Spermidine in health and disease

The Hallmarks of Aging

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Mitochondrial Dysfunction and Oxidative Stress in Neurodegenerative Diseases

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Inflamm‐aging: An Evolutionary Perspective on Immunosenescence

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Resveratrol improves health and survival of mice on a high-calorie diet

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Rapamycin fed late in life extends lifespan in genetically heterogeneous mice

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Immunogenic cell death in cancer and infectious disease

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Extending Healthy Life Span—From Yeast to Humans

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Autophagy in Human Health and Disease

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Autophagy and Aging

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FoxO3 Controls Autophagy in Skeletal Muscle In Vivo

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Spermidine exerts cardiometabolic protection in estrogen-deprived rats via mitigating cardiac mitochondrial dysfunction and apoptosis

Kaorop, W., Maneechote, C., Pratchayasakul, W., Kumfu, S., Arunsak, B., Kongkaew, A., Chattipakorn, S. C., & Chattipakorn, N. (2025) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2025.117399 · Cited by 2

Oxidized chitosan: Combining an “Adhesion-and-Kill” antibacterial strategy with immunoregulation and angiogenesis to enhance methicillin-resistant Staphylococcus Aureus-infected wound healing

Mu, D., Chen, Q., Gao, B., Xu, H., Chen, W., Wang, K., Wu, X., Yan, C., Zhang, S., & Ke, S. (2025) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2025.145664 · Cited by 2

Polyamine metabolism related gene index prediction of prognosis and immunotherapy response in breast cancer

Wang, R., Cai, S., Gao, Q., Chen, Y., Han, X., Shang, F., Liang, C., Zhu, G., & Chen, B. (2025) · Frontiers in Oncology · doi:10.3389/fonc.2025.1613458 · Cited by 2

The roles of microglia and astrocytes in inflammasomes and neurological disorders

Xia, Y., Huang, Y., Liu, Y., Zhang, X., Kang, H., Liu, Y., Yu, C., Gan, C., & Zhang, H. (2025) · Neural Regeneration Research · doi:10.4103/nrr.nrr-d-24-01574 · Cited by 2

Polyamines in Bee and Floral Pollen: Botanical Origin and Potential as Functional Food Ingredients

Spremo, J., Radišić, P., Kebert, M., Kojić, D. K., Purać, J. S., Đorđievski, S., Čelić, T. V., & Vukašinović, E. L. (2025) · Chemistry & Biodiversity · doi:10.1002/cbdv.202501540 · Cited by 2

A short photoperiod alters brain metabolism and cold resistance in Drosophila melanogaster

Sapre, M., Hovhanyan, A., Schmitz, W., Deppisch, P., Gera, J., Mueller, M. J., Menegazzi, P., Fekete, Á., & Helfrich‐Förster, C. (2025) · Scientific Reports · doi:10.1038/s41598-025-22793-7 · Cited by 2

Putrescine functions as a metabolic checkpoint in replication stress-induced senescence

Vasilogiannakopoulou, T., Begou, O., Karali, C. S., Efthymiou, G., Roubelakis, M. G., Gorgoulis, V. G., Gkouskou, K. K., Gika, H., & Eliopoulos, A. G. (2025) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-025-05962-9 · Cited by 3

Spermidine Secreted by Apoptotic Cells Enhances Chemotherapy Resistance by Modulating β-Catenin Activity in Osteosarcoma

Yu, Q., Geng, M., Lu, Y., Zhang, X., Tong, S., Wang, Y., Ye, X., Xu, W. F., & Li, Z. (2025) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-24-4275 · Cited by 2

Mesenchymal stem cell extracellular vesicles ameliorate radiation-caused dry mouth via modulating immune balance and cell metabolism

Jaiswal, J., Zhao, Q., Shahsavari, A., Ibrahim, M. J., Chang, E., Zhang, Y., Yu, V., Zheng, R., Wewel, E., Chen, T., et al. (2025) · Stem Cell Research & Therapy · doi:10.1186/s13287-025-04709-4 · Cited by 3

Human Umbilical Cord Plasma Metabolomics Uncover Potential Metabolites for Combating Aging

Liu, J., Jiang, S., Shen, Y., Wang, R., Jin, Z., Cao, Y., Li, J., Liu, Y., Qi, Q., Guo, Y., et al. (2025) · Aging Cell · doi:10.1111/acel.70295 · Cited by 3

Growth hormone-releasing peptide 6 (GHRP-6) hydrogel for acute kidney injury therapy via metabolic regulation

Zhao, X., Pan, K., Li, R., Liu, M., Li, D., Jia, P., Han, Z., Han, Z., Guo, Z., Li, Z., et al. (2025) · Journal of Nanobiotechnology · doi:10.1186/s12951-025-03888-9 · Cited by 2

WGX ‐50 Promotes Healthy Ageing in Caenorhabditis elegans : A Combined Computational and Experimental Study

Jia, G., Li, J., Khan, A., Kaushik, A. C., Wu, D., Chen, H., Li, R., Wang, J., Zhang, C., Farooq, A., et al. (2025) · Chemical Biology & Drug Design · doi:10.1111/cbdd.70214 · Cited by 2

Bacteroides finegoldii and Parabacteroides goldsteinii Mediate Fucoidan-Induced Attenuation of Intestinal Inflammation in Mice Through Betaine- and Spermidine-Related Pathways

Qin, T., Wei, Y., Zheng, W., Li, S., Song, S., & Ai, C. (2026) · Foods · doi:10.3390/foods15020203 · Cited by 2

Yeast protein modulates metabolites derived from the human gut microbiota of older male adults ex vivo to strengthen gut barrier function and reduce inflammation

den Abbeele, P. V., Vu, L. D., Poppe, J., van Hengel, I. A. J., Baudot, A., Zhang, Y., Chen, Z., & Yan, J. (2026) · Frontiers in Microbiology · doi:10.3389/fmicb.2025.1697734 · Cited by 2

Integrative analysis of plasma small-molecule and gut-microbiome markers of sarcopenia in a pilot study within an Indian cohort

Hashmi, M. A., Verma, S., Math, R. G. H., Muralidharan, S., Pranesh, G., Sahana, M. P., Hariharan, N., C, M., Kamath, V., Yaligod, V., et al. (2026) · Scientific Reports · doi:10.1038/s41598-026-35476-8 · Cited by 2

Probiotic and microbial modulation of polyamine production: an emerging avenue for neuroprotection in neurodegenerative disorders

Adhikari, T., & Saha, P. (2026) · Amino Acids · doi:10.1007/s00726-026-03505-5 · Cited by 2

Anshen Bunao syrup as a potential anti-aging agent: mechanistic insights and pharmacological evidence

Sun, Y., Xia, Q., Wu, R., Liu, G., Wang, Y., Yan, S., Jin, H., Zhang, X., Xiao, X., & Li, S. (2026) · Frontiers in Aging · doi:10.3389/fragi.2026.1768671 · Cited by 2

Yeast Chronological Lifespan Model as a Tool for Screening Aging Interventions

Xu, P., Zhang, X., Wang, Y., Rahman, S. U., Huang, D., & Wu, Z. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27062633 · Cited by 2

Spermidine and spermine in elderly patients with coronary artery disease: a cross-sectional study of dietary intake and plasma and skeletal muscle concentrations

Thorup, C. V., Jensen, T., Jeppesen, C. N. A., Tinggaard, A. B., Johannsen, M., Hansen, J., Hvas, C. L., Rud, C. L., Wang, J., Farup, J., et al. (2026) · Clinical Nutrition · doi:10.1016/j.clnu.2026.106651 · Cited by 2

Transcriptomic Analysis Reveals the Beneficial Effects of Spermidine in an ALS Mouse Model

Fiorucci, C., Rossi, M. N., Santo, R. D., Salvatori, I., Scaricamazza, S., Giuliani, S., Carletta, O., Filomena, E., Laurenti, D., Mattioli, R., et al. (2026) · Biomolecules · doi:10.3390/biom16040566 · Cited by 2

Age-Specific Ex Vivo Modulation of Gut–Brain Axis-Associated Metabolites by Galacto-Oligosaccharides and Nutrient Blends in Early Childhood

Ferrier, L., Dogra, S. K., Vu, L. D., Kanellopoulos, A. K., Poppe, J., Biehl, L., Baudot, A., & den Abbeele, P. V. (2026) · Metabolites · doi:10.3390/metabo16040255 · Cited by 2

Da-Bu-Yin-Wan and Qian-Zheng-San regulate neuroinflammation and intestinal permeability through the microbiota-gut-brain axis in Parkinson's disease mice

Zhu, H., Feng, J., Xu, H., Cai, D., Wei, R., & Gai, C. (2026) · Phytomedicine · doi:10.1016/j.phymed.2026.158200 · Cited by 2

Spermidine in the aging brain: mechanisms, preclinical evidence, and clinical perspectives

Pandolfi, S., Bjørklund, G., Ghezzi, C., Paone, F. M., & Chirumbolo, S. (2026) · Molecular Biology Reports · doi:10.1007/s11033-026-11827-6 · Cited by 2

Polyamines and autophagy as a dynamic regulatory network in skeletal muscle regeneration and aging

Attili, L., Rossi, M. N., Santo, R. D., Duranti, G., Ceci, R., & Cervelli, M. (2026) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2026.112188 · Cited by 3

Autophagy decline during ageing: Molecular regulation, tissue specificity, and therapeutic potential

Goyal, A., Kumari, A., Agrawal, N., & Yadav, H. N. (2026) · Pathology - Research and Practice · doi:10.1016/j.prp.2026.156568 · Cited by 2

Methionine-supplemented longevity diet increases growth hormone, GLP-1, and FGF21; reduces frailty; and promotes healthspan

Fanti, M., Brandhorst, S., Navarrete, G., Diaz, A., Giuliani, G., Chowdhury, D., Antunes, G. C., Morgan, T. E., Dubeau, L., Villani, V., et al. (2026) · Cell Metabolism · doi:10.1016/j.cmet.2026.05.015 · Cited by 4

Psychological stress drives aging-like hematopoietic stem cell dysfunction through a brain-gut-bone marrow axis

Tian, X., Wu, B., Yang, K., Wang, Y., Li, Y., Guan, J., Wang, K., Zhao, Y., Sun, K., Ling, Y., et al. (2026) · Cell stem cell · doi:10.1016/j.stem.2026.05.012 · Cited by 2

Dietary bioactive compounds and inflammaging: Pro-inflammatory triggers and geroprotective countermeasures

Moskalev, A., Veselova, O., Calabrese, V., Rashan, L. J., & Franceschi, C. (2026) · Ageing Research Reviews · doi:10.1016/j.arr.2026.103241 · Cited by 5

Assessing autophagic flux in yeast

Kainz, K., Pendl, T., Madeo, F., & Carmona‐Gutiérrez, D. (2020) · Methods in cell biology · doi:10.1016/bs.mcb.2020.10.014 · Cited by 2

Solid-Phase Synthesis of Selectively Mono-Fluorobenz(o)ylated Polyamines as a Basis for the Development of 18F-Labeled Radiotracers

Wodtke, R., Pietzsch, J., & Löser, R. (2021) · Molecules · doi:10.3390/molecules26227012 · Cited by 2

Small molecules that enhance mitophagy to delay aging and neurodegeneration

Dorn, G. W. (2022) · The Journal of Cardiovascular Aging · doi:10.20517/jca.2022.36 · Cited by 2

Polyamine transport inhibition and cisplatin synergistically enhance tumor control through oxidative stress in murine head and neck cancer models

Yassin‐Kassab, A., Wang, N. S., Foley, J. R., Stewart, T. M., Burns, M. R., Casero, R. A., Harbison, R. A., & Duvvuri, U. (2023) · Oral Oncology Reports · doi:10.1016/j.oor.2023.100123 · Cited by 2

Effect of Triadica cochinchinensis honey supplementation on liver metabolomics and gut microbiota in naturally aging mice

Yi, S., Yu, W., Chen, L., Zhang, G., Sun, Q., & Luo, L. (2024) · Food Bioscience · doi:10.1016/j.fbio.2024.104863 · Cited by 3

Understanding the microbiome as a mediator of bladder cancer progression and therapeutic response

Golshani, M., Taylor, J. A., & Woolbright, B. L. (2024) · Urologic Oncology Seminars and Original Investigations · doi:10.1016/j.urolonc.2024.07.004 · Cited by 2

Fasting in Science and Clinics: A Report on Proceedings from the International Scientific Symposium and Conference on Fasting in Berlin (June 2023)

Breinlinger, C., Meiß, S., Hanslian, E., Jordan, S., Boschmann, M., Khokhar, A. R., Michalsen, A., & Koppold, D. A. (2024) · Complementary Medicine Research · doi:10.1159/000540668 · Cited by 2

Spermidine limits diabetes by modulating RIPK1-mediated cell death and inflammation

(2024) · Nature Cell Biology · doi:10.1038/s41556-024-01542-4 · Cited by 2

Metabolic characteristics of prostate cancer cells with high metastatic potential revealed by (S)-ethyl 1-(3-(4-chlorophenoxy)-2-hydroxypropyl)-3-(4-methoxyphenyl)-1H-pyrazole-5-carboxylate inhibition

Ding, B., Meng, W., Zang, X., & Lv, Z. (2024) · Journal of Pharmaceutical and Biomedical Analysis · doi:10.1016/j.jpba.2024.116611 · Cited by 2

Multi-tissue metabolomics analysis reveals susceptible factors for chemotherapy-induced hepatotoxicity in colorectal cancer patients

Xu, H., Li, M., Yao, H., Chen, G., Chen, J., Hou, X., Yang, H., Yu, C.-S., Lin, Z., Zhu, J., et al. (2025) · Frontiers in Pharmacology · doi:10.3389/fphar.2025.1517446 · Cited by 2

Efficient cell factory design by combining meta-heuristic algorithm with enzyme-constrained metabolic models

Liao, W., Gao, G., Wang, H., Fan, X., Wang, L., He, S., Xiang, G., Yan, X., & Lu, H. (2026) · Bioresource Technology · doi:10.1016/j.biortech.2026.134706 · Cited by 2

Epigenetic Insights Into Aging: Emerging Roles of Natural Products in Therapeutic Interventions

Pang, Y., Zhang, H., Li, H., Wang, X., Wei, P., Yi, L., & Lin, S. (2025) · Phytotherapy Research · doi:10.1002/ptr.70003 · Cited by 3

Possibilities of Using the New Lactiplantibacillus plantarum EK11 Strain as a Starter Culture for the Fermentation of the Fruiting Bodies of Edible Mushrooms

Jabłońska-Ryś, E. D., & Przygoński, K. (2025) · Foods · doi:10.3390/foods14162833 · Cited by 2

Analysis of Low Cancer Mortality Rates in the Wine Regions of Tokaj and Balaton in Hungary

Sipka, S., Nagy, J., Sipka, P., Kocsis, J., Tóth, J., Árkosy, P., & Horváth, Z. (2020) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph17186759 · Cited by 2

Metabolomic analysis of SMP30/GNL knockout mice treated with fermented vegetable and fruit extract (OM-X®)

Wakame, K., Takahata, M., Miyake, Y., Yasuda, E., Shimomiya, Y., Nakata, A., Sato, K., Mihara, Y., Takaguri, A., & Komatsu, K. (2020) · Functional Foods in Health and Disease · doi:10.31989/ffhd.v10i3.674 · Cited by 2

Cytological and Biochemical Markers of Autophagy in Wheat Suspension Culture Cells under Abiotic Stress

Mazina, A. B., Анатольевна, Д. С., Renkova, A. G., Valitova, Y. N., Khabibrakhmanova, V. R., & Minibayeva, F. V. (2020) · Učënye zapiski Kazanskogo universiteta. Seriâ Estestvennye nauki/Učënye zapiski Kazanskogo universiteta. Seriâ Estestvennye nauki/Učenye zapiski Kazanskogo gosudarstvennogo universiteta. Seriâ Estestvennye nauki · doi:10.26907/2542-064x.2020.4.541-556 · Cited by 2

Characterizing the homeostatic regulation of the polyamine pathway using the Drosophila melanogaster model system

Morales, T. S., Catteau, M. D., Hepp, R. B., Foley, J. R., Stewart, T. M., Casero, R. A., DiAngelo, J. R., & Nowotarski, S. L. (2021) · Gene Reports · doi:10.1016/j.genrep.2021.101269 · Cited by 2

Multifarious Translational Regulation during Replicative Aging in Yeast

Zhao, T., Chida, A., Shichino, Y., Choi, D., Mizunuma, M., Iwasaki, S., & Ohya, Y. (2022) · Journal of Fungi · doi:10.3390/jof8090938 · Cited by 2

Influence of anti-hyperlipidemic activity by co-administration of polyamines and rutin with simvastatin

Patil, R. R., Aswar, M. K., Bhise, S. B., & Ramnath, N. S. (2022) · Journal of Herbmed Pharmacology · doi:10.34172/jhp.2023.13 · Cited by 2

C-Methylated Spermidine Derivatives: Convenient Syntheses and Antizyme-Related Effects

Хомутов, М. А., Salikhov, A. I., Mitkevich, V. A., Tunitskaya, V. L., Smirnova, O. A., Korolev, S. P., Chizhov, A. O., Gottikh, M., Kochetkov, S. N., & Khomutov, A. R. (2023) · Biomolecules · doi:10.3390/biom13060916 · Cited by 2

Possible Role of Cellular Polyamine Metabolism in Neuronal Apoptosis

Ji, X., Yu, W., Jin, M.-J., Lu, L., Yin, H., & Wang, H. (2024) · Current Medical Science · doi:10.1007/s11596-024-2843-9 · Cited by 2

Placental polyamines regulate acetyl-coA and histone acetylation in a sex-specific mannerPreprint

Aye, I. L. M. H., Gong, S., Avellino, G., Barbagallo, R., Gaccioli, F., Jenkins, B., Koulman, A., Murray, A. J., Jones, D. S., & Smith, G. C. S. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.06.09.447192 · Cited by 2

The autophagy activator Spermidine reduces neuroinflammation and soluble amyloid beta in an Alzheimer’s disease mouse modelPreprint

Freitag, K., Sterczyk, N., Obermayer, B., Schulz, J., Houtman, J., Fleck, L., Braeuning, C., Sansevrino, R., Hoffmann, C., Milovanović, D., et al. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.10.28.466219 · Cited by 2

Reduction of Spermine Synthase Suppresses Tau Accumulation Through Autophagy Modulation in TauopathyPreprint

Tao, X., Liu, J., Diaz-Perez, Z., Foley, J. R., Stewart, T. M., Casero, R. A., & Zhai, R. G. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.03.17.533015 · Cited by 2

Bioengineering Microbes for Improved Nutritional Value and Health Benefits.Preprint

Pandya, J., Adiga, R. S., Akash, K., Chadhmika, C. H., Niveditha, K., & Kar, D. (2023) · Preprints.org · doi:10.20944/preprints202305.0057.v1 · Cited by 2

Special Issue “Mitochondrial Dysfunction: A Common Trigger in Neurodegenerative and Metabolic Non-Communicable Diseases”

Fortini, P., & Pascucci, B. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25074004 · Cited by 2

AZIN2-dependent polyamine metabolism determines adipocyte progenitor fate and protects against obesity and dysmetabolismPreprint

Mund, C., Sinha, A. N., Aderhold, A., Mateska, I., Hagag, E., Traikov, S., Gercken, B., Soto, A., Pollock, J., Arndt, L., et al. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.11.19.621837 · Cited by 2

Inflammation, insulin resistance and the pathophysiology of depression: implications for novel antidepressant developments

Leonard, B. E., & Arıcıoğlu, F. (2020) · Psychiatry and Clinical Psychopharmacology · doi:10.5455/pcp.20200215032026 · Cited by 1

The Effect of Spermidine Supplementation on Cognitive Function in Adults: A Mini-Review

Facultad de Ciencias de la Salud, U. I., Zarama, V., Mattos, P., Instituto D’Or de Pesquisa e Ensino, R. D. J., Gomez, K. P., Oliveira, A., Leonhardt, A., Cysne, D. N., Instituto D’Or de Pesquisa e Ensino, R. D. J., Fernández, D. M., et al. (2023) · Principles and Practice of Clinical Research Journal · doi:10.21801/ppcrj.2023.93.7 · Cited by 1

Bridging Biochemistry and Aging: A Journey Towards Prolonged Health span

Panchal, N. (2024) · Biosciences Biotechnology Research Asia · doi:10.13005/bbra/3226 · Cited by 1

Plasma polyamines during pregnancy and their relationships with maternal allergies and the immune response of the neonates

Gázquez, A., García‐Serna, A. M., Hernández‐Caselles, T., Martín‐Orozco, E., Cantero‐Cano, E., Prieto‐Sánchez, M. T., Molina‐Ruano, M. D., Castillo‐Lacalle, R., Vioqué, J., Morales, E., et al. (2024) · Pediatric Allergy and Immunology · doi:10.1111/pai.14167 · Cited by 1

Quantitative Endogenous Polyamine Analysis via Capillary Electrophoresis/Mass Spectrometry: Characterization and Practical Considerations

Kaminsky, C. J., Mill, J., Raife, T. J., & Li, L. (2024) · Electrophoresis · doi:10.1002/elps.202400165 · Cited by 1

The beneficial effects of spermidine via autophagy: a systematic review

Gai, S. (2025) · Theoretical and Natural Science · doi:10.54254/2753-8818/2024.19803 · Cited by 1

A practical and versatile synthetic strategy for homogeneous polymers of 1,3-propanediamine

Ohnishi, T., Irie, R., Inai, M., Kan, T., & Oikawa, M. (2025) · Bulletin of the Chemical Society of Japan · doi:10.1093/bulcsj/uoaf014 · Cited by 1

Microwave Pretreatment-Induced Significant Nutrient and Metabolite Changes in Sea Cucumber Apostichopus japonicus

Song, D., Fang, L., Jia, A., Liu, X., Cui, T., Zhang, H., & Zhang, M. (2025) · Marine Drugs · doi:10.3390/md23060249 · Cited by 1

Autophagy and Intracellular Membrane Dynamics in Aging and Age-Related Diseases

Minami, S., Nakamura, S., & Yoshimori, T. (2025) · Learning materials in biosciences · doi:10.1007/978-3-031-88121-3_7 · Cited by 1

Fermentation of Microalgae as a Platform for Naturally Encapsulated Oil Powders: Characterization of a High-Oleic Algal Powder Ingredient

Rakitsky, W. G., Parker, L., Ward, K., Pilarski, T., Price, J., Correa, M., Miller, R., Benites, V. T., Athanasiadis, D., Doherty, B., et al. (2025) · Microorganisms · doi:10.3390/microorganisms13071659 · Cited by 1

Neurobehavioral and metabolic effects of prenatal low-dose chlorpyrifos in C57BL/6J mice

Kendricks, D. R., Stallone, J., Thomas, D. S., Wilson, L. R., Kirkwood‐Donelson, K. I., Jarmusch, A. K., McPherson, C. A., & Cushman, J. D. (2025) · NeuroToxicology · doi:10.1016/j.neuro.2025.08.001 · Cited by 1

Effects of spermidine-rich diet on follicle development and steroidogenesis in Sichuan white geese

Wang, X., Kang, L., Guo, Y., Jiang, Y., Wang, Z., & Kang, B. (2025) · Veterinary Research Communications · doi:10.1007/s11259-025-10845-2 · Cited by 1

Age-Dependent Redistribution of the Life-Important Enzyme in the Retina: Adult Müller Glial Cells’ Endfeet Lack Spermine Synthase Expression

Zayas‐Santiago, A., Malpica-Nieves, C. J., Santiago, J. M., Hernández, Y., Rivera-Aponte, D. E., Méndez-González, M. P., Veh, R. W., Rojas, L. V., & Skatchkov, S. N. (2025) · Biomolecules · doi:10.3390/biom15101374 · Cited by 1

Bioinsecticide matrine causes a cliff-like decline and disorder of gut microbiota, transcriptomics, and metabolomics profiles in honey bees (Apis cerana)

Yu, Y., Zhang, Z., Fan, Y., Zhou, W., Yao, D., Zhan, H., He, X., Li, Y., Wan, W., & Wei, X. (2025) · Pesticide Biochemistry and Physiology · doi:10.1016/j.pestbp.2025.106742 · Cited by 1

Spermidine reduces peri-implant inflammation and fibrosis to nurture osseointegration

Liu, Q., Wu, Q., Cao, T., Miao, R., Wang, C., Zhang, J., Gao, X., Wang, L., Shi, G., Lai, J., et al. (2025) · Bioactive Materials · doi:10.1016/j.bioactmat.2025.09.036 · Cited by 2

The Effects of Spermidine on Functional and Transcriptomic Markers in Human Primary Keratinocytes

Anglin, D. A., Mattingly, M. L., Kontos, N. J., & Roberts, M. D. (2025) · Physiologia · doi:10.3390/physiologia5040043 · Cited by 1

Bacillus Subtilis LN077 as a Probiotic Feed Additive Improves Goat Growth, Immunity, and Rumen Health

Zhou, X., Xiang, W., & Shen, X. (2025) · Probiotics and Antimicrobial Proteins · doi:10.1007/s12602-025-10809-7 · Cited by 1

Integrative Omics Reveal Female‐Specific Benefits of p16 + Cell Clearance in Aging Mice

Lin, Y., Wang, B., Huang, M., Wolters, J. C., & Demaria, M. (2025) · Advanced Science · doi:10.1002/advs.202509444 · Cited by 1

Integrative Multi-Omics Analysis of the Rumen in Tan Sheep with Contrasting Average Daily Gain

Zheng, H., Han, X., Shen, W., Zhang, X., Shi, A., Liu, T., Yang, C., & Tao, J. (2025) · Microorganisms · doi:10.3390/microorganisms13122882 · Cited by 1

A programmable ribozyme for RNA signal transduction

Lim, M. Y. T., Tan, C., Subhramanyam, C. S., Teo, S. J., DeFalco, L., Pasaribu, S. K., Koh, C. H., Rayamajhi, D., Chi, J., Li, S., et al. (2026) · Nature Communications · doi:10.1038/s41467-025-68175-5 · Cited by 1

Spermidine diminishes lipopolysaccharide-induced myocardial ferroptosis through the Keap1-Nrf2/HO-1 pathway

He, J., Zhang, X., Jiang, H., Liu, Z., Dai, Y., Zhao, P., & Kuai, J. (2026) · Free Radical Research · doi:10.1080/10715762.2026.2620031 · Cited by 1

Trehalose Improves Postharvest Kyoho Grapes Quality Based on Transcriptome and Metabolome Analysis

Li, Y., Zhang, R., Zhou, X., Ahmed, N., Nong, Y., & Jia, H. (2026) · Journal of Food Safety · doi:10.1111/jfs.70057 · Cited by 1

A novel fasting mimetic (Mimio) creates fasting-like benefits to hunger control, oxidative stress, and cardiometabolic health in humans

Grant, A. D., Erfe, M. C. B., Kazaryan, A., Oliver, P. L., Moos, J., Luna, V., Craft, N., & Rhodes, C. H. (2026) · Scientific Reports · doi:10.1038/s41598-026-38495-7 · Cited by 2

Pathological progression features-guided biphasic drug delivery supramolecular hydrogel for synergistic cartilage protection in osteoarthritis

Lin, J., Cai, R., Li, S., Peng, Z., Wang, Y., Chen, Y., & Zhou, D. (2026) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2026.03.032 · Cited by 1

Decoding the Regulatory Mechanism of Astaxanthin on Autophagy: Insights for Anti-Inflammatory Intervention

Feng, L., Yu, M., Ma, X., Qin, P., & Zhang, Y. (2026) · Biomolecules · doi:10.3390/biom16030477 · Cited by 1

Adaptive crosstalk between polyamine metabolism, translation, and autophagy sustains energy homeostasis in mammals during starvation: a scoping review

Karimi, K., Roberts, S. C., Carter, N. S., Hofer, S. J., & Karimi, R. (2026) · Amino Acids · doi:10.1007/s00726-026-03512-6 · Cited by 1

Spermidine Attenuates Neuroimmune Dysfunction in Gulf War Illness via Modulation of the Gut- Brain Axis

Trivedi, A., Roy, S., More, M., Bose, D., Saha, P., Kumar, R., Sarkar, S., Skupsky, J., Tuteja, A. K., Sullivan, K. A., et al. (2026) · Molecular Neurobiology · doi:10.1007/s12035-026-05763-6 · Cited by 1

Autophagy Research in Food Functional Science

Hara, T., Yano, S., & Marugame, Y. (2026) · Springer eBooks · doi:10.1007/978-981-95-7068-3_64 · Cited by 1

Glioblastoma region-specific metabolic signatures reflect patient survival duration

Goodin, D. A., Chen, J., Williams, B. J., & Frieboes, H. B. (2026) · Journal of Neuro-Oncology · doi:10.1007/s11060-026-05588-2 · Cited by 1

Clostridium butyricum and its metabolite spermidine delay cognitive decline during natural brain aging by reducing inflammation and oxidative stress

Wu, S., Zhang, J., Yin, Y., Enhui, L., Zhang, Y., Li, J., Yang, X., Zhao, X., Zan, X., Guo, Z., et al. (2026) · Behavioural Brain Research · doi:10.1016/j.bbr.2026.116253 · Cited by 1

Targeting Age-Associated Immune Senescence via Nanoparticle-Based Metabolic Reprogramming

Nair, P. G., Unnikrishnan, B. S., Vijayan, V. V., Howlett, S. E., Cullis, P. R., & Gujar, S. A. (2026) · ACS Nano · doi:10.1021/acsnano.5c18638 · Cited by 2

Versatile Nano‐Crosslinker Enhanced Injectable Hydrogel Toward Rapid Hemostasis and Efficient Trauma Repair

Peng, X., Chen, F., Zhang, Y., Wang, M., Fan, Y., Zheng, G., Wang, P., Lu, Y., Cai, Z., & Wu, D. (2026) · Advanced Materials · doi:10.1002/adma.73277 · Cited by 1

Dysregulation of arginase and arginine pathways in neurodegenerative diseases: Metabolic and cellular dysfunction and therapeutic implications

Nalepa, M., Skweres, A., & Węgrzynowicz, M. (2026) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2026.05.285 · Cited by 1

AMD1-mediated polyamine metabolism governs tubular repair fate by restraining senescence after kidney injury

Mao, B., Zheng, Z., Fu, W., Cheng, G., Wang, L., Bao, J., Liu, X., Zhan, H., Pan, M., & Liu, J. (2026) · Renal Failure · doi:10.1080/0886022x.2026.2680375 · Cited by 1

A multi-organ metabolomics atlas reveals molecular dysregulations in Alzheimer’s disease mouse models

Zuffa, S., Allaband, C., Charron‐Lamoureux, V., Caraballo‐Rodríguez, A. M., Patan, A., Mohanty, I., Agongo, J., Bostick, J. W., Connerly, T. J., Thron, T., et al. (2026) · Cell Reports · doi:10.1016/j.celrep.2026.117499 · Cited by 18

The gut microbiota–metabolome axis mediates the adaptive protective effects of a high-altitude probiotic against distinct aging etiologies

Sun, H., Liu, Z., Wen, D., Xin, D., Feng, Y., Pang, M., Huang, X., Wang, W., & Li, B. (2026) · Food & Function · doi:10.1039/d6fo02156e · Cited by 1

Microbiome and aging: Trajectories of microbiome age across human ecosystems and their systemic effects

Ni, Z., Xie, J., Zhang, Z., Zhang, K., Ding, J., Chang, M., Su, Y., Zhang, Y., Yao, M., Wang, C., et al. (2026) · iMeta · doi:10.1002/imt2.70148 · Cited by 1

Polyamine-mediated inhibition of ferroptosis contributes to geroprotection

Madeo, F., Carmona‐Gutiérrez, D., & Kroemer, G. (2026) · Cell Stress · doi:10.15698/cst2026.07.318 · Cited by 1

Duodenal resident Limosilactobacillus improves feed efficiency through ornithine-mediated optimization of gut microbiota and nutrient absorption via the Nrf2 signaling

Deng, Z., Huang, Y., Cao, K.-X., Peng, Z., Refaie, A., Khalil, M. M., Zhao, L., Guan, L. L., & Sun, L. (2026) · Microbiome · doi:10.1186/s40168-026-02461-2 · Cited by 1

Molecular signatures of the gut microbiota that affect longevity

Beyoğlu, D., & Idle, J. R. (2026) · Biochemical Pharmacology · doi:10.1016/j.bcp.2026.118267 · Cited by 1

Self-assembled paclitaxel-loaded spermidine-geranic acid ionic liquid nanoaggregates: preparation, enhanced cellular uptake, and antitumor efficacy

Yang, K., Ma, D., Liu, B., Zhu, B., Qi, M., Ren, G., & Hong, M. (2026) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2026.127257 · Cited by 1

Natural Bioactive Compounds Targeting Key Hallmarks of Aging: Functional Food Potential of Spermidine, Fisetin, Berberine, and Urolithin A

Rzeski, W., & Rzeska, W. (2026) · Nutrients · doi:10.3390/nu18152511 · Cited by 2

Hyperosmotic niche adaptation and tissue polyamines underlie MRSA persistence in the kidney

Kanazawa, N., Martens, C. P., Makino, S., Heruye, S., Zollman, A., Myslinski, J., White, A., Poudel, C., Yanagida, J., Syed, F., et al. (2026) · Science Translational Medicine · doi:10.1126/scitranslmed.aed4200 · Cited by 1

Spermidine and its role in inducing autophagy in cardiac muscle to prevent cardiac dysfunction

Hassan, I., & Mirbahai, L. (2020) · Reinvention an International Journal of Undergraduate Research · doi:10.31273/reinvention.v13i1.519 · Cited by 1

The Beneficial Role of Natural Antioxidants in Alleviating Neuroinflammatory Disorders Including Neurodegeneration

Das, M., & Devi, K. P. (2022) · Reference series in phytochemistry · doi:10.1007/978-3-030-78160-6_31 · Cited by 1

Mechanisms of spermidine-induced autophagy and geroprotection

Hofer, S. J., Simon, A. K., Bergmann, M., Eisenberg, T., Kroemer, G., & Madeo, F. (2022) · Nature Aging · doi:10.1038/s43587-022-00322-9 · Cited by 218

Geroprotective insights into the natural metabolite spermidine in aging and age-related diseases

Jiang, Z., Tong, S., Kirkland, J. L., & Sun, Y. (2026) · npj Aging · doi:10.1038/s41514-026-00448-9

Molecular targets of spermidine: implications for cancer suppression

Zimmermann, A., Hofer, S. J., & Madeo, F. (2023) · Cell Stress · doi:10.15698/cst2023.07.281 · Cited by 23

Cardioprotective benefits of dietary spermidine

Huynh, K. (2017) · Nature Reviews Cardiology · doi:10.1038/nrcardio.2016.222 · Cited by 4

Spermidine: A physiological autophagy inducer acting as an anti-aging vitamin in humans?

Madeo, F., Bauer, M. A., Carmona-Gutierrez, D., & Kroemer, G. (2019) · Autophagy · doi:10.1080/15548627.2018.1530929 · Cited by 212