The two tales of hippocampal sharp-wave ripple content: The rigid and the plastic
Open accessAbstract
Sharp-wave ripples, prominently in the CA1 region of the hippocampus, are short oscillatory events accompanied by bursts of neural firing. Ripples and associated hippocampal place cell sequences communicate with cortical ensembles during slow-wave sleep, which has been shown to be critical for systems consolidation of episodic memories. This consolidation is not limited to a newly formed memory trace; instead, ripples appear to reactivate and consolidate memories spanning various experiences. Despite this broad spanning influence, ripples remain capable of producing precise memories. The underlying mechanisms that enable ripples to consolidate memories broadly and with specificity across experiences remain unknown. In this review, we discuss data that uncovers circuit-level processes that generate ripples and influence their characteristics during consolidation. Based on current knowledge, we propose that memory emerges from the integration of two parallel consolidation pathways in CA1: the rigid and plastic pathways. The rigid pathway generates ripples stochastically, providing a backbone upon which dynamic plastic pathway inputs carrying novel information are integrated.
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A large repertoire of ripple sequences pre-exists encounters with new environments.
“the discovery of a large repertoire of ripple sequences that pre-exist encounters with new environments263”
From Consciousness and sleep (2024) · cites this paper as [263]
In “Integration of rigid and plastic pathways,” the review says ripples can preplay sequences not yet experienced and cites an estimate of at least 15 preplay motifs. It says a large repertoire of CA1 pre-configurations is implied by a recent study, but also notes controversy over preplay. Calling the large repertoire a discovery states more certainty than the source does. (LLM, conf=0.83)
Experimental — accuracy not yet measuredRipple sequences undergo differential amplification during encounters with new environments.
“undergo differential amplification during those encounters”
From Consciousness and sleep (2024) · cites this paper as [263]
The Integration of rigid and plastic pathways section (page unavailable) says preplay sequences recruit fewer CA1 neurons than post-learning replays, and the Conclusions (page unavailable) propose that novel experiences strengthen connectivity and add information to existing ripple motifs. These passages support experience-related changes in ripple content, but do not establish that ripple sequences undergo differential amplification during encounters with new environments. (LLM, conf=0.79)
Experimental — accuracy not yet measured
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Median Raphe Nonserotonergic Neurons Modulate Hippocampal Theta Oscillations
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Self-citationPatel, J. (2015) · Journal of Neuroscience · doi:10.1523/jneurosci.4215-14.2015 · Cited by 5 · see citing works
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Emerging many-to-one weighted mapping in hippocampus-amygdala network underlies memory formationPreprint
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Self-citationEmerging many-to-one weighted mapping in hippocampus-amygdala network underlies memory formationPreprint
Wang, D. V., Liu, J., & Hall, A. (2023) · Research Square · doi:10.21203/rs.3.rs-3232225/v1
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A cortical–hippocampal communication undergoes rebalancing after new learningPreprint
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Hall, A. F., & Wang, D. V. (2025) · eLife · doi:10.7554/elife.107370.1
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A cortical–hippocampal communication undergoes rebalancing after new learningPreprint
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Self-citationMiliou, A., Giannakopoulou, P., Erda, A., Tsiokou, I.-A., Mavriki, E.-D., Tsotsokou, G., Sotiropoulou, I.-M., & Papatheodoropoulos, C. (2026) · Receptors · doi:10.3390/receptors5030030
- Authors
- Hall, A. F., & Wang, D. V.
- Affiliations
- Drexel University (US)
- Corresponding author
- Wang, Dong V.
- Venue
- Progress in Neurobiology
- Publisher
- Elsevier BV
- Published
- 2023-02
- Volume
- 221
- Pages
- 102396
- ISSN
- 0301-0082 (ISSN-L)
- PMC
- PMC9899323
- OpenAlex
- W4313379852
- Cited by
- 23
- References
- 101
- Citations by year
- 2026: 9 · 2025: 4 · 2024: 5 · 2023: 5
- FWCI
- 0.49
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- www.elsevier.com/legal/tdmrep-license (tdm)
- www.elsevier.com/open-access/userlicense/1.0/ (am, 324 d)
- doi.org/10.15223/policy-017 (stm-asf)
- doi.org/10.15223/policy-037 (stm-asf)
- doi.org/10.15223/policy-012 (stm-asf)
- doi.org/10.15223/policy-029 (stm-asf)
- doi.org/10.15223/policy-004 (stm-asf)
- Locations
- Progress in Neurobiology (acceptedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Mental Health (F31MH134582, R01MH119102)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Keywords
- sharp-wave ripples, hippocampal CA1, memory consolidation, episodic memory, slow-wave sleep, memory reactivation, synaptic plasticity
- MeSH terms
- Hippocampus, Humans, Sleep
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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