Natural selection interacts with recombination to shape the evolution of hybrid genomes
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Abstract
Selection, recombination, and hybrid evolution: Hybridization is an important force in evolution. The effects of hybridization across the whole genome are not understood. Using a fine-scale genetic map, Schumer et al. examined local ancestry in replicate natural hybrid populations of swordtail fish. Each parental species contributes different proportions of genetic material to the genomes of their descendants. Genes from the “minor” (less well-represented) parent occur in regions of the genome that are subject to higher recombination rates and where there are fewer potentially deleterious genes. Neanderthal ancestry in human genomes shows similar patterns. Science , this issue p. 656
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Non-deleterious archaic variants were more likely to be retained in the human gene pool when they could be uncoupled from deleterious archaic variants by recombination.
“Taken together, these observations indicate that non-deleterious archaic variants were more likely to be retained in the human gene pool when they could be uncoupled from deleterious archaic variants by recombination 25 .”
From The nature of Neanderthal introgression revealed by 27,566 Icelandic genomes (2020) · cites this paper as [25]
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Selection against archaic hominin genetic variation in regulatory regions
Telis, N., Aguilar, R., & Harris, K. (2020) · Nature Ecology & Evolution · doi:10.1038/s41559-020-01284-0 · Cited by 51 · see citing works
Zhang, X., Kim, B., Singh, A., Sankararaman, S., Durvasula, A., & Lohmueller, K. E. (2023) · Molecular Biology and Evolution · doi:10.1093/molbev/msad001 · Cited by 29 · see citing works
Self-citationOwens, G. L., Todesco, M., Bercovich, N., Légaré, J., Mitchell, N., Whitney, K. D., & Rieseberg, L. H. (2021) · Molecular Ecology · doi:10.1111/mec.16008 · Cited by 20 · see citing works
- Authors
- Schumer, M., Xu, C., Powell, D. L., Durvasula, A., Skov, L., Holland, C., Blazier, J. C., Sankararaman, S., Andolfatto, P., Rosenthal, G. G., & Przeworski, M.
- Affiliations
- Howard Hughes Medical Institute (US)
- University of California, Berkeley (US)
- Centro de Investigaciones Cientifícas de las Huastecas 'Aguazarca' (MX)
- University of California, Los Angeles (US)
- Aarhus University (DK)
- Texas A&M University (US)
- Princeton University (US)
- Columbia University (US)
- Corresponding author
- Schumer, Molly
- Andolfatto, Peter
- Rosenthal, Gil G.
- Przeworski, Molly
- ORCID
- Venue
- Science
- Published
- 2018-05-11
- Volume
- 360
- Issue
- 6389
- Pages
- 656-660
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- PMC
- PMC6069607
- OpenAlex
- W2802885717
- Cited by
- 412
- References
- 91
- Citations by year
- 2026: 43 · 2025: 41 · 2024: 66 · 2023: 43 · 2022: 47 · 2021: 50 · 2020: 56 · 2019: 44 · 2018: 20
- FWCI
- 26.07
- Type
- journal article
- Language
- en
- Open access
- green
- doi.org
- Locations
- Science (publishedVersion)
- bioRxiv (Cold Spring Harbor Laboratory) (acceptedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Padua Research Archive (University of Padova) (submittedVersion)
- Funders
- National Science Foundation (DEB-1405232)
- National Institutes of Health (R01 GM83098)
- Howard Hughes Medical Institute (Hanna H. Gray)
- Harvard University (Milton Fund)
- Cancer Prevention Research Institute of Texas
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Evolution and Genetic Dynamics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic diversity and population structure
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Chromosomal and Genetic Variations
- Keywords
- hybridization, hybrid genomes, recombination, natural selection, swordtail fish, hybrid populations, ancestry inference, epistasis, deleterious alleles, hybrid incompatibility
- MeSH terms
- Alleles, Animals, Chimera, Epistasis, Genetic, Fishes, Hybridization, Genetic, Recombination, Genetic, Selection, Genetic, Evolution, Molecular
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