Cited by 267Memory and Neural MechanismsMemory Processes and InfluencesNeural dynamics and brain function

Coupled ripple oscillations between the medial temporal lobe and neocortex retrieve human memory

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Vaz, Alex P., Inati, Sara K., Brunel, Nicolas, Zaghloul, Kareem A.·2019·Science

Abstract

Coupled ripples in memory: Short-lived, high-frequency oscillations in the brain called ripples have been implicated as substrates for memory formation. There is, however, little evidence linking ripple activity with awake memory retrieval in humans. Vaz et al. analyzed intracranial recordings in human subjects (see the Perspective by Gelinas). They found that ripple oscillations in the brain's medial temporal lobe were coupled with ripple oscillations in the temporal cortex. This coupling was enhanced just before successful memory retrieval. During successful retrievals with ripples, patterns of oscillations were recapitulated across multiple electrodes, consistent with the initial encoding. The observation that ripple oscillations occur before successful memory retrieval suggests that they may play a mechanistic role in the retrieval process. Science , this issue p. 975 ; see also p. 927

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  • Retrieval of human memories involves coupled ripple oscillations in the EEG between the medial temporal lobe and the neocortex.

    “Even more remarkably, a recent study has demonstrated that retrieval of human memories involved coupled ripple oscillations in the EEG between the medial temporal lobe and the neocortex (Vaz et al., 2019).”

    From Consciousness: Matter or EMF? (2023) · cites this paper as Vaz et al., 2019

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Authors
Vaz, A. P., Inati, S. K., Brunel, N., & Zaghloul, K. A.
Affiliations
  • National Institutes of Health (US)
  • Duke University (US)
Corresponding author
Zaghloul, Kareem A.
Venue
Science
Published
2019-03
Volume
363
Issue
6430
Pages
975-978
ISSN
  • 0036-8075 (ISSN-L)
  • 1095-9203
OpenAlex
W2915880198
Cited by
267
References
35
Citations by year
2026: 29 · 2025: 35 · 2024: 40 · 2023: 36 · 2022: 37 · 2021: 39 · 2020: 30 · 2019: 20
FWCI
18.31
Type
journal article
Language
en
Open access
Locations
  • Science (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
  • Archivio istituzionale della Ricerca - Bocconi (submittedVersion)
Funders
  • National Institute of General Medical Sciences (T32 GM007171)
  • National Institute of Neurological Disorders and Stroke (Intramural Funding)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory Processes and Influences
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
Keywords
ripple oscillations, episodic memory retrieval, medial temporal lobe, temporal association cortex, neocortex, verbal memory, intracranial EEG
MeSH terms
Drug Resistant Epilepsy, Electrocorticography, Memory and Learning Tests, Adult, Brain Mapping, Electrodes, Female, Humans, Male, Mental Recall, Temporal Lobe, Neocortex, Memory, Episodic

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