Spermidine in health and disease

The Hallmarks of Aging

López-Otín, C., Blasco, M. A., Partridge, L., Serrano, M., & Kroemer, G. (2013) · Cell · doi:10.1016/j.cell.2013.05.039 · Cited by 14,982

Mitochondrial Dysfunction and Oxidative Stress in Neurodegenerative Diseases

Lin, M. T., & Beal, M. F. (2006) · Nature · doi:10.1038/nature05292 · Cited by 6,455

Inflamm‐aging: An Evolutionary Perspective on Immunosenescence

FRANCESCHI, C., BONAFÈ, M., VALENSIN, S., OLIVIERI, F., DE LUCA, M., OTTAVIANI, E., & DE BENEDICTIS, G. (2000) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2000.tb06651.x · Cited by 5,358

Resveratrol improves health and survival of mice on a high-calorie diet

Baur, J. A., Pearson, K. J., Price, N. L., Jamieson, H. A., Lerin, C., Kalra, A., Prabhu, V. V., Allard, J. S., Lopez-Lluch, G., Lewis, K., et al. (2006) · Nature · doi:10.1038/nature05354 · Cited by 4,290

Rapamycin fed late in life extends lifespan in genetically heterogeneous mice

Harrison, D. E., Strong, R., Sharp, Z. D., Nelson, J. F., Astle, C. M., Flurkey, K., Nadon, N. L., Wilkinson, J. E., Frenkel, K., Carter, C. S., et al. (2009) · Nature · doi:10.1038/nature08221 · Cited by 3,766

Immunogenic cell death in cancer and infectious disease

Galluzzi, L., Buqué, A., Kepp, O., Zitvogel, L., & Kroemer, G. (2017) · Nature Reviews Immunology · doi:10.1038/nri.2016.107 · Cited by 3,119

Extending Healthy Life Span—From Yeast to Humans

Fontana, L., Partridge, L., & Longo, V. D. (2010) · Science · doi:10.1126/science.1172539 · Cited by 3,023

Autophagy in Human Health and Disease

Choi, A. M. K., Ryter, S. W., & Levine, B. (2013) · New England Journal of Medicine · doi:10.1056/nejmra1205406 · Cited by 2,583

Autophagy and Aging

Rubinsztein, D. C., Mariño, G., & Kroemer, G. (2011) · Cell · doi:10.1016/j.cell.2011.07.030 · Cited by 2,107

FoxO3 Controls Autophagy in Skeletal Muscle In Vivo

Mammucari, C., Milan, G., Romanello, V., Masiero, E., Rudolf, R., Del Piccolo, P., Burden, S. J., Di Lisi, R., Sandri, C., Zhao, J., et al. (2007) · Cell Metabolism · doi:10.1016/j.cmet.2007.11.001 · Cited by 1,953

Submerged and Solid-State Fermentation of Spirulina with Lactic Acid Bacteria Strains: Antimicrobial Properties and the Formation of Bioactive Compounds of Protein Origin

Tolpežnikaitė, E., Bartkevičs, V., Skrastina, A., Pavlenko, R., Ružauskas, M., Starkutė, V., Zokaitytė, E., Klupšaitė, D., Ruibys, R., Rocha, J. M., et al. (2023) · Biology · doi:10.3390/biology12020248 · Cited by 22

Diagnostic, Prognostic and Mechanistic Biomarkers of COVID-19 Identified by Mass Spectrometric Metabolomics

Bourgin, M., Durand, S., & Kroemer, G. (2023) · Metabolites · doi:10.3390/metabo13030342 · Cited by 21

Polyamines and Physical Activity in Musculoskeletal Diseases: A Potential Therapeutic Challenge

Galasso, L., Cappella, A., Mulè, A., Castelli, L., Ciorciari, A. M., Stacchiotti, A., & Montaruli, A. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24129798 · Cited by 25

Maize polyamine oxidase in the presence of spermine/spermidine induces the apoptosis of LoVo human colon adenocarcinoma cells

Ohkubo, S., Mancinelli, R., Miglietta, S., Cona, A., Angelini, R., Canettieri, G., Spandidos, D. A., Gaudio, E., & Agostinelli, E. (2019) · International Journal of Oncology · doi:10.3892/ijo.2019.4780 · Cited by 20

Comedications influence immune infiltration and pathological response to neoadjuvant chemotherapy in breast cancer

Hamy, A., Derosa, L., Valdelièvre, C., Yonekura, S., Opolon, P., Priour, M., Guerin, J., Pierga, J., Asselain, B. J. R., Croze, D. D., et al. (2019) · OncoImmunology · doi:10.1080/2162402x.2019.1677427 · Cited by 22

Prevention of Atherosclerosis by the Induction of Microbial Polyamine Production in the Intestinal Lumen

Matsumoto, M. (2020) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.b19-00855 · Cited by 20

Identification of a Spermidine Synthase Gene from Soybean by Recombinant Expression, Transcriptional Verification, and Sequence Analysis

Zou, D., Yu, M., Liu, Y., Wei, X., & Wang, J. (2020) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.9b07443 · Cited by 20

Aging at the Crossroads of Organ Interactions: Implications for the Heart

Sen, I., Trzaskalski, N. A., Hsiao, Y., Liu, P. P., Shimizu, I., & Dérumeaux, G. (2025) · Circulation Research · doi:10.1161/circresaha.125.325637 · Cited by 20

Tolerance to NADH/NAD+ imbalance anticipates aging and anti-aging interventions

Alonso-Lavin, A. J., Bajić, D., & Poyatos, J. F. (2021) · iScience · doi:10.1016/j.isci.2021.102697 · Cited by 17

Unconventional metabolites in chromatin regulation

Gapa, L., Alfardus, H., & Fischle, W. (2022) · Bioscience Reports · doi:10.1042/bsr20211558 · Cited by 21

Research Progress and Potential Applications of Spermidine in Ocular Diseases

Han, W., Li, H., & Chen, B. (2022) · Pharmaceutics · doi:10.3390/pharmaceutics14071500 · Cited by 19

The association of dietary spermidine with all-cause mortality and CVD mortality: The U.S. National Health and Nutrition Examination Survey, 2003 to 2014

Wu, H., Wang, J., Jiang, H., Liu, X., Sun, X., Chen, Y., Hu, C., Wang, Z., Han, T., Sun, C., et al. (2022) · Frontiers in Public Health · doi:10.3389/fpubh.2022.949170 · Cited by 19

Spermidine activates adipose tissue thermogenesis through autophagy and fibroblast growth factor 21

Ni, Y., Zheng, L., Zhang, L., Li, J., Pan, Y., Du, H., Wang, Z., & Fu, Z. (2024) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2024.109569 · Cited by 18

A novel comprehensive paradigm for the etiopathogenesis of multiple sclerosis: therapeutic approaches and future perspectives on its treatment

Gasperoni, F., Turini, P., & Agostinelli, E. (2019) · Amino Acids · doi:10.1007/s00726-019-02718-1 · Cited by 19

Polyamine Transport Protein PotD Protects Mice against Haemophilus parasuis and Elevates the Secretion of Pro-Inflammatory Cytokines of Macrophage via JNK–MAPK and NF–κB Signal Pathways through TLR4

Dai, K., Ma, X., Yang, Z. L., Chang, Y., Cao, S., Zhao, Q., Huang, X., Wu, R. J., Huang, Y., Yan, Q., et al. (2019) · Vaccines · doi:10.3390/vaccines7040216 · Cited by 19

Beneficial effects of spermidine on cardiovascular health and longevity suggest a cell type-specific import of polyamines by cardiomyocytes

Nilsson, B., & Persson, L. (2018) · Biochemical Society Transactions · doi:10.1042/bst20180622 · Cited by 19

Metabolomic changes associated with frontotemporal lobar degeneration syndromes

Murley, A. G., Jones, P. S., Coyle Gilchrist, I., Bowns, L., Wiggins, J., Tsvetanov, K. A., & Rowe, J. B. (2020) · Journal of Neurology · doi:10.1007/s00415-020-09824-1 · Cited by 18

Chronic Sleep Deprivation Causes Anxiety, Depression and Impaired Gut Barrier in Female Mice—Correlation Analysis from Fecal Microbiome and Metabolome

Li, L., Meng, Z., Huang, Y., Xu, L., Chen, Q., Qiao, D., & Yue, X. (2024) · Biomedicines · doi:10.3390/biomedicines12122654 · Cited by 21

Food Nutrients and Bioactive Compounds for Managing Metabolic Dysfunction-Associated Steatotic Liver Disease: A Comprehensive Review

Dungubat, E., Fujikura, K., Kuroda, M., Toshio, F., & Takahashi, Y. (2025) · Nutrients · doi:10.3390/nu17132211 · Cited by 22

Mitochondrial DNA: a molecular switch driving sterile neuroinflammation

Jauhari, A., Singh, T., Carlisle, D. L., & Friedlander, R. M. (2026) · Translational Neurodegeneration · doi:10.1186/s40035-026-00540-w · Cited by 20

Spermidine Regulates Mitochondrial Function by Enhancing eIF5A Hypusination and Contributes to Reactive Oxygen Species Production and Ganoderic Acid Biosynthesis in Ganoderma lucidum

Han, X., Shangguan, J., Wang, Z., Li, Y., Fan, J., Ren, A., & Zhao, M. (2022) · Applied and Environmental Microbiology · doi:10.1128/aem.02037-21 · Cited by 18

A brain-wide form of presynaptic active zone plasticity orchestrates resilience to brain aging in Drosophila

Huang, S., Piao, C., Beuschel, C. B., Zhao, Z., & Sigrist, S. J. (2022) · PLoS Biology · doi:10.1371/journal.pbio.3001730 · Cited by 14

Differential Role of Active Compounds in Mitophagy and Related Neurodegenerative Diseases

Makarov, M., & Korkotian, E. (2023) · Toxins · doi:10.3390/toxins15030202 · Cited by 18

Nutritional Factors: Benefits in Glaucoma and Ophthalmologic Pathologies

Musa, M., Zeppieri, M., Atuanya, G. N., Enaholo, E. S., Topah, E. K., Ojo, O. M., & Salati, C. (2023) · Life · doi:10.3390/life13051120 · Cited by 20

Wheat germ, a byproduct of the wheat milling industry, as a beneficial source of anti‐aging polyamines: A quantitative comparison of various forms

Mohajeri, M., Ayatollahi, S. A., Kobarfard, F., Goli, M., Khandan, M., Mokhtari, S., & Khodadoost, M. (2023) · Food Science & Nutrition · doi:10.1002/fsn3.3650 · Cited by 18

Acylspermidines are conserved mitochondrial sirtuin-dependent metabolites

Zhang, B., Mullmann, J. J., Ludewig, A. H., Fernandez, I. R., Bales, T. R., Weiss, R. S., & Schroeder, F. C. (2024) · Nature Chemical Biology · doi:10.1038/s41589-023-01511-2 · Cited by 19

Influence of cocoa clones on the quality and functional properties of chocolate – Nitrogenous compounds

Deus, V. L., Bispo, E. S., França, A. S., & Glória, M. B. A. (2020) · LWT · doi:10.1016/j.lwt.2020.110202 · Cited by 18

Placental sex-dependent spermine synthesis regulates trophoblast gene expression through acetyl-coA metabolism and histone acetylation

Aye, I. L. M. H., Gong, S., Avellino, G., Barbagallo, R., Gaccioli, F., Jenkins, B., Koulman, A., Murray, A. J., Jones, D. S., & Smith, G. C. S. (2022) · Communications Biology · doi:10.1038/s42003-022-03530-6 · Cited by 18

The curious case of polyamines: spermidine drives reversal of B cell senescence

Metur, S. P., & Klionsky, D. J. (2019) · Autophagy · doi:10.1080/15548627.2019.1698210 · Cited by 18

Structural insights into polyamine spermidine uptake by the ABC transporter PotD-PotABC

Zhu, Q., Do, P. H., Yeo, J. Y., Ero, R., Li, Z., Zhan, L., Basak, S., & Gao, Y. (2024) · Science Advances · doi:10.1126/sciadv.ado8107 · Cited by 17

Spermine is an endogenous iron chelator that inhibits ferroptosis

Li, M., Yu, X., Ouyang, S., Chen, X., Yu, H., Liu, Y., Li, Z., Yu, C., Kang, R., Gaillet, C., et al. (2026) · Nature · doi:10.1038/s41586-026-10597-2 · Cited by 17

Ghost messages: cell death signals spread

Zhang, M., Lin, Y., Chen, R., Yu, H., Li, Y., Chen, M., Dou, C., Yin, P., Zhang, L., & Tang, P. (2023) · Cell Communication and Signaling · doi:10.1186/s12964-022-01004-0 · Cited by 18

Change in serum polyamine metabolome pattern after bariatric surgery in obese patients with metabolic syndrome

Ocaña-Wilhelmi, L., Cardona, F., Garrido‐Sánchez, L., Fernández‐García, D., Tinahones, F. J., & Ramos‐Molina, B. (2019) · Surgery for Obesity and Related Diseases · doi:10.1016/j.soard.2019.10.024 · Cited by 17

COVID-19: A Challenge to Physiology of Aging

Golubev, A. G. (2020) · Frontiers in Physiology · doi:10.3389/fphys.2020.584248 · Cited by 18

Multi-omics analysis reveals neuroinflammation, activated glial signaling, and dysregulated synaptic signaling and metabolism in the hippocampus of aged mice

Lu, Y., Xu, K., Lin, D., Wang, S., Fu, R., Deng, X., Croppi, G., & Zhang, J. (2022) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2022.964429 · Cited by 18

The significance of caloric restriction mimetics as anti-aging drugs

Nassar, K., El-mekawey, D., Elmasry, A. E., Refaey, M. S., El-Sayed Ghoneim, M., & Elshaier, Y. A. M. M. (2024) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2023.149354 · Cited by 16

The memory- and cognition-facilitating effects of spermidine in aging and aging-related disorders

Zou, M., Li, D., & Yang, Y. (2025) · Ageing Research Reviews · doi:10.1016/j.arr.2025.102787 · Cited by 18

Targeting programmed cell death with natural products: a potential therapeutic strategy for diminished ovarian reserve and fertility preservation

Ju, W., Zhao, S., Li, D., Zhang, J., Xiang, S., & Lian, F. (2025) · Frontiers in Pharmacology · doi:10.3389/fphar.2025.1546041 · Cited by 16

Effect of a lifestyle intervention program with energy-restricted Mediterranean diet and exercise on the serum polyamine metabolome in individuals at high cardiovascular disease risk: a randomized clinical trial

Fernández‐García, J. C., Martínez‐Sánchez, M. A., Bernal-López, M. R., Muñoz‐Garach, A., Martínez‐González, M. Á., Fitó, M., Salas‐Salvadó, J., Tinahones, F. J., & Ramos‐Molina, B. (2020) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/nqaa064 · Cited by 16

Insights into the lipidome and primary metabolome of the uterus from day 14 cyclic and pregnant sheep

O’Neil, E. V., & Spencer, T. E. (2021) · Biology of Reproduction · doi:10.1093/biolre/ioab053 · Cited by 16

Atg32-dependent mitophagy sustains spermidine and nitric oxide required for heat-stress tolerance in Saccharomyces cerevisiae

Kaur, J., Goldsmith, J., Tankka, A. T., Eguiguren, S. B., Gimenez, A. A., Vick, L., Debnath, J., & Vlahakis, A. (2021) · Journal of Cell Science · doi:10.1242/jcs.253781 · Cited by 17

Spermidine Supplementation Protects the Liver Endothelium from Liver Damage in Mice

Campreciós, G., Ruart, M., Anton, A., Suárez-Herrera, N., Montironi, C., Martínez–Sánchez, C., Jiménez, N., Lafoz, E., García‐Calderó, H., Vilaseca, M., et al. (2021) · Nutrients · doi:10.3390/nu13113700 · Cited by 16

Role of Diet in Stem and Cancer Stem Cells

Puca, F., Fedele, M., Rasio, D., & Battista, S. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23158108 · Cited by 17

ApoE isoform-dependent effects of xanthohumol on high fat diet-induced cognitive impairments and hippocampal metabolic pathways

Kundu, P., Holden, S. J., Paraiso, I. L., Sudhakar, R., McQuesten, C., Choi, J., Miranda, C. L., Maier, C. S., Bobe, G., Stevens, J. F., et al. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.954980 · Cited by 17

Potent New Targets for Autophagy Enhancement to Delay Neuronal Ageing

Szinyákovics, J., Keresztes, F., Kiss, E. A., Falcsik, G., Vellai, T., & Kovács, T. (2023) · Cells · doi:10.3390/cells12131753 · Cited by 16

Proteostasis in T cell aging

Gressler, A. E., Leng, H., Zinecker, H., & Simon, A. K. (2023) · Seminars in Immunology · doi:10.1016/j.smim.2023.101838 · Cited by 15

The potential links between human gut microbiota and cardiovascular health and disease - is there a gut-cardiovascular axis?

Almeida, C., Nobre, J. G., Costa, D. A., & Barata, P. (2023) · Frontiers in Gastroenterology · doi:10.3389/fgstr.2023.1235126 · Cited by 17

Polyamines in Ovarian Aging and Disease

Kang, B., Wang, X., An, X., Ji, C., Ling, W., Qi, Y., Li, S., & Jiang, D. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms242015330 · Cited by 18

Circulating Metabolomic Associations with Neurocognitive Outcomes in Pediatric CKD

Lee, A. M., Xu, Y., Hooper, S. R., Abraham, A. G., Hu, J., Xiao, R., Matheson, M. B., Brunson, C., Rhee, E. P., Coresh, J., et al. (2023) · Clinical Journal of the American Society of Nephrology · doi:10.2215/cjn.0000000000000318 · Cited by 18

Enzymatically prepared neoagarooligosaccharides improve gut health and function through promoting the production of spermidine by Faecalibacterium in chickens

La, A. L. T. Z., Li, D., Cheng, Z., Qiu, W., Hu, D., Jin, X., Liu, D., Feng, Y., Guo, Y., Cheng, G., et al. (2023) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2023.169057 · Cited by 18

Spermidine improves the antioxidant capacity and morphology of intestinal tissues and regulates intestinal microorganisms in Sichuan white geese

Wang, Z., Jiang, D., Wang, X., Jiang, Y., Sun, Q., Ling, W., An, X., Ji, C., Li, S., Qi, Y., et al. (2024) · Frontiers in Microbiology · doi:10.3389/fmicb.2023.1292984 · Cited by 16

The discovery of regional neurotoxicity-associated metabolic alterations induced by carbon quantum dots in brain of mice using a spatial metabolomics analysis

Chen, M., Chen, S., Wang, X., Ye, Z., Liu, K., Qian, Y., Tang, M. X., & Wu, T. (2024) · Particle and Fibre Toxicology · doi:10.1186/s12989-024-00580-y · Cited by 16

Reduction of spermine synthase enhances autophagy to suppress Tau accumulation

Tao, X., Liu, J., Diaz-Perez, Z., Foley, J. R., Nwafor, A. C., Stewart, T. M., Casero, R. A., & Zhai, R. G. (2024) · Cell Death and Disease · doi:10.1038/s41419-024-06720-8 · Cited by 19

Inflammation primes the murine kidney for recovery by activating AZIN1 adenosine-to-inosine editing

Heruye, S., Myslinski, J., Zeng, C., Zollman, A., Makino, S., Nanamatsu, A., Mir, Q., Janga, S. C., Doud, E. H., Eadon, M. T., et al. (2024) · Journal of Clinical Investigation · doi:10.1172/jci180117 · Cited by 16

Climbing the longevity pyramid: overview of evidence-driven healthcare prevention strategies for human longevity

Martinović, A., Mantovani, M., Trpchevska, N., Novak, E., Milev, N. B., Bode, L., Ewald, C. Y., Bischof, E. Y., Reichmuth, T., Lapides, R. A., et al. (2024) · Frontiers in Aging · doi:10.3389/fragi.2024.1495029 · Cited by 19

Spermidine Enhances Mitochondrial Bioenergetics in Young and Aged Human-Induced Pluripotent Stem Cell-Derived Neurons

Szabo, L., Lejri, I., Grimm, A., & Eckert, A. (2024) · Antioxidants · doi:10.3390/antiox13121482 · Cited by 18

Phenylbutyrate modulates polyamine acetylase and ameliorates Snyder-Robinson syndrome in a Drosophila model and patient cells

Tao, X., Zhu, Y., Diaz-Perez, Z., Yu, S., Foley, J. R., Stewart, T. M., Casero, R. A., Steet, R., & Zhai, R. G. (2022) · JCI Insight · doi:10.1172/jci.insight.158457 · Cited by 15

The Precision Control of Autophagic Flux and Vesicle Dynamics—A Micropattern Approach

du Toit, A., de Wet, S., Hofmeyr, J. S., Müller-Nedebock, K. K., & Loos, B. (2018) · Cells · doi:10.3390/cells7080094 · Cited by 16

Aspirin induces autophagy via inhibition of the acetyltransferase EP300

Castoldi, F., Pietrocola, F., Maiuri, M. C., & Kroemer, G. (2018) · Oncotarget · doi:10.18632/oncotarget.25364 · Cited by 16

Caloric restriction promotes the stemness and antitumor activity of T lymphocytes

Pietrocola, F., & Kroemer, G. (2019) · OncoImmunology · doi:10.1080/2162402x.2019.1616153 · Cited by 15

Live Longer, but How? Nutrition and Aging

Güzeldere, H. K. B., & Aksoy, M. (2021) · Geriatrik Bilimler Dergisi · doi:10.47141/geriatrik.905089 · Cited by 16

Electrophilicity Modulation for Sub‐ppm Visualization and Discrimination of EDA

Zhao, H., Liu, Y., Li, G., Lei, D., Du, Y., Li, Y., Tang, H., & Dou, X. (2024) · Advanced Science · doi:10.1002/advs.202400361 · Cited by 15

Serine metabolism in aging and age-related diseases

Shan, S., & Hoffman, J. M. (2024) · GeroScience · doi:10.1007/s11357-024-01444-1 · Cited by 15

Polyamine supplementation reduces DNA damage in adipose stem cells cultured in 3-D

Minguzzi, M., Guidotti, S., Platano, D., D’Adamo, S., Cetrullo, S., Assirelli, E., Santi, S., Mariani, E., Trisolino, G., Filardo, G., et al. (2019) · Scientific Reports · doi:10.1038/s41598-019-50543-z · Cited by 15

Polyamines polarized Th2/Th9 cell-fate decision by regulating GATA3 expression

Nakamura, A., Takahashi, D., Nakamura, Y., Yamada, T., Matsumoto, M., & Hase, K. (2020) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2020.108587 · Cited by 15

Hierarchical Assembly Pathways of Spermine-Induced Tubulin Conical-Spiral Architectures

Dharan, R., Shemesh, A., Millgram, A., Zalk, R., Frank, G. A., Levi‐Kalisman, Y., Ringel, I., & Raviv, U. (2021) · ACS Nano · doi:10.1021/acsnano.1c01374 · Cited by 15

Heat stress promotes the conversion of putrescine to spermidine and plays an important role in regulating ganoderic acid biosynthesis in Ganoderma lucidum

Tao, Y., Han, X., Ren, A., Li, J., Song, H., Xie, B., & Zhao, M. (2021) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-021-11373-0 · Cited by 15

Modulating gut microbiota in autoimmune diseases: a cutting-edge strategy from prophylaxis to therapeutics

Wang, M., Liu, Y., Zhao, L., & Zhang, X. (2021) · 中国科学通报：英文版 · doi:10.1016/j.scib.2021.12.021 · Cited by 15

A metabolomic study on the effect of prenatal exposure to Benzophenone-3 on spontaneous fetal loss in mice

Han, X., Lu, T., Hu, Y., Duan, J., Guan, Y., Huang, X., Zhou, J., Huang, R., Tang, M., Sun, R., et al. (2022) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2022.113347 · Cited by 17

Mechanisms through which lithocholic acid delays yeast chronological aging under caloric restriction conditions

Arlia‐Ciommo, A., Leonov, A., Mohammad, K., Beach, A., Richard, V. R., Bourque, S. D., Burstein, M. T., Goldberg, A. A., Kyryakov, P., Gomez-Perez, A., et al. (2018) · Oncotarget · doi:10.18632/oncotarget.26188 · Cited by 14

A Multi-Organ Murine Metabolomics Atlas Reveals Molecular Dysregulations in Alzheimer’s DiseasePreprint

Zuffa, S., Allaband, C., Charron‐Lamoureux, V., Caraballo‐Rodríguez, A. M., Patan, A., Mohanty, I., Agongo, J., Bostick, J. W., Connerly, T. J., Thron, T., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.04.28.651123 · Cited by 15

Genetic and environmental factors associated with alteration of filtration slit proteins and their functions: a scoping review

Adepoju, A. A., Muhammad, M. A., Adamson, M., Adewale, S. A., Adekunle, A. T., Ojulari, L. S., & Alagbonsi, A. I. (2025) · Frontiers in Nephrology · doi:10.3389/fneph.2025.1678502 · Cited by 14

Interactions between the 5′ UTR mRNA of the spe2 gene and spermidine regulate translation in S. pombe

Sun, W., Zhang, X., Chen, D., & Murchie, A. I. H. (2019) · RNA · doi:10.1261/rna.072975.119 · Cited by 16

Astrocytes as Perspective Targets of Exercise- and Caloric Restriction‐Mimetics

Lalo, U., & Pankratov, Y. (2021) · Neurochemical Research · doi:10.1007/s11064-021-03277-2 · Cited by 14

Salivary Polyamines Help Detect High-Risk Patients with Pancreatic Cancer: A Prospective Validation Study

Nose, D., Sugimoto, M., Muta, T., & Miura, S.-I. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24032998 · Cited by 14

Metabolic reprogramming in inflammaging and aging in T cells

Bevilacqua, A., Ho, P., & Franco, F. (2023) · Life Metabolism · doi:10.1093/lifemeta/load028 · Cited by 14

Anti‐Inflammatory Nanotherapies Based on Bioactive Cyclodextrin Materials

Li, L., Chen, B., Li, G., Chen, S., & Zhang, J. (2023) · Advanced NanoBiomed Research · doi:10.1002/anbr.202300106 · Cited by 14

Phytochemistry, pharmacological applications, and therapeutic effects of green synthesized nanomaterials using Cichorium species—a comprehensive review

Sishu, N. K., & Selvaraj, C. I. (2024) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-024-03221-5 · Cited by 14

Pillar[n]arene‐Based Fluorescence Turn‐On Chemosensors for the Detection of Spermine, Spermidine, and Cadaverine in Saline Media and Biofluids

Prabodh, A., Grimm, L., Biswas, P. K., Mahram, V., & Biedermann, F. (2024) · Chemistry - A European Journal · doi:10.1002/chem.202401071 · Cited by 14

Scientific landscape of oxidative stress in sarcopenia: from bibliometric analysis to hotspots review

Wang, L., Guo, D., Huang, Y., Long, P., Zhang, X., Bai, L., Liu, J., Hu, X., Pang, R., & Gou, X. (2024) · Frontiers in Medicine · doi:10.3389/fmed.2024.1472413 · Cited by 15

Alterations of amino acids in older adults with Alzheimer’s Disease and Vascular Dementia

Ma, X., Wang, X.-M., Tang, G.-Z., Wang, Y., Liu, X., Wang, S.-D., Peng, P., Qi, X.-H., Qin, X., Wang, C., et al. (2025) · Amino Acids · doi:10.1007/s00726-024-03442-1 · Cited by 15

Enzymatic Spermine Metabolites Induce Apoptosis Associated with Increase of p53, caspase-3 and miR-34a in Both Neuroblastoma Cells, SJNKP and the N-Myc-Amplified Form IMR5

Kanamori, Y., Finotti, A., Magno, L. D., Canettieri, G., Tahara, T., Timeus, F. S., Greco, A., Tirassa, P., Gasparello, J., Fino, P., et al. (2021) · Cells · doi:10.3390/cells10081950 · Cited by 14

Circulating acetylated polyamines correlate with Covid-19 severity in cancer patients

Bourgin, M., Derosa, L., Silva, C. A. C., Goubet, A., Dubuisson, A., Danlos, F., Grajeda‐Iglesias, C., Cerbone, L., Géraud, A., Laparra, A., et al. (2021) · Aging · doi:10.18632/aging.203525 · Cited by 15

A Single Human-Relevant Fast Food Meal Rapidly Reorganizes Metabolomic and Transcriptomic Signatures in a Gut Microbiota-Dependent Manner#

Osborn, L. J., Orabi, D., Goudarzi, M., Sangwan, N., Banerjee, R., Brown, A. L., Kadam, A., Gromovsky, A. D., Linga, P., Cresci, G., et al. (2021) · Immunometabolism · doi:10.20900/immunometab20210029 · Cited by 14

Non-linear association between serum spermidine and mild cognitive impairment: Results from a cross-sectional and longitudinal study

Xu, J., Sun, Z., Zhang, R., Li, R., Yu, Z., Zhang, Q., Ma, Y., Xing, F., & Zheng, L. (2022) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2022.924984 · Cited by 16

Content of Biogenic Amines and Physical Properties of Lacto-Fermented Button Mushrooms

Jabłońska‐Ryś, E., Sławińska, A., Skrzypczak, K., Kowalczyk, D., & Stadnik, J. (2022) · Applied Sciences · doi:10.3390/app12188957 · Cited by 15

CA9 Silencing Promotes Mitochondrial Biogenesis, Increases Putrescine Toxicity and Decreases Cell Motility to Suppress ccRCC Progression

Xu, J., Zhu, S., Xu, L., Liu, X., Ding, W., Wang, Q., Chen, Y., & Deng, H. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21165939 · Cited by 14

Untitled work

(1986) · PubMed · Cited by 14

Mitochondrial Quality Control in Neurodegeneration and Cancer: A Common Denominator, Distinct Therapeutic Challenges

Dominiak, A., Gawinek, E., Banaszek, A. A., & Wilkaniec, A. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26178693 · Cited by 14

Mitophagy in Alzheimer's disease and its potential as a therapeutic target

Wei, J., Xiao, T., Lyu, J., Zhao, Y., Zhang, Y., Du, X., He, Y., Zhao, M., Yang, X., Yao, Y., et al. (2025) · Neurobiology of Disease · doi:10.1016/j.nbd.2025.107162 · Cited by 13

Metabolic support protects mucosa from ferroptosis in radiation-induced mucositis

Yu, W., Jiao, K., Wang, K., Li, X., Wan, Q., Qin, W., Hao, X., Wan, M., Ma, Y., Wu, J., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-67214-5 · Cited by 15

The Role of Sirtuins in Osteogenic Differentiation of Vascular Smooth Muscle Cells and Vascular Calcification

Wang, S., & Hu, S. (2022) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2022.894692 · Cited by 13

PARK2 Induces Osteoclastogenesis through Activation of the NF-κB Pathway

Hong, S. J., Jung, S., Jang, J. S., Mo, S., Kwon, J., Kim, M. K., & Kim, H. (2022) · Molecules and Cells · doi:10.14348/molcells.2022.0058 · Cited by 13

The Impact of Spermidine on C2C12 Myoblasts Proliferation, Redox Status and Polyamines Metabolism under H2O2 Exposure

Ceci, R., Duranti, G., Giuliani, S., Rossi, M. N., Dimauro, I., Sabatini, S., Mariottini, P., & Cervelli, M. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms231910986 · Cited by 13

Bioengineering of Escherichia coli Nissle 1917 for Production and Excretion of Spermidine, a Key Metabolite in Human Health

Caffaratti, C., Plazy, C., Cunin, V., Toussaint, B., & Gouëllec, A. L. (2022) · Metabolites · doi:10.3390/metabo12111061 · Cited by 14

A back-door insight into the modulation of Src kinase activity by the polyamine spermidine

Rossini, S., Gargaro, M., Scalisi, G., Bianconi, E., Ambrosino, S., Panfili, E., Volpi, C., Orabona, C., Macchiarulo, A., Fallarino, F., et al. (2023) · eLife · doi:10.7554/elife.85872 · Cited by 13

Spatially resolved visualization of reprogrammed metabolism in hepatocellular carcinoma by mass spectrometry imaging

Ma, B., Zhang, Y., Ma, J., Chen, X., Sun, C., & Qin, C. (2023) · Cancer Cell International · doi:10.1186/s12935-023-03027-0 · Cited by 13

Anonna crassiflora suppresses colonic carcinogenesis through its antioxidant effects, bioactive amines, and phenol content in rats

Ávila, P. F., Todescato, A. P., dos Santos, M. D. M. C., Ramos, L. F., Menon, I. C., Carvalho, M. O., do Vale-Oliveira, M., Custódio, F. B., Glória, M. B. A., Paula, B. M. D., et al. (2023) · Food Research International · doi:10.1016/j.foodres.2023.113666 · Cited by 13

Exploring autophagy in treating SARS-CoV-2 spike protein-related pathology

Halma, M. T. J., Marik, P. E., & Saleeby, Y. M. (2024) · Endocrine and Metabolic Science · doi:10.1016/j.endmts.2024.100163 · Cited by 14

Mechanism of electro-acupuncture in alleviating intestinal injury in septic mice via polyamine-related M2-macrophage polarization

Xu, X., Huang, X., Xiao, L., Wang, J., Yang, X., & Wu, Y. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1373876 · Cited by 14

Mechanisms of spermidine-induced autophagy and geroprotection

Hofer, S. J., Simon, A. K., Bergmann, M., Eisenberg, T., Kroemer, G., & Madeo, F. (2022) · Nature Aging · doi:10.1038/s43587-022-00322-9 · Cited by 218

Geroprotective insights into the natural metabolite spermidine in aging and age-related diseases

Jiang, Z., Tong, S., Kirkland, J. L., & Sun, Y. (2026) · npj Aging · doi:10.1038/s41514-026-00448-9

Molecular targets of spermidine: implications for cancer suppression

Zimmermann, A., Hofer, S. J., & Madeo, F. (2023) · Cell Stress · doi:10.15698/cst2023.07.281 · Cited by 23

Cardioprotective benefits of dietary spermidine

Huynh, K. (2017) · Nature Reviews Cardiology · doi:10.1038/nrcardio.2016.222 · Cited by 4

Spermidine: A physiological autophagy inducer acting as an anti-aging vitamin in humans?

Madeo, F., Bauer, M. A., Carmona-Gutierrez, D., & Kroemer, G. (2019) · Autophagy · doi:10.1080/15548627.2018.1530929 · Cited by 212