Coupled ripple oscillations between the medial temporal lobe and neocortex retrieve human memory
Open accessAbstract
Coupled ripples in memory: Short-lived, high-frequency oscillations in the brain called ripples have been implicated as substrates for memory formation. There is, however, little evidence linking ripple activity with awake memory retrieval in humans. Vaz et al. analyzed intracranial recordings in human subjects (see the Perspective by Gelinas). They found that ripple oscillations in the brain's medial temporal lobe were coupled with ripple oscillations in the temporal cortex. This coupling was enhanced just before successful memory retrieval. During successful retrievals with ripples, patterns of oscillations were recapitulated across multiple electrodes, consistent with the initial encoding. The observation that ripple oscillations occur before successful memory retrieval suggests that they may play a mechanistic role in the retrieval process. Science , this issue p. 975 ; see also p. 927
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Retrieval of human memories involves coupled ripple oscillations in the EEG between the medial temporal lobe and the neocortex.
“Even more remarkably, a recent study has demonstrated that retrieval of human memories involved coupled ripple oscillations in the EEG between the medial temporal lobe and the neocortex (Vaz et al., 2019).”
From Consciousness: Matter or EMF? (2023) · cites this paper as Vaz et al., 2019
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Cites
Nonparametric statistical testing of EEG- and MEG-data
Maris, E., & Oostenveld, R. (2007) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2007.03.024 · Cited by 8,496 · see citing works
LOSS OF RECENT MEMORY AFTER BILATERAL HIPPOCAMPAL LESIONS
Scoville, W. B., & Milner, B. (1957) · Journal of Neurology, Neurosurgery & Psychiatry · doi:10.1136/jnnp.20.1.11 · Cited by 7,322 · see citing works
Resting-State Functional Connectivity Reflects Structural Connectivity in the Default Mode Network
Greicius, M. D., Supekar, K., Menon, V., & Dougherty, R. F. (2009) · Cerebral Cortex · doi:10.1093/cercor/bhn059 · Cited by 2,175 · see citing works
Reverse replay of behavioural sequences in hippocampal place cells during the awake state
Foster, D. J., & Wilson, M. A. (2006) · Nature · doi:10.1038/nature04587 · Cited by 1,727 · see citing works
Two-stage model of memory trace formation: A role for “noisy” brain states
Buzsáki, G. (1989) · Neuroscience · doi:10.1016/0306-4522(89)90423-5 · Cited by 1,709 · see citing works
Selective suppression of hippocampal ripples impairs spatial memory
Girardeau, G., Benchenane, K., Wiener, S. I., Buzsáki, G., & Zugaro, M. B. (2009) · Nature Neuroscience · doi:10.1038/nn.2384 · Cited by 1,560 · see citing works
Forward and reverse hippocampal place-cell sequences during ripples
Diba, K., & Buzsáki, G. (2007) · Nature Neuroscience · doi:10.1038/nn1961 · Cited by 1,205 · see citing works
Hippocampal replay in the awake state: a potential substrate for memory consolidation and retrieval
Carr, M. F., Jadhav, S. P., & Frank, L. M. (2011) · Nature Neuroscience · doi:10.1038/nn.2732 · Cited by 958 · see citing works
Communication between neocortex and hippocampus during sleep in rodents
Sirota, A., Csicsvari, J., Buhl, D., & Buzsáki, G. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0437938100 · Cited by 930 · see citing works
Awake hippocampal sharp-wave ripples support spatial memory
Jadhav, S. P., Kemere, C., German, P. W., & Frank, L. M. (2012) · Science · doi:10.1126/science.1217230 · Cited by 924 · see citing works
Staresina, B. P., Bergmann, T. O., Bonnefond, M., van der Meij, R., Jensen, O., Deuker, L., Elger, C. E., Axmacher, N., & Fell, J. (2015) · Nature Neuroscience · doi:10.1038/nn.4119 · Cited by 831 · see citing works
Attention modulates synchronized neuronal firing in primate somatosensory cortex
Steinmetz, P. N., Roy, A., Fitzgerald, P. J., Hsiao, S. S., Johnson, K. O., & Niebur, E. (2000) · Nature · doi:10.1038/35004588 · Cited by 725 · see citing works
Coincident but Distinct Messages of Midbrain Dopamine and Striatal Tonically Active Neurons
Morris, G., Arkadir, D., Nevet, A., Vaadia, E., & Bergman, H. (2004) · Neuron · doi:10.1016/j.neuron.2004.06.012 · Cited by 574 · see citing works
On the Integration of Space, Time, and Memory
Eichenbaum, H. (2017) · Neuron · doi:10.1016/j.neuron.2017.06.036 · Cited by 512 · see citing works
Kahn, I., Andrews‐Hanna, J. R., Vincent, J. L., Snyder, A. Z., & Buckner, R. L. (2008) · Journal of Neurophysiology · doi:10.1152/jn.00077.2008 · Cited by 490 · see citing works
Gradual changes in hippocampal activity support remembering the order of events
Manns, J. R., Howard, M. W., & Eichenbaum, H. (2007) · Neuron · doi:10.1016/j.neuron.2007.08.017 · Cited by 397 · see citing works
High‐frequency oscillations: The state of clinical research
Frauscher, B., Bartoloméi, F., Kobayashi, K., Cimbálník, J., Klooster, M. A. V. ’., Rampp, S., Otsubo, H., Höller, Y., Wu, J. Y., Asano, E., et al. (2017) · Epilepsia · doi:10.1111/epi.13829 · Cited by 396 · see citing works
Ripples in the medial temporal lobe are relevant for human memory consolidation
Axmacher, N., Elger, C. E., & Fell, J. (2008) · Brain · doi:10.1093/brain/awn103 · Cited by 372 · see citing works
Neural Activity in Human Hippocampal Formation Reveals the Spatial Context of Retrieved Memories
Miller, J. F., Neufang, M., Solway, A., Brandt, A., Trippel, M., Mader, I., Hefft, S., Merkow, M. B., Polyn, S. M., Jacobs, J., et al. (2013) · Science · doi:10.1126/science.1244056 · Cited by 370 · see citing works
Learning-enhanced coupling between ripple oscillations in association cortices and hippocampus
Khodagholy, D., Gelinas, J. N., & Buzsáki, G. (2017) · Science · doi:10.1126/science.aan6203 · Cited by 357 · see citing works
Frequency-specific network connectivity increases underlie accurate spatiotemporal memory retrieval
Watrous, A. J., Tandon, N., Conner, C. R., Pieters, T., & Ekstrom, A. D. (2013) · Nature Neuroscience · doi:10.1038/nn.3315 · Cited by 296 · see citing works
Ward, A. M., Schultz, A. P., Huijbers, W., Dijk, K. R. A. V., Hedden, T., & Sperling, R. A. (2013) · Human Brain Mapping · doi:10.1002/hbm.22234 · Cited by 271 · see citing works
Recollection and the Reinstatement of Encoding-Related Cortical Activity
Johnson, J. D., & Rugg, M. D. (2007) · Cerebral Cortex · doi:10.1093/cercor/bhl156 · Cited by 261 · see citing works
Memory Consolidation by Replay of Stimulus-Specific Neural Activity
Deuker, L., Olligs, J., Fell, J., Kranz, T. A., Mormann, F., Montag, C., Reuter, M., Elger, C. E., & Axmacher, N. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.0414-13.2013 · Cited by 260 · see citing works
Jadhav, S. P., Rothschild, G., Roumis, D. K., & Frank, L. M. (2016) · Neuron · doi:10.1016/j.neuron.2016.02.010 · Cited by 250 · see citing works
Ripple classification helps to localize the seizure‐onset zone in neocortical epilepsy
Wang, S., Wang, I. Z., Bulacio, J. C., et al. (2012) · Epilepsia · doi:10.1111/j.1528-1167.2012.03721.x · Cited by 236 · see citing works
Sharp wave ripples during learning stabilize the hippocampal spatial map
Roux, L., Hu, B., Eichler, R., Stark, E., & Buzsáki, G. (2017) · Nature Neuroscience · doi:10.1038/nn.4543 · Cited by 229 · see citing works
Episodic reinstatement in the medial temporal lobe
Staresina, B. P., Henson, R. N. A., Kriegeskorte, N., & Alink, A. (2012) · The Journal of Neuroscience · doi:10.1523/jneurosci.4156-12.2012 · Cited by 228 · see citing works
The Medial Temporal-Lobe Amnesic Syndrome
Milner, B. A. (2005) · Psychiatric Clinics of North America · doi:10.1016/j.psc.2005.06.002 · Cited by 187 · see citing works
Yaffe, R. B., Kerr, M. S. D., Damera, S. R., Sarma, S. V., Inati, S. K., & Zaghloul, K. A. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1417017112 · Cited by 144 · see citing works
Self-citationManifestation of ocular-muscle EMG contamination in human intracranial recordings
Kovach, C. K., Tsuchiya, N., Kawasaki, H., Oya, H., Howard, M. A., & Adolphs, R. (2010) · NeuroImage · doi:10.1016/j.neuroimage.2010.08.002 · Cited by 122 · see citing works
Sharp-Wave Ripples in Primates Are Enhanced near Remembered Visual Objects.
Leonard, T. K., & Hoffman, K. (2017) · Current Biology · doi:10.1016/j.cub.2016.11.027 · Cited by 61 · see citing works
Jang, A. I., Wittig, J. H., Inati, S. K., et al. (2017) · Current Biology · doi:10.1016/j.cub.2017.05.014 · Cited by 59 · see citing works
Self-citationVaz, A. P., Yaffe, R. B., Wittig, J. H., Inati, S. K., & Zaghloul, K. A. (2017) · NeuroImage · doi:10.1016/j.neuroimage.2017.01.001 · Cited by 56 · see citing works
Self-citationSurface based electrode localization and standardized regions of interest for intracranial EEG
Trotta, M., Cocjin, J. B., Whitehead, E., Damera, S. R., Wittig, J. H., Saad, Z. S., Inati, S. K., & Zaghloul, K. A. (2017) · Human Brain Mapping · doi:10.1002/hbm.23876 · Cited by 35 · see citing works
Self-citation
Flagged first, then by citations
Cited by
Sorted by citations
Mechanisms of systems memory consolidation during sleep
Klinzing, J. G., Niethard, N., & Born, J. (2019) · Nature Neuroscience · doi:10.1038/s41593-019-0467-3 · Cited by 1,176 · see citing works
Brain–machine interfaces from motor to mood
Shanechi, M. M. (2019) · Nature Neuroscience · doi:10.1038/s41593-019-0488-y · Cited by 263 · see citing works
Hippocampal sharp-wave ripples linked to visual episodic recollection in humans
Norman, Y., Yeagle, E. M., Khuvis, S., Harel, M., Mehta, A. D., & Malach, R. (2019) · Science · doi:10.1126/science.aax1030 · Cited by 270 · see citing works
Bidirectional prefrontal-hippocampal dynamics organize information transfer during sleep in humans
Helfrich, R. F., Lendner, J. D., Mander, B. A., Guillen, H., Paff, M., Mnatsakanyan, L., Vadera, S., Walker, M. P., Lin, J. J., & Knight, R. T. (2019) · Nature Communications · doi:10.1038/s41467-019-11444-x · Cited by 222 · see citing works
Shin, J. D., Tang, W., & Jadhav, S. P. (2019) · Neuron · doi:10.1016/j.neuron.2019.09.012 · Cited by 199 · see citing works
Gilboa, A., & Moscovitch, M. (2021) · Neuron · doi:10.1016/j.neuron.2021.04.025 · Cited by 174 · see citing works
Memory and Sleep: How Sleep Cognition Can Change the Waking Mind for the Better
Paller, K. A., Creery, J. D., & Schechtman, E. (2021) · Annual Review of Psychology · doi:10.1146/annurev-psych-010419-050815 · Cited by 150 · see citing works
Slow oscillation-spindle coupling predicts enhanced memory formation from childhood to adolescence
Hahn, M. A., Heib, D., Schabus, M., Hoedlmoser, K., & Helfrich, R. F. (2020) · eLife · doi:10.7554/elife.53730 · Cited by 140 · see citing works
Hippocampo-cortical circuits for selective memory encoding, routing, and replay
Harvey, R. E., Robinson, H. L., Liu, C., Oliva, A., & Fernandez-Ruiz, A. (2023) · Neuron · doi:10.1016/j.neuron.2023.04.015 · Cited by 101 · see citing works
A mechanism for learning with sleep spindles
Peyrache, A., & Seibt, J. (2020) · Philosophical Transactions of the Royal Society B: Biological Sciences · doi:10.1098/rstb.2019.0230 · Cited by 89 · see citing works
Widespread ripples synchronize human cortical activity during sleep, waking, and memory recall
Dickey, C. W., Verzhbinsky, I. A., Jiang, X., Rosen, B. Q., Kajfez, S., Stedelin, B., Shih, J. J., Ben-Haim, S., Raslan, A. M., Eskandar, E. N., et al. (2022) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2107797119 · Cited by 87 · see citing works
Mental navigation and the neural mechanisms of insight
Aru, J., Drüke, M., Pikamäe, J., & Larkum, M. E. (2023) · Trends in Neurosciences · doi:10.1016/j.tins.2022.11.002 · Cited by 38 · see citing works
McFadden, J. (2023) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2022.1024934 · Cited by 27 · see citing works
“Even more remarkably, a recent study has demonstrated that retrieval of human memories involved coupled ripple oscillations in the EEG between the medial temporal lobe and the neocortex (Vaz et al., 2019).”
Background
- Authors
- Vaz, A. P., Inati, S. K., Brunel, N., & Zaghloul, K. A.
- Affiliations
- National Institutes of Health (US)
- Duke University (US)
- Corresponding author
- Zaghloul, Kareem A.
- Venue
- Science
- Published
- 2019-03
- Volume
- 363
- Issue
- 6430
- Pages
- 975-978
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- PMC
- PMC6478623
- OpenAlex
- W2915880198
- Cited by
- 267
- References
- 35
- Citations by year
- 2026: 29 · 2025: 35 · 2024: 40 · 2023: 36 · 2022: 37 · 2021: 39 · 2020: 30 · 2019: 20
- FWCI
- 18.31
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Archivio istituzionale della Ricerca - Bocconi (submittedVersion)
- Funders
- National Institute of General Medical Sciences (T32 GM007171)
- National Institute of Neurological Disorders and Stroke (Intramural Funding)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory Processes and Influences
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Keywords
- ripple oscillations, episodic memory retrieval, medial temporal lobe, temporal association cortex, neocortex, verbal memory, intracranial EEG
- MeSH terms
- Drug Resistant Epilepsy, Electrocorticography, Memory and Learning Tests, Adult, Brain Mapping, Electrodes, Female, Humans, Male, Mental Recall, Temporal Lobe, Neocortex, Memory, Episodic
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