Spermidine in health and disease

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Long-term weight loss maintenance

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Induction of autophagy by spermidine promotes longevity

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Enhancing CD8 T-cell memory by modulating fatty acid metabolism

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Immunological effects of conventional chemotherapy and targeted anticancer agents

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Declining NAD+ Induces a Pseudohypoxic State Disrupting Nuclear-Mitochondrial Communication during Aging

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Metformin improves healthspan and lifespan in mice

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Acetyl coenzyme A: a central metabolite and second messenger

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Autophagy-Dependent Anticancer Immune Responses Induced by Chemotherapeutic Agents in Mice

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Resveratrol Ameliorates Aging-Related Metabolic Phenotypes by Inhibiting cAMP Phosphodiesterases

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Autophagy maintains stemness by preventing senescence

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NAD + repletion improves mitochondrial and stem cell function and enhances life span in mice

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The NAD+/Sirtuin Pathway Modulates Longevity through Activation of Mitochondrial UPR and FOXO Signaling

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Glucose restriction extends Caenorhabditis elegans life span by inducing mitochondrial respiration and increasing oxidative stress

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Cardioprotection and lifespan extension by the natural polyamine spermidine

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Polyamines and cancer: old molecules, new understanding

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Resveratrol delays age-related deterioration and mimics transcriptional aspects of dietary restriction without extending life span

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Metformin as a tool to target aging

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Mechanisms of Life Span Extension by Rapamycin in the Fruit Fly Drosophila Melanogaster

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Fasting, Circadian Rhythms, and Time-Restricted Feeding in Healthy Lifespan

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Metformin retards aging in C. elegans by altering microbial folate and methionine metabolism

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Long-Term Administration of Nicotinamide Mononucleotide Mitigates Age-Associated Physiological Decline in Mice

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Modulation of cellular function by polyamines

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Mammalian polyamine metabolism and function

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GABA from reactive astrocytes impairs memory in mouse models of Alzheimer's disease

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The Ancient Drug Salicylate Directly Activates AMP-Activated Protein Kinase

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Metabolic Control of Longevity

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Fasting Cycles Retard Growth of Tumors and Sensitize a Range of Cancer Cell Types to Chemotherapy

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Intermittent fasting dissociates beneficial effects of dietary restriction on glucose metabolism and neuronal resistance to injury from calorie intake

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Anticancer Chemotherapy-Induced Intratumoral Recruitment and Differentiation of Antigen-Presenting Cells

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Functions of Polyamines in Mammals

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TOR Signaling and Rapamycin Influence Longevity by Regulating SKN-1/Nrf and DAF-16/FoxO

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Rapamycin‐mediated lifespan increase in mice is dose and sex dependent and metabolically distinct from dietary restriction

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PINK1/Parkin-mediated mitophagy in mammalian cells

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The GH/IGF-1 axis in ageing and longevity

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Polyamines: Natural and engineered abiotic and biotic stress tolerance in plants

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Caloric restriction mimetics enhance anticancer immunosurveillance

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Critical role of acetylation in tau-mediated neurodegeneration and cognitive deficits

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Spermidine and resveratrol induce autophagy by distinct pathways converging on the acetylproteome

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Regulation of autophagy by cytosolic acetyl-coenzyme A

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Nicotinamide N-methyltransferase knockdown protects against diet-induced obesity

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A dual role for autophagy in a murine model of lung cancer

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Chemotherapy-induced antitumor immunity requires formyl peptide receptor 1

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Acarbose, 17-α-estradiol, and nordihydroguaiaretic acid extend mouse lifespan preferentially in males

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Fasting-Mimicking Diet Reduces HO-1 to Promote T Cell-Mediated Tumor Cytotoxicity

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Metformin Inhibits Hepatic Mtorc1 Signaling via Dose-Dependent Mechanisms Involving AMPK and the TSC Complex

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Engineered polyamine accumulation in tomato enhances phytonutrient content, juice quality, and vine life

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The SIRT1 Activator SRT1720 Extends Lifespan and Improves Health of Mice Fed a Standard Diet

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SIRT1 Negatively Regulates the Mammalian Target of Rapamycin

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Resveratrol Supplementation Does Not Improve Metabolic Function in Nonobese Women with Normal Glucose Tolerance

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Increased monoamine oxidase b activity in plaque-associated astrocytes of Alzheimer brains revealed by quantitative enzyme radioautography

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Autophagy activators rescue and alleviate pathogenesis of a mouse model with proteinopathies of the TAR DNA-binding protein 43

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Restoring polyamines protects from age-induced memory impairment in an autophagy-dependent manner

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Rapamycin extends murine lifespan but has limited effects on aging

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Amyloid-binding compounds maintain protein homeostasis during ageing and extend lifespan

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Autophagy is a critical regulator of memory CD8+ T cell formation

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Spermidine induces autophagy by inhibiting the acetyltransferase EP300

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Nordihydroguaiaretic acid and aspirin increase lifespan of genetically heterogeneous male mice

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The Search for Antiaging Interventions: From Elixirs to Fasting Regimens

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Autophagy and neurodegeneration

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Reduced Levels of IGF-I Mediate Differential Protection of Normal and Cancer Cells in Response to Fasting and Improve Chemotherapeutic Index

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Spermine inhibits proinflammatory cytokine synthesis in human mononuclear cells: a counterregulatory mechanism that restrains the immune response

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SRT1720 improves survival and healthspan of obese mice

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Polyamines and cancer: implications for chemotherapy and chemoprevention

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Metabolic Disturbances Identified in Plasma Are Associated With Outcomes in Patients With Heart Failure

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Metabolomic Analysis of Pressure-Overloaded and Infarcted Mouse Hearts

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Exogenous spermidine improves seed germination of sweet corn via involvement in phytohormone interactions, H2O2 and relevant gene expression

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Polyamines Confer Salt Tolerance in Mung Bean (Vigna radiata L.) by Reducing Sodium Uptake, Improving Nutrient Homeostasis, Antioxidant Defense, and Methylglyoxal Detoxification Systems

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Rapamycin and Other Longevity-Promoting Compounds Enhance the Generation of Mouse Induced Pluripotent Stem Cells

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Spermidine coupled with exercise rescues skeletal muscle atrophy from D-gal-induced aging rats through enhanced autophagy and reduced apoptosis via AMPK-FOXO3a signal pathway

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Spermidine alleviates experimental autoimmune encephalomyelitis through inducing inhibitory macrophages

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Spermine prevents endonuclease activation and apoptosis in thymocytes*1

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Spermidine Prolongs Lifespan and Prevents Liver Fibrosis and Hepatocellular Carcinoma by Activating MAP1S-Mediated Autophagy

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Anti-inflammatory effects of spermidine in lipopolysaccharide-stimulated BV2 microglial cells

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Safety and tolerability of spermidine supplementation in mice and older adults with subjective cognitive decline

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The phytochemical, EGCG , extends lifespan by reducing liver and kidney function damage and improving age‐associated inflammation and oxidative stress in healthy rats

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Circadian Clock Control by Polyamine Levels through a Mechanism that Declines with Age

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Macrophage PTEN Regulates Expression and Secretion of Arginase I Modulating Innate and Adaptive Immune Responses

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Spermidine pretreatment enhances heat tolerance in rice seedlings through modulating antioxidative and glyoxalase systems

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Spermidine protects against α-synuclein neurotoxicity

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Modulation of cadmium toxicity and enhancing cadmium-tolerance in wheat seedlings by exogenous application of polyamines

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Long-Term Oral Polyamine Intake Increases Blood Polyamine Concentrations

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Spermidine and spermine are enriched in whole blood of nona/centenarians

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Spermidine Protects against Oxidative Stress in Inflammation Models Using Macrophages and Zebrafish

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ATM mediates spermidine-induced mitophagy via PINK1 and Parkin regulation in human fibroblasts

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Protective effect of spermidine on salt stress induced oxidative damage in two Kentucky bluegrass (Poa pratensis L.) cultivars

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Lycibarbarspermidines A–O, New Dicaffeoylspermidine Derivatives from Wolfberry, with Activities against Alzheimer’s Disease and Oxidation

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Loss of the RNA polymerase III repressor MAF1 confers obesity resistancePreprint

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Alzheimer's disease–like pathology has transient effects on the brain and blood metabolome

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Polyamines in renal failure

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Spermine Promotes Acclimation to Osmotic Stress by Modifying Antioxidant, Abscisic Acid, and Jasmonic Acid Signals in Soybean

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Spermidine Suppresses Age-Associated Memory Impairment by Preventing Adverse Increase of Presynaptic Active Zone Size and Release

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Induction of autophagy by spermidine is neuroprotective via inhibition of caspase 3-mediated Beclin 1 cleavage

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Exploring the therapeutic space around NAD+

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Caloric restriction mimetics: natural/physiological pharmacological autophagy inducers

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Spermine protects mice against lethal sepsis partly by attenuating surrogate inflammatory markers

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The natural polyamines spermidine and spermine prevent bone loss through preferential disruption of osteoclastic activation in ovariectomized mice

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Identification of a mammalian vesicular polyamine transporter

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Spermidine promotes stress resistance in Drosophila melanogaster through autophagy-dependent and -independent pathways

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Autophagy couteracts weight gain, lipotoxicity and pancreatic β-cell death upon hypercaloric pro-diabetic regimens

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Perturbation of spermine synthase Gene Expression and Transcript Profiling Provide New Insights on the Role of the Tetraamine Spermine in Arabidopsis Defense against Pseudomonas viridiflava

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Polyamines-induced aluminum tolerance in mung bean: A study on antioxidant defense and methylglyoxal detoxification systems

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Increased Polyamine Intake Inhibits Age-Associated Alteration in Global DNA Methylation and 1,2-Dimethylhydrazine-Induced Tumorigenesis

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Waterlogging tolerance of Welsh onion (Allium fistulosum L.) enhanced by exogenous spermidine and spermine

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Reactive Oxygen Species, AMP-activated Protein Kinase, and the Transcription Cofactor p300 Regulate α-Tubulin Acetyltransferase-1 (αTAT-1/MEC-17)-dependent Microtubule Hyperacetylation during Cell Stress

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Modulation of learning and memory by natural polyamines

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Spermidine ameliorates 3-nitropropionic acid (3-NP)-induced striatal toxicity: Possible role of oxidative stress, neuroinflammation, and neurotransmitters

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Spermidine reduces lipid accumulation and necrotic core formation in atherosclerotic plaques via induction of autophagy

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Spermidine alleviates the growth of saline-stressed ginseng seedlings through antioxidative defense system

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Reactivation of autophagy by spermidine ameliorates the myopathic defects of collagen VI-null mice

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Polyamines in biological samples: Rapid and robust quantification by solid-phase extraction online-coupled to liquid chromatography–tandem mass spectrometry

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Macrophage ABHD5 promotes colorectal cancer growth by suppressing spermidine production by SRM

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The Effect of Exogenous Spermidine Concentration on Polyamine Metabolism and Salt Tolerance in Zoysiagrass (Zoysia japonica Steud) Subjected to Short-Term Salinity Stress

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Exogenous Spermidine Alleviates Low Temperature Injury in Mung Bean (Vigna radiata L.) Seedlings by Modulating Ascorbate-Glutathione and Glyoxalase Pathway

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Reactive oxygen species trigger motoneuron death in non-cell-autonomous models of ALS through activation of c-Abl signaling

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Spermine reverses lipopolysaccharide-induced memory deficit in mice

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