A. P., Ponweiser, E., et al. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.03.25.586519
Shen, Y., Huang, Q., Zhang, Y., Hsueh, C., & Zhou, L. F. (2022) · Figshare · doi:10.6084/m9.figshare.20279378
Shen, Y., Huang, Q., Zhang, Y., Hsueh, C., & Zhou, L. F. (2022) · Figshare · doi:10.6084/m9.figshare.20279375
Shen, Y., Huang, Q., Zhang, Y., Hsueh, C., & Zhou, L. F. (2022) · Figshare · doi:10.6084/m9.figshare.20279351
Shen, Y., Huang, Q., Zhang, Y., Hsueh, C., & Zhou, L. F. (2022) · Figshare · doi:10.6084/m9.figshare.20279354
Shen, Y., Huang, Q., Zhang, Y., Hsueh, C., & Zhou, L. F. (2022) · Figshare · doi:10.6084/m9.figshare.20279381
A noncanonical polyamine from bacteria antagonizes animal mitochondrial functionPreprint
Nauta, K. M., Gates, D. R., Weiland, M., Llontop, M. E. M., Wang, X., Nguyen, K., Isaguirre, C. N., Genjdar, M., Sheldon, R. D., Krawczyk, C. M., et al. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.04.29.591726
Unveiling the microbial metabolites in ruminant milk for medicinal purposes
Jia, Q., Yang, T., Chang, F., Zhang, Q., Liang, J., Liao, X., & Shi, H. (2024) · Food Frontiers · doi:10.1002/fft2.471 · Cited by 1
Effectiveness of Treatments for Long Vax: Protocol for a Prospective Cohort Study (Preprint)Preprint
Halma, M. T. J. (2024) · doi:10.2196/preprints.70342
Mitochondrial Autophagy in Brain
Watzlawik, J. O., Hou, X., Fiesel, F. C., & Springer, W. (2024) · Springer eBooks · doi:10.1007/978-3-031-68237-7_9
He, W., Gao, S., Du, L., Han, T., Yao, D., Wu, H., Li, Q., Wang, Y., & Ge, W. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.01.22.634226
Spermine attenuates TGF-β-induced EMT by downregulating fibronectin
Liu, H., & Chen, Y. (2025) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2025.108352
Efthymiou, C., Drury, S., & Lee, K. P. K. (2025) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/bs.mie.2025.01.069
Spermidine reduces ISGylation and enhances ISG15–USP18 interaction
Etori, H., Asoshina, R., Obita, T., & Okumura, F. (2025) · Scientific Reports · doi:10.1038/s41598-025-01425-0
Polyamine Metabolism in Optic Nerve: Spatial Metabolomics with AP/MALDI Mass Spectrometry Imaging
Meehan, S. D., O’Connor, C., Moskovets, E. V., Novoselov, K., Bhattacharya, N., & Bhattacharya, S. K. (2025) · Methods in molecular biology · doi:10.1007/978-1-0716-4534-5_11
Ma, X., Zhu, P.-P., Ning, J.-D., Long, Y., Tao, Y., Ou, C., Zhou, Q., & Li, L. (2025) · The journal of nutrition health & aging · doi:10.1016/j.jnha.2025.100610
Murillo-Cancho, A. F., Soriano, B. J. N., & Lozano‐Paniagua, D. (2025) · Ars Pharmaceutica (Internet) · doi:10.30827/ars.v66i3.32081
Gao, Y., Zhang, D., Tan, K., Wu, M., Tai, Q., Zhu, G., Chen, J., Zhou, C., Zhu, Y. H., Zhang, Y., et al. (2025) · Research Square · doi:10.21203/rs.3.rs-7023955/v1
Aere perennius: how chromatin fidelity is maintained and lost in disease
Fetch, D. R., Jumamyradova, A., Chapa, C. M., Ge, Y., Mohamadzadeh, M., & Soshnev, A. A. (2025) · NAR Molecular Medicine · doi:10.1093/narmme/ugaf026
Liu, L., Wang, Y., Wang, H., Wu, H., Xue, R., Zhang, X., Tang, J., Wang, Z., Gu, T., Wang, D., et al. (2025) · Fundamental Research · doi:10.1016/j.fmre.2025.08.001
Metadata
- Authors
- Madeo, F., Eisenberg, T., Pietrocola, F., & Kroemer, G.
- Affiliations
- University of Graz (AT)
- Inserm (FR)
- Karolinska University Hospital (SE)
- Corresponding author
- Madeo, Frank
- Eisenberg, Tobias
- Kroemer, Guido
- Venue
- Science
- Published
- 2018-01-26
- Volume
- 359
- Issue
- 6374
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2784734859
- Cited by
- 1,154
- References
- 275
- Citations by year
- 2026: 179 · 2025: 179 · 2024: 154 · 2023: 132 · 2022: 150 · 2021: 113 · 2020: 122 · 2019: 74 · 2018: 50
- FWCI
- 6.03
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Association pour la Recherche sur le Cancer
- European Commission (ERA-Net for Research on Rare Diseases)
- European Research Council
- Agence Nationale de la Recherche (Projets blancs)
- Fondation Leducq
- Austrian Science Fund (P23490-B20, P29262, P24381, P29203 P27893, I1000, W1226, and ‘SFB Lipotox’ (F3012))
- FFG Austria (COIN-project 855987)
- RHU Torino Lumière
- SIRIC Cancer Research and Personalized Medicine
- Fondation pour la Recherche Médicale
- Ligue Contre le Cancer
- Labex
- Institut Universitaire de France
- Institut National Du Cancer
- Cancéropôle Île-de-France
- BMWFW Austria and the Karl-Franzens University
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Polyamine Metabolism and Applications
- Health Sciences › Medicine › Geriatrics and Gerontology › Sirtuins and Resveratrol in Medicine
- Keywords
- spermidine, polyamines, caloric restriction mimetics, aging, age-related diseases, cardioprotection, neuroprotection, mitochondrial function, anti-inflammatory activity, stem cell senescence, protein deacetylation, autophagy, cardiovascular mortality, cancer mortality
- MeSH terms
- Aging, Animals, Anti-Inflammatory Agents, Non-Steroidal, Autophagy, Biological Transport, Cardiovascular Diseases, Humans, Spermidine, Neuroprotective Agents, Dietary Supplements, Metabolic Syndrome, Caloric Restriction, Carcinogenesis
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review