Spermidine in health and disease

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Spermidine improves gut barrier integrity and gut microbiota function in diet-induced obese mice

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Meta-hallmarks of aging and cancer

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Molecular Probes, Chemosensors, and Nanosensors for Optical Detection of Biorelevant Molecules and Ions in Aqueous Media and Biofluids

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Polyamines in cancer: integrating organismal metabolism and antitumour immunity

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Spatially resolved multi-omics highlights cell-specific metabolic remodeling and interactions in gastric cancer

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Polyamines control eIF5A hypusination, TFEB translation, and autophagy to reverse B cell senescence

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ATP13A2 deficiency disrupts lysosomal polyamine export

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Mnemonic Similarity Task: A Tool for Assessing Hippocampal Integrity

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Intermittent and periodic fasting, longevity and disease

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Epigenetic changes during aging and their reprogramming potential

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Hallmarks of cardiovascular ageing

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Polyamines in Food

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Making sense of the ageing methylome

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Polyamine catabolism and oxidative damage

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Targeting Autophagy in Aging and Aging-Related Cardiovascular Diseases

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Mitophagy in Alzheimer’s Disease and Other Age-Related Neurodegenerative Diseases

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Pleiotropic effects of mitochondria in aging

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Dietary and Gut Microbiota Polyamines in Obesity- and Age-Related Diseases

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Age-Associated Mitochondrial Dysfunction Accelerates Atherogenesis

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Spermidine activates mitochondrial trifunctional protein and improves antitumor immunity in mice

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Spermidine: A physiological autophagy inducer acting as an anti-aging vitamin in humans?

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Mechanisms of spermidine-induced autophagy and geroprotection

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The multifaceted regulation of mitophagy by endogenous metabolites

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Regulating T-cell differentiation through the polyamine spermidine

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Dietary regulation in health and disease

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Hormetic Effects of Phytochemicals on Health and Longevity

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A metabolomics comparison of plant-based meat and grass-fed meat indicates large nutritional differences despite comparable Nutrition Facts panels

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Spermidine endows macrophages anti-inflammatory properties by inducing mitochondrial superoxide-dependent AMPK activation, Hif-1α upregulation and autophagy

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Protective role of spermidine in colitis and colon carcinogenesis

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Polyamines: their significance for maintaining health and contributing to diseases

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MitophAging: Mitophagy in Aging and Disease

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Mitochondrial contributions to vascular endothelial dysfunction, arterial stiffness, and cardiovascular diseases

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Polyamines and Kynurenines at the Intersection of Immune Modulation

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Cross-species metabolomic analysis identifies uridine as a potent regeneration promoting factor

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eIF5A hypusination, boosted by dietary spermidine, protects from premature brain aging and mitochondrial dysfunction

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Yeast as a tool to identify anti-aging compounds

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Autophagy in health and disease: From molecular mechanisms to therapeutic target

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Multifunctional Copper‐Phenolic Nanopills Achieve Comprehensive Polyamines Depletion to Provoke Enhanced Pyroptosis and Cuproptosis for Cancer Immunotherapy

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A metabolic profile of polyamines in parkinson disease: A promising biomarker

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The path toward using microbial metabolites as therapies

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Spermidine attenuates bleomycin-induced lung fibrosis by inducing autophagy and inhibiting endoplasmic reticulum stress (ERS)-induced cell death in mice

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New Insights into the Roles and Mechanisms of Spermidine in Aging and Age-Related Diseases

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Autophagy in T cells from aged donors is maintained by spermidine and correlates with function and vaccine responses

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The road ahead for health and lifespan interventions

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Spermine Alleviates Acute Liver Injury by Inhibiting Liver-Resident Macrophage Pro-Inflammatory Response Through ATG5-Dependent Autophagy

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Carbotoxicity—Noxious Effects of Carbohydrates

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CD4+ T-cell differentiation and function: Unifying glycolysis, fatty acid oxidation, polyamines NAD mitochondria

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Spermidine reduces neuroinflammation and soluble amyloid beta in an Alzheimer’s disease mouse model

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Spermine synthase and MYC cooperate to maintain colorectal cancer cell survival by repressing Bim expression

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Spermidine alleviates cardiac aging by improving mitochondrial biogenesis and function

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Nutritional Aspects of Spermidine

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Effects of anti-aging interventions on intestinal microbiota

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