Cited by 23Memory and Neural MechanismsSleep and Wakefulness ResearchNeural dynamics and brain function

The two tales of hippocampal sharp-wave ripple content: The rigid and the plastic

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Hall, Arron F., Wang, Dong V.·2023·Progress in Neurobiology

Abstract

Sharp-wave ripples, prominently in the CA1 region of the hippocampus, are short oscillatory events accompanied by bursts of neural firing. Ripples and associated hippocampal place cell sequences communicate with cortical ensembles during slow-wave sleep, which has been shown to be critical for systems consolidation of episodic memories. This consolidation is not limited to a newly formed memory trace; instead, ripples appear to reactivate and consolidate memories spanning various experiences. Despite this broad spanning influence, ripples remain capable of producing precise memories. The underlying mechanisms that enable ripples to consolidate memories broadly and with specificity across experiences remain unknown. In this review, we discuss data that uncovers circuit-level processes that generate ripples and influence their characteristics during consolidation. Based on current knowledge, we propose that memory emerges from the integration of two parallel consolidation pathways in CA1: the rigid and plastic pathways. The rigid pathway generates ripples stochastically, providing a backbone upon which dynamic plastic pathway inputs carrying novel information are integrated.

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Crossref · 10.1016/j.pneurobio.2022.102396

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  • A large repertoire of ripple sequences pre-exists encounters with new environments.

    “the discovery of a large repertoire of ripple sequences that pre-exist encounters with new environments263”

    From Consciousness and sleep (2024) · cites this paper as [263]

    In “Integration of rigid and plastic pathways,” the review says ripples can preplay sequences not yet experienced and cites an estimate of at least 15 preplay motifs. It says a large repertoire of CA1 pre-configurations is implied by a recent study, but also notes controversy over preplay. Calling the large repertoire a discovery states more certainty than the source does. (LLM, conf=0.83)

    Experimental — accuracy not yet measured
  • Ripple sequences undergo differential amplification during encounters with new environments.

    “undergo differential amplification during those encounters”

    From Consciousness and sleep (2024) · cites this paper as [263]

    The Integration of rigid and plastic pathways section (page unavailable) says preplay sequences recruit fewer CA1 neurons than post-learning replays, and the Conclusions (page unavailable) propose that novel experiences strengthen connectivity and add information to existing ripple motifs. These passages support experience-related changes in ripple content, but do not establish that ripple sequences undergo differential amplification during encounters with new environments. (LLM, conf=0.79)

    Experimental — accuracy not yet measured

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Authors
Hall, A. F., & Wang, D. V.
Affiliations
Drexel University (US)
Corresponding author
Wang, Dong V.
Venue
Progress in Neurobiology
Publisher
Elsevier BV
Published
2023-02
Volume
221
Pages
102396
ISSN
0301-0082 (ISSN-L)
OpenAlex
W4313379852
Cited by
23
References
101
Citations by year
2026: 9 · 2025: 4 · 2024: 5 · 2023: 5
FWCI
0.49
Type
journal article
Language
en
Open access
Locations
  • Progress in Neurobiology (acceptedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
National Institute of Mental Health (F31MH134582, R01MH119102)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
Keywords
sharp-wave ripples, hippocampal CA1, memory consolidation, episodic memory, slow-wave sleep, memory reactivation, synaptic plasticity
MeSH terms
Hippocampus, Humans, Sleep

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