The commensal microbiome is associated with anti-PD-1 efficacy in metastatic melanoma patients

Matson, Vyara, Fessler, Jessica, Bao, Riyue, Chongsuwat, Tara, Zha, Yuanyuan, Alegre, Maria-Luisa, Luke, Jason J., Gajewski, Thomas F.·2018·Science

DOI 10.1126/science.aao3290

Cited by (3,140)

Items 201–300 of 3,140

The cancer microbiome
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Gut microbiota and metabolites associate with outcomes of immune checkpoint inhibitor–treated unresectable hepatocellular carcinoma
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Dysregulation of ILC3s unleashes progression and immunotherapy resistance in colon cancer
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Targeting the RNA m6A modification for cancer immunotherapy
Xinxin Li, Shoubao Ma, Youcai Deng, Ping Yi, Jianhua Yu · 2022 · Molecular Cancer
Melanoma models for the next generation of therapies
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Breelyn Ann Wilky · 2019 · Immunological Reviews
Cancer immunotherapy: it’s time to better predict patients’ response
Charlotte Pilard, Marie Ancion, Philippe Delvenne, Guy Jérusalem, Pascale Hubert, Michael F. Herfs · 2021 · British Journal of Cancer
Gut Microbiome–Brain Alliance: A Landscape View into Mental and Gastrointestinal Health and Disorders
Janet M. Sasso, Ramy M. Ammar, Rumiana Tenchov, Steven A. Lemmel, Olaf Kelber, Malte Grieswelle, Qiongqiong Angela Zhou · 2023 · ACS Chemical Neuroscience
Immune-based therapies for hepatocellular carcinoma
David James Pinato, Nadia Guerra, Petros Fessas, Ravindhi Murphy, Takashi Mineo, Francesco Angelo Mauri, Sujit K. Mukherjee, Mark R. Thursz, Ching Ngar Wong, Rohini Sharma et al. · 2020 · Oncogene
Pathobiont release from dysbiotic gut microbiota biofilms in intestinal inflammatory diseases: a role for iron?
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Gut Microbiome Components Predict Response to Neoadjuvant Chemoradiotherapy in Patients with Locally Advanced Rectal Cancer: A Prospective, Longitudinal Study
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Immune Checkpoint Inhibitors in Triple Negative Breast Cancer Treatment: Promising Future Prospects
Remy Thomas, Ghaneya Al‐Khadairi, Julie V. Decock · 2021 · Frontiers in Oncology
Cumulative Antibiotic Use Significantly Decreases Efficacy of Checkpoint Inhibitors in Patients with Advanced Cancer
Tinsley, Nadina, Zhou, Cong, Tan, Grace, Rack, Samuel, Lorigan, Paul, Blackhall, Fiona, Krebs, Matthew, Carter, Louise, Thistlethwaite, Fiona, Graham, Donna et al. · 2020 · The Oncologist
Fecal microbiota transplantation improves anti-PD-1 inhibitor efficacy in unresectable or metastatic solid cancers refractory to anti-PD-1 inhibitor
Yunjae Kim, Gihyeon Kim, Sujeong Kim, Beomki Cho, Sang‐Yeob Kim, Eunju Do, Dong‐Jun Bae, Seungil Kim, Mi‐Na Kweon, Joon Seon Song et al. · 2024 · Cell Host & Microbe
The Use of Immune Checkpoint Inhibitors in Oncology and the Occurrence of AKI: Where Do We Stand?
Rossana Franzin, Giuseppe Stefano Netti, Federica Spadaccino, Camillo Porta, Loreto Gesualdo, Giovanni Stallone, Giuseppe Castellano, Elena Ranieri · 2020 · Frontiers in Immunology
Exploiting bacteria for cancer immunotherapy
Seong Young Kwon, Hien Thi-Thu Ngo, Jinbae Son, Yeongjin Hong, Jung-Joon Min · 2024 · Nature Reviews Clinical Oncology
Existing and Emerging Biomarkers for Immune Checkpoint Immunotherapy in Solid Tumors
Sanjeevani Arora, Rodion A. Velichinskii, Randy W. Lesh, Usman Ali, Michal Jakub Kubiak, Pranshu Bansal, Hossein Borghaei, Martin Joseph Edelman, Yanis Boumber · 2019 · Advances in Therapy
Effects of Intestinal Microbial–Elaborated Butyrate on Oncogenic Signaling Pathways
Jiezhong Chen, Kong‐Nan Zhao, Luis Vitetta · 2019 · Nutrients
Stool Microbiome Profiling of Patients with Metastatic Renal Cell Carcinoma Receiving Anti–PD-1 Immune Checkpoint Inhibitors
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Chronic obstructive pulmonary disease (COPD) and lung cancer: common pathways for pathogenesis
Brielle A. Parris, Hannah E. O’Farrell, Kwun Meng Fong, Ian A. Yang · 2019 · Journal of Thoracic Disease
Commensal Clostridiales strains mediate effective anti-cancer immune response against solid tumors
Ana Montalban‐Arques, Egle Katkeviciutė, Philipp Busenhart, Anna Bircher, Jakob Wirbel, Georg Zeller, Yasser Morsy, Lubor Borsig, Jesus Francisco Glaus Garzon, Anne Mueller et al. · 2021 · Cell Host & Microbe
Effect of probiotics and gut microbiota on anti-cancer drugs: Mechanistic perspectives
Aja Badgeley, Hina Anwar, Karan Modi, Paige Murphy, Ashakumary Lakshmikuttyamma · 2020 · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer
Trapping of Lipopolysaccharide to Promote Immunotherapy against Colorectal Cancer and Attenuate Liver Metastasis
Wantong Song, Karthik Tiruthani, Ying Wang, Limei Shen, Mengying Hu, Oleksandra Dorosheva, Kunyu Qiu, Karina Kinghorn, Rihe Liu, Leaf Huang · 2018 · Advanced Materials
Fusobacterium nucleatum and cancer
Tamar Alon‐Maimon, Ofer Mandelboim, Gilad Bachrach · 2022 · Periodontology 2000
Future prospects of immune checkpoint blockade in cancer: from response prediction to overcoming resistance
Young‐Jun Park, Da‐Sol Kuen, Yeonseok Chung · 2018 · Experimental & Molecular Medicine
Study and analysis of antitumor resistance mechanism of PD1/PD‐L1 immune checkpoint blocker
Zhengyi Wang, Xiaoying Wu · 2020 · Cancer Medicine
Predictive biomarkers of response for immune checkpoint inhibitors in non–small-cell lung cancer
Arsela Prelaj, Rebecca Yin Tay, Roberto Ferrara, Nathalie Chaput, Benjamin Besse, Raffaele Califano · 2018 · European Journal of Cancer
Gut Microbiota Shapes the Efficiency of Cancer Therapy
Weidong Ma, Qixing Mao, Wenjie Xia, Gaochao Dong, Changhua Yu, Feng Jiang · 2019 · Frontiers in Microbiology
Prebiotic-Induced Anti-tumor Immunity Attenuates Tumor Growth
Li, Yan, Elmén, Lisa, Segota, Igor, Xian, Yibo, Tinoco, Roberto, Feng, Yongmei, Fujita, Yu, Segura Muñoz, Rafael R., Schmaltz, Robert, Bradley, Linda M. et al. · 2020 · Cell Reports
Resistance mechanisms to immune checkpoint inhibitors: updated insights
Besan H. Al-Saafeen, Bassam R. Ali, Eyad Elkord · 2025 · Molecular Cancer
Meta-analysis of the gut microbiota in predicting response to cancer immunotherapy in metastatic melanoma
Limeta, Angelo, Ji, Boyang, Levin, Max, Gatto, Francesco, Nielsen, Jens · 2020 · JCI Insight
Targeting PD-L2–RGMb overcomes microbiome-related immunotherapy resistance
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The microbiome and cancer
Goodman, Brian, Gardner, Humphrey · 2018 · The Journal of Pathology
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Gut Microbiota Condition the Therapeutic Efficacy of Trastuzumab in HER2-Positive Breast Cancer
Di Modica, Martina, Gargari, Giorgio, Regondi, Viola, Bonizzi, Arianna, Arioli, Stefania, Belmonte, Beatrice, De Cecco, Loris, Fasano, Elena, Bianchi, Francesca, Bertolotti, Alessia et al. · 2021 · Cancer Research
Role of the Gut–Liver Axis in Liver Inflammation, Fibrosis, and Cancer: A Special Focus on the Gut Microbiota Relationship
Ohtani, Naoko, Kawada, Norifumi · 2019 · Hepatology Communications
Current issues and perspectives in PD-1 blockade cancer immunotherapy
Kenji Chamoto, Ryusuke Hatae, Tasuku Honjo · 2020 · International Journal of Clinical Oncology
New Insights Into the Cancer–Microbiome–Immune Axis: Decrypting a Decade of Discoveries
Tejeshwar Jain, Prateek Sharma, Abhi C. Are, Selwyn Maurice Vickers, Vikas Dudeja · 2021 · Frontiers in Immunology
Commensal bacteria stimulate antitumor responses via T cell cross-reactivity
Catherine Ami Bessell, Ariel Isser, Jonathan J. Havel, Sangyun Lee, David R. Bell, John W. Hickey, Worarat Chaisawangwong, Joan Glick Bieler, Raghvendra Mohan Srivastava, Fengshen Kuo et al. · 2020 · JCI Insight
Gut microbiome modulates efficacy of immune checkpoint inhibitors
Yi, Ming, Yu, Shengnan, Qin, Shuang, Liu, Qian, Xu, Hanxiao, Zhao, Weiheng, Chu, Qian, Wu, Kongming · 2018 · Journal of Hematology & Oncology
The Microbiome and Genitourinary Cancer: A Collaborative Review
Mark Christopher Markowski, Stephen Anthony Boorjian, Jeremy P. Burton, Noah M. Hahn, Molly A. Ingersoll, Saman Maleki Vareki, Sumanta Kumar Pal, Karen Sandell Sfanos · 2019 · European Urology
Akkermansia muciniphila and Faecalibacterium prausnitzii in Immune-Related Diseases
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Critical role of the gut microbiota in immune responses and cancer immunotherapy
Zehua Li, Weixi Xiong, Liang Wei Zhu, Jinyu Wang, Ziyi Zeng, Damian Kołat, Xi Li, Dong Zhou, Xuewen Xu, Lin-Yong Zhao · 2024 · Journal of Hematology & Oncology
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Gut Microbiome Influences the Efficacy of PD-1 Antibody Immunotherapy on MSS-Type Colorectal Cancer via Metabolic Pathway
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Intestinal microbiota influences clinical outcome and side effects of early breast cancer treatment
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Host mitochondria influence gut microbiome diversity: A role for ROS
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NSCLC Immunotherapy Efficacy and Antibiotic Use: A Systematic Review and Meta-Analysis
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Irradiation at Ultra-High (FLASH) Dose Rates Reduces Acute Normal Tissue Toxicity in the Mouse Gastrointestinal System
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Genomic diversity and ecology of human-associated Akkermansia species in the gut microbiome revealed by extensive metagenomic assembly
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Gut microbiota influence tumor development and Alter interactions with the human immune system
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Gut microbiota: A new insight into lung diseases
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The microbiome and the hallmarks of cancer
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Impact of Different Types of Diet on Gut Microbiota Profiles and Cancer Prevention and Treatment
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Fecal Microbiota Transplantation as New Therapeutic Avenue for Human Diseases
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Towards modulating the gut microbiota to enhance the efficacy of immune-checkpoint inhibitors
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Longitudinal gut microbiome changes in immune checkpoint blockade-treated advanced melanoma
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Cancer Immunotherapy: Beyond Checkpoint Blockade
Michael Lawrence Dougan, Glenn Dranoff, Stephanie K. Dougan · 2018 · Annual Review of Cancer Biology
Gut microbiota shapes cancer immunotherapy responses
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