Spermidine in health and disease

The Hallmarks of Aging

López-Otín, C., Blasco, M. A., Partridge, L., Serrano, M., & Kroemer, G. (2013) · Cell · doi:10.1016/j.cell.2013.05.039 · Cited by 14,982

Mitochondrial Dysfunction and Oxidative Stress in Neurodegenerative Diseases

Lin, M. T., & Beal, M. F. (2006) · Nature · doi:10.1038/nature05292 · Cited by 6,455

Inflamm‐aging: An Evolutionary Perspective on Immunosenescence

FRANCESCHI, C., BONAFÈ, M., VALENSIN, S., OLIVIERI, F., DE LUCA, M., OTTAVIANI, E., & DE BENEDICTIS, G. (2000) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2000.tb06651.x · Cited by 5,358

Resveratrol improves health and survival of mice on a high-calorie diet

Baur, J. A., Pearson, K. J., Price, N. L., Jamieson, H. A., Lerin, C., Kalra, A., Prabhu, V. V., Allard, J. S., Lopez-Lluch, G., Lewis, K., et al. (2006) · Nature · doi:10.1038/nature05354 · Cited by 4,290

Rapamycin fed late in life extends lifespan in genetically heterogeneous mice

Harrison, D. E., Strong, R., Sharp, Z. D., Nelson, J. F., Astle, C. M., Flurkey, K., Nadon, N. L., Wilkinson, J. E., Frenkel, K., Carter, C. S., et al. (2009) · Nature · doi:10.1038/nature08221 · Cited by 3,766

Immunogenic cell death in cancer and infectious disease

Galluzzi, L., Buqué, A., Kepp, O., Zitvogel, L., & Kroemer, G. (2017) · Nature Reviews Immunology · doi:10.1038/nri.2016.107 · Cited by 3,119

Extending Healthy Life Span—From Yeast to Humans

Fontana, L., Partridge, L., & Longo, V. D. (2010) · Science · doi:10.1126/science.1172539 · Cited by 3,023

Autophagy in Human Health and Disease

Choi, A. M. K., Ryter, S. W., & Levine, B. (2013) · New England Journal of Medicine · doi:10.1056/nejmra1205406 · Cited by 2,583

Autophagy and Aging

Rubinsztein, D. C., Mariño, G., & Kroemer, G. (2011) · Cell · doi:10.1016/j.cell.2011.07.030 · Cited by 2,107

FoxO3 Controls Autophagy in Skeletal Muscle In Vivo

Mammucari, C., Milan, G., Romanello, V., Masiero, E., Rudolf, R., Del Piccolo, P., Burden, S. J., Di Lisi, R., Sandri, C., Zhao, J., et al. (2007) · Cell Metabolism · doi:10.1016/j.cmet.2007.11.001 · Cited by 1,953

Chemoproteomic Identification of Spermidine-Binding Proteins and Antitumor-Immunity Activators

Singh, V. P., Hirose, S., Takemoto, M., Farrag, A. M. A. S., Sato, S., Honjo, T., Chamoto, K., & Uesugi, M. (2024) · Journal of the American Chemical Society · doi:10.1021/jacs.3c14615 · Cited by 15

Nicotinamide Riboside Supplementation Benefits in Patients With Werner Syndrome: A Double‐Blind Randomized Crossover Placebo‐Controlled Trial

Shoji, M., Kato, H., Koshizaka, M., Kaneko, H., Baba, Y., Ishikawa, T., Teramoto, N., Kinoshita, D., Yamaguchi, A., Maeda, Y., et al. (2025) · Aging Cell · doi:10.1111/acel.70093 · Cited by 16

A two-enzyme cascade system for the bio-production of spermidine from putrescine

Liu, Y., Guo, X., Wang, X., Chen, K., & Ouyang, P. (2021) · Molecular Catalysis · doi:10.1016/j.mcat.2021.111439 · Cited by 13

Analysis of Main Components and Prospects of Natto

Liu, Y., Han, Y., Cao, L., Wang, X., & Dou, S. (2021) · Advances in Enzyme Research · doi:10.4236/aer.2021.91001 · Cited by 13

Serum Spermidine in Relation to Risk of Stroke: A Multilevel Study

Zheng, L., Xie, Y., Sun, Z., Zhang, R., Ma, Y., Xu, J., Zheng, J., Xu, Q., Zhao, L., Guo, X., et al. (2022) · Frontiers in Nutrition · doi:10.3389/fnut.2022.843616 · Cited by 13

A systematic exploration reveals the potential of spermidine for hypopigmentation treatment through the stabilization of melanogenesis-associated proteins

Brito, S., Heo, H., Cha, B., Lee, S.-H., Chae, S., Lee, M., Kwak, B.-M., & Bin, B. (2022) · Scientific Reports · doi:10.1038/s41598-022-18629-3 · Cited by 13

The Role of Intestinal Flora in Anti-Tumor Antibiotic Therapy

Ye, X., Wang, A., Lin, W., Xu, Y., Dong, X., Zhou, Y., Tian, K., & Xu, X. (2022) · Frontiers in Bioscience-Landmark · doi:10.31083/j.fbl2710281 · Cited by 13

The Impact of Hormesis, Neuronal Stress Response, and Reproduction, upon Clinical Aging: A Narrative Review

Kyriazis, M., Swas, L., & Orlova, T. (2023) · Journal of Clinical Medicine · doi:10.3390/jcm12165433 · Cited by 8

Spermidine-functionalized biomaterials to modulate implant-induced immune response and enhance wound healing

Wang, L., Zhong, Y., Wu, Q., Wang, Y., Tang, R., Zhou, S., Yang, J., Liu, Q., Shi, G., Tang, Y., et al. (2023) · Chemical Engineering Journal · doi:10.1016/j.cej.2023.146416 · Cited by 14

Polyamines and microbiota in bicuspid and tricuspid aortic valve aortopathy

Forte, A., Balistreri, C. R., FEO, M. D., Corte, A. D., Hellstrand, P., Persson, L., & Nilsson, B. (2019) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2019.02.014 · Cited by 13

Polyamines Disrupt the KaiABC Oscillator by Inducing Protein Denaturation

Li, J., Zhang, L., Xiong, J., Cheng, X., Huang, Y., Su, Z., Yi, M., & Liu, S. (2019) · Molecules · doi:10.3390/molecules24183351 · Cited by 13

Perfluorooctane sulfonic acid impairs spermatogenesis via the liver-gut microbiota-testis axis: a central role of chenodeoxycholic acid metabolism

Wang, Y., Zou, P., He, S., Cui, H., Yang, Z., An, H., Chen, Q., Huang, W., Guo, H., Liu, J., et al. (2025) · Journal of Advanced Research · doi:10.1016/j.jare.2025.06.037 · Cited by 12

Intestinal aging-related immune dysfunction: mechanisms and interventions

Shen, X., Gao, X., & Wang, L. (2025) · Acta Biochimica et Biophysica Sinica · doi:10.3724/abbs.2025157 · Cited by 13

Impact of covid-19 on mental health and aging

Sharma, P., & Sharma, R. K. (2021) · Saudi Journal of Biological Sciences · doi:10.1016/j.sjbs.2021.07.087 · Cited by 14

Dynamic Mitochondrial Proteome Under Polyamines Treatment in Cardiac Aging

Zhang, H., Meng, Y., Liu, T., Wei, P., Chai, N., Li, L., Wang, J., Yu, X., Yan, L., Qiu, B., et al. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.840389 · Cited by 12

Dietary polyamines promote intestinal adaptation in an experimental model of short bowel syndrome

Kasahara, N., Teratani, T., Yokota, S., Sakuma, Y., Sasanuma, H., Fujimoto, Y., Ijichi, T., Urahashi, T., Yoshitomi, H., Kitayama, J., et al. (2024) · Scientific Reports · doi:10.1038/s41598-024-55258-4 · Cited by 12

Tyrosol regulates hepatic lipid metabolism in high-fat diet-induced NAFLD mice

Wang, Y., Hou, J., Li, X., Chen, P., Chen, F., Pan, Y., Deng, Z., Li, J., Liu, R., & Luo, T. F. (2024) · Food & Function · doi:10.1039/d3fo05345h · Cited by 12

Unveiling the hidden players: noncoding RNAs orchestrating polyamine metabolism in disease

Rossi, M. N., Fiorucci, C., Mariottini, P., & Cervelli, M. (2024) · Cell & Bioscience · doi:10.1186/s13578-024-01235-3 · Cited by 13

Chemically programmed metabolism drives a superior cell fitness for cartilage regeneration

Chen, Y.-S., Yan, Y.-Y., Tian, R., Sheng, Z.-X., Li, L.-M., Chen, J., Liao, Y., Wen, Y., Lu, J.-T., Liu, X., et al. (2024) · Science Advances · doi:10.1126/sciadv.adp4408 · Cited by 11

Spermidine Enhances Mitochondrial Function and Mitigates Aortic Valve Calcification

Song, N., Ji, E., Yu, J. E., Choi, K., Kim, D., Song, J., Kang, D., Song, J., Yu, J., Kim, K., et al. (2025) · JACC Basic to Translational Science · doi:10.1016/j.jacbts.2024.11.011 · Cited by 12

Methionine metabolite spermidine inhibits tumor pyroptosis by enhancing MYO6-mediated endocytosis

Wu, J., Ding, C., Zhang, C., Xu, Z., Deng, Z., Wei, H., He, T., Long, L., Tang, L., Ma, J., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-57511-4 · Cited by 15

Deciphering the Neurosensory Olfactory Pathway and Associated Neo-Immunometabolic Vulnerabilities Implicated in COVID-Associated Mucormycosis (CAM) and COVID-19 in a Diabetes Backdrop—A Novel Perspective

Sharma, M., Vanam, H. P., Panda, N. K., Patro, S. K., Arora, R., Bhadada, S. K., Rudramurthy, S. M., Singh, M. P., & Koppula, P. R. (2022) · Diabetology · doi:10.3390/diabetology3010013 · Cited by 13

Effect of Serum Spermidine on the Prognosis in Patients with Acute Myocardial Infarction: A Cohort Study

Yu, Z., Jiao, Y., Zhang, J., Xu, Q., Xu, J., Li, R., Yuan, W., Guo, H., Sun, Z., & Zheng, L. (2022) · Nutrients · doi:10.3390/nu14071394 · Cited by 12

High Intensity Concentric-Eccentric Exercise Under Hypoxia Changes the Blood Metabolome of Trained Athletes

Dünnwald, T., Paglia, G., Weiß, G., Denti, V., Faulhaber, M., Schobersberger, W., & Wackerhage, H. (2022) · Frontiers in Physiology · doi:10.3389/fphys.2022.904618 · Cited by 12

Bifidobacterium animalis subsp. lactis and arginine mixture intake improves cognitive flexibility in mice

Ikuta, K., Joho, D., Kakeyama, M., & Matsumoto, M. (2023) · Frontiers in Nutrition · doi:10.3389/fnut.2023.1164809 · Cited by 13

Study on the relationship between tea polyphenols alleviating osteoporosis and the changes of microorganism-metabolite-intestinal barrier

Wen, X., Wu, P., Li, F., & Pi, G. (2024) · Microbial Pathogenesis · doi:10.1016/j.micpath.2024.106564 · Cited by 13

Antidepressant-Like Effects of Coumaroylspermidine Extract From Safflower Injection Residues

Li, S.-F., Li, T., Jin, Y., Qin, X., Tian, J., & Zhang, L. (2020) · Frontiers in Pharmacology · doi:10.3389/fphar.2020.00713 · Cited by 12

Natural products as geroprotectors: An autophagy perspective

Raj, S. D., Fann, D. Y., Wong, E. S. P., & Kennedy, B. K. (2021) · Medicinal Research Reviews · doi:10.1002/med.21815 · Cited by 12

Polyamines sustain epithelial regeneration in aged intestines by modulating protein homeostasis

Minetti, A., Omrani, O., Brenner, C., Cansiz, F., Imada, S., Rösler, J., Khawaled, S., Allies, G., Meckelmann, S. W., Gebert, N., et al. (2025) · Nature Cell Biology · doi:10.1038/s41556-025-01804-9 · Cited by 11

Oral and Gut Health, (Neuro) Inflammation, and Central Sensitization in Chronic Pain: A Narrative Review of Mechanisms, Treatment Opportunities, and Research Agenda

Ahmed, I., Nijs, J., Vanroose, M., Vandeputte, D., Kindt, S., Elma, Ö., Hendrix, J., Huysmans, E., & Lahousse, A. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms27010114 · Cited by 12

Modulating the Gut Microbiome in Type 2 Diabetes: Nutritional and Therapeutic Strategies

Nikolaidis, C. G., Gyriki, D., Stavropoulou, E., Karlafti, E., Didangelos, T., Tsigalou, C., & Thanopoulou, A. C. (2025) · Nutrients · doi:10.3390/nu18010089 · Cited by 14

Oral Supplementation with the Polyamine Spermidine Affects Hepatic but Not Pulmonary Lipid Metabolism in Lean but Not Obese Mice

Pankoke, S., Pfarrer, C. D., Glage, S., Mühlfeld, C., & Schipke, J. (2022) · Nutrients · doi:10.3390/nu14204318 · Cited by 11

Deciphering the Antibacterial Mechanism of Hollow Sphere Metal–Organic Frameworks against Staphylococcus aureus and Its Application in Wound Healing

Zhang, Q., Liu, R., Yan, S., Yan, X., & Lv, Y. (2025) · Chemistry of Materials · doi:10.1021/acs.chemmater.4c03165 · Cited by 11

Spermine alleviates myocardial cell aging by inhibiting mitochondrial oxidative stress damage

Yang, J., Zhang, C., Li, Z., Gao, Y.-H., Jiang, L., Zhang, J., Wang, P., & Liu, T. (2025) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2025.177477 · Cited by 13

Genetically encoded fluorescent reporter for polyamines

Sharma, P., Kim, C. Y., Keys, H. R., Imada, S., Joseph, A. B., Ferro, L. S., Kunchok, T., Anderson, R., Sun, Y., Yilmaz, Ö. H., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-60147-z · Cited by 11

Uncovering Natural Longevity Alleles from Intercrossed Pools of Aging Fission Yeast Cells

Ellis, D., Mustonen, V., Rodríguez‐López, M., Rallis, C., Małecki, M., Jeffares, D. C., & Bähler, J. (2018) · Genetics · doi:10.1534/genetics.118.301262 · Cited by 11

Spermidine promotes melanin production through an MITF signalling pathway

Kang, S., & Kim, M. (2021) · Cell Biochemistry and Function · doi:10.1002/cbf.3619 · Cited by 11

Wheat Germ Spermidine and Clove Eugenol in Combination Stimulate Autophagy In Vitro Showing Potential in Supporting the Immune System against Viral Infections

Truzzi, F., Whittaker, A., D’Amen, E., Tibaldi, C., Abate, A., Valerii, M. C., Spisni, E., & Dinelli, G. (2022) · Molecules · doi:10.3390/molecules27113425 · Cited by 13

LncRNA GAS5 promotes spermidine‑induced autophagy through the miRNA‑31‑5p/NAT8L axis in pulmonary artery endothelial cells of patients with CTEPH

Wu, Q., Zhou, X., Wang, Y., & Hu, Y. (2022) · Molecular Medicine Reports · doi:10.3892/mmr.2022.12813 · Cited by 11

Association between Serum Spermidine and TyG Index: Results from a Cross-Sectional Study

Zhang, R., Xu, J., Li, R., Yu, Z., Yuan, W., Gao, H., Feng, W., Gu, C., Sun, Z., & Zheng, L. (2022) · Nutrients · doi:10.3390/nu14183847 · Cited by 11

ATP13A2 modifies mitochondrial localization of overexpressed TOM20 to autolysosomal pathway

Hatori, Y., Kanda, Y., Nonaka, S., Nakanishi, H., & Kitazawa, T. (2022) · PLoS ONE · doi:10.1371/journal.pone.0276823 · Cited by 11

Pentafluoropropionic Anhydride Derivatization and GC-MS Analysis of Histamine, Agmatine, Putrescine, and Spermidine: Effects of Solvents and Starting Column Temperature

Tsikas, D., Beckmann, B., Baskal, S., & Brunner, G. H. G. (2023) · Molecules · doi:10.3390/molecules28030939 · Cited by 11

Polyamines and hormesis: Making sense of a dose response dichotomy

Calabrese, E. J., Hayes, A. W., Pressman, P., Kapoor, R., Dhawan, G., Calabrese, V., & Agathokleous, E. (2023) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2023.110748 · Cited by 11

Pairwise combinations of chemical compounds that delay yeast chronological aging through different signaling pathways display synergistic effects on the extent of aging delay

Dakik, P., McAuley, M., Chancharoen, M., Mitrofanova, D., Rodriguez, M. E. L., Junio, J. A. B., Lutchman, V., Cortes, B., Simard, É., & Titorenko, V. I. (2019) · Oncotarget · doi:10.18632/oncotarget.26553 · Cited by 13

Urinary Spermidine Predicts and Associates with In-Hospital Acute Kidney Injury after Cardiac Surgery

Martin‐Lorenzo, M., Ramos-Barron, M. A., Gutierrez-Garcia, P., Martín-Blázquez, A., Santiago‐Hernandez, A., Rodrigo, E., Gómez-Alamillo, C., & Álvarez‐Llamas, G. (2021) · Antioxidants · doi:10.3390/antiox10060896 · Cited by 11

Spermidine Affects Cardiac Function in Heart Failure Mice by Influencing the Gut Microbiota and Cardiac Galectin-3

Chen, Y., Guo, Z., Li, S., Liu, Z., & Chen, P. (2021) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2021.765591 · Cited by 11

Spermidine Promotes Nb CAR-T Mediated Cytotoxicity to Lymphoma Cells Through Elevating Proliferation and Memory

Wang, H., Jiang, D., Liu, L., Zhang, Y., Qin, M., Qu, Y., Wang, L., Wu, S., Zhou, H., Xu, T., et al. (2022) · OncoTargets and Therapy · doi:10.2147/ott.s382540 · Cited by 11

Cardioprotective effects of autophagy induction in sepsis

Abdellatif, M., Sedej, S., Madeo, F., & Kroemer, G. (2018) · Annals of Translational Medicine · doi:10.21037/atm.2018.10.23 · Cited by 11

Discovery to Launch of Anti-allergy (Emadine; Patanol/Pataday/Pazeo) and Anti-glaucoma (Travatan; Simbrinza) Ocular Drugs, and Generation of Novel Pharmacological Tools Such as AL-8810

Sharif, N. A. (2020) · ACS Pharmacology & Translational Science · doi:10.1021/acsptsci.0c00137 · Cited by 11

Contents of Polyamines and Biogenic Amines in Canned Pet (Dogs and Cats) Food on the Austrian Market

Paulsen, P., Bauer, S., Bauer, F., & Dicakova, Z. (2021) · Foods · doi:10.3390/foods10102365 · Cited by 11

Multi-dimensional metabolomic remodeling under diverse muscle atrophic stimuli in vivo

Oyabu, M., Sato, T., Kawaguchi, R., Yoshioka, K., Ito, N., Eguchi, T., Gotoh, H., Yoshizawa, T., Ogawa, Y., Ono, Y., et al. (2025) · Cell Reports · doi:10.1016/j.celrep.2025.116097 · Cited by 11

Sustained oral spermidine supplementation rescues functional and structural defects in COL6-deficient myopathic mice

Gambarotto, L., Metti, S., Corpetti, M., Baraldo, M., Sabatelli, P., Castagnaro, S., Cescon, M., Blaauw, B., & Bonaldo, P. (2023) · Autophagy · doi:10.1080/15548627.2023.2241125 · Cited by 10

Effects of Methionine Restriction from Different Sources on Sperm Quality in Aging Mice

Wu, Y., Li, H., Miao, Y., Peng, J., & Wei, H. (2023) · Nutrients · doi:10.3390/nu15224782 · Cited by 10

Enzymatic-related network of catalysis, polyamine, and tumors for acetylpolyamine oxidase: from calculation to experiment

Fang, D., Zhang, Z., Zhai, J., Guo, B., Li, P., Liu, X., Song, J., Xie, S., Wu, R., Zhao, Y., et al. (2023) · Chemical Science · doi:10.1039/d3sc06037c · Cited by 10

SIN-3 transcriptional coregulator maintains mitochondrial homeostasis and polyamine flux

Giovannetti, M., Rodríguez‐Palero, M. J., Fabrizio, P., Nicolle, O., Bedet, C., Michaux, G., Witting, M. A., Artal‐Sanz, M., & Palladino, F. (2024) · iScience · doi:10.1016/j.isci.2024.109789 · Cited by 10

The network of cardiac KIR2.1: its function, cellular regulation, electrical signaling, diseases and new drug avenues

Li, E., & van der Heyden, M. A. G. (2024) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-024-03116-5 · Cited by 10

Exploring the neuroprotective role of artesunate in mouse models of anti-NMDAR encephalitis: insights from molecular mechanisms and transmission electron microscopy

Liu, J., Huang, Y., Qian, T., Chen, J., Ding, Y., Lai, Z., Zhong, X., Lai, M., Zhang, H., Wang, Y., et al. (2024) · Cell Communication and Signaling · doi:10.1186/s12964-024-01652-4 · Cited by 10

Attenuating intervertebral disc degeneration through spermidine-delivery nanoplatform based on polydopamine for persistent regulation of oxidative stress

Wang, D., Lu, K., Zou, G., Wu, D., Cheng, Y., & Sun, Y. A. (2024) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2024.132881 · Cited by 11

Neuroforensomics: metabolites as valuable biomarkers in cerebrospinal fluid of lethal traumatic brain injuries

Bohnert, S., Reinert, C., Trella, S., Cattaneo, A., Preiß, U., Bohnert, M., Zwirner, J., Büttner, A., Schmitz, W., & Ondruschka, B. (2024) · Scientific Reports · doi:10.1038/s41598-024-64312-0 · Cited by 10

Phytonutrients in the promotion of healthspan: a new perspective

Jacquier, E. F., Kassis, A. N., Marcu, D. E., Contractor, N., Hong, J., Hu, C., Kuehn, M., Lenderink, C., & Rajgopal, A. (2024) · Frontiers in Nutrition · doi:10.3389/fnut.2024.1409339 · Cited by 12

Unraveling the meta-hallmarks between senescent and tumor cells: A new perspective for senolytic drug discovery

Liu, W., Fan, B., Fang, T., Li, H., Zhang, J., Liu, B., & Liu, Z. (2025) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2025.08.010 · Cited by 10

Diet induced the change of mtDNA copy number and metabolism in Angus cattle

Bai, Y., Carrillo, J. A., Li, Y., He, Y., & Song, J. (2020) · Journal of Animal Science and Biotechnology/Journal of animal science and biotechnology · doi:10.1186/s40104-020-00482-x · Cited by 10

Effect of spermidine on radiation-induced long-term bone marrow cell injury

Guan, B., Li, C., Yang, Y., Lu, Y., Sun, Y., Su, L., Shi, G., Bai, L., Liu, J., & Meng, A. (2022) · International Immunopharmacology · doi:10.1016/j.intimp.2022.109557 · Cited by 10

Natural Mitochondria Targeting Substances and Their Effect on Cellular Antioxidant System as a Potential Benefit in Mitochondrial Medicine for Prevention and Remediation of Mitochondrial Dysfunctions

Schniertshauer, D., Wespel, S. L., & Bergemann, J. (2023) · Current Issues in Molecular Biology · doi:10.3390/cimb45050250 · Cited by 11

Peptide fraction from B. jararaca snake venom protects against oxidative stress-induced changes in neuronal PC12 cell but not in astrocyte-like C6 cell

Santos, H. Q. P., da Silva, J. C. A., da Silva, B. R., Echeverry, M. B., & Alberto-Silva, C. (2023) · Toxicon · doi:10.1016/j.toxicon.2023.107178 · Cited by 10

Spore-Forming Lactic Acid-Producing Bacterium Bacillus coagulans Synthesizes and Excretes Spermidine into the Extracellular Space

Suzuki, H., Fujiwara, Y., Thongbhubate, K., Maeda, M., & Kanaori, K. (2023) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.3c02184 · Cited by 10

The contribution of polyamine pathway to determinations of diagnosis for treatment-resistant depression: A metabolomic analysis

You, Z., Wang, C., Lan, X., Li, W., Shang, D., Zhang, F., Ye, Y., Liu, H., Zhou, Y., & Ning, Y. (2023) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2023.110849 · Cited by 12

Enteral citrulline supplementation versus placebo on SOFA score on day 7 in mechanically ventilated critically ill patients: the IMMUNOCITRE randomized clinical trial

Tadié, J., Locher, C., Maamar, A., Reignier, J., Asfar, P., Commereuc, M., Lesouhaitier, M., Grégoire, M., Pabic, E. L., Bendavid, C., et al. (2023) · Critical Care · doi:10.1186/s13054-023-04651-y · Cited by 11

Polyamine profiling in honey bee products: A contribution to functional nutrition

Vukašinović, E. L., Kebert, M., Radišić, P., Đorđievski, S., Čelić, T. V., Pihler, I. I., Kojić, D. K., & Purać, J. S. (2023) · Journal of Food Composition and Analysis · doi:10.1016/j.jfca.2023.105856 · Cited by 10

Identification and validation of N-acetylputrescine in combination with non-canonical clinical features as a Parkinson’s disease biomarker panel

Peng, K., Klotz, A., Güven, A., Kapadnis, U., Ravipaty, S., Tolstikov, V., Vemulapalli, V., Rodrigues, L. O., Li, H., Kellogg, M. D., et al. (2024) · Scientific Reports · doi:10.1038/s41598-024-60872-3 · Cited by 10

Structural Insights into the Mechanisms Underlying Polyaminopathies

Wu, B. C., & Liu, S. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25126340 · Cited by 10

Presence of PTPN2 SNP rs1893217 Enhances the Anti-inflammatory Effect of Spermidine

Niechcial, A., Butter, M., Manz, S., Obialo, N. M., Bäbler, K., van der Lely, L., Lang, S., Gottier, C., McCole, D. F., Scharl, M. M., et al. (2020) · Inflammatory Bowel Diseases · doi:10.1093/ibd/izaa013 · Cited by 10

Discovery of fifteen new geroprotective plant extracts and identification of cellular processes they affect to prolong the chronological lifespan of budding yeast

Dakik, P., Rodriguez, M. E. L., Junio, J. A. B., Mitrofanova, D., Medkour, Y., Tafakori, T., Taifour, T., Lutchman, V., Samson, E., Arlia‐Ciommo, A., et al. (2020) · Oncotarget · doi:10.18632/oncotarget.27615 · Cited by 10

Early galactooligosaccharide intervention alters the metabolic profile, improves the antioxidant capacity of mitochondria and activates the AMPK/Nrf2 signaling pathway in suckling piglet liver

Wang, J., Tian, S., Wang, J., & Zhu, W. (2020) · Food & Function · doi:10.1039/d0fo01486a · Cited by 10

Molecular and functional characteristics of megakaryocytes and platelets in aging

Esparza, O., Higa, K. C., & Davizon‐Castillo, P. (2020) · Current Opinion in Hematology · doi:10.1097/moh.0000000000000601 · Cited by 11

A structurally unique Fusobacterium nucleatum tannase provides detoxicant activity against gallotannins and pathogen resistance

Mancheño, J. M., Atondo, E., Tomás‐Cortázar, J., Lavín, J. L., Plaza‐Vinuesa, L., Martín‐Ruiz, I., Barriales, D., Palacios, A., Navo, C. D., Sampedro, L., et al. (2020) · Microbial Biotechnology · doi:10.1111/1751-7915.13732 · Cited by 11

Understanding the partitioning of polyamines in micelles and delivery to the carrier protein: Thermodynamic approach

Tinku, Prajapati, A. K., & Choudhary, S. (2021) · Journal of Molecular Liquids · doi:10.1016/j.molliq.2021.118303 · Cited by 10

Mitochondrial Targeted Interventions for AgingPreprint

Liu, S. Z., Chiao, Y. A., Rabinovitch, P. S., & Marcinek, D. J. (2023) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a041199 · Cited by 11

Involvement of mammalian SoLute Carriers (SLC) in the traffic of polyamines

Pochini, L. (2024) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2024.1452184 · Cited by 9

The arginase-polyamine signaling axis in immune cells: Implications for immune modulation and host-pathogen interactions

Aziz, S., Ahmed, A., Singh, P., & Mukhopadhyay, S. (2025) · iScience · doi:10.1016/j.isci.2025.114363 · Cited by 10

Host‐driven hepatic conversion of gut microbiota‐derived putrescine to spermidine mediates mannose's protective effects against hepatic steatosis in zebrafish

Meng, D., Zhang, Z., Teame, T., Niemann, B. E., Xia, R., Xu, S., Zhao, Y., Yang, Y., Ran, C., Guan, L. L., et al. (2025) · iMeta · doi:10.1002/imt2.70101 · Cited by 9

Aging and Alzheimer’s: the critical role of mitochondrial dysfunction and synaptic alterations

Pinky, Wali, Z., Neha, Tiwari, P., El‐Tanani, M., Rabbani, S. A., & Parvez, S. (2026) · Frontiers in Synaptic Neuroscience · doi:10.3389/fnsyn.2025.1676317 · Cited by 11

Rapid Evaluation of Spermidine from 12 Bean Cultivars by Direct Real-Time Mass Spectrometry Analysis

Wu, T., Wu, X., Yuan, X., Wang, Y., Zhou, W., & Li, W. (2018) · Molecules · doi:10.3390/molecules23092138 · Cited by 9

Elevation of Serum Spermidine in Obese Patients: Results from a Cross-Sectional and Follow-Up Study

Gao, H., Zhang, Q., Xu, J., Yuan, W., Li, R., Guo, H., Gu, C., Feng, W., Ma, Y., Sun, Z., et al. (2022) · Nutrients · doi:10.3390/nu14132613 · Cited by 9

The impact of microbially modified metabolites associated with obesity and bariatric surgery on antitumor immunity

Wang, M., Huang, Y., Xin, M., Li, T., Wang, X., Fang, Y., Liang, S., Cai, T., Xu, X., Dong, L., et al. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1156471 · Cited by 11

Loss of temporal coherence in the circadian metabolome across multiple tissues during ageing in mice

Buijink, M. R., van Weeghel, M., Harms, A. C., Murli, D. S., Meijer, J. H., Hankemeier, T., Michel, S. H., & Kervezee, L. (2024) · European Journal of Neuroscience · doi:10.1111/ejn.16428 · Cited by 9

Modulation of Gut Microbial Biomarkers and Metabolites in Cancer Management by Tea Compounds

Leung, H. K. M., Lo, E. K. K., Zhang, F., Felicianna, Ismaiah, M. J., Chen, C., & El-Nezami, H. S. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25126348 · Cited by 9

Deep enzymatic hydrolysis of bee pollen with multiple enzymes: Improves nutrient release and potential biological activity of bee pollen

Li, K., Zhao, J., Yu, W., Qiao, Y., Shu, X., Ning, F., & Luo, L. (2024) · Food Bioscience · doi:10.1016/j.fbio.2024.105001 · Cited by 9

Improved profiling of polyamines using two-dimensional gas chromatography mass spectrometry

Yu, Z., Huang, H., Zhang, H., & Kessler, B. M. (2019) · Talanta · doi:10.1016/j.talanta.2019.02.062 · Cited by 9

Autophagic flux restoration enhances the antitumor efficacy of tumor infiltrating lymphocytes

Zhang, C., Sun, Y., Li, S., Shen, L., Teng, X., Xiao, Y., Wu, N., & Lu, Z. (2022) · Journal for ImmunoTherapy of Cancer · doi:10.1136/jitc-2022-004868 · Cited by 9

Extending the mode of action of triethylenetetramine (trientine): Autophagy besides copper chelation

Pietrocola, F., Castoldi, F., Zischka, H., & Kroemer, G. (2020) · Journal of Hepatology · doi:10.1016/j.jhep.2020.05.046 · Cited by 8

Effects of exogenous spermidine on autophagy and antioxidant capacity in ovaries and granulosa cells of Sichuan white geese

Jiang, D., Sun, Q., Jiang, Y., Zhou, X., Kang, L., Wang, Z., Wang, X., An, X., Ji, C., Ling, W., et al. (2023) · Journal of Animal Science · doi:10.1093/jas/skad301 · Cited by 8

Human AKR1C3 binds agonists of GPR84 and participates in an expanded polyamine pathway

Dudkina, N., Park, H. B., Song, D., Jain, A., Khan, S. A., Flavell, R. A., Johnson, C. H., Palm, N. W., & Crawford, J. M. (2024) · Cell chemical biology · doi:10.1016/j.chembiol.2024.07.011 · Cited by 7

Maternal supplementation spermidine during gestation improves placental angiogenesis and reproductive performance of high prolific sows

Duan, B., Ran, S., Wu, L., Dai, T., Peng, J., & Zhou, Y. (2024) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2024.109792 · Cited by 8

Spermidine Inhibits M1 Microglia Polarization in a Mouse Model of Parkinson's Disease and BV2 Cells via NF‐κB/STAT‐1 Pathway

Shu, J., Jiao, Y., Wei, W., & Yan, A. (2025) · Brain and Behavior · doi:10.1002/brb3.70410 · Cited by 8

Metabolite Profiling Under Dietary Myo-Inositol Supplementation in Laying Hens from Two High-Performing Strains

Szent‐Györgyi, A., Sommerfeld, V., Rodehutscord, M., & Huber, K. (2025) · Animals · doi:10.3390/ani15101392 · Cited by 8

Effects of alcohol on the transcriptome, methylome and metabolome of in vitro gastrulating human embryonic cells

Wallén, E., Rämö, K., Vehvilainen, J., Sokka, J., Lehtonen, M., Otonkoski, T., Trokovic, R., Auvinen, P., Kärkkäinen, O. K., & Kaminen‐Ahola, N. (2025) · Disease Models & Mechanisms · doi:10.1242/dmm.052150 · Cited by 7

Multi-strategy metabolic reprogramming of Serratia marcescens HBQA7 for high-efficiency spermidine biosynthesis via the carboxyaminopropylagmatine pathway

Gou, L., Wang, J., Liu, D., Wu, S., Zhou, X., Fan, T., & Cai, Y. (2025) · Chemical Engineering Journal · doi:10.1016/j.cej.2025.167413 · Cited by 9

Lubiprostone in chronic kidney disease: Insights into mitochondrial function and polyamines from a randomized phase 2 clinical trial

Watanabe, S., Nakayama, M., Yokoo, T., Sanada, S., Ubara, Y., Komatsuda, A., Asanuma, K., Suzuki, Y., Konta, T., Kazama, J. J., et al. (2025) · Science Advances · doi:10.1126/sciadv.adw3934 · Cited by 8

Asparaginase and Autophagy Inhibitors Effectively Remove Senescent Cells by Synergistically Limiting Asparagine Supply

Huang, Z., Liu, X., Zhou, X., Chen, K., Diao, H., Wang, M., Wei, J., Li, Z., Yang, Y., Mao, Z., et al. (2025) · Aging Cell · doi:10.1111/acel.70203 · Cited by 8

Mechanisms of spermidine-induced autophagy and geroprotection

Hofer, S. J., Simon, A. K., Bergmann, M., Eisenberg, T., Kroemer, G., & Madeo, F. (2022) · Nature Aging · doi:10.1038/s43587-022-00322-9 · Cited by 218

Geroprotective insights into the natural metabolite spermidine in aging and age-related diseases

Jiang, Z., Tong, S., Kirkland, J. L., & Sun, Y. (2026) · npj Aging · doi:10.1038/s41514-026-00448-9

Molecular targets of spermidine: implications for cancer suppression

Zimmermann, A., Hofer, S. J., & Madeo, F. (2023) · Cell Stress · doi:10.15698/cst2023.07.281 · Cited by 23

Cardioprotective benefits of dietary spermidine

Huynh, K. (2017) · Nature Reviews Cardiology · doi:10.1038/nrcardio.2016.222 · Cited by 4

Spermidine: A physiological autophagy inducer acting as an anti-aging vitamin in humans?

Madeo, F., Bauer, M. A., Carmona-Gutierrez, D., & Kroemer, G. (2019) · Autophagy · doi:10.1080/15548627.2018.1530929 · Cited by 212