Spermidine in health and disease

The Hallmarks of Aging

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Mitochondrial Dysfunction and Oxidative Stress in Neurodegenerative Diseases

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Inflamm‐aging: An Evolutionary Perspective on Immunosenescence

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Resveratrol improves health and survival of mice on a high-calorie diet

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Rapamycin fed late in life extends lifespan in genetically heterogeneous mice

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Immunogenic cell death in cancer and infectious disease

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Extending Healthy Life Span—From Yeast to Humans

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Autophagy in Human Health and Disease

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Autophagy and Aging

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FoxO3 Controls Autophagy in Skeletal Muscle In Vivo

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Stress is an agonist for the induction of programmed cell death: A review

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Stress and ageing in yeast

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Epigenetic changes during ageing and their underlying mechanisms

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Isobacachalcone induces autophagy and improves the outcome of immunogenic chemotherapy

Wu, Q., Tian, A.-L., Durand, S., Aprahamian, F., Nirmalathasan, N., Xie, W., Liu, P., Zhao, L., Zhang, S., Pan, H., et al. (2020) · Cell Death and Disease · doi:10.1038/s41419-020-03226-x · Cited by 31

Loss-of-function variants in SAT1 cause X-linked childhood-onset systemic lupus erythematosus

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Molecular mechanism of caloric restriction mimetics-mediated neuroprotection of age-related neurodegenerative diseases: an emerging therapeutic approach

Sharma, A., & Singh, A. K. (2023) · Biogerontology · doi:10.1007/s10522-023-10045-y · Cited by 33

Spermidine improves angiogenic capacity of senescent endothelial cells, and enhances ischemia-induced neovascularization in aged mice

Ueno, D., Ikeda, K., Yamazaki, E., Katayama, A., Urata, R., & Matoba, S. (2023) · Scientific Reports · doi:10.1038/s41598-023-35447-3 · Cited by 32

Polyamine-containing natural products: structure, bioactivity, and biosynthesis

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The probiotic enhances donor microbiota stability and improves the efficacy of fecal microbiota transplantation for treating colitis

Fan, J., Wu, Y., Wang, X., Ullah, H., Ling, Z., Liu, P., Wang, Y. H. D., Feng, P., Ji, J., & Li, X. (2025) · Journal of Advanced Research · doi:10.1016/j.jare.2025.03.017 · Cited by 30

Production of β-glucan, glutathione, and glutathione derivatives by probiotic Saccharomyces cerevisiae isolated from cucumber jangajji

Hong, J.-Y., Son, S.-H., Hong, S.-P., Yi, S.-H., Kang, S. H., Lee, N., & Paik, H. (2018) · LWT · doi:10.1016/j.lwt.2018.10.048 · Cited by 30

Chemical profiling of spermidines in goji berry by strong cation exchange solid-phase extraction (SCX-SPE) combined with ultrahigh-performance liquid chromatography-quadrupole time-of-flight mass spectrometry (UPLC-Q-TOF/MS/MS)

Ahad, H., Jin, H., Liu, Y., Wang, J., Sun, G., Liang, X., & Aisa, H. A. (2019) · Journal of Chromatography B · doi:10.1016/j.jchromb.2019.121923 · Cited by 30

Genistein Reduces the Risk of Local Mammary Cancer Recurrence and Ameliorates Alterations in the Gut Microbiota in the Offspring of Obese Dams

Andrade, F. D. O., Liu, F., Zhang, X., Rosim, M., Dani, C., Cruz, I. M., Wang, T. T. Y., Helferich, W. G., Li, R. W., & Hilakivi-Clarke, L. A. (2021) · Nutrients · doi:10.3390/nu13010201 · Cited by 29

Polyamine Metabolism in Leishmania Parasites: A Promising Therapeutic Target

Carter, N. S., Kawasaki, Y., Nahata, S. S., Elikaee, S., Rajab, S., Salam, L., Alabdulal, M. Y., Broessel, K. K., Foroghi, F., Abbas, A., et al. (2022) · Medical Sciences · doi:10.3390/medsci10020024 · Cited by 30

Spermidine dietary supplementation and polyamines level in reference to survival and lifespan of honey bees

Đorđievski, S., Vukašinović, E. L., Čelić, T. V., Pihler, I. I., Kebert, M., Kojić, D. K., & Purać, J. S. (2023) · Scientific Reports · doi:10.1038/s41598-023-31456-4 · Cited by 30

Untargeted metabolomics for uncovering biological markers of human skeletal muscle ageing

Wilkinson, D. J., Blanco, G. R., Dunn, W. B., Phillips, B. E., Williams, J. P., Greenhaff, P. L., Smith, K., Gallagher, I. J., & Atherton, P. J. (2020) · Aging · doi:10.18632/aging.103513 · Cited by 29

Biosynthesis of a Novel Bioactive Metabolite of Spermidine from Bacillus amyloliquefaciens : Gene Mining, Sequence Analysis, and Combined Expression

Zou, D., Li, L., Min, Y., Ji, A., Liu, Y., Wei, X., Wang, J., & Wen, Z. (2020) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.0c07143 · Cited by 29

Tricoumaroylspermidine from rose exhibits inhibitory activity against ethanol-induced apoptosis in HepG2 cells

Zhou, Q., Wang, L., Liu, B., Xiao, J., Cheng, K., Chen, F., & Wang, M. (2021) · Food & Function · doi:10.1039/d1fo00800e · Cited by 29

c-Jun N-terminal kinase signaling in cellular senescence

Deng, Y., Adam, V., Nepovimová, E., Heger, Z., Valko, M., Wu, Q., Wei, W., & Kuča, K. (2023) · Archives of Toxicology · doi:10.1007/s00204-023-03540-1 · Cited by 29

Review of arginase as a promising biocatalyst: characteristics, preparation, applications and future challenges

Li, M., Qin, J., Xiong, K., Jiang, B., & Zhang, T. (2021) · Critical Reviews in Biotechnology · doi:10.1080/07388551.2021.1947962 · Cited by 29

The effects and cell barrier mechanism of main dietary nutrients on intestinal barrier

Fan, J., Yang, Y., Ma, C., Liu, X., Wang, Y., Chen, F., Wang, B., Bian, X., Yang, C., & Zhang, N. (2022) · Current Opinion in Food Science · doi:10.1016/j.cofs.2022.100942 · Cited by 28

Mitochondrial mechanisms in Alzheimer’s disease: Quest for therapeutics

Kalani, K., Chaturvedi, P., Chaturvedi, P., Verma, V. K., Lal, N., Awasthi, S. K., & Kalani, A. (2023) · Drug Discovery Today · doi:10.1016/j.drudis.2023.103547 · Cited by 28

Stem cell rejuvenation and the role of autophagy in age retardation by caloric restriction: An update

Bi, S., Wang, H., & Kuang, W. (2018) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2018.07.005 · Cited by 27

Synergistic effect of spermidine and ciprofloxacin against Alzheimer's disease in male rat via ferroptosis modulation

Youssef, M. A. M., Mohamed, T. M., Bakry, A. A., & El-Keiy, M. M. (2024) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2024.130387 · Cited by 27

Unveiling the Longevity Potential of Natural Phytochemicals: A Comprehensive Review of Active Ingredients in Dietary Plants and Herbs

Wang, Y., Cao, X., Ma, J., Liu, S., Jin, X., & Liu, B. (2024) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.4c07756 · Cited by 31

Microbiota-derived metabolites in inflammatory bowel disease

Guggeis, M. A., Harris, D. M. M., Welz, L., Rosenstiel, P. C., & Aden, K. (2025) · Seminars in Immunopathology · doi:10.1007/s00281-025-01046-9 · Cited by 31

Beneficial effects of a combination of natural product activators of autophagy on endothelial cells and platelets

Carnevale, R., Nocella, C., Schiavon, S., Cammisotto, V., Cotugno, M., Forte, M., Valenti, V., Marchitti, S., Vecchio, D., Biondi‐Zoccai, G., et al. (2021) · British Journal of Pharmacology · doi:10.1111/bph.15399 · Cited by 27

Radiation-Induced Senescence Reprograms Secretory and Metabolic Pathways in Colon Cancer HCT-116 Cells

Nagineni, C. N., Naz, S., Choudhuri, R., Chandramouli, G. V. R., Krishna, M. C., Brender, J., Cook, J. A., & Mitchell, J. B. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22094835 · Cited by 28

Bioactive compounds of probiotic Saccharomyces cerevisiae strains isolated from cucumber jangajji

Lee, N., Hong, J.-Y., Yi, S.-H., Hong, S.-P., Lee, J., & Paik, H. (2019) · Journal of Functional Foods · doi:10.1016/j.jff.2019.04.059 · Cited by 27

Supplementation of spermidine enhances the quality of postovulatory aged porcine oocytes

Bai, J., Zhang, Y., Li, N., Cui, Z., Zhang, H., Liu, Y., Miao, Y., Sun, S., & Xiong, B. (2024) · Cell Communication and Signaling · doi:10.1186/s12964-024-01881-7 · Cited by 26

The involvement of polyamine uptake and synthesis pathways in the proliferation of neonatal astrocytes

Malpica-Nieves, C. J., Rivera-Aponte, D. E., Tejeda-Bayron, F. A., Mayor, Á. M., Phanstiel, O., Veh, R. W., Eaton, M. J., & Skatchkov, S. N. (2020) · Amino Acids · doi:10.1007/s00726-020-02881-w · Cited by 26

Inosine: novel microbiota-derived immunostimulatory metabolite

Kroemer, G., & Zitvogel, L. (2020) · Cell Research · doi:10.1038/s41422-020-00417-1 · Cited by 28

Synaptic proteostasis in Parkinson's disease

Nachman, E., & Verstreken, P. (2021) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2021.09.001 · Cited by 27

Comparisons of Metabolic Profiles for Carbohydrates, Amino Acids, Lipids, Fragrance and Flavones During Grain Development in indica Rice Cultivars

Yibo, C., Zhidong, W., Wang, C., Li, H., Daoqiang, H., Zhou, D., Zhao, L., Yangyang, P., Rong, G., & Shao-chuan, Z. (2022) · Rice Science · doi:10.1016/j.rsci.2022.01.004 · Cited by 26

Effects of Spermidine on Gut Microbiota Modulation in Experimental Abdominal Aortic Aneurysm Mice

Liu, S., Liu, Y., Zhao, J., Yang, P., Wang, W., & Liao, M. (2022) · Nutrients · doi:10.3390/nu14163349 · Cited by 28

Spermidine and other functional phytochemicals in soybean seeds: Spatial distribution as visualized by mass spectrometry imaging

Sagara, T., Bhandari, D. R., Spengler, B., & Vollmann, J. (2019) · Food Science & Nutrition · doi:10.1002/fsn3.1356 · Cited by 26

Scocycamides, a Pair of Macrocyclic Dicaffeoylspermidines with Butyrylcholinesterase Inhibition and Antioxidation Activity from the Roots of Scopolia tangutica

Wang, J., Zhao, Y., Du, N., Han, Y., Li, H., Wang, R., Xu, Y., Liu, Y., & Liang, X. (2020) · Organic Letters · doi:10.1021/acs.orglett.0c02838 · Cited by 26

Novel Beneficial Cardiovascular Effects of Natural Activators of Autophagy

Frati, G., Vecchione, C., & Sciarretta, S. (2018) · Circulation Research · doi:10.1161/circresaha.118.313530 · Cited by 26

Association of spermidine plasma levels with brain aging in a population‐based study

Wortha, S. M., Frenzel, S., Bahls, M., Habes, M., Wittfeld, K., der Auwera, S. V., Bülow, R., Zylla, S., Friedrich, N., Nauck, M. A., et al. (2022) · Alzheimer s & Dementia · doi:10.1002/alz.12815 · Cited by 25

Metabolic plasticity of T cell fate decision

Pan, X., Wang, J., Zhang, L., Li, G., & Huang, B. (2023) · Chinese Medical Journal · doi:10.1097/cm9.0000000000002989 · Cited by 26

Autophagy alterations in obesity, type 2 diabetes, and metabolic dysfunction-associated steatotic liver disease: the evidence from human studies

Jakubek, P., Pakula, B., Rossmeisl, M., Pinton, P., Rimessi, A., & Wieckowski, M. R. (2024) · Internal and Emergency Medicine · doi:10.1007/s11739-024-03700-w · Cited by 30

Supplementation of spermidine at 40 mg/day has minimal effects on circulating polyamines: An exploratory double-blind randomized controlled trial in older men

Keohane, P., Everett, J. R., Pereira, R., Cook, C. M., Blonquist, T. M., & Mah, E. (2024) · Nutrition Research · doi:10.1016/j.nutres.2024.09.012 · Cited by 25

Spermidine Prevents Ethanol and Lipopolysaccharide-Induced Hepatic Injury in Mice

Adhikari, R., Shah, R., Reyes‐Gordillo, K., Arellanes‐Robledo, J., Cheng, Y., Ibrahim, J., & Tuma, P. L. (2021) · Molecules · doi:10.3390/molecules26061786 · Cited by 26

Investigating the Role of Spermidine in a Model System of Alzheimer’s Disease Using Correlative Microscopy and Super-resolution Techniques

Lumkwana, D., Peddie, C. J., Kriel, J., Michie, L. L., Heathcote, N., Collinson, L., Kinnear, C. J., & Loos, B. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.819571 · Cited by 25

Spermidine Crosslinked Gellan Gum-Based “Hydrogel Nanofibers” as Potential Tool for the Treatment of Nervous Tissue Injuries: A Formulation Study

Vigani, B., Valentino, C., Sandri, G., Caramella, C. M., Ferrari, F., & Rossi, S. (2022) · International Journal of Nanomedicine · doi:10.2147/ijn.s368960 · Cited by 25

Spermine is a natural suppressor of AR signaling in castration-resistant prostate cancer

Li, X., Li, F., Ye, F., Guo, H., Chen, W., Jin, J., Wang, Y., Dai, P., Shi, H., Tao, H., et al. (2023) · Cell Reports · doi:10.1016/j.celrep.2023.112798 · Cited by 25

Metabolism of Polyamines and Kidney Disease: A Promising Therapeutic Target

Luo, D., Lu, X., Li, Y., Xu, Y., Zhou, Y., & Mao, H. (2023) · Kidney Diseases · doi:10.1159/000533296 · Cited by 27

Unveiling the dual role of autophagy in vascular remodelling and its related diseases

Ren, H., Dai, R., Nabil, W. N. N., Xi, Z., Wang, F., & Xu, H. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.115643 · Cited by 25

Potent immunosuppressive effects of the oncometaboliteR-2-hydroxyglutarate

Galluzzi, L., & Kroemer, G. (2018) · OncoImmunology · doi:10.1080/2162402x.2018.1528815 · Cited by 25

Interactions between wheat germ polysaccharide and gut microbiota through in vitro batch fecal fermentation and an aging mice model: Targeting enrichment of Bacteroides uniformis and Bifidobacterium pseudocatenulatum

Duan, H., Yu, Q., Ni, Y., Li, J., Yu, L., & Fan, L. (2023) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2023.127559 · Cited by 22

A new clinical age of aging research

Zhang, Z., Yang, R., Zi, Z., & Liu, B. (2024) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2024.08.004 · Cited by 25

Spermidine attenuates chondrocyte inflammation and cellular pyroptosis through the AhR/NF-κB axis and the NLRP3/caspase-1/GSDMD pathway

Guo, X., Feng, X., Yang, Y., Zhang, H., & Bai, L. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1462777 · Cited by 26

Antiaging Therapies, Cognitive Impairment, and Dementia

Wahl, D., Anderson, R. M., & Couteur, D. G. L. (2019) · The Journals of Gerontology Series A · doi:10.1093/gerona/glz135 · Cited by 25

Sex differences in metabolic pathways are regulated by Pfkfb3 and Pdk4 expression in rodent muscle

Christianto, A., Baba, T., Takahashi, F., Inui, K., Inoue, M., Suyama, M., Ono, Y., Ohkawa, Y., & Morohashi, K.-I. (2021) · Communications Biology · doi:10.1038/s42003-021-02790-y · Cited by 26

Metabolic response of the sea cucumber Apostichopus japonicus during the estivation-arousal cycles

Zhao, Y., Wang, H., Wang, H., Pi, Y., & Chen, M. (2022) · Frontiers in Marine Science · doi:10.3389/fmars.2022.980221 · Cited by 24

Spermine Suppresses Adipocyte Differentiation and Exerts Anti-Obesity Effects In Vitro and In Vivo

Nakatani, S., Horimoto, Y., Nakabayashi, N., Karasawa, M., Wada, M., & Kobata, K. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms231911818 · Cited by 24

Probiotic induced synthesis of microbiota polyamine as a nutraceutical for metabolic syndrome and obesity-related type 2 diabetes

Bui, T. I., Britt, E. A., Muthukrishnan, G., & Gill, S. R. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.1094258 · Cited by 27

Conformational cycle of human polyamine transporter ATP13A2

Mu, J., Xue, C., Fu, L., Yu, Z., Nie, M., Wu, M., Chen, X., Liu, K., Bu, R., Huang, Y. R., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-37741-0 · Cited by 24

Researches and applications of nitroimidazole heterocycles in medicinal chemistry

Li, Z., Maddili, S. K., Tangadanchu, V. K. R., Bheemanaboina, R. R. Y., Lin, J.-M., Yang, R.-G., Cai, G., & Zhou, C. (2018) · Scientia Sinica Chimica · doi:10.1360/n032018-00098 · Cited by 24

Identification and Biosynthetic Study of the Siderophore Lysochelin in the Biocontrol Agent Lysobacter enzymogenes

Miller, A. L., Li, S., Eichhorn, C. D., Zheng, Y., & Du, L. (2023) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.3c01250 · Cited by 23

Next-generation prebiotics: Maillard-conjugates of 2′-fucosyllactose and lactoferrin hydrolysates beneficially modulate gut microbiome composition and health promoting activity in a murine model

Peled, S., Freilich, S., Hanani, H., Kashi, Y., & Livney, Y. D. (2023) · Food Research International · doi:10.1016/j.foodres.2023.113830 · Cited by 24

New Insights into Identification, Distribution, and Health Benefits of Polyamines and Their Derivatives

Qiao, J., Cai, W., Wang, K., Haubruge, É., Dong, J. N., El-Seedi, H. R., Xu, X., & Zhang, H. (2024) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.3c08556 · Cited by 23

Multifunctional GelMA hydrogel doped with spermidine-ferrocene polymeric nanoparticles for accelerative diabetic wound healing

Xie, L., Zhang, X., Wang, X., Zhang, Z., Nie, T., Wu, J., & Xu, X. (2025) · Chinese Chemical Letters · doi:10.1016/j.cclet.2025.110848 · Cited by 23

Integrative metabolomics and genomics reveal molecular signatures for type 2 diabetes and its cardiovascular complications

Cheng, C., Liu, Y., Sun, L., Fan, J., Sun, X., Zheng, J., Lin, Z., Zhu, Y., & Zhou, D. (2025) · Cardiovascular Diabetology · doi:10.1186/s12933-025-02718-4 · Cited by 23

Molecular Mechanisms of Sepsis-Associated Acute Kidney Injury

Hato, T., & Dagher, P. C. (2025) · Journal of the American Society of Nephrology · doi:10.1681/asn.0000000809 · Cited by 24

The Polyphenol Pterostilbene Ameliorates the Myopathic Phenotype of Collagen VI Deficient Mice via Autophagy Induction

Metti, S., Gambarotto, L., Chrisam, M., Spina, M. L., Baraldo, M., Braghetta, P., Blaauw, B., & Bonaldo, P. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.580933 · Cited by 25

Ablation of polyamine catabolic enzymes provokes Purkinje cell damage, neuroinflammation, and severe ataxia

Zahedi, K. A., Brooks, M., Barone, S., Rahmati, N., Stewart, T. M., Dunworth, M., Shields, C. E. D., Dasgupta, N., Davidson, S., Lindquist, D. M., et al. (2020) · Journal of Neuroinflammation · doi:10.1186/s12974-020-01955-6 · Cited by 23

Spermidine at supraphysiological doses induces oxidative stress and granulosa cell apoptosis in mouse ovaries

Jiang, D., Jiang, Y., Long, S., Chen, Z., Li, Y., Mo, G., Bai, L., Hao, X., Yan, Y., Li, L., et al. (2021) · Theriogenology · doi:10.1016/j.theriogenology.2021.03.026 · Cited by 23

Current Status of Autophagy Enhancers in Metabolic Disorders and Other Diseases

Park, K., & Lee, M. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.811701 · Cited by 24

Distinct designer diamines promote mitophagy, and thereby enhance healthspan in C. elegans and protect human cells against oxidative damage

Srivastava, V., Zelmanovich, V., Shukla, V., Abergel, R., Cohen, I., Ben‐Sasson, S. A., & Gross, E. (2022) · Autophagy · doi:10.1080/15548627.2022.2078069 · Cited by 24

Advances in Immunosuppressive Agents Based on Signal Pathway

Xu, Z., & Chu, M. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.917162 · Cited by 24

Human fasting modulates macrophage function and upregulates multiple bioactive metabolites that extend lifespan in Caenorhabditis elegans: a pilot clinical study

Rhodes, C. H., Zhu, C., Agus, J., Tang, X., Li, Q., Engebrecht, J., & Zivkovic, A. M. (2022) · American Journal of Clinical Nutrition · doi:10.1016/j.ajcnut.2022.10.015 · Cited by 23

Dietary modulation of mitochondrial DNA damage: implications in aging and associated diseases

Lam, J., & McKeague, M. (2018) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2018.07.003 · Cited by 23

Spermidine Exhibits Protective Effects Against Traumatic Brain Injury

Huang, J., Zhang, H., Zhang, J., Yu, H., Lin, Z., & Cai, Y. (2020) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-019-00783-4 · Cited by 23

Cardiovascular ageing: hallmarks, signaling pathways, diseases and therapeutic targets

Zheng, P., Yan, W., Ding, Y.-N., Zhang, Y., Chen, Z., Qian, J., & Ge, J. (2026) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-026-02630-7 · Cited by 26

Translational control in cell ageing: an update

Woodward, K., & Shirokikh, N. E. (2021) · Biochemical Society Transactions · doi:10.1042/bst20210844 · Cited by 21

Long-term treatment with chloroquine increases lifespan in middle-aged male mice possibly via autophagy modulation, proteasome inhibition and glycogen metabolism

Doeppner, T. R., Coman, C., Burdusel, D., Ancuța, D.-L., Brockmeier, U., Pirici, D. N., Kuang, Y., Hermann, D. M., & Popa‐Wagner, A. (2022) · Aging · doi:10.18632/aging.204069 · Cited by 22

The untapped potential of spermidine alkaloids: Sources, structures, bioactivities and syntheses

Shi, Y., Zhang, J., Wang, Y., Ding, K., Yu, Y., Xia, C., Li, X.-X., He, J., Zhang, W., & Xu, J. (2022) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2022.114600 · Cited by 22

Therapeutics That Can Potentially Replicate or Augment the Anti-Aging Effects of Physical Exercise

Lages, A. D. S., Lopes, V., Horta, J., Espregueira‐Mendes, J., Andrade, R., & Rebelo‐Marques, A. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23179957 · Cited by 23

Mitochondrial Distress in Methylmalonic Acidemia: Novel Pathogenic Insights and Therapeutic Perspectives

Keller, S. A., & Luciani, A. (2022) · Cells · doi:10.3390/cells11193179 · Cited by 24

Nature spermidine and spermine alkaloids: Occurrence and pharmacological effects

Zhang, L., Gu, C., & Liu, J. (2022) · Arabian Journal of Chemistry · doi:10.1016/j.arabjc.2022.104367 · Cited by 22

Molecular targets of spermidine: implications for cancer suppression

Zimmermann, A., Hofer, S. J., & Madeo, F. (2023) · Cell Stress · doi:10.15698/cst2023.07.281 · Cited by 23

Probiotics and their metabolite spermidine enhance IFN-γ+CD4+ T cell immunity to inhibit hepatitis B virus

Wang, T., Fan, Y., Tan, S., Wang, Z., Li, M., Guo, X., Yu, X., Lin, Q., Song, X., Xu, L., et al. (2024) · Cell Reports Medicine · doi:10.1016/j.xcrm.2024.101822 · Cited by 21

Asparagine prevents intestinal stem cell aging via the autophagy‐lysosomal pathway

Luo, T., Zhao, L., Feng, C., Yan, J., Yu, Y., & Chen, H. (2024) · Aging Cell · doi:10.1111/acel.14423 · Cited by 21

Z-DNA at the crossroads: untangling its role in genome dynamics

Sahayasheela, V. J., Ooga, M., Kumagai, T., & Sugiyama, H. (2025) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2025.01.001 · Cited by 21

Spermidine-Regulated Biosynthesis of Heat-Stable Antifungal Factor (HSAF) in Lysobacter enzymogenes OH11

Chen, Y., Yu, L., Liu, F., & Du, L. (2018) · Frontiers in Microbiology · doi:10.3389/fmicb.2018.02984 · Cited by 21

Cellular senescence and its impact on the circadian clock

Ahmed, R., Reza, H. M., Shinohara, K., & Nakahata, Y. (2021) · The Journal of Biochemistry · doi:10.1093/jb/mvab115 · Cited by 20

The effect of spermidine on autoimmunity and beta cell function in NOD mice

Karacay, C., Prietl, B., Harer, C., Ehall, B., Haudum, C. W., Bounab, K., Franz, J., Eisenberg, T., Madeo, F., Kolb, D., et al. (2022) · Scientific Reports · doi:10.1038/s41598-022-08168-2 · Cited by 21

Spermidine inhibits LPS-induced pro-inflammatory activation of macrophages by acting on Nrf2 signaling but not autophagy

Guo, F., Meng, F.-G., Zhang, X., & Zeng, T. (2022) · Journal of Functional Foods · doi:10.1016/j.jff.2022.105115 · Cited by 22

Bioactive spermidine nanoparticles for effective cardiovascular recovery and diabetic therapy

Nie, T., Fang, Z., Liu, H., Zhang, X., Fang, Y., Xu, X., Huang, H. W., & Wu, J. (2022) · Chemical Engineering Journal · doi:10.1016/j.cej.2022.137353 · Cited by 21

The acute effect of different NAD+ precursors included in the combined metabolic activators

Li, X., Yang, H., Jin, H., Türkez, H., Öztürk, G., Doğanay, H. L., Zhang, C., Nielsen, J., Uhlén, M., Borén, J., et al. (2023) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2023.05.032 · Cited by 22

Hyaluronic acid methacrylate/Pluronic F127 hydrogel enhanced with spermidine-modified mesoporous polydopamine nanoparticles for efficient synergistic periodontitis treatment

Liu, Y., Wei, X., Yang, T., Wang, X., Li, T., Sun, M., Jiao, K., Jia, W., Yang, Y., Yan, Y., et al. (2024) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2024.136085 · Cited by 26

Autophagic Organelles in DNA Damage Response

Kim, J., Lee, S.-M., Kim, H., Lee, H., Seong, K. M., Youn, H., & Youn, B. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.668735 · Cited by 21

Polyamine Metabolism and Functions: Key Roles in Cellular Health and Disease

Rossi, M. N., & Cervelli, M. (2024) · Biomolecules · doi:10.3390/biom14121570 · Cited by 21

P53-dependent hypusination of eIF5A affects mitochondrial translation and senescence immune surveillance

Jiang, X., Baig, A. H., Palazzo, G., Pizzo, R. D., Borteçen, T., Groessl, S., Zaal, E. A., Ramirez, C. C. A., Kowar, A., Huerta, D. A., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-51901-w · Cited by 20

Spermine modulation of Alzheimer’s Tau and Parkinson’s α-synuclein: implications for biomolecular condensation and neurodegeneration

Sun, X., Saha, D., Wang, X. B., Mörman, C., Sternke‐Hoffmann, R., Gerez, J., Herranz-Trillo, F., Riek, R., Zheng, W., & Luo, J. (2025) · Nature Communications · doi:10.1038/s41467-025-65426-3 · Cited by 20

GC–MS measurement of spermidine and putrescine in serum of elderly subjects: intriguing association between spermidine and homoarginine

Hanff, E., Bollenbach, A., Beckmann, B., Brunner, G. H. G., & Tsikas, D. (2019) · Amino Acids · doi:10.1007/s00726-019-02786-3 · Cited by 20

Implication of the Gut Microbiota in Metabolic Inflammation Associated with Nutritional Disorders and Obesity

Rodriguez, J., Olivares, M., & Delzenne, N. M. (2020) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201900481 · Cited by 20

Oligoethyleneimine‐Conjugated Hyaluronic Acid Modulates Inflammatory Responses and Enhances Therapeutic Efficacy for Ulcerative Colitis

Nishiguchi, A., & Taguchi, T. (2021) · Advanced Functional Materials · doi:10.1002/adfm.202100548 · Cited by 20

Effects of Spermidine on Cell Proliferation, Migration, and Inflammatory Response in Porcine Enterocytes

Wei, Z., Cai, L., Zhao, X., Jiang, X., & Li, X. (2022) · Frontiers in Bioscience-Landmark · doi:10.31083/j.fbl2706194 · Cited by 20

Highly efficient biosynthesis of spermidine from L-homoserine and putrescine using an engineered Escherichia coli with NADPH self-sufficient system

Liang, X., Deng, H., Bai, Y., Fan, T., Zheng, X., & Cai, Y. (2022) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-022-12110-x · Cited by 20

Mechanisms of spermidine-induced autophagy and geroprotection

Hofer, S. J., Simon, A. K., Bergmann, M., Eisenberg, T., Kroemer, G., & Madeo, F. (2022) · Nature Aging · doi:10.1038/s43587-022-00322-9 · Cited by 218

Geroprotective insights into the natural metabolite spermidine in aging and age-related diseases

Jiang, Z., Tong, S., Kirkland, J. L., & Sun, Y. (2026) · npj Aging · doi:10.1038/s41514-026-00448-9

Molecular targets of spermidine: implications for cancer suppression

Zimmermann, A., Hofer, S. J., & Madeo, F. (2023) · Cell Stress · doi:10.15698/cst2023.07.281 · Cited by 23

Cardioprotective benefits of dietary spermidine

Huynh, K. (2017) · Nature Reviews Cardiology · doi:10.1038/nrcardio.2016.222 · Cited by 4

Spermidine: A physiological autophagy inducer acting as an anti-aging vitamin in humans?

Madeo, F., Bauer, M. A., Carmona-Gutierrez, D., & Kroemer, G. (2019) · Autophagy · doi:10.1080/15548627.2018.1530929 · Cited by 212